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BindingDB Data by Target and Substrate

Target NameSubstrate NameEnz. Inhib.
Data
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) cortisone 56
11-beta-Hydroxysteroid Dehydrogenase 2 (11-beta-HSD2) cortisol 38
17-beta-Hydroxysteroid Dehydrogenase 1 (17-beta-HSD1) 17beta-estradiol (E2) 3
Estrone (E1) 3
17-beta-Hydroxysteroid Dehydrogenase 5 (17-beta-HSD5, AKR1C3) 3alpha-Androstanediol 2
Androstenedione 3
Androsterone 2
testosterone 1
3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) AKT2 75
PDK1 Peptide Substrate 1
PDKtide 11
SGK1 15
3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Mutant (A162V) PDKtide 2
3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Mutant (E166D) PDKtide 2
3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Mutant (L159M) PDKtide 2
3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Mutant (T222A) PDKtide 2
3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Mutant (V143T) PDKtide 2
3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Mutant (V143T/T222A) PDKtide 2
ABL Biotinylated peptide substrate 14
biotinylated SB202190 7
[Val5]-Angiotensin II 30
ABL Mutant (E255K) biotinylated SB202190 7
ABL Mutant (F359V) biotinylated SB202190 7
ABL Mutant (H396P) biotinylated SB202190 7
ABL Mutant (M351T) biotinylated SB202190 7
ABL Mutant (Q252H) biotinylated SB202190 7
ABL Mutant (T315I) biotinylated SB202190 7
ABL Mutant (T315N) biotinylated SB202190 7
ABL Mutant (Y253F) biotinylated SB202190 7
Acetylcholinesterase (AChE) acetylcholine 93
acetylthiocholine 700
Activated Protein C (APC) Chromogenic Substrate S-2366 1
Adenosine A3 Receptor [3H]AB-MECA 29
Adenosine Deaminase Adenosine 5
Adenosine Kinase (AK) Adenosine 8
Adenosine Receptor A1 [3H]DPCPX 69
Adenosine Receptor A2A [3H]-ZM241385 59
[3H]NECA 29
Aldehyde Reductase (ALR1) D,L-glyceraldehyde 40
Aldose Reductase (ALR2) benzyl alcohol 15
D,L-glyceraldehyde 50
D-glyceraldehyde 77
D-xylose 4
xylitol 10
Aldose Reductase (ALR2) Mutant (C298A) benzyl alcohol 2
Aldose Reductase (ALR2) Mutant (C298A/W219Y) xylitol 12
Aldosterone Synthase (CYP11B2) deoxycorticosterone 94
alpha-Glucosidase (alpha-Glu) 4-methylumbelliferyl alpha-glucoside 14
alpha-Methylacyl-CoA Racemase (25S)-THC-CoA 10
Alpha2 Adrenoreceptor Clonidine 4
Androgen Receptor (AR) DHT 167
Mibolerone 62
Not Available 27
Testosterone 11
Angiotensin-Converting Enzyme Abz-Gly-p-nitro-Phe-Pro-OH 6
Mca-Ala-Ser-Asp-Lys-Dpa-OH 4
N-Cbz-Phe-His-Leu 29
Angiotensin-Converting Enzyme 2 Mca-APK(Dnp)OH 36
Anthrax Lethal Factor (LF) fluorogenic LF protease substrate III 21
