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Target Names
Target Sequence
Compound Name
Target Names &
Ki
IC50
Kd
EC50
ΔG°
ΔH°
-TΔS°
pH (Enzymatic Assay)
pH (ITC)
Substrate or Competitor
Compound Mol. Wt.
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Chemical Structure
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All Compounds
Target Names &
Ki
IC50
Kd
EC50
ΔG°
ΔH°
-TΔS°
Virtual Screening
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Enter Data
ITC
Enzyme Inhibition
Continue Deposition
Sent Commments
BindingDB Data by Target and Substrate
Target Name
Substrate Name
Enz. Inhib.
Data
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)
cortisone
56
11-beta-Hydroxysteroid Dehydrogenase 2 (11-beta-HSD2)
cortisol
38
17-beta-Hydroxysteroid Dehydrogenase 1 (17-beta-HSD1)
17beta-estradiol (E2)
3
Estrone (E1)
3
17-beta-Hydroxysteroid Dehydrogenase 5 (17-beta-HSD5, AKR1C3)
3alpha-Androstanediol
2
Androstenedione
3
Androsterone
2
testosterone
1
3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1)
AKT2
75
PDK1 Peptide Substrate
1
PDKtide
11
SGK1
15
3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Mutant (A162V)
PDKtide
2
3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Mutant (E166D)
PDKtide
2
3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Mutant (L159M)
PDKtide
2
3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Mutant (T222A)
PDKtide
2
3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Mutant (V143T)
PDKtide
2
3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Mutant (V143T/T222A)
PDKtide
2
ABL
Biotinylated peptide substrate
14
biotinylated SB202190
7
[Val5]-Angiotensin II
30
ABL Mutant (E255K)
biotinylated SB202190
7
ABL Mutant (F359V)
biotinylated SB202190
7
ABL Mutant (H396P)
biotinylated SB202190
7
ABL Mutant (M351T)
biotinylated SB202190
7
ABL Mutant (Q252H)
biotinylated SB202190
7
ABL Mutant (T315I)
biotinylated SB202190
7
ABL Mutant (T315N)
biotinylated SB202190
7
ABL Mutant (Y253F)
biotinylated SB202190
7
Acetylcholinesterase (AChE)
acetylcholine
93
acetylthiocholine
700
Activated Protein C (APC)
Chromogenic Substrate S-2366
1
Adenosine A3 Receptor
[3H]AB-MECA
29
Adenosine Deaminase
Adenosine
5
Adenosine Kinase (AK)
Adenosine
8
Adenosine Receptor A1
[3H]DPCPX
69
Adenosine Receptor A2A
[3H]-ZM241385
59
[3H]NECA
29
Aldehyde Reductase (ALR1)
D,L-glyceraldehyde
40
Aldose Reductase (ALR2)
benzyl alcohol
15
D,L-glyceraldehyde
50
D-glyceraldehyde
77
D-xylose
4
xylitol
10
Aldose Reductase (ALR2) Mutant (C298A)
benzyl alcohol
2
Aldose Reductase (ALR2) Mutant (C298A/W219Y)
xylitol
12
Aldosterone Synthase (CYP11B2)
deoxycorticosterone
94
alpha-Glucosidase (alpha-Glu)
4-methylumbelliferyl alpha-glucoside
14
