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11997326 7 Identification of lactate as a driving force for prostanoid transport by prostaglandin transporter PGT.EBI Am J Physiol Renal Physiol 282: 1097-102 (2002) Albert Einstein College of Medicine 2D 3D TSV
11992791 53 Solid-phase synthesis of FKBP12 inhibitors: N-sulfonyl and N-carbamoylprolyl/pipecolyl amides.EBI Bioorg Med Chem Lett 12: 1429-33 (2002) Guilford Pharmaceuticals Inc. 2D 3D TSV
11992790 40 Use of parallel-synthesis combinatorial libraries for rapid identification of potent FKBP12 inhibitors.EBI Bioorg Med Chem Lett 12: 1421-8 (2002) Guilford Pharmaceuticals Inc. 2D 3D TSV
11992789 2 Aromatic farnesyl diphosphate analogues: vinyl triflate-mediated synthesis and preliminary enzymatic evaluation.EBI Bioorg Med Chem Lett 12: 1417-20 (2002) Wayne State University 2D 3D TSV
11992787 37 Identification of potent and selective oxytocin antagonists. Part 2: further investigation of benzofuran derivatives.EBI Bioorg Med Chem Lett 12: 1405-11 (2002) GlaxoSmithKline 2D 3D TSV
11992786 42 Identification of potent and selective oxytocin antagonists. Part 1: indole and benzofuran derivatives.EBI Bioorg Med Chem Lett 12: 1399-404 (2002) GlaxoSmithKline 2D 3D TSV
11992783 78 Synthesis and biological activity of selective pipecolic acid-based TNF-alpha converting enzyme (TACE) inhibitors.EBI Bioorg Med Chem Lett 12: 1387-90 (2002) Pfizer Global Research and Development 2D 3D TSV
11992782 6 Syntheses and bioactivities of novel carbamates combining platelet activating factor (PAF) receptor antagonist with thromboxane synthase inhibitor (TxSI).EBI Bioorg Med Chem Lett 12: 1383-6 (2002) Nikken Chemicals Co., Ltd. 2D 3D TSV
11992781 31 Synthesis of highly potent and selective hetaryl ureas as integrin alpha(V)beta3-receptor antagonists.EBI Bioorg Med Chem Lett 12: 1379-82 (2002) BASF AG 2D 3D TSV
11992780 1 Shikonin derivatives: synthesis and inhibition of human telomerase.EBI Bioorg Med Chem Lett 12: 1375-8 (2002) Chinese Academy of Science 2D 3D TSV
11992778 26 Structure-based design of peptidomimetic antagonists of p56(lck) SH2 domain.EBI Bioorg Med Chem Lett 12: 1365-9 (2002) Roche Products Limited 2D 3D TSV
11992777 46 Discovery and initial SAR of imidazoquinoxalines as inhibitors of the Src-family kinase p56(Lck).EBI Bioorg Med Chem Lett 12: 1361-4 (2002) Bristol Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
11992776 70 Bicyclic piperazinylbenzenesulphonamides are potent and selective 5-HT6 receptor antagonists.EBI Bioorg Med Chem Lett 12: 1357-60 (2002) GlaxoSmithKline 2D 3D TSV
11992773 10 Design, synthesis and biochemical evaluation of AC ring mimics as novel inhibitors of the enzyme estrone sulfatase (ES).EBI Bioorg Med Chem Lett 12: 1343-6 (2002) Kingston University 2D 3D TSV
11992772 34 A novel type of nonsteroidal estrone sulfatase inhibitors.EBI Bioorg Med Chem Lett 12: 1339-42 (2002) Hans-Kn�ll Institute of Natural Products Research 2D 3D TSV
11992771 19 Discovery of phenyl alanine derived ketoamides carrying benzoyl residues as novel calpain inhibitors.EBI Bioorg Med Chem Lett 12: 1335-8 (2002) Abbott GmbH&Co. KG 2D 3D TSV
11992769 93 Design and synthesis of a piperazinylalkylisoxazole library for subtype selective dopamine receptor ligands.EBI Bioorg Med Chem Lett 12: 1327-30 (2002) Institute of Science and Technology 2D 3D TSV
11985477 20 Design and synthesis of a novel series of 1,2-disubstituted cyclopentanes as small, potent potentiators of 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic acid (AMPA) receptors.EBI J Med Chem 45: 2101-11 (2002) NPS Allelix Corporation 2D 3D TSV
11985476 35 Adenine nucleotide analogues locked in a Northern methanocarba conformation: enhanced stability and potency as P2Y(1) receptor agonists.EBI J Med Chem 45: 2090-100 (2002) National Institute of Diabetes 2D 3D TSV
11985472 185 Structure-activity relationships of a novel class of endothelin-A receptor antagonists and discovery of potent and selective receptor antagonist, 2-(benzo[1,3]dioxol-5-yl)-6-isopropyloxy-4-(4-methoxyphenyl)-2H-chromene-3-carboxylic acid (S-1255). 1. Study on structure-activity relationships and basEBI J Med Chem 45: 2041-55 (2002) Shionogi & Co., Ltd. 2D 3D TSV
11985469 22 Structure-based design of a parallel synthetic array directed toward the discovery of irreversible inhibitors of human rhinovirus 3C protease.EBI J Med Chem 45: 2016-23 (2002) Pfizer Global R&D-La Jolla/Agouron Pharmaceuticals 2D 3D TSV
11985468 21 Synthesis, in vitro receptor binding, and in vivo evaluation of fluorescein and carbocyanine peptide-based optical contrast agents.EBI J Med Chem 45: 2003-15 (2002) Washington University School of Medicine 2D 3D TSV
11985465 22 Solid-phase library synthesis, screening, and selection of tight-binding reduced peptide bond inhibitors of a recombinant Leishmania mexicana cysteine protease B.EBI J Med Chem 45: 1971-82 (2002) Carlsberg Laboratory 2D 3D TSV
11985463 12 Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines.BDB J Med Chem 45: 1963-6 (2002) GlaxoSmithKline 2D 3D TSV
11985462 3 Nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase with potent antibacterial activity against gram-positive pathogens.EBI J Med Chem 45: 1959-62 (2002) TBA 2D 3D TSV
11983514 17 Pyrazolo[3,4-b]quinoxalines. A new class of cyclin-dependent kinases inhibitors.BDB Bioorg Med Chem 10: 2177-84 (2002) Universidad de Navarra 2D 3D TSV
11983334 6 Aminoglycosides modified by resistance enzymes display diminished binding to the bacterial ribosomal aminoacyl-tRNA site.BDB Chem Biol 9: 455-63 (2002) Wayne State University 2D 3D TSV
11975521 2 Haploscleridamine, a novel tryptamine-derived alkaloid from a sponge of the order haplosclerida: an inhibitor of cathepsin K.EBI J Nat Prod 65: 628-9 (2002) Millennium Pharmaceuticals Inc. 2D 3D TSV
11975520 3 A new dimeric dihydrochalcone and a new prenylated flavone from the bud covers of Artocarpus altilis: potent inhibitors of cathepsin K.EBI J Nat Prod 65: 624-7 (2002) Millennium Pharmaceuticals Inc. 2D 3D TSV
11975517 3 Two new furanoditerpenes from Saururus chinenesis and their effects on the activation of peroxisome proliferator-activated receptor gamma.EBI J Nat Prod 65: 616-7 (2002) Korea Research Institute of Bioscience and Biotechnology 2D 3D TSV
11975483 10 New antiinfective and human 5-HT2 receptor binding natural and semisynthetic compounds from the Jamaican sponge Smenospongia aurea.EBI J Nat Prod 65: 476-80 (2002) The University of Mississippi 2D 3D TSV
11975475 1 Synthesis and biological evaluation of hyperforin analogues. Part I. Modification of the enolized cyclohexanedione moiety.EBI J Nat Prod 65: 433-8 (2002) Universit£ di Milano 2D 3D TSV
11965381 22 Novel diamide-based inhibitors of IMPDH.EBI Bioorg Med Chem Lett 12: 1323-6 (2002) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
11965379 94 Enantiospecific, selective cyclooxygenase-2 inhibitors.EBI Bioorg Med Chem Lett 12: 1315-8 (2002) Vanderbilt University School of Medicine 2D 3D TSV
11965378 78 Benzimidazole-based fXa inhibitors with improved thrombin and trypsin selectivity.EBI Bioorg Med Chem Lett 12: 1311-4 (2002) Berlex Biosciences 2D 3D TSV
11965377 66 Design and synthesis of aminophenol-based factor Xa inhibitors.EBI Bioorg Med Chem Lett 12: 1307-10 (2002) Berlex Biosciences 2D 3D TSV
11965376 19 Optimization of the 4-aryl group of 4-aryl-pyridine glucagon antagonists: development of an efficient, alternative synthesis.EBI Bioorg Med Chem Lett 12: 1303-6 (2002) Bayer Research Center 2D 3D TSV
11965374 43 Small ligands interacting with the phosphotyrosine binding pocket of the Src SH2 protein.EBI Bioorg Med Chem Lett 12: 1295-8 (2002) Aventis Pharma 2D 3D TSV
11965373 30 Discovery of highly potent Src SH2 binders: structure-activity studies and X-ray structures.EBI Bioorg Med Chem Lett 12: 1291-4 (2002) Aventis Pharma 2D 3D TSV
11965372 4 Imidazole-based ligands of the Src SH2 protein.EBI Bioorg Med Chem Lett 12: 1287-9 (2002) Aventis Pharma 2D 3D TSV
11965371 4 Synthesis of a novel fluorescent probe for estrogen receptor.EBI Bioorg Med Chem Lett 12: 1283-5 (2002) Abbott Laboratories 2D 3D TSV
11965370 18 The mechanism of the irreversible inhibition of estrone sulfatase (ES) through the consideration of a range of methane- and amino-sulfonate-based compounds.EBI Bioorg Med Chem Lett 12: 1279-82 (2002) Kingston University 2D 3D TSV
11965369 10 Design, synthesis and biological activity of novel non-peptidyl endothelin converting enzyme inhibitors, 1-phenyl-tetrazole-formazan analogues.EBI Bioorg Med Chem Lett 12: 1275-8 (2002) Sumitomo Pharmaceuticals Co., Ltd. 2D 3D TSV
11965368 64 Potent inhibitors of farnesyltransferase and geranylgeranyltransferase-I.EBI Bioorg Med Chem Lett 12: 1269-73 (2002) Merck Research Laboratories 2D 3D TSV
11965364 36 Enantioselective synthesis of S-(+)-2beta-carboalkoxy-3alpha-[bis(4-fluorophenyl)methoxy]tropanes as novel probes for the dopamine transporter.EBI Bioorg Med Chem Lett 12: 1249-52 (2002) National Institute on Drug Abuse-Intramural Research Program 2D 3D TSV
11965363 11 Structure-activity relationships for mini atrial natriuretic peptide by proline-scanning mutagenesis and shortening of peptide backbone.EBI Bioorg Med Chem Lett 12: 1245-7 (2002) Institute for Bioorganic Research 2D 3D TSV
11965361 1 Synthesis of a molecular mimic of the Glc1Man9 oligoside as potential inhibitor of calnexin binding to DeltaF508 CFTR protein.EBI Bioorg Med Chem Lett 12: 1237-40 (2002) UMR 176 CNRS-Institut Curie 2D 3D TSV
11964599 4 Interaction of morphine, fentanyl, sufentanil, alfentanil, and loperamide with the efflux drug transporter P-glycoprotein.EBI Anesthesiology 96: 913-20 (2002) Vanderbilt University 2D 3D TSV
11961113 36 Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein.EBI Mol Pharmacol 61: 964-73 (2002) Lilly Research Laboratories 2D 3D TSV
11961071 4 Agonist, antagonist, and inverse agonist characteristics of TIPP (H-Tyr-Tic-Phe-Phe-OH), a selective delta-opioid receptor ligand.BDB J Pharmacol Exp Ther 301: 661-71 (2002) University of Arkansas 2D 3D TSV
11961053 26 Biochemical and behavioral characterization of novel methylphenidate analogs.BDB J Pharmacol Exp Ther 301: 527-35 (2002) Mercer University 2D 3D TSV
11960504 14 Synthesis of N-[4-[1-ethyl-2-(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid as an antifolate.EBI J Med Chem 45: 1942-8 (2002) Duquesne University 2D 3D TSV
11960503 140 Further studies on conformationally constrained tricyclic tropane analogues and their uptake inhibition at monoamine transporter sites: synthesis of (Z)-9-(substituted arylmethylene)-7-azatricyclo[4.3.1.0(3,7)]decanes as a novel class of serotonin transporter inhibitors.EBI J Med Chem 45: 1930-41 (2002) Georgetown University Medical Center 2D 3D TSV
11960501 1 Synthesis and biological evaluation of structurally highly modified analogues of the antimitotic natural product curacin A.EBI J Med Chem 45: 1901-17 (2002) University of Pittsburgh 2D 3D TSV
11960500 109 3-Heteroaryl-2-pyridones: benzodiazepine site ligands with functional delectivity for alpha 2/alpha 3-subtypes of human GABA(A) receptor-ion channels.EBI J Med Chem 45: 1887-900 (2002) Merck Sharp & Dohme Research Laboratories 2D 3D TSV
11960499 7 Halogenated diazirines as photolabel mimics of the inhaled haloalkane anesthetics.EBI J Med Chem 45: 1879-86 (2002) University of Pennsylvania Health System 2D 3D TSV
11960497 36 Synthesis of nitroindole derivatives with high affinity and selectivity for melatoninergic binding sites MT(3).EBI J Med Chem 45: 1853-9 (2002) Institut de Chimie Pharmaceutique Albert Lespagnol 2D 3D TSV
11960496 50 5'-Deoxy congeners of 9-(3-amido-3-deoxy-beta-D-xylofuranosyl)-N(6)-cyclopentyladenine: new adenosine A(1) receptor antagonists and inverse agonists.EBI J Med Chem 45: 1845-52 (2002) Ghent University 2D 3D TSV
11960491 22 Identification of nonpeptidic urotensin II receptor antagonists by virtual screening based on a pharmacophore model derived from structure-activity relationships and nuclear magnetic resonance studies on urotensin II.EBI J Med Chem 45: 1799-805 (2002) Aventis Pharma Germany GmbH 2D 3D TSV
11960490 3 Investigation of potential bioisosteric replacements for the carboxyl groups of peptidomimetic inhibitors of protein tyrosine phosphatase 1B: identification of a tetrazole-containing inhibitor with cellular activity.EBI J Med Chem 45: 1785-98 (2002) Biovitrum AB 2D 3D TSV
11960489 10 Binding mode analysis of 3-(4-benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: a new synthetic histone deacetylase inhibitor inducing histone hyperacetylation, growth inhibition, and terminal cell differentiation.EBI J Med Chem 45: 1778-84 (2002) Università degli Studi di Roma La Sapienza 2D 3D TSV
11960488 3 Vinyl sulfide cyclized analogues of angiotensin II with high affinity and full agonist activity at the AT(1) receptor.EBI J Med Chem 45: 1767-77 (2002) Uppsala University 2D 3D TSV
11960487 30 Structure-based design of novel potent nonpeptide thrombin inhibitors.EBI J Med Chem 45: 1757-66 (2002) Boehringer Ingelheim Pharma KG 2D 3D TSV