MAPKKide 82
Peptide Substrate 50
Apoptosis Regulator Bcl-2 Fluorescein-labeled BAX peptide 52
Apoptosis Regulator Bcl-xL Fluorescein-labeled BAD peptide 52
Aromatase (CYP19) Androstenedione 279
Testosterone 60
Aurora Kinase A (Aurora-A) Biotinylated Peptide Substrate 11
CHOCKtide 35
Histone H3 23
Not Specified 1
Aurora Kinase B (Aurora-B) CHOCKtide 6
Not Specified 1
Aurora Kinase C (Aurora-C) Not Specified 1
B-RAF MEK-1 1
B-RAF Mutant (V599E) MEK-1 1
beta-Secretase (BACE-1) APP_NFEV 23
BACE Peptide Substrate 51
BACE Substrate Peptide 56
BACE-1 Peptide Substrate 16
BACE-1 Substrate Peptide 36
ELGY-9 7
fluorescent substrate FS-2 7
Fluorogenic Substrate 37
FS1 FRET Substrate 4
MBPAPPC125 30
beta-Secretase (BACE-2) BACE Peptide Substrate 5
BACE Substrate Peptide 7
Fluorogenic Substrate 12
Butyrylcholinesterase (BuChE) butyrylthiocholine 460
c-Kit Biotinylated Her2 Peptide Substrate 1
biotinylated peptide substrate 41
biotinylated synthetic peptide 39
Poly (E:Y) 1
poly(Glu:Tyr) 12
c-Kit Mutant (N822K) biotinylated SB202190 7
c-Kit Mutant (V559D) biotinylated SB202190 7
c-Kit Mutant (V559D/T670I) biotinylated SB202190 7
CaM Kinase II Autocamtide-2 38
CaM Kinase II Peptide Substrate 4
cAMP-Dependent Protein Kinase (PKA) biotinylated kemptide 30
histone (type H IIas) 15
histone (type Vs) 61
Histone H1 10
Histone type HL 67
Histone VII-S 13
ING Peptide 16
Kemptide 64
Lys-rich histone 97
Peptide Substrate 11
PKA Peptide Substrate 5
PKA-specific peptide substrate 21
stathmin 1
cAMP-Dependent Protein Kinase (PKA) Mutant PKAR1 (1) Kemptide 5
cAMP-Dependent Protein Kinase (PKA) Mutant PKAR1 (2) Kemptide 5
cAMP-Dependent Protein Kinase (PKA) Mutant PKAR1 (3) Kemptide 5
cAMP-Dependent Protein Kinase (PKA) Mutant PKAR1 (4) Kemptide 5
cAMP-Dependent Protein Kinase (PKA) Mutant PKAR2 (1) Kemptide 5
cAMP-Dependent Protein Kinase (PKA) Mutant PKAR2 (2) Kemptide 1
cAMP-Dependent Protein Kinase (PKA) Mutant PKAR2 (3) Kemptide 3
cAMP-Dependent Protein Kinase (PKA) Mutant PKAR3 Kemptide 5
cAMP-Dependent Protein Kinase (PKA) Mutant PKAR3 (1) Kemptide 5
cAMP-Dependent Protein Kinase (PKA) Mutant PKAR4 Kemptide 5
cAMP-Dependent Protein Kinase (PKA) Mutant PKAR5 Kemptide 5
Cannabinoid Receptor 1 [3H]CP55940 91
Cannabinoid Receptor 2 [3H]CP55940 91
Carbonic Anhydrase (hpCA) Carbon Dioxide 47
Carbonic Anhydrase I 4-nitrophenyl acetate 140
Carbon Dioxide 217
dansylamide 5
Carbonic Anhydrase II 4-nitrophenyl acetate 174
Carbon Dioxide 303
dansylamide 52
Carbonic Anhydrase II Mutant (F131V) dansylamide 11
Carbonic Anhydrase IV 4-nitrophenyl acetate 134