alpha-Methylacyl-CoA Racemase
(25S)-THC-CoA
10
Alpha2 Adrenoreceptor
Clonidine
4
Androgen Receptor (AR)
DHT
167
Mibolerone
62
Not Available
27
Testosterone
11
Angiotensin-Converting Enzyme
Abz-Gly-p-nitro-Phe-Pro-OH
6
Mca-Ala-Ser-Asp-Lys-Dpa-OH
4
N-Cbz-Phe-His-Leu
29
Angiotensin-Converting Enzyme 2
Mca-APK(Dnp)OH
36
Anthrax Lethal Factor (LF)
fluorogenic LF protease substrate III
21
MAPKKide
82
Peptide Substrate
50
Apoptosis Regulator Bcl-2
Fluorescein-labeled BAX peptide
52
Apoptosis Regulator Bcl-xL
Fluorescein-labeled BAD peptide
52
Aromatase (CYP19)
Androstenedione
279
Testosterone
60
Aurora Kinase A (Aurora-A)
Biotinylated Peptide Substrate
11
CHOCKtide
35
Histone H3
23
Not Specified
1
Aurora Kinase B (Aurora-B)
CHOCKtide
6
Not Specified
1
Aurora Kinase C (Aurora-C)
Not Specified
1
B-RAF
MEK-1
1
B-RAF Mutant (V599E)
MEK-1
1
beta-Secretase (BACE-1)
APP_NFEV
23
BACE Peptide Substrate
51
BACE Substrate Peptide
56
BACE-1 Peptide Substrate
16
BACE-1 Substrate Peptide
36
ELGY-9
7
fluorescent substrate FS-2
7
Fluorogenic Substrate
37
FS1 FRET Substrate
4
MBPAPPC125
30
beta-Secretase (BACE-2)
BACE Peptide Substrate
5
BACE Substrate Peptide
7
Fluorogenic Substrate
12
Butyrylcholinesterase (BuChE)
butyrylthiocholine
460
c-Kit
Biotinylated Her2 Peptide Substrate
1
biotinylated peptide substrate
41
biotinylated synthetic peptide
39
Poly (E:Y)
1
poly(Glu:Tyr)
12
c-Kit Mutant (N822K)
biotinylated SB202190
7
c-Kit Mutant (V559D)
biotinylated SB202190
7
c-Kit Mutant (V559D/T670I)
biotinylated SB202190
7
CaM Kinase II
Autocamtide-2
38
CaM Kinase II Peptide Substrate
4
cAMP-Dependent Protein Kinase (PKA)
biotinylated kemptide
30
histone (type H IIas)
15
histone (type Vs)
61
Histone H1
10
Histone type HL
67
Histone VII-S
13
ING Peptide
16
Kemptide
64
Lys-rich histone
97
Peptide Substrate
11
PKA Peptide Substrate
5
PKA-specific peptide substrate
21
stathmin
1
cAMP-Dependent Protein Kinase (PKA) Mutant PKAR1 (1)
Kemptide
5
cAMP-Dependent Protein Kinase (PKA) Mutant PKAR1 (2)
Kemptide
5
cAMP-Dependent Protein Kinase (PKA) Mutant PKAR1 (3)
Kemptide
5
cAMP-Dependent Protein Kinase (PKA) Mutant PKAR1 (4)
Kemptide
5
cAMP-Dependent Protein Kinase (PKA) Mutant PKAR2 (1)
Kemptide
5
cAMP-Dependent Protein Kinase (PKA) Mutant PKAR2 (2)
Kemptide
1
cAMP-Dependent Protein Kinase (PKA) Mutant PKAR2 (3)
Kemptide
3
cAMP-Dependent Protein Kinase (PKA) Mutant PKAR3
Kemptide
5
cAMP-Dependent Protein Kinase (PKA) Mutant PKAR3 (1)
Kemptide
5
cAMP-Dependent Protein Kinase (PKA) Mutant PKAR4
Kemptide
5
cAMP-Dependent Protein Kinase (PKA) Mutant PKAR5
Kemptide
5
Cannabinoid Receptor 1
[3H]CP55940
91
Cannabinoid Receptor 2
[3H]CP55940
91
Carbonic Anhydrase (hpCA)
Carbon Dioxide
47
Carbonic Anhydrase I