11960486 6 Exploration of the pharmacophore of 3-alkyl-5-arylimidazolidinediones as new CB(1) cannabinoid receptor ligands and potential antagonists: synthesis, lipophilicity, affinity, and molecular modeling.EBI J Med Chem 45: 1748-56 (2002) Universit£ de Lausanne 2D 3D TSV
11960485 18 Structure-based design and synthesis of 2-benzylidene-benzofuran-3-ones as flavopiridol mimics.BDB J Med Chem 45: 1741-7 (2002) Novartis Pharmaceuticals 2D 3D TSV
11959009 7 Bivalent inhibition of beta-tryptase: distance scan of neighboring subunits by dibasic inhibitors.EBI Bioorg Med Chem Lett 12: 985-8 (2002) Institut für Biochemie 2D 3D TSV
11959007 27 Benzimidazole-4,7-diones as inhibitors of protozoal (Toxoplasma gondii) purine nucleoside phosphorylase.EBI Bioorg Med Chem Lett 12: 977-9 (2002) Universit£ Lyon I 2D 3D TSV
11959006 10 Design, synthesis and bioactivity evaluation of tribactam beta lactamase inhibitors.EBI Bioorg Med Chem Lett 12: 971-5 (2002) Lek d.d. 2D 3D TSV
11959005 19 Novel N-[1-(1-substituted 4-piperidinylmethyl)-4-piperidinyl]benzamides as potent colonic prokinetic agents.EBI Bioorg Med Chem Lett 12: 967-70 (2002) Dainippon Pharmaceutical Co., Ltd. 2D 3D TSV
11958998 22 Identification of a novel, orally bioavailable histamine H(3) receptor antagonist based on the 4-benzyl-(1H-imidazol-4-yl) template.EBI Bioorg Med Chem Lett 12: 937-41 (2002) The Schering Plough Research Institute 2D 3D TSV
11958997 53 Oxal hydroxamic acid derivatives with inhibitory activity against matrix metalloproteinases.EBI Bioorg Med Chem Lett 12: 933-6 (2002) University of Bielefeld 2D 3D TSV
11958995 9 Synthesis and evaluation of pseudopeptide analogues of a specific CXCR4 inhibitor, T140: the insertion of an (E)-alkene dipeptide isostere into the betaII'-turn moiety.EBI Bioorg Med Chem Lett 12: 923-8 (2002) Kyoto University 2D 3D TSV
11958994 31 Benzimidazoles and isosteric compounds as potent and selective factor Xa inhibitors.EBI Bioorg Med Chem Lett 12: 919-22 (2002) Aventis Pharmaceuticals 2D 3D TSV
11958993 23 Structure-activity study of L-cysteine-based N-type calcium channel blockers: optimization of N- and C-terminal substituents.EBI Bioorg Med Chem Lett 12: 915-8 (2002) Minase Research Institute 2D 3D TSV
11958992 10 Hydrophobic modifications at 1-phosphate of inositol 1,4,5-trisphosphate analogues enhance receptor binding.EBI Bioorg Med Chem Lett 12: 911-3 (2002) The University of Tokyo 2D 3D TSV
11958989 60 QSAR study on adenosine kinase inhibition of pyrrolo[2,3-d]pyrimidine nucleoside analogues using the hansch approach.EBI Bioorg Med Chem Lett 12: 899-902 (2002) Jadavpur University 2D 3D TSV
11958985 21 Tricyclic isoxazoles are novel inhibitors of the multidrug resistance protein (MRP1).EBI Bioorg Med Chem Lett 12: 883-6 (2002) Eli Lilly and Company 2D 3D TSV
11958984 24 Dermorphin and deltorphin heptapeptide analogues: replacement of Phe residue by Dmp greatly improves opioid receptor affinity and selectivity.EBI Bioorg Med Chem Lett 12: 879-81 (2002) Tohoku Pharmaceutical University 2D 3D TSV
11958981 25 Imidazo[5,1-f]triazin-4(3H)-ones, a new class of potent PDE 5 inhibitors.EBI Bioorg Med Chem Lett 12: 865-8 (2002) BAYER AG 2D 3D TSV
11958976 30 Synthesis of iodinated 3beta-aryltropanes with selective binding to either the dopamine or serotonin transporters.EBI Bioorg Med Chem Lett 12: 845-7 (2002) State University of New York 2D 3D TSV
11934595 80 Amino acid derived sulfonamide hydroxamates as inhibitors of procollagen C-proteinase. Part 2: Solid-phase optimization of side chains.EBI Bioorg Med Chem Lett 12: 1233-5 (2002) Roche Bioscience 2D 3D TSV
11934593 1 A practical synthesis of (S) 3-tert-butoxycarbonylamino-2-oxo-2,3,4,5-tetrahydro-1,5-benzodiazepine-1-acetic acid methyl ester as a conformationally restricted dipeptido-mimetic for caspase-1 (ICE) inhibitors.EBI Bioorg Med Chem Lett 12: 1225-7 (2002) Vertex Pharmaceuticals, Inc. 2D 3D TSV
11934592 24 Photochemical preparation of a pyridone containing tetracycle: a Jak protein kinase inhibitor.EBI Bioorg Med Chem Lett 12: 1219-23 (2002) Merck Research Laboratories 2D 3D TSV
11934589 57 Non-covalent thrombin inhibitors featuring P(3)-heterocycles with P(1)-monocyclic arginine surrogates.EBI Bioorg Med Chem Lett 12: 1203-8 (2002) Corvas International, Inc. 2D 3D TSV
11934588 69 Anthranilate sulfonamide hydroxamate TACE inhibitors. Part 2: SAR of the acetylenic P1' group.EBI Bioorg Med Chem Lett 12: 1199-202 (2002) Wyeth-Ayerst Research 2D 3D TSV
11934587 19 Anthranilate sulfonamide hydroxamate TACE inhibitors. Part 1: Structure-based design of novel acetylenic P1' groups.EBI Bioorg Med Chem Lett 12: 1195-8 (2002) Wyeth-Ayerst Research 2D 3D TSV
11934585 8 Synthesis and in vitro evaluation of a novel iodinated resiniferatoxin derivative that is an agonist at the human vanilloid VR1 receptor.EBI Bioorg Med Chem Lett 12: 1189-92 (2002) Johnson& Johnson Pharmaceutical Research and Development 2D 3D TSV
11934583 20 Novel bicyclic lactam inhibitors of thrombin: highly potent and selective inhibitors.EBI Bioorg Med Chem Lett 12: 1181-4 (2002) Shire BioChem. 2D 3D TSV
11934581 32 Novel potent antagonists of human neuropeptide Y Y5 receptor. Part 1: 2-oxobenzothiazolin-3-acetic acid derivatives.EBI Bioorg Med Chem Lett 12: 1171-5 (2002) Fujisawa Pharmaceutical Co., Ltd. 2D 3D TSV
11934578 12 Solid-phase synthesis and pharmacological evaluation of analogues of PhTX-12-A potent and selective nicotinic acetylcholine receptor antagonist.EBI Bioorg Med Chem Lett 12: 1159-62 (2002) The Royal Danish School of Pharmacy 2D 3D TSV
11934576 85 Synthesis and pharmacological evaluation of 6-piperidino- and 6-piperazinoalkyl-2(3H)-benzothiazolones as mixed sigma/5-HT(1A) ligands.EBI Bioorg Med Chem Lett 12: 1149-52 (2002) Université de Lille 2 2D 3D TSV
11934574 8 Design and synthesis of lignostilbene-alpha,beta-dioxygenase inhibitors.EBI Bioorg Med Chem Lett 12: 1139-42 (2002) RIKEN 2D 3D TSV
11931626 124 A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening.EBI J Med Chem 45: 1712-22 (2002) Northwestern University 2D 3D TSV
11931625 20 Potent, orally active heterocycle-based combretastatin A-4 analogues: synthesis, structure-activity relationship, pharmacokinetics, and in vivo antitumor activity evaluation.EBI J Med Chem 45: 1697-711 (2002) Abbott Laboratories 2D 3D TSV
11931624 6 Synthesis and in vitro antitumor activity of new deaza analogues of the nonpolyglutamatable antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine (PT523).EBI J Med Chem 45: 1690-6 (2002) Harvard Medical School 2D 3D TSV
11931623 6 Synthesis and biological characterization of L-N(6)-(1-iminoethyl)lysine 5-tetrazole-amide, a prodrug of a selective iNOS inhibitor.EBI J Med Chem 45: 1686-9 (2002) Pfizer Inc. 2D 3D TSV
11931620 40 Human somatostatin receptor specificity of backbone-cyclic analogues containing novel sulfur building units.EBI J Med Chem 45: 1665-71 (2002) Hebrew University 2D 3D TSV
11931619 19 Geometry-affinity relationships of the selective serotonin receptor ligand 9-(aminomethyl)-9,10-dihydroanthracene.EBI J Med Chem 45: 1656-64 (2002) Virginia Commonwealth University 2D 3D TSV
11931617 36 Structure-activity relationships in 1,4-benzodioxan-related compounds. 7. Selectivity of 4-phenylchroman analogues for alpha(1)-adrenoreceptor subtypes.EBI J Med Chem 45: 1633-43 (2002) University of Camerino 2D 3D TSV
11931615 46 Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 6. Structure-activity studies of orally bioavailable, 2-pyridone-containing peptidomimetics.EBI J Med Chem 45: 1607-23 (2002) Pfizer Global Research and Development-La Jolla/Agouron Pharmaceuticals 2D 3D TSV
11931611 7 Synthesis, biological evaluation, and binding mode of novel 1-[2-(diarylmethoxy)ethyl]-2-methyl-5-nitroimidazoles targeted at the HIV-1 reverse transcriptase.BDB J Med Chem 45: 1567-76 (2002) Universita degli Studi di Roma La Sapienza 2D 3D TSV
11931610 4 Beta-C-mannosides as selectin inhibitors.EBI J Med Chem 45: 1563-6 (2002) Wyeth Research 2D 3D TSV
11931608 17 Inhibition of protein-protein association by small molecules: approaches and progress.EBI J Med Chem 45: 1543-58 (2002) Pfizer Global Research and Development 2D 3D TSV
11927256 30 Insight into binding of calyculin A to protein phosphatase 1: isolation of hemicalyculin a and chemical transformation of calyculin A.BDB Chem Biol 9: 309-19 (2002) The University of Tokyo 2D 3D TSV
11916147 11 Evaluation of 7-hydroxy-flavones as inhibitors of oestrone and oestradiol biosynthesis.BDB J Enzym Inhib 16: 417-24 (2001) Cardiff University 2D 3D TSV
11916140 21 Carbonic anhydrase activity modulators: synthesis of inhibitors and activators incorporating 2-substituted-thiazol-4-yl-methyl scaffolds.BDB J Enzym Inhib 16: 351-8 (2001) Università degli Studi 2D 3D TSV
11909733 30 Beta-carbolines as specific inhibitors of cyclin-dependent kinases.EBI Bioorg Med Chem Lett 12: 1129-32 (2002) Institute of Molecular and Cell Biology 2D 3D TSV
11909727 35 Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 3: synthesis and SAR of potent and specific 2,8-diazaspiro[4.5]decanes.EBI Bioorg Med Chem Lett 12: 1103-7 (2002) COR Therapeutics, Inc. 2D 3D TSV
11909726 36 5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition.EBI Bioorg Med Chem Lett 12: 1099-102 (2002) Novartis Pharma AG 2D 3D TSV
11909724 35 Sulfide analogues as potent and selective M(2) muscarinic receptor antagonists.EBI Bioorg Med Chem Lett 12: 1087-91 (2002) Schering-Plough Research Institute 2D 3D TSV
11909720 8 Benzoindoloquinolines interact with DNA tetraplexes and inhibit telomerase.EBI Bioorg Med Chem Lett 12: 1071-4 (2002) INSERM 2D 3D TSV
11909718 53 Design, synthesis and in vitro evaluation of potent, novel, small molecule inhibitors of plasminogen activator inhibitor-1.EBI Bioorg Med Chem Lett 12: 1063-6 (2002) Xenova Limited 2D 3D TSV
11909717 7 New aromatase inhibitors. Synthesis and inhibitory activity of pyridinyl-substituted flavanone derivatives.EBI Bioorg Med Chem Lett 12: 1059-61 (2002) UPRES EA 1085 2D 3D TSV
11909715 73 Squaric acid derivatives as VLA-4 integrin antagonists.EBI Bioorg Med Chem Lett 12: 1051-4 (2002) Celltech R&D Ltd 2D 3D TSV
11909713 42 Thalidomide and its analogues as cyclooxygenase inhibitors.EBI Bioorg Med Chem Lett 12: 1043-6 (2002) The University of Tokyo 2D 3D TSV
11909712 124 N-alkylaminoacids and their derivatives interact with melanocortin receptors.EBI Bioorg Med Chem Lett 12: 1039-42 (2002) Uppsala University 2D 3D TSV
11909711 86 Reductive amination products containing naphthalene and indole moieties bind to melanocortin receptors.EBI Bioorg Med Chem Lett 12: 1035-8 (2002) Uppsala University 2D 3D TSV
11909707 69 Noncovalent tripeptidic thrombin inhibitors incorporating amidrazone, amine and amidine functions at P1.EBI Bioorg Med Chem Lett 12: 1017-22 (2002) Life Science R&D, LGCI 2D 3D TSV
11909705 19 Novel potent antagonists of human neuropeptide Y-Y5 receptor. Part 4: tetrahydrodiazabenzazulene derivatives.EBI Bioorg Med Chem Lett 12: 1009-11 (2002) Fujisawa Pharmaceutical Co., Ltd. 2D 3D TSV
11909704 43 Azapeptides as inhibitors of the hepatitis C virus NS3 serine protease.EBI Bioorg Med Chem Lett 12: 1005-8 (2002) Schering-Plough Research Institute 2D 3D TSV
11909701 35 Thiophene derivatives: a new series of potent norepinephrine and serotonin reuptake inhibitors.EBI Bioorg Med Chem Lett 12: 993-5 (2002) Georgetown University Medical Center 2D 3D TSV
11909604 23 Interaction of human organic anion transporters with various cephalosporin antibiotics.EBI Eur J Pharmacol 438: 137-42 (2002) Kyorin University School of Medicine 2D 3D TSV
11909603 1 T-226296: a novel, orally active and selective melanin-concentrating hormone receptor antagonist.BDB Eur J Pharmacol 438: 129-35 (2002) Takeda Chemical Industries, Ltd. 2D 3D TSV
11908961 3 Cyclotheonamide E4 and E5, new potent tryptase inhibitors from an Ircinia species of sponge.EBI J Nat Prod 65: 259-61 (2002) Kirin Brewery Co., Ltd. 2D 3D TSV
11907190 4 4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]5-methyl-N-(2-propynyl)-1,3-thiazol-2-amine hydrochloride (SSR125543A): a potent and selective corticotrophin-releasing factor(1) receptor antagonist. I. Biochemical and pharmacological characterization.BDB J Pharmacol Exp Ther 301: 322-32 (2002) Sanofi-Synthelabo 2D 3D TSV
11907155 384 Elucidation of vasoactive intestinal peptide pharmacophore for VPAC(1) receptors in human, rat, and guinea pig.BDB J Pharmacol Exp Ther 301: 37-50 (2002) National Institutes of Health 2D 3D TSV
11906293 7 Novel 5-substituted 2,4-thiazolidinedione and 2,4-oxazolidinedione derivatives as insulin sensitizers with antidiabetic activities.EBI J Med Chem 45: 1518-34 (2002) Takeda Chemical Industries, Ltd. 2D 3D TSV
11906292 32 4-(4-cycloalkyl/aryl-oxazol-5-yl)benzenesulfonamides as selective cyclooxygenase-2 inhibitors: enhancement of the selectivity by introduction of a fluorine atom and identification of a potent, highly selective, and orally active COX-2 inhibitor JTE-522(1).EBI J Med Chem 45: 1511-7 (2002) Central Pharmaceutical Research Institute 2D 3D TSV