Carbon Dioxide 70
Carbonic Anhydrase IX Carbon Dioxide 206
Carbonic Anhydrase VA Carbon Dioxide 88
Carbonic Anhydrase VB Carbon Dioxide 42
Carbonic Anhydrase VII Carbon Dioxide 8
Carbonic Anhydrase XII Carbon Dioxide 8
Carbonic Anhydrase XIII Carbon Dioxide 6
Carbonic Anhydrase XIV Carbon Dioxide 8
Carboxypeptidase A (CPA) Furylacryloyl-Phe-Phe 15
Casein Kinase I Casein 8
CK1 Peptide Substrate 4
Casein Kinase II CK-2 Peptide Substrate 15
CK2 Peptide Substrate 1
stathmin 1
Caspase-1 Caspase-1 Fluorogenic Substrate 115
Caspase-1 Fluorogenic Substrate Ac-Trp-Glu-His-Asp-AFC 9
Fluorometric Tetrapeptide Ac-DEVD-AMC 1
Caspase-2 Caspase Substrate 7
Caspase-2 Fluorogenic Substrate 8
Caspase-2 Fluorogenic Substrate Ac-Val-Asp-Val-Ala-Asp-AFC 9
Caspase-3 Ac-DEVD-AFC 7
Caspase Fluorogenic Substrate 188
Caspase-3 (7) Fluorogenic Substrate 11
Caspase-3 Fluorogenic Substrate 35
Caspase-3 Fluorogenic Substrate Ac-Asp-Glu-Val-Asp-AFC 49
Caspase-3 Substrate 51
Fluorometric Tetrapeptide Ac-DEVD-AMC 1
Caspase-4 Caspase-4 Fluorogenic Substrate 8
Caspase-4 Fluorometric Substrate Ac-Trp-Glu-His-Asp-AFC 9
Caspase-5 Caspase-5 Fluorometric Substrate Ac-Trp-Glu-His-Asp-AFC 9
Caspase-6 Caspase Fluorogenic Substrate 8
Caspase Substrate 7
Caspase-6 Fluorogenic Substrate 29
Caspase-6 Fluorometric Substrate Ac-Val-Glu-Ile-Asp-AFC 9
Caspase-7 Caspase Fluorogenic Substrate 85
Caspase Substrate 7
Caspase-3 (7) Fluorogenic Substrate 11
Caspase-7 Fluorometric Substrate Ac-Asp-Glu-Val-Asp-AFC 9
Caspase-8 Caspase Substrate 7
Caspase-8 Fluorogenic Substrate 96
Caspase-8 Fluorometric Substrate Ac-Ile-Glu-Thr-Asp-AFC 9
Caspase-9 Caspase-9 Fluorogenic Substrate 8
Cathepsin B Boc-Leu-Lys-Arg-AMC 100
Cbz-Phe-Arg-AMC 36
Z-Phe-Arg-NMec 13
Cathepsin D Cathepsin D FRET Substrate 1
Cathepsin D Peptide Substrate 46
Cathepsin D/Pepsin Peptide Substrate 5
Peptide Substrate 104
Cathepsin K Ac-Lys-His-Pro-Lys-ACMC 170
Cbz-Leu-Arg-AMC 173
Cbz-Phe-Arg-AMC 103
Z-Leu-Arg-NHMec 48
Cathepsin L Ac-His-Lys-Phe-Lys-ACMC 170
Cbz-Leu-Arg-AMC 100
Cbz-Phe-Arg-AMC 76
Cbz-Phe-Arg-MCA 13
Z-Phe-Arg-NHMec 52
Cathepsin S Ac-His-Pro-Val-Lys-ACMC 180
Cbz-Leu-Arg-AMC 8
Cbz-Phe-Arg-AMC 9
Z-Leu-Leu-Arg-AMC 32
Z-Val-Val-Arg-AMC 130
Z-Val-Val-Arg-NHMec 48
Cathepsin V Cbz-Phe-Arg-AMC 2
cFMS Tyrosine Kinase Biotinylated Her2 Peptide Substrate 1
cFMS 9
cFMS Tyrosine Kinase Mutant (FGFR KID Chimera) cFMS -FGFR Chimera 7
cFMS Tyrosine Kinase Mutant (Tie2 KID Chimera) cFMS -Tie-2 Chimera 7
cGMP-Dependent Protein Kinase Histone H1 10
Histone II-A 13
Checkpoint Kinase (Chk1) biotinylated cdc25c peptide substrate 2