4-nitrophenyl acetate
140
Carbon Dioxide
217
dansylamide
5
Carbonic Anhydrase II
4-nitrophenyl acetate
174
Carbon Dioxide
303
dansylamide
52
Carbonic Anhydrase II Mutant (F131V)
dansylamide
11
Carbonic Anhydrase IV
4-nitrophenyl acetate
134
Carbon Dioxide
70
Carbonic Anhydrase IX
Carbon Dioxide
206
Carbonic Anhydrase VA
Carbon Dioxide
88
Carbonic Anhydrase VB
Carbon Dioxide
42
Carbonic Anhydrase VII
Carbon Dioxide
8
Carbonic Anhydrase XII
Carbon Dioxide
8
Carbonic Anhydrase XIII
Carbon Dioxide
6
Carbonic Anhydrase XIV
Carbon Dioxide
8
Carboxypeptidase A (CPA)
Furylacryloyl-Phe-Phe
15
Casein Kinase I
Casein
8
CK1 Peptide Substrate
4
Casein Kinase II
CK-2 Peptide Substrate
15
CK2 Peptide Substrate
1
stathmin
1
Caspase-1
Caspase-1 Fluorogenic Substrate
115
Caspase-1 Fluorogenic Substrate Ac-Trp-Glu-His-Asp-AFC
9
Fluorometric Tetrapeptide Ac-DEVD-AMC
1
Caspase-2
Caspase Substrate
7
Caspase-2 Fluorogenic Substrate
8
Caspase-2 Fluorogenic Substrate Ac-Val-Asp-Val-Ala-Asp-AFC
9
Caspase-3
Ac-DEVD-AFC
7
Caspase Fluorogenic Substrate
188
Caspase-3 (7) Fluorogenic Substrate
11
Caspase-3 Fluorogenic Substrate
35
Caspase-3 Fluorogenic Substrate Ac-Asp-Glu-Val-Asp-AFC
49
Caspase-3 Substrate
51
Fluorometric Tetrapeptide Ac-DEVD-AMC
1
Caspase-4
Caspase-4 Fluorogenic Substrate
8
Caspase-4 Fluorometric Substrate Ac-Trp-Glu-His-Asp-AFC
9
Caspase-5
Caspase-5 Fluorometric Substrate Ac-Trp-Glu-His-Asp-AFC
9
Caspase-6
Caspase Fluorogenic Substrate
8
Caspase Substrate
7
Caspase-6 Fluorogenic Substrate
29
Caspase-6 Fluorometric Substrate Ac-Val-Glu-Ile-Asp-AFC
9
Caspase-7
Caspase Fluorogenic Substrate
85
Caspase Substrate
7
Caspase-3 (7) Fluorogenic Substrate
11
Caspase-7 Fluorometric Substrate Ac-Asp-Glu-Val-Asp-AFC
9
Caspase-8
Caspase Substrate
7
Caspase-8 Fluorogenic Substrate
96
Caspase-8 Fluorometric Substrate Ac-Ile-Glu-Thr-Asp-AFC
9
Caspase-9
Caspase-9 Fluorogenic Substrate
8
Cathepsin B
Boc-Leu-Lys-Arg-AMC
100
Cbz-Phe-Arg-AMC
36
Z-Phe-Arg-NMec
13
Cathepsin D
Cathepsin D FRET Substrate
1
Cathepsin D Peptide Substrate
46
Cathepsin D/Pepsin Peptide Substrate
5
Peptide Substrate
104
Cathepsin K
Ac-Lys-His-Pro-Lys-ACMC
170
Cbz-Leu-Arg-AMC
173
Cbz-Phe-Arg-AMC
103
Z-Leu-Arg-NHMec
48
Cathepsin L
Ac-His-Lys-Phe-Lys-ACMC
170
Cbz-Leu-Arg-AMC
100
Cbz-Phe-Arg-AMC
76
Cbz-Phe-Arg-MCA
13
Z-Phe-Arg-NHMec
52
Cathepsin S
Ac-His-Pro-Val-Lys-ACMC
180
Cbz-Leu-Arg-AMC
8
Cbz-Phe-Arg-AMC
9
Z-Leu-Leu-Arg-AMC
32
Z-Val-Val-Arg-AMC
130
Z-Val-Val-Arg-NHMec
48
Cathepsin V
Cbz-Phe-Arg-AMC
2
cFMS Tyrosine Kinase
Biotinylated Her2 Peptide Substrate
1
cFMS
9
cFMS Tyrosine Kinase Mutant (FGFR KID Chimera)
cFMS -FGFR Chimera
7
cFMS Tyrosine Kinase Mutant (Tie2 KID Chimera)
cFMS -Tie-2 Chimera
7