11906291 129 1,8-disubstituted xanthine derivatives: synthesis of potent A2B-selective adenosine receptor antagonists.EBI J Med Chem 45: 1500-10 (2002) University of Bonn 2D 3D TSV
11906289 87 Toward an optimal joint recognition of the S1' subsites of endothelin converting enzyme-1 (ECE-1), angiotensin converting enzyme (ACE), and neutral endopeptidase (NEP).BDB J Med Chem 45: 1477-86 (2002) CNRS 2D 3D TSV
11906288 713 Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.EBI J Med Chem 45: 1466-76 (2002) Universit£ degli Studi di Firenze 2D 3D TSV
11906287 9 Modeling of binding modes and inhibition mechanism of some natural ligands of farnesyl transferase using molecular docking.EBI J Med Chem 45: 1460-5 (2002) University of Milan 2D 3D TSV
11906286 34 Molecular interaction of the antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1- (2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide with the CB1 cannabinoid receptor.EBI J Med Chem 45: 1447-59 (2002) University of South Carolina 2D 3D TSV
11906282 6 Molecular dynamics and free energy analyses of cathepsin D-inhibitor interactions: insight into structure-based ligand design.EBI J Med Chem 45: 1412-9 (2002) University of California 2D 3D TSV
11906281 22 Identification of novel cyclooxygenase-2 selective inhibitors using pharmacophore models.EBI J Med Chem 45: 1402-11 (2002) Laboratorios Menarini S.A. 2D 3D TSV
11906280 38 Toward selective ERbeta agonists for central nervous system disorders: synthesis and characterization of aryl benzthiophenes.BDB J Med Chem 45: 1399-401 (2002) Novartis Pharmaceuticals 2D 3D TSV
11906279 2 Design, synthesis, and evaluation of opioid analogues with non-peptidic beta-turn scaffold: enkephalin and endomorphin mimetics.EBI J Med Chem 45: 1395-8 (2002) TBA 2D 3D TSV
11896401 3 Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site.BDB Nat Struct Biol 9: 268-72 (2002) Boehringer Ingelheim Pharmaceuticals Inc. 2D 3D TSV
11888271 2 Kinetic and structural studies on the interaction of cholinesterases with the anti-Alzheimer drug rivastigmine.BDB Biochemistry 41: 3555-64 (2002) Weizmann Institute of Science 2D 3D TSV
11883641 8 Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport.EBI Pharm Res 19: 147-53 (2002) Kitasato University 2D 3D TSV
11882920 41 Characterization of phospholipase C activity at h5-HT2C compared with h5-HT2B receptors: influence of novel ligands upon membrane-bound levels of [3H]phosphatidylinositols.BDB Naunyn Schmiedebergs Arch Pharmacol 365: 242-52 (2002) Institut de Recherches Servier 2D 3D TSV
11882004 67 Design and synthesis of a novel and potent series of inhibitors of cytosolic phospholipase A(2) based on a 1,3-disubstituted propan-2-one skeleton.EBI J Med Chem 45: 1348-62 (2002) AstraZeneca R&D Charnwood 2D 3D TSV
11882001 34 Development of long-acting dopamine transporter ligands as potential cocaine-abuse therapeutic agents: chiral hydroxyl-containing derivatives of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine.EBI J Med Chem 45: 1321-9 (2002) National Institute of Diabetes and Digestive and Kidney Diseases 2D 3D TSV
11881999 123 Novel 4-anilinoquinazolines with C-7 basic side chains: design and structure activity relationship of a series of potent, orally active, VEGF receptor tyrosine kinase inhibitors.BDB J Med Chem 45: 1300-12 (2002) AstraZeneca 2D 3D TSV
11881998 32 First non-ATP competitive glycogen synthase kinase 3 beta (GSK-3beta) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease.BDB J Med Chem 45: 1292-9 (2002) Instituto de Quimica Medica (CSIC) 2D 3D TSV
11881997 14 Carbocyclic dinucleoside polyphosphonates: interaction with HIV reverse transcriptase and antiviral activity.EBI J Med Chem 45: 1284-91 (2002) Russian Academy of Sciences 2D 3D TSV
11881994 42 Substituted diphenyl sulfides as selective serotonin transporter ligands: synthesis and in vitro evaluation.EBI J Med Chem 45: 1253-8 (2002) INSERM 2D 3D TSV
11881993 175 Development of 2,4-diaminopyrimidines as antimalarials based on inhibition of the S108N and C59R+S108N mutants of dihydrofolate reductase from pyrimethamine-resistant Plasmodium falciparum.EBI J Med Chem 45: 1244-52 (2002) National Center for Genetic Engineering and Biotechnology 2D 3D TSV
11881991 21 PRO_SELECT: combining structure-based drug design and array-based chemistry for rapid lead discovery. 2. The development of a series of highly potent and selective factor Xa inhibitors.EBI J Med Chem 45: 1221-32 (2002) Protherics Molecular Design 2D 3D TSV
11881989 7 Synthesis and biological evaluation of 2-substituted 3beta-tolyltropane derivatives at dopamine, serotonin, and norepinephrine transporters.EBI J Med Chem 45: 1203-10 (2002) University of New Orleans 2D 3D TSV
11881988 16 Ribose-modified nucleosides as ligands for adenosine receptors: synthesis, conformational analysis, and biological evaluation of 1'-C-methyl adenosine analogues.EBI J Med Chem 45: 1196-202 (2002) Universit£ di Camerino 2D 3D TSV
11881986 24 3-(1H-Pyrrol-1-yl)-2-oxazolidinones as reversible, highly potent, and selective inhibitors of monoamine oxidase type A.EBI J Med Chem 45: 1180-3 (2002) Universit£ degli Studi di Roma La Sapienza 2D 3D TSV
11881985 48 6,7-Dihydro-2-benzothiophen-4(5H)-ones: a novel class of GABA-A alpha5 receptor inverse agonists.EBI J Med Chem 45: 1176-9 (2002) Merck Sharp & Dohme Research Laboratories 2D 3D TSV
11881984 61 Serine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies.EBI J Med Chem 45: 1151-75 (2002) The University of Newcastle 2D 3D TSV
11861823 10 Characterization of (2S,4R)-1-[5-chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidine carboxamide (SSR149415), a selective and orally active vasopressin V1b receptor antagonist.BDB J Pharmacol Exp Ther 300: 1122-30 (2002) Sanofi-Synthelabo Recherche 2D 3D TSV
11861807 8 A structure/activity relationship study on arvanil, an endocannabinoid and vanilloid hybrid.BDB J Pharmacol Exp Ther 300: 984-91 (2002) Istituto di Chimica Biomolecolare 2D 3D TSV
11861777 6 Functional involvement of rat organic anion transporter 3 (rOat3; Slc22a8) in the renal uptake of organic anions.EBI J Pharmacol Exp Ther 300: 746-53 (2002) University of Tokyo 2D 3D TSV
11859013 93 Structure-activity relationships of oxime neurokinin antagonists: oxime modifications.EBI Bioorg Med Chem Lett 12: 833-6 (2002) Schering-Plough Research Institute 2D 3D TSV
11859012 86 2-Arylindoles as gonadotropin releasing hormone (GnRH) antagonists: optimization of the tryptamine side chain.EBI Bioorg Med Chem Lett 12: 827-32 (2002) Merck Research Laboratories 2D 3D TSV
11859009 16 Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 2: 4-substituted 6-nitroquipazines.EBI Bioorg Med Chem Lett 12: 811-5 (2002) Inha University 2D 3D TSV
11859006 15 Novel potent antagonists of human neuropeptide Y Y5 receptors. Part 3: 7-methoxy-1-hydroxy-1-substituted tetraline derivatives.EBI Bioorg Med Chem Lett 12: 799-802 (2002) Fujisawa Pharmaceutical Co., Ltd. 2D 3D TSV
11859005 24 Synthesis and structure-activity relationships of M(2)-selective muscarinic receptor ligands in the 1-[4-(4-arylsulfonyl)-phenylmethyl]-4-(4-piperidinyl)-piperazine family.EBI Bioorg Med Chem Lett 12: 795-8 (2002) Schering-Plough Research Institute 2D 3D TSV
11859004 18 Substituted 2-(R)-methyl piperazines as muscarinic M(2) selective ligands.EBI Bioorg Med Chem Lett 12: 791-4 (2002) Schering-Plough Research Institute 2D 3D TSV
11859003 63 Potent nonsteroidal progesterone receptor agonists: synthesis and SAR study of 6-aryl benzoxazines.EBI Bioorg Med Chem Lett 12: 787-90 (2002) Wyeth Research 2D 3D TSV
11859001 30 Synthesis and activity of a new methoxytetrahydropyran derivative as dual cyclooxygenase-2/5-lipoxygenase inhibitor.EBI Bioorg Med Chem Lett 12: 779-82 (2002) Laboratoires Innothera 2D 3D TSV
11858999 21 Novel agents combining platelet activating factor (PAF) receptor antagonist with thromboxane synthase inhibitor (TxSI).EBI Bioorg Med Chem Lett 12: 771-4 (2002) Nikken Chemicals Co., Ltd. 2D 3D TSV
11858996 32 Novel potent antagonists of human neuropeptide Y Y5 receptors. Part 2: substituted benzo[a]cycloheptene derivatives.EBI Bioorg Med Chem Lett 12: 757-61 (2002) Fujisawa Pharmaceutical Co., Ltd. 2D 3D TSV
11858995 1 Anionic cyclophanes as potential reversal agents of muscle relaxants by chemical chelation.EBI Bioorg Med Chem Lett 12: 753-5 (2002) Organon Laboratories Ltd. 2D 3D TSV
11858994 7 Synthesis of an alpha-fucosidase inhibitor, 5a-carba-beta-L-fucopyranosylamine, and fucose-type alpha- and beta-DL-valienamine unsaturated derivatives.EBI Bioorg Med Chem Lett 12: 749-52 (2002) Keio University 2D 3D TSV
11858993 60 Novel, potent non-covalent thrombin inhibitors incorporating p(3)-lactam scaffolds.EBI Bioorg Med Chem Lett 12: 743-8 (2002) Corvas International, Inc. 2D 3D TSV
11858990 20 N-aryl 2,6-dimethoxybiphenylalanine analogues as VLA-4 antagonists.EBI Bioorg Med Chem Lett 12: 729-31 (2002) Merck Research Laboratories 2D 3D TSV
11858756 25 New sugar-mimic alkaloids from the pods of Angylocalyx pynaertii.EBI J Nat Prod 65: 198-202 (2002) Hokuriku University 2D 3D TSV
11858749 32 Constituents of the bark and twigs of Artocarpus dadah with cyclooxygenase inhibitory activity.EBI J Nat Prod 65: 163-9 (2002) University of Illinois at Chicago 2D 3D TSV
11855993 91 Development of a new class of nonimidazole histamine H(3) receptor ligands with combined inhibitory histamine N-methyltransferase activity.EBI J Med Chem 45: 1128-41 (2002) Freie Universität Berlin 2D 3D TSV
11855991 27 Side-chain lactam-bridge conformational constraints differentiate the activities of salmon and human calcitonins and reveal a new design concept for potent calcitonin analogues.EBI J Med Chem 45: 1108-21 (2002) Rutgers University 2D 3D TSV
11855986 24 Synthesis and nicotinic binding studies on enantiopure diazine analogues of the novel (2-chloro-5-pyridyl)-9-azabicyclo[4.2.1]non-2-ene UB-165.EBI J Med Chem 45: 1064-72 (2002) Institut f£r Pharmazeutische Chemie der Philipps-Universit£t Marburg 2D 3D TSV
11855984 102 Nanomolar small molecule inhibitors for alphav(beta)6, alphav(beta)5, and alphav(beta)3 integrins.EBI J Med Chem 45: 1045-51 (2002) Merck KGaA 2D 3D TSV
11855983 18 Synthesis and biological evaluation of a new set of pyrazolo[1,5-c]quinazoline-2-carboxylates as novel excitatory amino acid antagonists.EBI J Med Chem 45: 1035-44 (2002) Universita' di Firenze 2D 3D TSV
11855980 46 Bis(1H-2-indolyl)methanones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase.BDB J Med Chem 45: 1002-18 (2002) University of Regensburg 2D 3D TSV
11855979 13 Identification of novel inhibitors of the transforming growth factor beta1 (TGF-beta1) type 1 receptor (ALK5).EBI J Med Chem 45: 999-1001 (2002) GlaxoSmithKline Pharmaceuticals 2D 3D TSV
11844706 30 Evolution, synthesis and SAR of tripeptide alpha-ketoacid inhibitors of the hepatitis C virus NS3/NS4A serine protease.EBI Bioorg Med Chem Lett 12: 705-8 (2002) IRBM, MRL Rome 2D 3D TSV
11844705 13 A designed P1 cysteine mimetic for covalent and non-covalent inhibitors of HCV NS3 protease.EBI Bioorg Med Chem Lett 12: 701-4 (2002) IRBM, MRL Rome 2D 3D TSV
11844703 14 Insertion of 2-carboxysuccinate and tricarballylic acid fragments into cyclic-pseudopeptides: new antagonists for the human tachykinin NK-2 receptor.EBI Bioorg Med Chem Lett 12: 693-6 (2002) Menarini Ricerche S.p.A. Laboratori di Firenze 2D 3D TSV
11844702 14 Pyridazine based inhibitors of p38 MAPK.EBI Bioorg Med Chem Lett 12: 689-92 (2002) Merck Research Laboratories 2D 3D TSV
11844701 5 Identification of unique VLA-4 antagonists from a combinatorial library.EBI Bioorg Med Chem Lett 12: 685-8 (2002) Merck Research Laboratories 2D 3D TSV
11844699 16 CCR5 antagonists: bicyclic isoxazolidines as conformationally constrained N-1-substituted pyrrolidines.EBI Bioorg Med Chem Lett 12: 677-9 (2002) Merck Research Laboratories 2D 3D TSV
11844695 35 Human glucagon receptor antagonists based on alkylidene hydrazides.EBI Bioorg Med Chem Lett 12: 663-6 (2002) Pfizer Global Research and Development 2D 3D TSV
11844693 35 Synthesis and biological evaluation of imidazol-2-one and 2-cyanoiminoimidazole derivatives: novel series of PDE4 inhibitors.EBI Bioorg Med Chem Lett 12: 653-8 (2002) Janssen-Cilag 2D 3D TSV
11844691 107 4-amidinobenzylamine-based inhibitors of urokinase.EBI Bioorg Med Chem Lett 12: 645-8 (2002) Universitat Jena 2D 3D TSV
11844690 8 Solution and solid-phase synthesis of potent inhibitors of hepatitis C virus NS3 proteinase.EBI Bioorg Med Chem Lett 12: 641-3 (2002) Roche Discovery Welwyn 2D 3D TSV
11844689 51 Substituted N-(3,5-dichlorobenzenesulfonyl)-L-prolyl-phenylalanine analogues as potent VLA-4 antagonists.EBI Bioorg Med Chem Lett 12: 637-40 (2002) Merck Research Laboratories 2D 3D TSV
11844688 102 Di- and trisubstituted pyrazolo[1,5-a]pyridine derivatives: synthesis, dopamine receptor binding and ligand efficacy.EBI Bioorg Med Chem Lett 12: 633-6 (2002) Friedrich-Alexander University 2D 3D TSV