Biotinylated Peptide Substrate 24
Cdc25C peptide substrate 124
Chktide 31
Synthetic Chk1 Peptide Substrate 3
Chitinase fluorogenic substrate 12
Not Available 3
Chitinase Mutant (A217G) Not Available 3
Chitinase Mutant (D175A) Not Available 3
Chitinase Mutant (D246A) Not Available 1
Chitinase Mutant (E177A) Not Available 1
Chitinase Mutant (E322A) Not Available 3
Chitinase Mutant (M243A) Not Available 3
Chitinase Mutant (R301K) Not Available 3
Chitinase Mutant (T138A) Not Available 3
Chitinase Mutant (Y245F) Not Available 2
Cholecystokinin-1 Receptor [125I]CCK-8 17
Cholecystokinin-2 Receptor [125I]CCK-8 17
Chymase Chymase/Chymotrypsin Chromogenic Substrate 2
Chymotrypsin Chymase/Chymotrypsin Chromogenic Substrate 2
cIAP1-BIR3 AVP-diPhe-FAM 3
cIAP2-BIR3 AVP-diPhe-FAM 3
Collagenase (ChC) Collagenase Substrate 187
Corticotropin-releasing Factor Receptor 1 radioligand [125I]-CRF 61
CSF1-R biotinylated peptide substrate 4
Cyclin-Dependent Kinase 1 (CDK1) biotinylated CDK peptide substrate 3
Biotinylated CDK1 Peptide Substrate 99
Biotinylated peptide substrate 4
GST-Rb fusion protein 85
Histidine-tagged retinoblastoma protein 26
Histone H1 623
Peptide Substrate 102
S1 peptide 5
Cyclin-Dependent Kinase 2 (CDK2) biotinylated CDK peptide substrate 3
Biotinylated Peptide Substrate 15
Biotinylated peptide substrate 76
CDK2 biotinylated peptide substrate 4
CDKtide 3
GST-Rb fusion protein 675
Histidine-tagged Rb 68
Histidine-tagged retinoblastoma protein 26
Histone H1 473
ING Peptide 144
Peptide Substrate 132
Rb(21) 8
S1 peptide 13
Cyclin-Dependent Kinase 2 (CDK2) Mutant (F82H) Histone H1 1
Cyclin-Dependent Kinase 2 (CDK2) Mutant (F82H/L83V/H84D) Histone H1 2
Cyclin-Dependent Kinase 2 (CDK2) Mutant (F82H/L83V/H84D/K89T) Histone H1 2
Cyclin-Dependent Kinase 2 (CDK2) Mutant (K89T) Histone H1 2
Cyclin-Dependent Kinase 2 (CDK2) Mutant (L83V/H84D) Histone H1 1
Cyclin-Dependent Kinase 4 (CDK4) Biotinylated Peptide Substrate 30
G1 peptide 43
GST-Rb fusion protein 665
Histidine-tagged retinoblastoma protein 26
Histone H1 9
ING Peptide 160
Rb 1
Rb(21) 95
Retinoblastoma (Rb) 13
Cyclin-Dependent Kinase 5 (CDK5) Histone H1 294
Cyclin-Dependent Kinase 6 (CDK6) G1 peptide 1
Histone H1 7
Cyclin-Dependent Kinase 7 (CDK7) Biotinylated Peptide Substrate 7
FAM-CDK7 derived peptide 18
Cyclin-Dependent Kinase 9 (CDK9) Biotinylated Peptide Substrate 7
Cytochrome P450 1A2 Ethoxyresorufin 1
Cytochrome P450 2A6 Coumarin 31
Cytochrome P450 2C19 S-Mephenytoin 1
Cytochrome P450 2C9 Diclofenac 1
MFC 21
Cytochrome P450 2D6 Bufuralol 1
Cytochrome P450 3A4 BFC 21
Midazolam 1
Testosterone