cGMP-Dependent Protein Kinase
Histone H1
10
Histone II-A
13
Checkpoint Kinase (Chk1)
biotinylated cdc25c peptide substrate
2
Biotinylated Peptide Substrate
24
Cdc25C peptide substrate
124
Chktide
31
Synthetic Chk1 Peptide Substrate
3
Chitinase
fluorogenic substrate
12
Not Available
3
Chitinase Mutant (A217G)
Not Available
3
Chitinase Mutant (D175A)
Not Available
3
Chitinase Mutant (D246A)
Not Available
1
Chitinase Mutant (E177A)
Not Available
1
Chitinase Mutant (E322A)
Not Available
3
Chitinase Mutant (M243A)
Not Available
3
Chitinase Mutant (R301K)
Not Available
3
Chitinase Mutant (T138A)
Not Available
3
Chitinase Mutant (Y245F)
Not Available
2
Cholecystokinin-1 Receptor
[125I]CCK-8
17
Cholecystokinin-2 Receptor
[125I]CCK-8
17
Chymase
Chymase/Chymotrypsin Chromogenic Substrate
2
Chymotrypsin
Chymase/Chymotrypsin Chromogenic Substrate
2
cIAP1-BIR3
AVP-diPhe-FAM
3
cIAP2-BIR3
AVP-diPhe-FAM
3
Collagenase (ChC)
Collagenase Substrate
187
Corticotropin-releasing Factor Receptor 1
radioligand [125I]-CRF
61
CSF1-R
biotinylated peptide substrate
4
Cyclin-Dependent Kinase 1 (CDK1)
biotinylated CDK peptide substrate
3
Biotinylated CDK1 Peptide Substrate
99
Biotinylated peptide substrate
4
GST-Rb fusion protein
85
Histidine-tagged retinoblastoma protein
26
Histone H1
623
Peptide Substrate
102
S1 peptide
5
Cyclin-Dependent Kinase 2 (CDK2)
biotinylated CDK peptide substrate
3
Biotinylated Peptide Substrate
15
Biotinylated peptide substrate
76
CDK2 biotinylated peptide substrate
4
CDKtide
3
GST-Rb fusion protein
675
Histidine-tagged Rb
68
Histidine-tagged retinoblastoma protein
26
Histone H1
473
ING Peptide
144
Peptide Substrate
132
Rb(21)
8
S1 peptide
13
Cyclin-Dependent Kinase 2 (CDK2) Mutant (F82H)
Histone H1
1
Cyclin-Dependent Kinase 2 (CDK2) Mutant (F82H/L83V/H84D)
Histone H1
2
Cyclin-Dependent Kinase 2 (CDK2) Mutant (F82H/L83V/H84D/K89T)
Histone H1
2
Cyclin-Dependent Kinase 2 (CDK2) Mutant (K89T)
Histone H1
2
Cyclin-Dependent Kinase 2 (CDK2) Mutant (L83V/H84D)
Histone H1
1
Cyclin-Dependent Kinase 4 (CDK4)
Biotinylated Peptide Substrate
30
G1 peptide
43
GST-Rb fusion protein
665
Histidine-tagged retinoblastoma protein
26
Histone H1
9
ING Peptide
160
Rb
1
Rb(21)
95
Retinoblastoma (Rb)
13
Cyclin-Dependent Kinase 5 (CDK5)
Histone H1
294
Cyclin-Dependent Kinase 6 (CDK6)
G1 peptide
1
Histone H1
7
Cyclin-Dependent Kinase 7 (CDK7)
Biotinylated Peptide Substrate
7
FAM-CDK7 derived peptide
18
Cyclin-Dependent Kinase 9 (CDK9)
Biotinylated Peptide Substrate
7
Cytochrome P450 1A2
Ethoxyresorufin
1
Cytochrome P450 2A6
Coumarin
31
Cytochrome P450 2C19
S-Mephenytoin
1
Cytochrome P450 2C9
Diclofenac
1
MFC
21
Cytochrome P450 2D6
Bufuralol
1
Cytochrome P450 3A4
BFC
21
Midazolam
1
Testosterone