11844687 11 A new class of type I protein geranylgeranyltransferase (GGTase I) inhibitor.EBI Bioorg Med Chem Lett 12: 629-32 (2002) Banyu Tsukuba Research Institute 2D 3D TSV
11844685 20 A novel series of hybrid compounds derived by combining 2-aminotetralin and piperazine fragments: binding activity at D2 and D3 receptors.EBI Bioorg Med Chem Lett 12: 619-22 (2002) Wayne State University 2D 3D TSV
11844683 31 The discovery of acylated beta-amino acids as potent and orally bioavailable VLA-4 antagonists.EBI Bioorg Med Chem Lett 12: 611-4 (2002) Merck Research Laboratories 2D 3D TSV
11844682 36 Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 2.EBI Bioorg Med Chem Lett 12: 607-10 (2002) Nippon Roche Research Center 2D 3D TSV
11844681 45 Synthesis of 5,6-dihydro-11H-benzo[5,6]-cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidine-N-cyanoguanidine derivatives as inhibitors of ras farnesyl protein transferase.EBI Bioorg Med Chem Lett 12: 601-5 (2002) Schering-Plough Research Institute 2D 3D TSV
11844676 48 Encounter with unexpected collagenase-1 selective inhibitor: switchover of inhibitor binding pocket induced by fluorine atom.EBI Bioorg Med Chem Lett 12: 581-4 (2002) Organon K.K. 2D 3D TSV
11844675 114 2-(anilinomethyl)imidazolines as alpha1A adrenergic receptor agonists: 2'-heteroaryl and 2'-oxime ether series.EBI Bioorg Med Chem Lett 12: 575-9 (2002) GlaxoSmithKline 2D 3D TSV
11844674 59 Studies on quinazolinones as dual inhibitors of Pgp and MRP1 in multidrug resistance.EBI Bioorg Med Chem Lett 12: 571-4 (2002) Xenova Ltd. 2D 3D TSV
11844670 27 Design and synthesis of peptide-based carboxylic acid-containing transition-state inhibitors of human neutrophil elastase.EBI Bioorg Med Chem Lett 12: 551-5 (2002) Dainippon Pharmaceutical Co., Ltd. 2D 3D TSV
11844666 31 Structure-based design of cyclooxygenase-2 selectivity into ketoprofen.EBI Bioorg Med Chem Lett 12: 533-7 (2002) Laboratorios Menarini S.A. 2D 3D TSV
11844665 38 A combinatorial library of indinavir analogues and its in vitro and in vivo studies.EBI Bioorg Med Chem Lett 12: 529-32 (2002) Merck Research Laboratories 2D 3D TSV
11844664 35 Differential inhibition of polymerase and strand-transfer activities of HIV-1 reverse transcriptase.EBI Bioorg Med Chem Lett 12: 525-8 (2002) University of Toledo 2D 3D TSV
11844663 54 Amide derivatives of meclofenamic acid as selective cyclooxygenase-2 inhibitors.EBI Bioorg Med Chem Lett 12: 521-4 (2002) Vanderbilt University School of Medicine 2D 3D TSV
11844662 34 Biphenylsulfonamide endothelin receptor antagonists. Part 3: structure-activity relationship of 4'-heterocyclic biphenylsulfonamides.EBI Bioorg Med Chem Lett 12: 517-20 (2002) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
11837698 8 Transport activity of human MRP3 expressed in Sf9 cells: comparative studies with rat MRP3.EBI Pharm Res 19: 34-41 (2002) The University of Tokyo 2D 3D TSV
11831912 43 Selective antagonists at group I metabotropic glutamate receptors: synthesis and molecular pharmacology of 4-aryl-3-isoxazolol amino acids.EBI J Med Chem 45: 988-91 (2002) The Royal Danish School of Pharmacy 2D 3D TSV
11831911 15 Cyclohexylmethylpiperidinyltriphenylpropioamide: a selective muscarinic M(3) antagonist discriminating against the other receptor subtypes.EBI J Med Chem 45: 984-7 (2002) Banyu Tsukuba Research Institute 2D 3D TSV
11831909 4 Novel antagonists acting at the P2Y(1) purinergic receptor: synthesis and conformational analysis using potentiometric and nuclear magnetic resonance titration techniques.EBI J Med Chem 45: 962-72 (2002) Universit£ Louis Pasteur 2D 3D TSV
11831905 33 New strategy for antedrug application: development of metalloproteinase inhibitors as antipsoriatic drugs.EBI J Med Chem 45: 930-6 (2002) Organon K.K. 2D 3D TSV
11831904 172 New type of metalloproteinase inhibitor: design and synthesis of new phosphonamide-based hydroxamic acids.EBI J Med Chem 45: 919-29 (2002) Nippon Organon K.K. 2D 3D TSV
11831903 31 Cysteine derivatives as inhibitors for carboxypeptidase A: synthesis and structure-activity relationships.EBI J Med Chem 45: 911-8 (2002) Pohang University of Science and Technology 2D 3D TSV
11831902 12 Pyridophens: binary pyridostigmine-aprophen prodrugs with differential inhibition of acetylcholinesterase, butyrylcholinesterase, and muscarinic receptors.EBI J Med Chem 45: 902-10 (2002) Institute of Research 2D 3D TSV
11831896 8 Structural basis of RasGRP binding to high-affinity PKC ligands.EBI J Med Chem 45: 853-60 (2002) Georgetown University Medical Center 2D 3D TSV
11831895 47 CoMFA and CoMSIA 3D QSAR and docking studies on conformationally-restrained cinnamoyl HIV-1 integrase inhibitors: exploration of a binding mode at the active site.EBI J Med Chem 45: 841-52 (2002) University of Tennessee Health Science Center 2D 3D TSV
11831892 46 Novel tricyclic-alpha-alkyloxyphenylpropionic acids: dual PPARalpha/gamma agonists with hypolipidemic and antidiabetic activity.EBI J Med Chem 45: 789-804 (2002) Novo Nordisk A/S 2D 3D TSV
11831890 278 Synthesis, biological activity, and molecular modeling investigation of new pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as human A(3) adenosine receptor antagonists.EBI J Med Chem 45: 770-80 (2002) Università degli Studi di Ferrara 2D 3D TSV
11828475 5 Dynamic deconvolution of a pre-equilibrated dynamic combinatorial library of acetylcholinesterase inhibitors.BDB Chembiochem 2: 438-44 (2001) Université Louis Pasteur 2D 3D TSV
11828463 20 Inhibition studies of porphobilinogen synthase from Escherichia coli differentiating between the two recognition sites.BDB Chembiochem 2: 343-54 (2001) University of Neuchâtel 2D 3D TSV
11818398 1 Localization of organic anion transport protein 2 in the apical region of rat retinal pigment epithelium.EBI Invest Ophthalmol Vis Sci 43: 510-4 (2002) University Hospital 2D 3D TSV
11817957 58 Complexation and chiral recognition thermodynamics of 6-amino-6-deoxy-beta-cyclodextrin with anionic, cationic, and neutral chiral guests: counterbalance between van der Waals and coulombic interactions.BDB J Am Chem Soc 124: 813-26 (2002) Japan Science and Technology Agency 2D 3D TSV
11815391 5 Uraemic toxins induce proximal tubular injury via organic anion transporter 1-mediated uptake.EBI Br J Pharmacol 135: 555-63 (2002) Tokyo Women's Medical University 2D 3D TSV
11814830 26 7-Methoxyfuro[2,3-c]pyridine-4-carboxamides as PDE4 inhibitors: a potential treatment for asthma.EBI Bioorg Med Chem Lett 12: 509-12 (2002) Celltech R& D 2D 3D TSV
11814827 10 N-arylalkylpiperidines as high-affinity sigma-1 and sigma-2 receptor ligands: phenylpropylamines as potential leads for selective sigma-2 agents.EBI Bioorg Med Chem Lett 12: 497-500 (2002) University of Maryland 2D 3D TSV
11814826 14 Design and synthesis of 4,5-disubstituted-thiophene-2-amidines as potent urokinase inhibitors.EBI Bioorg Med Chem Lett 12: 491-5 (2002) 3-Dimensional Pharmaceuticals Inc. 2D 3D TSV
11814822 108 alpha(1)-Adrenoceptor agonists: the identification of novel alpha(1A )subtype selective 2'-heteroaryl-2-(phenoxymethyl)imidazolines.EBI Bioorg Med Chem Lett 12: 471-5 (2002) GlaxoSmithKline Research and Development 2D 3D TSV
11814821 6 Synthesis and biological evaluation of 2-indolyloxazolines as a new class of tubulin polymerization inhibitors. Discovery of A-289099 as an orally active antitumor agent.EBI Bioorg Med Chem Lett 12: 465-9 (2002) Abbott Laboratories 2D 3D TSV
11814820 28 Discovery of 5-hydroxyalkyl-4-phenylpyridines as a new class of glucagon receptor antagonists.EBI Bioorg Med Chem Lett 12: 461-4 (2002) Bayer Research Center 2D 3D TSV
11814819 3 Synthesis of an alpha-aminophosphonate nucleoside as an inhibitor of S-adenosyl-L-homocysteine hydrolase.EBI Bioorg Med Chem Lett 12: 457-60 (2002) University of Waterloo 2D 3D TSV
11814816 30 Synthesis and SAR of N-substituted dibenzazepinone derivatives as novel potent and selective alpha(V)beta(3) antagonists.EBI Bioorg Med Chem Lett 12: 441-6 (2002) Knoll GmbH 2D 3D TSV
11814815 13 alpha(1)-Adrenoceptor antagonists. Rational design, synthesis and biological evaluation of new trazodone-like compounds.EBI Bioorg Med Chem Lett 12: 437-40 (2002) Universit£ di Pisa 2D 3D TSV
11814812 12 4-Anilino-3-cyanobenzo[g]quinolines as kinase inhibitors.EBI Bioorg Med Chem Lett 12: 423-5 (2002) Wyeth-Ayerst Research 2D 3D TSV
11814808 6 [(3)H]-M-MPEP, a potent, subtype-selective radioligand for the metabotropic glutamate receptor subtype 5.EBI Bioorg Med Chem Lett 12: 407-9 (2002) Novartis Pharma AG 2D 3D TSV
11814807 30 A novel synthesis of 2-arylpyrrolo[1,2-a]pyrimid-7-ones and their structure-activity relationships as potent GnRH receptor antagonists.EBI Bioorg Med Chem Lett 12: 403-6 (2002) Neurocrine Biosciences, Inc. 2D 3D TSV
11814806 39 Initial structure-activity relationship studies of a novel series of pyrrolo[1,2-a]pyrimid-7-ones as GnRH receptor antagonists.EBI Bioorg Med Chem Lett 12: 399-402 (2002) Neurocrine Biosciences, Inc. 2D 3D TSV
11814804 9 The first two cantharidin analogues displaying PP1 selectivity.EBI Bioorg Med Chem Lett 12: 391-3 (2002) The University of Newcastle 2D 3D TSV
11814801 24 Dihydropyridine neuropeptide Y Y(1) receptor antagonists.EBI Bioorg Med Chem Lett 12: 379-82 (2002) Pharmaceutical Research Institute 2D 3D TSV
11814800 14 Design and synthesis of dual inhibitors for matrix metalloproteinase and cathepsin.EBI Bioorg Med Chem Lett 12: 375-8 (2002) Organon K.K. 2D 3D TSV
11814797 3 2-Amino-4-[3'-hydroxyphenyl]-4-hydroxybutanoic acid; a potent inhibitor of rat and recombinant human kynureninase.EBI Bioorg Med Chem Lett 12: 361-3 (2002) University of St Andrews 2D 3D TSV
11814792 18 Approach to dual-acting platelet activating factor (PAF) receptor antagonist/thromboxane synthase inhibitor (TxSI) based on the link of PAF antagonists and TxSIs.EBI Bioorg Med Chem Lett 12: 341-4 (2002) Nikken Chemicals Co., Ltd. 2D 3D TSV
11814791 13 Novel dihydropyrazine analogues as NPY antagonists.EBI Bioorg Med Chem Lett 12: 337-40 (2002) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
11814790 8 Enantio-dependent binding and transactivation of optically active phenylpropanoic acid derivatives at human peroxisome proliferator-activated receptor alpha.EBI Bioorg Med Chem Lett 12: 333-5 (2002) Kyorin Pharmaceutical Co., Ltd. 2D 3D TSV
11814789 7 Tyrosylprotein sulfotransferase inhibitors generated by combinatorial target-guided ligand assembly.EBI Bioorg Med Chem Lett 12: 329-32 (2002) University of California 2D 3D TSV
11814787 73 Discovery of a nonpeptidic small molecule antagonist of the human platelet thrombin receptor (PAR-1).EBI Bioorg Med Chem Lett 12: 319-23 (2002) Merck Research Laboratories 2D 3D TSV
11814784 53 Studies toward the discovery of the next generation of antidepressants. Part 2: incorporating a 5-HT(1A) antagonist component into a class of serotonin reuptake inhibitors.EBI Bioorg Med Chem Lett 12: 307-10 (2002) Wyeth-Ayerst Research Laboratories 2D 3D TSV
11814780 18 Synthesis and evaluation of imidazo[1,5-a]pyrazines as corticotropin releasing hormone receptor ligands.EBI Bioorg Med Chem Lett 12: 291-4 (2002) DuPont Pharmaceuticals Company 2D 3D TSV
11814779 8 Biotinylated lithocholic acids for affinity chromatography of mammalian DNA polymerases alpha and beta.EBI Bioorg Med Chem Lett 12: 287-90 (2002) Tokyo University of Science 2D 3D TSV
11814775 35 New generation dopaminergic agents. Part 8: heterocyclic bioisosteres that exploit the 7-OH-2-(aminomethyl)chroman D(2) template.EBI Bioorg Med Chem Lett 12: 271-4 (2002) Wyeth-Ayerst Research Laboratories 2D 3D TSV
11814774 50 Estimation of binding affinities for celecoxib analogues with COX-2 via Monte Carlo-extended linear response.EBI Bioorg Med Chem Lett 12: 267-70 (2002) Yale University 2D 3D TSV
11809867 38 A(3) adenosine receptors in human neutrophils and promyelocytic HL60 cells: a pharmacological and biochemical study.BDB Mol Pharmacol 61: 415-24 (2002) University of Ferrara 2D 3D TSV
11809864 10 Binding characteristics of cetirizine and levocetirizine to human H(1) histamine receptors: contribution of Lys(191) and Thr(194).BDB Mol Pharmacol 61: 391-9 (2002) UCB S.A. 2D 3D TSV
11809072 6 A prolyl endopeptidase-inhibiting benzofuran dimer from Polyozellus multiflex.EBI J Nat Prod 65: 76-8 (2002) Kyungpook National University 2D 3D TSV
11809055 1 New chlorinated diphenyl ethers from an Aspergillus species.EBI J Nat Prod 65: 7-10 (2002) University of Western Australia 2D 3D TSV
11806723 20 Evaluation of the Dmt-Tic pharmacophore: conversion of a potent delta-opioid receptor antagonist into a potent delta agonist and ligands with mixed properties.EBI J Med Chem 45: 713-20 (2002) University of Cagliary 2D 3D TSV
11806722 14 Novel mycophenolic adenine bis(phosphonate) analogues as potential differentiation agents against human leukemia.EBI J Med Chem 45: 703-12 (2002) Pharmasset Inc. 2D 3D TSV
11806720 6 Synthesis of 1-(3,4-dihydroxy-5-nitrophenyl)-2-phenyl-ethanone and derivatives as potent and long-acting peripheral inhibitors of catechol-O-methyltransferase.EBI J Med Chem 45: 685-95 (2002) Department of Research & Development 2D 3D TSV
11806719 61 Identification of potent and selective mechanism-based inhibitors of the cysteine protease cruzain using solid-phase parallel synthesis.EBI J Med Chem 45: 676-84 (2002) University of California 2D 3D TSV
11806718 15 Design and synthesis of motilin antagonists derived from the [1-4] fragment of porcine motilin.EBI J Med Chem 45: 670-5 (2002) Chugai Pharmaceutical Co. Ltd. 2D 3D TSV
11806716 44 Expansion of structure-activity studies of piperidine analogues of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (GBR 12935) compounds by altering substitutions in the N-benzyl moiety and behavioral pharmacology of selected molecules.EBI J Med Chem 45: 654-62 (2002) Wayne State University 2D 3D TSV
11806715 13 Synthesis and optimization of a new family of type 3 17 beta-hydroxysteroid dehydrogenase inhibitors by parallel liquid-phase chemistry.EBI J Med Chem 45: 640-53 (2002) Centre Hospitalier Universitaire de Qu£bec and Universit£ Laval 2D 3D TSV
11806713 8 Synthesis and preliminary characterization of a novel antiarrhythmic compound (KB130015) with an improved toxicity profile compared with amiodarone.EBI J Med Chem 45: 623-30 (2002) Karo Bio AB 2D 3D TSV
11806711 6 Antitumor polycyclic acridines. 8.(1) Synthesis and telomerase-inhibitory activity of methylated pentacyclic acridinium salts.EBI J Med Chem 45: 590-7 (2002) University of Nottingham 2D 3D TSV
11806709 63 Synthesis and evaluation of potent and selective beta(3) adrenergic receptor agonists containing acylsulfonamide, sulfonylsulfonamide, and sulfonylurea carboxylic acid isosteres.EBI J Med Chem 45: 567-83 (2002) GlaxoSmithKline 2D 3D TSV
11806708 2 Discovery of a 3-amino-6-phenyl-pyridazine derivative as a new synthetic antineuroinflammatory compound.EBI J Med Chem 45: 563-6 (2002) TBA 2D 3D TSV
11806706 7 Designing non-peptide peptidomimetics in the 21st century: inhibitors targeting conformational ensembles.EBI J Med Chem 45: 541-58 (2002) University of Wisconsin-Madison 2D 3D TSV
11805207 8 Preclinical pharmacology of fiduxosin, a novel alpha(1)-adrenoceptor antagonist with uroselective properties.BDB J Pharmacol Exp Ther 300: 478-86 (2002) Abbott Laboratories 2D 3D TSV
11792694 2 Effect of 17 beta-estradiol-D-17 beta-glucuronide on the rat organic anion transporting polypeptide 2-mediated transport differs depending on substrates.EBI Drug Metab Dispos 30: 220-3 (2002) the University of Tokyo 2D 3D TSV
11784158 28 4'-Arylpyrrolomorphinans: effect of a pyrrolo-N-benzyl substituent in enhancing delta-opioid antagonist activity.EBI J Med Chem 45: 537-40 (2002) University of Bristol 2D 3D TSV
11784157 14 Design, synthesis, and pharmacological evaluation of new farnesyl protein transferase inhibitors.EBI J Med Chem 45: 533-6 (2002) Universit£ de Lille 2 2D 3D TSV
11784156 20 Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1).EBI J Med Chem 45: 529-32 (2002) University of Utah 2D 3D TSV
11784155 64 Orally-effective, long-acting sorbitol dehydrogenase inhibitors: synthesis, structure-activity relationships, and in vivo evaluations of novel heterocycle-substituted piperazino-pyrimidines.EBI J Med Chem 45: 511-28 (2002) Pfizer Global Research and Development 2D 3D TSV
11784153 125 4-(Phenylsulfonyl)piperidines: novel, selective, and bioavailable 5-HT(2A) receptor antagonists.EBI J Med Chem 45: 492-503 (2002) Merck Sharp and Dohme 2D 3D TSV
11784148 81 Novel spiropiperidines as highly potent and subtype selective sigma-receptor ligands. Part 1.EBI J Med Chem 45: 438-48 (2002) Pharmazeutisches Institut der Universität Freiburg 2D 3D TSV
11784146 9 2,5'-Disubstituted adenosine derivatives: evaluation of selectivity and efficacy for the adenosine A(1), A(2A), and A(3) receptor.EBI J Med Chem 45: 420-9 (2002) Leiden/Amsterdam Center for Drug Research 2D 3D TSV
11784143 4 C-7 analogues of progesterone as potent inhibitors of the P-glycoprotein efflux pump.EBI J Med Chem 45: 390-8 (2002) Georgetown University School of Medicine 2D 3D TSV
11784141 11 Beta-strand mimicking macrocyclic amino acids: templates for protease inhibitors with antiviral activity.BDB J Med Chem 45: 371-81 (2002) University of Queensland 2D 3D TSV
11784139 82 Pyrrolo[1,3]benzothiazepine-based atypical antipsychotic agents. Synthesis, structure-activity relationship, molecular modeling, and biological studies.EBI J Med Chem 45: 344-59 (2002) Universit£ degli Studi di Siena 2D 3D TSV
11784138 36 Elucidating the inhibiting mode of AHPBA derivatives against HIV-1 protease and building predictive 3D-QSAR models.EBI J Med Chem 45: 333-43 (2002) Chinese Academy of Sciences 2D 3D TSV
11784136 100 Carbonic anhydrase inhibitors: anticonvulsant sulfonamides incorporating valproyl and other lipophilic moieties.EBI J Med Chem 45: 312-20 (2002) University of Namur 2D 3D TSV
11784131 2 Inhibition of nNOS activity in rat brain by synthetic kynurenines: structure-activity dependence.EBI J Med Chem 45: 263-74 (2002) Universidad de Granada 2D 3D TSV
11784130 42 Design of substrate-based inhibitors of human beta-secretase.EBI J Med Chem 45: 259-62 (2002) TBA 2D 3D TSV
11779105 4 Stable expression of a synthetic gene for the human motilin receptor: use in an aequorin-based receptor activation assay.BDB Anal Biochem 300: 146-51 (2002) Kosan Biosciences, Inc. 2D 3D TSV
11770010 3 Interaction of omeprazole, lansoprazole and pantoprazole with P-glycoprotein.EBI Naunyn Schmiedebergs Arch Pharmacol 364: 551-7 (2001) Institute of Clinical Pharmacology 2D 3D TSV
11758759 34 Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules.EBI Pharm Res 18: 1528-34 (2001) Kyoto University Hospital 2D 3D TSV
11755395 5 Drug design with a new transition state analog of the hydrated carbonyl: silicon-based inhibitors of the HIV protease.BDB Chem Biol 8: 1161-6 (2001) State University of New York 2D 3D TSV
11755367 38 First dual NK(1) antagonists-serotonin reuptake inhibitors: synthesis and SAR of a new class of potential antidepressants.EBI Bioorg Med Chem Lett 12: 261-4 (2001) UCB Pharma SA 2D 3D TSV
11755366 24 Cyclic acid anhydrides as a new class of potent, selective and non-peptidic inhibitors of geranylgeranyl transferase.EBI Bioorg Med Chem Lett 12: 255-9 (2001) University College London 2D 3D TSV
11755365 113 Synthesis and structure-activity relationship of 2-(aminoalkyl)-2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a]azepine derivatives: a novel series of 5-HT(2A/2C) receptor antagonists. Part 2.EBI Bioorg Med Chem Lett 12: 249-53 (2001) Janssen-Cilag 2D 3D TSV
11755364 104 Synthesis and structure-activity relationship of 2-(aminoalkyl)-2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a]azepine derivatives: a novel series of 5-HT(2A/2C) receptor antagonists. Part 1.EBI Bioorg Med Chem Lett 12: 243-8 (2001) Janssen-Cilag 2D 3D TSV
11755362 24 Synthesis of 4-(8-benzo[1,2,5]oxadiazol-5-yl-[1,7]naphthyridine-6-yl)-benzoic acid: a potent and selective phosphodiesterase type 4D inhibitor.EBI Bioorg Med Chem Lett 12: 233-5 (2001) Novartis Pharma AG 2D 3D TSV
11755361 24 N-Methylbenzanilide derivatives as a novel class of selective V(1A) receptor antagonists.EBI Bioorg Med Chem Lett 12: 229-32 (2001) Yamanouchi Pharmaceutical Co. Ltd. 2D 3D TSV
11755357 14 Synthesis and biological activities of YkFA analogues: effects of position 4 substitutions and altered ring size on in vitro opioid activity.EBI Bioorg Med Chem Lett 12: 213-6 (2001) University of Louisville 2D 3D TSV
11755355 32 Biphenyls as potent vitronectin receptor antagonists.EBI Bioorg Med Chem Lett 12: 205-8 (2001) Bayer AG 2D 3D TSV
11755353 61 3-Aryl pyridone derivatives. Potent and selective kappa opioid receptor agonists.EBI Bioorg Med Chem Lett 12: 197-200 (2001) AstraZeneca R&D Mölndal 2D 3D TSV
11755352 40 Oxyaniliniums as acetylcholinesterase inhibitors for the reversal of neuromuscular block.EBI Bioorg Med Chem Lett 12: 193-6 (2001) Organon Laboratories Ltd. 2D 3D TSV
11755351 24 Synthesis and pharmacology of isoquinuclidine derivatives as 5-HT(3) ligands.EBI Bioorg Med Chem Lett 12: 189-92 (2001) Universidad de Alcal£ 2D 3D TSV
11755350 31 Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 2: (3-Substituted-5-halo-2-pyridinyl)guanidines.EBI Bioorg Med Chem Lett 12: 185-7 (2001) Pfizer Global Research and Development 2D 3D TSV
11755349 24 Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 1: 2-Pyridinylguanidines.EBI Bioorg Med Chem Lett 12: 181-4 (2001) Pfizer Global Research and Development 2D 3D TSV
11755345 45 Synthesis and biological activity of 8beta-substituted hydrocodone indole and hydromorphone indole derivatives.EBI Bioorg Med Chem Lett 12: 165-8 (2001) NIDDK 2D 3D TSV
11755344 47 The discovery of small molecule carbamates as potent dual alpha(4)beta(1)/alpha(4)beta(7) integrin antagonists.EBI Bioorg Med Chem Lett 12: 159-63 (2001) Merck Research Laboratories 2D 3D TSV
11755343 54 Evaluation of isotryptamine derivatives at 5-HT(2) serotonin receptors.EBI Bioorg Med Chem Lett 12: 155-8 (2001) Virginia Commonwealth University 2D 3D TSV
11755341 50 Mixed lineage kinase activity of indolocarbazole analogues.EBI Bioorg Med Chem Lett 12: 147-50 (2001) Kyowa-Hakko Kogyo Co., Ltd. 2D 3D TSV
11755340 94 Synthesis and structure-activity relationships of oxime neurokinin antagonists: discovery of potent arylamides.EBI Bioorg Med Chem Lett 12: 141-5 (2001) Schering-Plough Research Institute 2D 3D TSV
11755339 33 N-acyl-L-phenylalanine derivatives as potent VLA-4 antagonists that mimic a cyclic peptide conformation.EBI Bioorg Med Chem Lett 12: 137-40 (2001) Hoffmann-La Roche Inc. 2D 3D TSV
11755338 24 Specific and dual antagonists of alpha(4)beta(1) and alpha(4)beta(7) integrins.EBI Bioorg Med Chem Lett 12: 133-6 (2001) Merck Research Laboratories 2D 3D TSV
11755336 43 The design and synthesis of a novel series of indole derived selective ET(A) antagonists.EBI Bioorg Med Chem Lett 12: 125-8 (2001) Pfizer Central Research 2D 3D TSV
11755332 10 Effects of the incorporation of IBTM beta-turn mimetics into the dipeptoid CCK(1) receptor agonist PD 170292.EBI Bioorg Med Chem Lett 12: 109-12 (2001) Instituto de Química Médica (CSIC) 2D 3D TSV
11754608 6 Screening of triterpenoids isolated from Phyllanthus flexuosus for DNA topoisomerase inhibitory activity.EBI J Nat Prod 64: 1545-7 (2001) Osaka University of Pharmaceutical Sciences 2D 3D TSV
11754594 59 Inhibition of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductases by 2,4-diamino-5-[2-methoxy-5-(omega-carboxyalkyloxy)benzyl]pyrimidines: marked improvement in potency relative to trimethoprim and species selectivity relative to piritrexim.EBI J Med Chem 45: 233-41 (2001) Harvard Medical School 2D 3D TSV
11754593 148 Phenoxyphenyl sulfone N-formylhydroxylamines (retrohydroxamates) as potent, selective, orally bioavailable matrix metalloproteinase inhibitors.EBI J Med Chem 45: 219-32 (2001) Abbott Laboratories 2D 3D TSV
11754592 21 Methanocarba modification of uracil and adenine nucleotides: high potency of Northern ring conformation at P2Y1, P2Y2, P2Y4, and P2Y11 but not P2Y6 receptors.EBI J Med Chem 45: 208-18 (2001) National Institute of Diabetes 2D 3D TSV
11754590 53 Design and synthesis of potent nonpeptidic farnesyltransferase inhibitors based on a terphenyl scaffold.EBI J Med Chem 45: 177-88 (2001) Yale University 2D 3D TSV
11754588 39 Design, synthesis, and discovery of novel trans-stilbene analogues as potent and selective human cytochrome P450 1B1 inhibitors.EBI J Med Chem 45: 160-4 (2001) Seoul National University 2D 3D TSV
11754583 112 7-Substituted 5-amino-2-(2-furyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as A2A adenosine receptor antagonists: a study on the importance of modifications at the side chain on the activity and solubility.EBI J Med Chem 45: 115-26 (2001) Università degli Studi di Ferrara 2D 3D TSV
11754581 12 Structure-based design and characterization of novel platforms for ricin and shiga toxin inhibition.EBI J Med Chem 45: 90-8 (2001) University of Texas 2D 3D TSV
11754579 82 New serotonin 5-HT(2A), 5-HT(2B), and 5-HT(2C) receptor antagonists: synthesis, pharmacology, 3D-QSAR, and molecular modeling of (aminoalkyl)benzo and heterocycloalkanones.EBI J Med Chem 45: 54-71 (2001) Universidad de Santiago de Compostela 2D 3D TSV
11754578 155 Pharmacophore mapping of a series of 2,4-diamino-5-deazapteridine inhibitors of Mycobacterium avium complex dihydrofolate reductase.EBI J Med Chem 45: 41-53 (2001) Lindsley F. Kimball Research Institute 2D 3D TSV
11754576 33 Novel 1-hydroxyazole bioisosteres of glutamic acid. Synthesis, protolytic properties, and pharmacology.EBI J Med Chem 45: 19-31 (2001) The Royal Danish School of Pharmacy 2D 3D TSV
11754575 51 Design and synthesis of pyrrolidine-5,5-trans-lactams (5-oxohexahydropyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 2. Potency and chirality.EBI J Med Chem 45: 1-18 (2001) GlaxoSmithKline Research and Development 2D 3D TSV
11752131 7 Nonpeptide tachykinin receptor antagonists. III. SB 235375, a low central nervous system-penetrant, potent and selective neurokinin-3 receptor antagonist, inhibits citric acid-induced cough and airways hyper-reactivity in guinea pigs.BDB J Pharmacol Exp Ther 300: 314-23 (2002) GlaxoSmithKline 2D 3D TSV
11752130 5 The effects of deleting the mouse neurotensin receptor NTR1 on central and peripheral responses to neurotensin.BDB J Pharmacol Exp Ther 300: 305-13 (2002) Merck Research Laboratories 2D 3D TSV
11751127 2 Interaction of common azole antifungals with P glycoprotein.EBI Antimicrob Agents Chemother 46: 160-5 (2001) Schering-Plough Research Institute 2D 3D TSV
11750183 29 Extended radioligand binding profile of iloperidone: a broad spectrum dopamine/serotonin/norepinephrine receptor antagonist for the management of psychotic disorders.BDB Neuropsychopharmacology 25: 904-14 (2001) Novartis Pharma 2D 3D TSV
11750180 139 Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors.BDB Neuropsychopharmacology 25: 871-80 (2001) Lilly Research Laboratories 2D 3D TSV
11743742 6 Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4.EBI Chem Res Toxicol 14: 1596-603 (2001) Schering-Plough Research Institute 2D 3D TSV
11741777 15 Synthesis of alkenyldiarylmethane (ADAM) non-nucleoside HIV-1 reverse transcriptase inhibitors with non-identical aromatic rings.BDB Bioorg Med Chem 10: 283-90 (2002) Purdue University 2D 3D TSV
11741491 12 Design and synthesis of non-peptidic inhibitors for the Syk C-terminal SH2 domain based on structure-based in-silico screening.EBI J Med Chem 44: 4737-40 (2001) Waseda University 2D 3D TSV
11741490 18 Synthesis, in vitro pharmacology, and molecular modeling of syn-huprines as acetylcholinesterase inhibitors.EBI J Med Chem 44: 4733-6 (2001) Universitat de Barcelona 2D 3D TSV
11741489 45 Dopamine D(3) receptor antagonists. 1. Synthesis and structure-activity relationships of 5,6-dimethoxy-N-alkyl- and N-alkylaryl-substituted 2-aminoindans.EBI J Med Chem 44: 4716-32 (2001) Pharmacia 2D 3D TSV
11741488 19 2-(2-Piperidyl)- and 2-(2-pyrrolidyl)chromans as nicotine agonists: synthesis and preliminary pharmacological characterization.EBI J Med Chem 44: 4704-15 (2001) University of Minnesota 2D 3D TSV
11741485 99 Diaminoindanes as microsomal triglyceride transfer protein inhibitors.EBI J Med Chem 44: 4677-87 (2001) Novartis Institute for Biomedical Reasearch 2D 3D TSV
11741480 41 A novel approach for the development of selective Cdk4 inhibitors: library design based on locations of Cdk4 specific amino acid residues.BDB J Med Chem 44: 4628-40 (2001) Banyu Tsukuba Research Institute 2D 3D TSV
11741479 28 Structure-based generation of a new class of potent Cdk4 inhibitors: new de novo design strategy and library design.BDB J Med Chem 44: 4615-27 (2001) Banyu Tsukuba Research Institute 2D 3D TSV
11741477 37 Structure of protein tyrosine phosphatase 1B in complex with inhibitors bearing two phosphotyrosine mimetics.EBI J Med Chem 44: 4584-94 (2001) University of Waterloo 2D 3D TSV
11741475 56 Design, synthesis, and biological characterization of bivalent 1-methyl-1,2,5,6-tetrahydropyridyl-1,2,5-thiadiazole derivatives as selective muscarinic agonists.EBI J Med Chem 44: 4563-76 (2001) The University of Toledo 2D 3D TSV
11741473 37 Synthetic 2-aroylindole derivatives as a new class of potent tubulin-inhibitory, antimitotic agents.EBI J Med Chem 44: 4535-53 (2001) University of Regensburg 2D 3D TSV
11741472 45 Identification of dipeptidyl nitriles as potent and selective inhibitors of cathepsin B through structure-based drug design.EBI J Med Chem 44: 4524-34 (2001) Novartis Pharmaceuticals Corporation 2D 3D TSV
11741471 13 Quadruplex-interactive agents as telomerase inhibitors: synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase.EBI J Med Chem 44: 4509-23 (2001) University of Texas at Austin 2D 3D TSV
11741470 40 Design, synthesis and biological evaluation of novel arachidonic acid derivatives as highly potent and selective endocannabinoid transporter inhibitors.EBI J Med Chem 44: 4505-8 (2001) Universidad Complutense 2D 3D TSV
11741469 8 Characterization of the 1H-cyclopentapyrimidine-2,4(1H,3H)-dione derivative (S)-CPW399 as a novel, potent, and subtype-selective AMPA receptor full agonist with partial desensitization properties.EBI J Med Chem 44: 4501-4 (2001) Universita' degli Studi di Siena 2D 3D TSV
11738604 13 Structure-based design of nonpeptide inhibitors of interleukin-1beta converting enzyme (ICE, caspase-1).BDB Bioorg Med Chem 10: 31-40 (2002) Pfizer 2D 3D TSV
11738583 45 Potent P1' biphenylmethyl substituted aggrecanase inhibitors.EBI Bioorg Med Chem Lett 12: 101-4 (2001) Bristol-Myers Squibb Pharma Company 2D 3D TSV
11738578 26 Modifications and structure-activity relationships at the 2-position of 4-sulfonamidopyrimidine derivatives as potent endothelin antagonists.EBI Bioorg Med Chem Lett 12: 81-4 (2001) Tanabe Seiyaku Co. Ltd. 2D 3D TSV
11738577 19 Design, synthesis and evaluation of substituted phenylpropanoic acid derivatives as peroxisome proliferator-activated receptor (PPAR) activators: novel human PPARalpha-selective activators.EBI Bioorg Med Chem Lett 12: 77-80 (2001) Kyorin Pharmaceutical Co., Ltd. 2D 3D TSV
11738574 36 4-Aryl/cycloalkyl-5-phenyloxazole derivatives as selective COX-2 inhibitors.EBI Bioorg Med Chem Lett 12: 65-8 (2001) Central Pharmaceutical Research Institute 2D 3D TSV
11738571 36 Potent, orally active inhibitors of lipoprotein-associated phospholipase A(2): 1-(biphenylmethylamidoalkyl)-pyrimidones.EBI Bioorg Med Chem Lett 12: 51-5 (2001) GlaxoSmithKline 2D 3D TSV
11738570 29 Molecular design and structure--activity relationships leading to the potent, selective, and orally active thrombin active site inhibitor BMS-189664.EBI Bioorg Med Chem Lett 12: 45-9 (2001) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
11738569 26 Thrombin active site inhibitors: chemical synthesis, in vitro and in vivo pharmacological profile of a novel and selective agent BMS-189090 and analogues.EBI Bioorg Med Chem Lett 12: 41-4 (2001) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
11738567 16 Non-peptide alpha(v)beta(3) antagonists. Part 3: identification of potent RGD mimetics incorporating novel beta-amino acids as aspartic acid replacements.EBI Bioorg Med Chem Lett 12: 31-4 (2001) Merck Research Laboratories 2D 3D TSV
11738566 20 Nonpeptide alpha(v)beta(3) antagonists. Part 2: constrained glycyl amides derived from the RGD tripeptide.EBI Bioorg Med Chem Lett 12: 25-9 (2001) Merck Research Laboratories 2D 3D TSV
11738564 9 Synthesis and biological evaluation of novel thio-substituted chromanes as high-affinity partial agonists for the estrogen receptor.EBI Bioorg Med Chem Lett 12: 17-9 (2002) Novo Nordisk A/S 2D 3D TSV
11738561 34 Phthalazine PDE4 inhibitors. Part 3: the synthesis and in vitro evaluation of derivatives with a hydrogen bond acceptor.EBI Bioorg Med Chem Lett 12: 5-8 (2002) Zambon Group 2D 3D TSV
11731301 192 Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets.BDB Chem Biol 8: 1107-21 (2001) Axys Pharmaceutical 2D 3D TSV
11728194 98 Nonsteroidal selective glucocorticoid modulators: the effect of C-5 alkyl substitution on the transcriptional activation/repression profile of 2,5-dihydro-10-methoxy-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines.EBI J Med Chem 44: 4481-91 (2001) Abbott Laboratories 2D 3D TSV
11728193 12 Synthesis and biological studies of novel nucleoside phosphoramidate prodrugs.EBI J Med Chem 44: 4475-80 (2001) Purdue University 2D 3D TSV
11728190 10 Novel tropane-based irreversible ligands for the dopamine transporter.EBI J Med Chem 44: 4453-61 (2001) National Institute on Drug Abuse-Intramural Research Program 2D 3D TSV
11728188 53 trans-4-[4-(Methoxyphenyl)cyclohexyl]-1-arylpiperazines: a new class of potent and selective 5-HT(1A) receptor ligands as conformationally constrained analogues of 4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]-1-arylpiperazines.EBI J Med Chem 44: 4431-42 (2001) Università Bari 2D 3D TSV
11728186 46 Synthesis and structure-activity relationships of N-(1-benzylpiperidin-4-yl)arylacetamide analogues as potent sigma1 receptor ligands.EBI J Med Chem 44: 4404-15 (2001) Wake Forest University School of Medicine 2D 3D TSV
11728185 55 Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction. 4. Structure-activity relationship of substituents on the benzene ring of the cinnamide.EBI J Med Chem 44: 4393-403 (2001) Abbott Laboratories 2D 3D TSV
11728184 20 Systematic structure-based design and stereoselective synthesis of novel multisubstituted cyclopentane derivatives with potent antiinfluenza activity.BDB J Med Chem 44: 4379-92 (2001) BioCryst Pharmaceuticals, Inc. 2D 3D TSV
11728182 28 [1,2,4]Triazino[4,3-a]benzimidazole acetic acid derivatives: a new class of selective aldose reductase inhibitors.EBI J Med Chem 44: 4359-69 (2001) Università di Pisa 2D 3D TSV
11728181 188 Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): design, synthesis, enzymatic activities, and X-ray crystallographic analysis.BDB J Med Chem 44: 4339-58 (2001) GlaxoSmithKline 2D 3D TSV
11728179 12 Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening.EBI J Med Chem 44: 4313-24 (2001) Georgetown University Medical Center 2D 3D TSV
11728178 15 Conformationally constrained analogues of diacylglycerol. 18. The incorporation of a hydroxamate moiety into diacylglycerol-lactones reduces lipophilicity and helps discriminate between sn-1 and sn-2 binding modes to protein kinase C (PK-C). Implications for isozyme specificity.EBI J Med Chem 44: 4309-12 (2001) Seoul National University 2D 3D TSV
11720869 9 Design, synthesis and preliminary evaluation of novel 3'-substituted carboxycyclopropylglycines as antagonists at group 2 metabotropic glutamate receptors.EBI Bioorg Med Chem Lett 11: 3179-82 (2001) Universit£ di Perugia 2D 3D TSV
11720868 14 Synthesis and HIV-1 integrase inhibitory activities of catechol and bis-catechol derivatives.EBI Bioorg Med Chem Lett 11: 3175-8 (2001) Université des Sciences et Technologies de Lille 2D 3D TSV
11720867 24 [3-cis-3,5-Dimethyl-(1-piperazinyl)alkyl]-bis-(4'-fluorophenyl)amine analogues as novel probes for the dopamine transporter.EBI Bioorg Med Chem Lett 11: 3169-73 (2001) National Institute on Drug Abuse - Intramural Research Program 2D 3D TSV
11720866 19 1-Alkyl-3-amino-5-aryl-1H-[1,2,4]triazoles: novel synthesis via cyclization of N-acyl-S-methylisothioureas with alkylhydrazines and their potent corticotropin-releasing factor-1 (CRF(1)) receptor antagonist activities.EBI Bioorg Med Chem Lett 11: 3165-8 (2001) Neurocrine Biosciences, Inc. 2D 3D TSV
11720865 11 Novel bicyclic lactam inhibitors of thrombin: potency and selectivity optimization through P1 residues.EBI Bioorg Med Chem Lett 11: 3161-4 (2001) Shire BioChem Inc. 2D 3D TSV
11720863 73 Solution-phase, parallel synthesis and pharmacological evaluation of acylguanidine derivatives as potential sodium channel blockers.EBI Bioorg Med Chem Lett 11: 3151-5 (2001) CeNeS Pharmaceuticals Inc. 2D 3D TSV
11720861 24 Discovery, total synthesis, HRV 3C-protease inhibitory activity, and structure-activity relationships of 2-methoxystypandrone and its analogues.EBI Bioorg Med Chem Lett 11: 3143-6 (2001) Merck Research Laboratories 2D 3D TSV
11720860 12 Combinatorial synthesis of CCR5 antagonists.EBI Bioorg Med Chem Lett 11: 3137-41 (2001) Merck Research Laboratories 2D 3D TSV
11720859 1 Modelling studies of the active site of human sorbitol dehydrogenase: an approach to structure-based inhibitor design of the enzyme.EBI Bioorg Med Chem Lett 11: 3133-6 (2001) Monash University (Parkville Campus) 2D 3D TSV
11720857 37 4-Aminopiperidine ureas as potent selective agonists of the human beta(3)-adrenergic receptor.EBI Bioorg Med Chem Lett 11: 3123-7 (2001) Wyeth-Ayerst Research 2D 3D TSV
11720854 48 Synthesis and biological activity of L-tyrosine-based PPARgamma agonists with reduced molecular weight.EBI Bioorg Med Chem Lett 11: 3111-3 (2001) GlaxoSmithKline 2D 3D TSV
11720852 51 Design, synthesis, and SAR of heterocycle-containing antagonists of the human CCR5 receptor for the treatment of HIV-1 infection.EBI Bioorg Med Chem Lett 11: 3103-6 (2001) Merck Research Laboratories 2D 3D TSV
11720851 52 Discovery of human CCR5 antagonists containing hydantoins for the treatment of HIV-1 infection.EBI Bioorg Med Chem Lett 11: 3099-102 (2001) Merck Research Laboratories 2D 3D TSV
11720533 3 A new dimeric stilbene with tyrosinase inhibitiory activity from Artocarpus gomezianus.EBI J Nat Prod 64: 1457-9 (2001) Chulalongkorn University 2D 3D TSV
11716514 103 Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors.EBI Biochem Biophys Res Commun 289: 580-5 (2001) Schering-Plough Research Institute 2D 3D TSV
11714898 21 Functional calcitonin gene-related peptide subtype 2 receptors in porcine coronary arteries are identified as calcitonin gene-related peptide subtype 1 receptors by radioligand binding and reverse transcription-polymerase chain reaction.BDB J Pharmacol Exp Ther 299: 1086-94 (2001) Creighton University 2D 3D TSV
11714892 4 N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-nitrophenyl) cyclohexanecarboxamide: a novel pre- and postsynaptic 5-hydroxytryptamine(1A) receptor antagonist active on the lower urinary tract.BDB J Pharmacol Exp Ther 299: 1027-37 (2001) Recordati S.p.A. 2D 3D TSV
11714875 18 Constitutive activity of histamine h(3) receptors stably expressed in SK-N-MC cells: display of agonism and inverse agonism by H(3) antagonists.BDB J Pharmacol Exp Ther 299: 908-14 (2001) Vrije Universiteit 2D 3D TSV
11714872 14 The pharmacological profile of (R)-3,4-dihydro-N-isopropyl-3-(N-isopropyl-N-propylamino)-2H-1-benzopyran-5-carboxamide, a selective 5-hydroxytryptamine(1A) receptor agonist.BDB J Pharmacol Exp Ther 299: 883-93 (2001) AstraZeneca R&D 2D 3D TSV
11714616 28 Identification of a novel family of nucleosides that specifically inhibit HIV-1 reverse transcriptase.EBI Bioorg Med Chem Lett 11: 3085-8 (2001) Instituto de Química Médica (C.S.I.C.) 2D 3D TSV
11714615 22 Dual neurokinin NK(1)/NK(2) antagonists: N-[(R,R)-(E)-1-arylmethyl-3-(2-oxo-azepan-3-yl)carbamoyl]allyl-N-methyl-3,5-bis(trifluoromethyl)benzamides and 3-[N'-3,5-bis(trifluoromethyl)benzoyl-N-arylmethyl-N'-methylhydrazino]-N-[(R)-2-oxo-azepan-3-yl]propionamides.EBI Bioorg Med Chem Lett 11: 3081-4 (2001) Novartis Pharma AG 2D 3D TSV
11714614 11 Synthesis and binding affinities of 2 beta-(3-iodoallyloxycarbonyl)-3 beta-(4-substituted-aryl)tropane analogues as ligands for the dopamine transporter studies.EBI Bioorg Med Chem Lett 11: 3077-80 (2001) Inha University 2D 3D TSV
11714612 19 A novel class of highly potent, selective, and non-peptidic inhibitor of Ras farnesyltransferase (FTase).EBI Bioorg Med Chem Lett 11: 3069-72 (2001) LGCI 2D 3D TSV
11714608 30 Synthesis and biological evaluation of a series of novel N- or O-fluoroalkyl derivatives of tropane: potential positron emission tomography (PET) imaging agents for the dopamine transporter.EBI Bioorg Med Chem Lett 11: 3049-53 (2001) Alcohol and Drug Abuse Research Center 2D 3D TSV
11714606 31 BMS-196085: a potent and selective full agonist of the human beta(3) adrenergic receptor.EBI Bioorg Med Chem Lett 11: 3041-4 (2001) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
11714605 39 Beta 3 agonists. Part 1: evolution from inception to BMS-194449.EBI Bioorg Med Chem Lett 11: 3035-9 (2001) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
11714604 19 2-Aryl indole NK(1) antagonists: optimisation of the amide substituent.EBI Bioorg Med Chem Lett 11: 3031-4 (2001) Merck Sharp & Dohme Research Laboratories 2D 3D TSV
11714603 7 Synthesis of antitumor dendritic imides.EBI Bioorg Med Chem Lett 11: 3027-9 (2001) University San Pablo-CEU 2D 3D TSV
11714602 18 7-Nitrobenzofurazan (NBD) derivatives of 5'-N-ethylcarboxamidoadenosine (NECA) as new fluorescent probes for human A(3) adenosine receptors.EBI Bioorg Med Chem Lett 11: 3023-6 (2001) Universit£ di Pisa 2D 3D TSV
11714601 9 Discovery and evaluation of piperidinyl carboxylic acid derivatives as potent alpha(4)beta(1) integrin antagonists.EBI Bioorg Med Chem Lett 11: 3019-21 (2001) Bayer AG 2D 3D TSV
11714600 10 Cyclopenta[g]quinazoline-based antifolates: the effect of the chirality at the 6-position on the inhibition of thymidylate synthase (TS).EBI Bioorg Med Chem Lett 11: 3015-7 (2001) CRC Laboratory 2D 3D TSV
11714597 5 Determination and use of a transition state for the enzyme estrone sulfatase (ES) from a proposed reaction mechanism.EBI Bioorg Med Chem Lett 11: 3001-5 (2001) Kingston University 2D 3D TSV
11714595 43 Discovery of a N'-hydroxyphenylformamidine derivative HET0016 as a potent and selective 20-HETE synthase inhibitor.EBI Bioorg Med Chem Lett 11: 2993-5 (2001) Taisho Pharmaceutical Co., Ltd. 2D 3D TSV
11708932 7 An orally active, water-soluble neurokinin-1 receptor antagonist suitable for both intravenous and oral clinical administration.EBI J Med Chem 44: 4296-9 (2001) Merck 2D 3D TSV
11708931 44 5,6-Diphenylpyridazine derivatives as acyl-CoA:cholesterol acyltransferase inhibitors.EBI J Med Chem 44: 4292-5 (2001) Università di Firenze 2D 3D TSV
11708928 17 Role of hydrophilic interaction in binding of hydroxylated 3-deoxy C(19) steroids to the active site of aromatase.BDB J Med Chem 44: 4277-83 (2001) Tohoku Pharmaceutical University 2D 3D TSV
11708927 8 A prodrug form of a Plasmodium falciparum glutathione reductase inhibitor conjugated with a 4-anilinoquinoline.EBI J Med Chem 44: 4268-76 (2001) UMR 8525 CNRS-Université Lille II-Institut Pasteur de Lille 2D 3D TSV
11708926 84 Design of selective and soluble inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).EBI J Med Chem 44: 4252-67 (2001) GlaxoSmithKline 2D 3D TSV
11708925 44 Estrogen receptor-beta potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues.EBI J Med Chem 44: 4230-51 (2001) University of Illinois 2D 3D TSV
11708921 28 5-(Tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-based potent and selective CCK(1) receptor antagonists: structure-activity relationship studies on the central 1,3-dioxoperhydropyrido[1,2-c]pyrimidine scaffold.EBI J Med Chem 44: 4196-206 (2001) Instituto de Qu£mica M£dica (CSIC) 2D 3D TSV
11708918 29 Design and pharmacological activity of phosphinic acid based NAALADase inhibitors.EBI J Med Chem 44: 4170-5 (2001) Guilford Pharmaceuticals Inc. 2D 3D TSV
11708917 33 Synthesis and biological evaluation of prostaglandin-F alkylphosphinic acid derivatives as bone anabolic agents for the treatment of osteoporosis.EBI J Med Chem 44: 4157-69 (2001) Procter & Gamble Pharmaceuticals 2D 3D TSV
11708915 52 Neoceptor concept based on molecular complementarity in GPCRs: a mutant adenosine A(3) receptor with selectively enhanced affinity for amine-modified nucleosides.EBI J Med Chem 44: 4125-36 (2001) National Institute of Diabetes and Digestive and Kidney Diseases 2D 3D TSV
11708914 4 Novel agouti-related-protein-based melanocortin-1 receptor antagonist.EBI J Med Chem 44: 4114-24 (2001) University of Florida 2D 3D TSV
11708913 41 The biological effects of structural variation at the meta position of the aromatic rings and at the end of the alkenyl chain in the alkenyldiarylmethane series of non-nucleoside reverse transcriptase inhibitors.BDB J Med Chem 44: 4092-113 (2001) Purdue University 2D 3D TSV
11708910 42 Methyl analogues of the experimental Alzheimer drug phenserine: synthesis and structure/activity relationships for acetyl- and butyrylcholinesterase inhibitory action.BDB J Med Chem 44: 4062-71 (2001) National Institutes of Health 2D 3D TSV
11708909 12 Monosaccharide-linked inhibitors of O(6)-methylguanine-DNA methyltransferase (MGMT): synthesis, molecular modeling, and structure-activity relationships.EBI J Med Chem 44: 4050-61 (2001) German Cancer Research Center 2D 3D TSV
11708908 55 Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25.EBI J Med Chem 44: 4042-9 (2001) University of Pittsburgh 2D 3D TSV
11708906 15 Design, synthesis, and biological activity of methoctramine-related polyamines as putative G(i) protein activators.EBI J Med Chem 44: 4035-8 (2001) University of Bologna 2D 3D TSV
11708905 20 N-[3-(2-Dimethylaminoethyl)-2-methyl-1H- indol-5-yl]-4-fluorobenzamide: a potent, selective, and orally active 5-HT(1F) receptor agonist potentially useful for migraine therapy.EBI J Med Chem 44: 4031-4 (2001) Lilly Research Laboratories 2D 3D TSV
11701096 24 Di-, tri- and tetra-5'-O-phosphorothioadenosyl substituted polyols as inhibitors of Fhit: Importance of the alpha-beta bridging oxygen and beta phosphorus replacement.BDB BMC Chem Biol 1: 3 (2001) Kimmel Cancer Center 2D 3D TSV
11697047 10 Glycosylasparaginase inhibition studies: competitive inhibitors, transition state mimics, noncompetitive inhibitors.BDB J Enzym Inhib 16: 269-74 (2001) University of North Carolina 2D 3D TSV
11689089 30 Structure-activity studies on nociceptin analogues: ORL1 receptor binding and biological activity of cyclic disulfide-containing analogues of nociceptin peptides.EBI J Med Chem 44: 4015-8 (2001) Tohoku Pharmaceutical University 2D 3D TSV
11689088 22 Synthesis and screening for antiacetylcholinesterase activity of (1-benzyl-4-oxopiperidin-3-ylidene)methylindoles and -pyrroles related to donepezil.EBI J Med Chem 44: 4011-4 (2001) Università di Bologna 2D 3D TSV
11689087 26 Discovery of a series of nonpeptide small molecules that inhibit the binding of insulin-like growth factor (IGF) to IGF-binding proteins.EBI J Med Chem 44: 4001-10 (2001) Neurocrine Biosciences, Inc. 2D 3D TSV
11689084 47 Pyrrolidine-3-carboxylic acids as endothelin antagonists. 5. Highly selective, potent, and orally active ET(A) antagonists.EBI J Med Chem 44: 3978-84 (2001) Abbott Laboratories 2D 3D TSV
11689083 41 Optimization of 4-phenylamino-3-quinolinecarbonitriles as potent inhibitors of Src kinase activity.BDB J Med Chem 44: 3965-77 (2001) Wyeth-Ayerst Research 2D 3D TSV
11689080 43 Synthesis and biological evaluation of tropane-like 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909) analogues.EBI J Med Chem 44: 3937-45 (2001) National Institute of Diabetes and Digestive and Kidney Diseases 2D 3D TSV
11689079 18 Antitumor Agents. 211. Fluorinated 2-phenyl-4-quinolone derivatives as antimitotic antitumor agents.EBI J Med Chem 44: 3932-6 (2001) University of North Carolina 2D 3D TSV
11689075 20 Pseudoproline-containing analogues of morphiceptin and endomorphin-2: evidence for a cis Tyr-Pro amide bond in the bioactive conformation.EBI J Med Chem 44: 3896-903 (2001) University of Lausanne 2D 3D TSV
11689074 112 N-Arylsulfonylindole derivatives as serotonin 5-HT(6) receptor ligands.EBI J Med Chem 44: 3881-95 (2001) Merck Sharp & Dohme Research Laboratories 2D 3D TSV
11689073 4 Iridals are a novel class of ligands for phorbol ester receptors with modest selectivity for the RasGRP receptor subfamily.EBI J Med Chem 44: 3872-80 (2001) University of Michigan Cancer Center 2D 3D TSV
11689072 49 Exploiting subsite S1 of trypsin-like serine proteases for selectivity: potent and selective inhibitors of urokinase-type plasminogen activator.EBI J Med Chem 44: 3856-71 (2001) Axys Pharmaceuticals Inc. 2D 3D TSV
11689071 40 Three-dimensional quantitative structure-activity relationship (3D-QSAR) models for a novel class of piperazine-based stromelysin-1 (MMP-3) inhibitors: applying a"divide and conquer" strategy.EBI J Med Chem 44: 3849-55 (2001) University of Missouri-St. Louis 2D 3D TSV
11689069 18 Synthesis and activity of novel and selective I(Ks)-channel blockers.EBI J Med Chem 44: 3831-7 (2001) Aventis Pharma Deutschland GmbH 2D 3D TSV
11689067 34 Acetylcholinesterase inhibitors: SAR and kinetic studies on omega-[N-methyl-N-(3-alkylcarbamoyloxyphenyl)methyl]aminoalkoxyaryl derivatives.BDB J Med Chem 44: 3810-20 (2001) University of Bologna 2D 3D TSV
11689065 27 Modeling of poly(ADP-ribose)polymerase (PARP) inhibitors. Docking of ligands and quantitative structure-activity relationship analysis.EBI J Med Chem 44: 3786-94 (2001) Università di Perugia 2D 3D TSV
11689063 28 Design and synthesis of 4-substituted benzamides as potent, selective, and orally bioavailable I(Ks) blockers.EBI J Med Chem 44: 3764-7 (2001) TBA 2D 3D TSV
11678667 1 Makaluvamine P, a new cytotoxic pyrroloiminoquinone from Zyzzya cf. fuliginosa.EBI J Nat Prod 64: 1354-6 (2001) Universit£ di Salerno 2D 3D TSV
11678659 1 Antimalarial (+)-trans-hexahydrodibenzopyran derivatives from Machaerium multiflorum.EBI J Nat Prod 64: 1322-5 (2001) University of Mississippi 2D 3D TSV
11678654 3 Inhibition of leukocyte functions by the alkaloid isaindigotone from Isatis indigotica and some new synthetic derivatives.EBI J Nat Prod 64: 1297-300 (2001) Universidad de Murcia 2D 3D TSV
11678653 1 Catalytic inhibition of topoisomerase IIalpha by demethylzeylasterone, a 6-oxophenolic triterpenoid from Kokoona zeylanica.EBI J Nat Prod 64: 1294-6 (2001) University of Arizona 2D 3D TSV
11678652 16 Aromatase inhibitors from Broussonetia papyrifera.EBI J Nat Prod 64: 1286-93 (2001) University of Illinois at Chicago 2D 3D TSV
11677140 4 Fipronil-based photoaffinity probe for Drosophila and human beta 3 GABA receptors.EBI Bioorg Med Chem Lett 11: 2979-81 (2001) University of California 2D 3D TSV
11677139 92 The discovery of anthranilic acid-based MMP inhibitors. Part 3: incorporation of basic amines.EBI Bioorg Med Chem Lett 11: 2975-8 (2001) Wyeth-Ayerst Research 2D 3D TSV
11677136 13 3-Aryl-4-aryloyl-1-(1H-imidazol-5-yl)methylpyrrole, a novel class of farnesyltransferase inhibitors.EBI Bioorg Med Chem Lett 11: 2963-5 (2001) LGCI 2D 3D TSV
11677135 21 Identification of a series of PPAR gamma/delta dual agonists via solid-phase parallel synthesis.EBI Bioorg Med Chem Lett 11: 2959-62 (2001) GlaxoSmithKline 2D 3D TSV
11677134 42 Design and synthesis of potent and selective inhibitors of integrin VLA-4.EBI Bioorg Med Chem Lett 11: 2955-8 (2001) Novartis Institute for Biomedical Research 2D 3D TSV
11677133 14 Discovery and parallel synthesis of a new class of cathepsin K inhibitors.EBI Bioorg Med Chem Lett 11: 2951-4 (2001) Bayer Research Center 2D 3D TSV
11677132 65 Design, synthesis, and SAR of amino acid derivatives as factor Xa inhibitors.EBI Bioorg Med Chem Lett 11: 2947-50 (2001) COR Therapeutics, Inc. 2D 3D TSV
11677131 42 Cantharimides: a new class of modified cantharidin analogues inhibiting protein phosphatases 1 and 2A.EBI Bioorg Med Chem Lett 11: 2941-6 (2001) The University of Newcastle 2D 3D TSV
11677124 67 Discovery of selective hydroxamic acid inhibitors of tumor necrosis factor-alpha converting enzyme.EBI Bioorg Med Chem Lett 11: 2907-10 (2001) Abbott Laboratories 2D 3D TSV
11677121 4 A unique ring-expanded acyclic nucleoside analogue that inhibits both adenosine deaminase (ADA) and guanine deaminase (GDA; guanase): synthesis and enzyme inhibition studies of 4,6-diamino-8H-1-hydroxyethoxymethyl-8-iminoimidazo[4,5-e][1,3]diazepine.EBI Bioorg Med Chem Lett 11: 2893-6 (2001) University of Maryland 2D 3D TSV
11606389 1 The farnesyl protein transferase inhibitor SCH66336 is a potent inhibitor of MDR1 product P-glycoprotein.EBI Cancer Res 61: 7525-9 (2001) Schering-Plough Research Institute 2D 3D TSV
11606139 11 Synthesis of 1-benzyl-3-(5'-hydroxymethyl-2'-furyl)indazole analogues as novel antiplatelet agents.EBI J Med Chem 44: 3746-9 (2001) Institute of Pharmaceutical Chemistry 2D 3D TSV
11606138 45 Hydrazinonaphthalene and azonaphthalene thrombopoietin mimics are nonpeptidyl promoters of megakaryocytopoiesis.EBI J Med Chem 44: 3730-45 (2001) GlaxoSmithKline 2D 3D TSV
11606136 10 Design, synthesis, and biological evaluation of novel nucleoside and nucleotide analogues as agents against DNA viruses and/or retroviruses.EBI J Med Chem 44: 3710-20 (2001) Institute of Chemistry 2D 3D TSV
11606131 92 Selective, high affinity peptide antagonists of alpha-melanotropin action at human melanocortin receptor 4: their synthesis and biological evaluation in vitro.EBI J Med Chem 44: 3665-72 (2001) Merck Research Laboratories 2D 3D TSV
11606129 4 Design, synthesis, and evaluation of a long-acting, potent analogue of gonadotropin-releasing hormone.EBI J Med Chem 44: 3645-52 (2001) Institute of Science 2D 3D TSV
11606127 96 Synthesis of sulfaphenazole derivatives and their use as inhibitors and tools for comparing the active sites of human liver cytochromes P450 of the 2C subfamily.EBI J Med Chem 44: 3622-31 (2001) Université Paris V 2D 3D TSV
11606122 7 Alpha-amino acid phenolic ester derivatives: novel water-soluble general anesthetic agents which allosterically modulate GABA(A) receptors.EBI J Med Chem 44: 3582-91 (2001) Organon Research 2D 3D TSV
11606121 152 Toward the quantitative prediction of T-cell epitopes: coMFA and coMSIA studies of peptides with affinity for the class I MHC molecule HLA-A*0201.EBI J Med Chem 44: 3572-81 (2001) Edward Jenner Institute for Vaccine Research 2D 3D TSV
11602689 2 Interaction of 2,3-dimercapto-1-propane sulfonate with the human organic anion transporter hOAT1.EBI J Pharmacol Exp Ther 299: 741-7 (2001) University of Arizona 2D 3D TSV
11602678 5 OPC-28326, a selective femoral vasodilator, is an alpha2C-adrenoceptor-selective antagonist.BDB J Pharmacol Exp Ther 299: 652-8 (2001) Otsuka Maryland Research Institute 2D 3D TSV
11597422 39 Derivatives of 17-(2-methylallyl)-substituted noroxymorphone: variation of the delta address and its effects on affinity and selectivity for the delta opioid receptor.EBI Bioorg Med Chem Lett 11: 2883-5 (2001) NIDDK 2D 3D TSV
11597420 5 Design and synthesis of Pfmrk inhibitors as potential antimalarial agents.EBI Bioorg Med Chem Lett 11: 2875-8 (2001) The Ohio State University 2D 3D TSV
11597419 105 2-(Anilinomethyl)imidazolines as alpha(1)-adrenoceptor agonists: the identification of alpha(1A) subtype selective 2'-carboxylic acid esters and amides.EBI Bioorg Med Chem Lett 11: 2871-4 (2001) GlaxoSmithKline 2D 3D TSV
11597418 47 Pyrimidinylimidazole inhibitors of p38: cyclic N-1 imidazole substituents enhance p38 kinase inhibition and oral activity.EBI Bioorg Med Chem Lett 11: 2867-70 (2001) GlaxoSmithKline Pharmaceuticals 2D 3D TSV
11597417 73 Dopaminergic 7-aminotetrahydroindolizines: ex-chiral pool synthesis and preferential D3 receptor binding.EBI Bioorg Med Chem Lett 11: 2863-6 (2001) Friedrich-Alexander University 2D 3D TSV
11597415 36 Synthesis and In vitro binding affinities of 1-azabicyclic compounds as muscarinic ligands.EBI Bioorg Med Chem Lett 11: 2855-7 (2001) Seoul National University 2D 3D TSV
11597414 10 Potent, low molecular weight thrombin receptor antagonists.EBI Bioorg Med Chem Lett 11: 2851-3 (2001) Schering-Plough Research Institute 2D 3D TSV
11597413 46 Design and synthesis of a novel class of histone deacetylase inhibitors.EBI Bioorg Med Chem Lett 11: 2847-50 (2001) MethylGene Inc. 2D 3D TSV
11597412 116 Novel (4-piperazin-1-ylquinolin-6-yl) arylsulfonamides with high affinity and selectivity for the 5-HT(6) receptor.EBI Bioorg Med Chem Lett 11: 2843-6 (2001) GlaxoSmithKline 2D 3D TSV
11597411 4 Synthesis, crystal structure determination, and biological properties of the DNA-dependent protein kinase (DNA-PK) inhibitor 3-cyano-6-hydrazonomethyl-5-(4-pyridyl)pyrid-[1H]-2-one (OK-1035).EBI Bioorg Med Chem Lett 11: 2837-41 (2001) The University 2D 3D TSV
11597408 12 A designed antagonist of the thyroid hormone receptor.EBI Bioorg Med Chem Lett 11: 2821-5 (2001) University of California 2D 3D TSV
11597407 13 Design, synthesis, and biological activity of diiminoisoindolines as complement component 3a antagonists.EBI Bioorg Med Chem Lett 11: 2817-20 (2001) The R. W. Johnson Pharmaceutical Research Institute 2D 3D TSV
11597405 24 3-D-QSAR/CoMFA and recognition models of benzimidazole derivatives at the 5-HT(4) receptor.EBI Bioorg Med Chem Lett 11: 2807-11 (2001) Universidad Complutense 2D 3D TSV
11597403 17 Antiviral drug design: computational analyses of the effects of the L100I mutation for HIV-RT on the binding of NNRTIs.EBI Bioorg Med Chem Lett 11: 2799-802 (2001) Yale University 2D 3D TSV
11591522 17 Structure-based design of caspase-1 inhibitor containing a diphenyl ether sulfonamide.BDB Bioorg Med Chem Lett 11: 2779-82 (2001) Pfizer 2D 3D TSV
11591521 39 Discovery of heterocyclic ureas as a new class of raf kinase inhibitors: identification of a second generation lead by a combinatorial chemistry approach.EBI Bioorg Med Chem Lett 11: 2775-8 (2001) Bayer Research Center 2D 3D TSV
11591520 6 Discovery of novel, orally active dual NK1/NK2 antagonists.EBI Bioorg Med Chem Lett 11: 2769-73 (2001) AstraZeneca Pharmaceuticals LP 2D 3D TSV
11591519 20 Simplified catechin-gallate inhibitors of HIV-1 reverse transcriptase.EBI Bioorg Med Chem Lett 11: 2763-7 (2001) University of Toledo 2D 3D TSV
11591515 42 Synthesis and progesterone receptor antagonist activities of 6-aryl benzimidazolones and benzothiazolones.EBI Bioorg Med Chem Lett 11: 2747-50 (2001) Wyeth-Ayerst Research 2D 3D TSV
11591514 61 1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 2: lead optimization affording selective, orally bioavailable compounds with potent anti-HIV activity.EBI Bioorg Med Chem Lett 11: 2741-5 (2001) Merck Research Laboratories 2D 3D TSV
11591513 87 Mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine abuse: synthesis and opioid receptor binding affinity of N-substituted derivatives of morphinan.EBI Bioorg Med Chem Lett 11: 2735-40 (2001) Harvard Medical School 2D 3D TSV
11591512 18 Small molecule somatostatin receptor subtype-2 antagonists.EBI Bioorg Med Chem Lett 11: 2731-4 (2001) Pfizer Inc 2D 3D TSV
11591511 12 Small molecule/nucleic acid affinity chromatography: application for the identification of telomerase inhibitors which target its key RNA/DNA heteroduplex.EBI Bioorg Med Chem Lett 11: 2727-30 (2001) University of Missouri 2D 3D TSV
11591510 57 alpha-Alkyl-alpha-amino-beta-sulphone hydroxamates as potent MMP inhibitors that spare MMP-1.EBI Bioorg Med Chem Lett 11: 2723-5 (2001) Pfizer Inc. 2D 3D TSV
11591509 46 alpha-Amino-beta-sulphone hydroxamates as potent MMP-13 inhibitors that spare MMP-1.EBI Bioorg Med Chem Lett 11: 2719-22 (2001) Pfizer Inc. 2D 3D TSV
11591508 18 Synthesis of N-propargylphenelzine and analogues as neuroprotective agents.EBI Bioorg Med Chem Lett 11: 2715-7 (2001) CV Technologies Inc. 2D 3D TSV
11591507 79 The discovery of sulfonylated dipeptides as potent VLA-4 antagonists.EBI Bioorg Med Chem Lett 11: 2709-13 (2001) Merck Research Laboratories 2D 3D TSV
11591503 7 Discovery and initial structure-activity relationships of trisubstituted ureas as thrombin receptor (PAR-1) antagonists.EBI Bioorg Med Chem Lett 11: 2691-6 (2001) Merck Research Laboratories 2D 3D TSV
11591502 51 Naphthalene derivatives: A new series of selective cyclooxygenase-2 inhibitors.EBI Bioorg Med Chem Lett 11: 2687-90 (2001) Rhône-Poulenc Rorer 2D 3D TSV
11590022 13 Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase.BDB Chem Biol 8: 981-95 (2001) University of California San Francisco 2D 3D TSV
11585456 8 Long lasting antinociceptive properties of enkephalin degrading enzyme (NEP and APN) inhibitor prodrugs.EBI J Med Chem 44: 3523-30 (2001) INSERM 2D 3D TSV
11585453 52 1,2-Benzothiazine 1,1-dioxide P(2)-P(3) peptide mimetic aldehyde calpain I inhibitors.EBI J Med Chem 44: 3488-503 (2001) Cephalon, Inc. 2D 3D TSV
11585452 291 Selective inhibition of ICAM-1 and E-selectin expression in human endothelial cells. 2. Aryl modifications of 4-(aryloxy)thieno[2,3-c]pyridines with fine-tuning at C-2 carbamides.EBI J Med Chem 44: 3469-87 (2001) Abbott Laboratories 2D 3D TSV
11585449 25 Synthesis and biological evaluation of s-triazine substituted polyamines as potential new anti-trypanosomal drugs.EBI J Med Chem 44: 3440-52 (2001) Cardiff University 2D 3D TSV
11585448 12 Statistical molecular design, parallel synthesis, and biological evaluation of a library of thrombin inhibitors.EBI J Med Chem 44: 3424-39 (2001) AstraZeneca 2D 3D TSV
11585446 6 Synthesis of novel, potent, diol-based HIV-1 protease inhibitors via intermolecular pinacol homocoupling of (2S)-2-benzyloxymethyl-4-phenylbutanal.BDB J Med Chem 44: 3407-16 (2001) Stockholm University 2D 3D TSV
11585445 10 Synthesis of potent C(2)-symmetric, diol-based hiv-1 protease inhibitors. Investigation of thioalkyl and thioaryl P1/P1' substituents.BDB J Med Chem 44: 3402-6 (2001) Stockholm University 2D 3D TSV
11585444 295 From hit to lead. Analyzing structure-profile relationships.EBI J Med Chem 44: 3391-401 (2001) F-59000 Lille 2D 3D TSV
11585443 137 From hit to lead. Combining two complementary methods for focused library design. Application to mu opiate ligands.EBI J Med Chem 44: 3378-90 (2001) F-59000 Lille 2D 3D TSV
11585442 20 Potent and selective ET-A antagonists. 2. Discovery and evaluation of potent and water soluble N-(6-(2-(aryloxy)ethoxy)-4-pyrimidinyl)sulfonamide derivatives.EBI J Med Chem 44: 3369-77 (2001) Tanabe Seiyaku Co., Ltd. 2D 3D TSV
11585441 70 Potent and selective ET-A antagonists. 1. Syntheses and structure-activity relationships of N-(6-(2-(aryloxy)ethoxy)-4-pyrimidinyl)sulfonamide derivatives.EBI J Med Chem 44: 3355-68 (2001) Tanabe Seiyaku Co., Ltd. 2D 3D TSV
11585440 76 Discovery of macrocyclic hydroxamic acids containing biphenylmethyl derivatives at P1', a series of selective TNF-alpha converting enzyme inhibitors with potent cellular activity in the inhibition of TNF-alpha release.EBI J Med Chem 44: 3351-4 (2001) DuPont Pharmaceuticals Company 2D 3D TSV
11585439 44 Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivatives as potent, selective, and orally bioavailable aggrecanase inhibitors.EBI J Med Chem 44: 3347-50 (2001) The DuPont Pharmaceuticals Company 2D 3D TSV
11585438 21 Piperazine-based CCR5 antagonists as HIV-1 inhibitors. II. Discovery of 1-[(2,4-dimethyl-3-pyridinyl)carbonyl]-4- methyl-4-[3(S)-methyl-4-[1(S)-[4-(trifluoromethyl)phenyl]ethyl]-1-piperazinyl]- piperidine N1-oxide (Sch-350634), an orally bioavailable, potent CCR5 antagonist.EBI J Med Chem 44: 3343-6 (2001) Schering-Plough Research Institute 2D 3D TSV
11585437 17 Discovery of 4-[(Z)-(4-bromophenyl)- (ethoxyimino)methyl]-1'-[(2,4-dimethyl-3- pyridinyl)carbonyl]-4'-methyl-1,4'- bipiperidine N-oxide (SCH 351125): an orally bioavailable human CCR5 antagonist for the treatment of HIV infection.EBI J Med Chem 44: 3339-42 (2001) Schering-Plough Research Institute 2D 3D TSV
11579444 23 Resolution, configurational assignment, and enantiopharmacology at glutamate receptors of 2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid (ACPA) and demethyl-ACPA.BDB Chirality 13: 523-32 (2001) The Royal Danish School of Pharmacy 2D 3D TSV
11572683 11 Fluoroaromatic-fluoroaromatic interactions between inhibitors bound in the crystal lattice of human carbonic anhydrase II.BDB J Am Chem Soc 123: 9620-7 (2001) University of Pennsylvania 2D 3D TSV
11567092 4 Crystal structure of Staphylococcus aureus tyrosyl-tRNA synthetase in complex with a class of potent and specific inhibitors.BDB Protein Sci 10: 2008-16 (2001) GSK 2D 3D TSV
11563931 42 Synthesis of potential antidipsotropic isoflavones: inhibitors of the mitochondrial monoamine oxidase-aldehyde dehydrogenase pathway.EBI J Med Chem 44: 3320-8 (2001) Harvard Medical School 2D 3D TSV
11563929 33 Arylcyclopropanecarboxyl guanidines as novel, potent, and selective inhibitors of the sodium hydrogen exchanger isoform-1.EBI J Med Chem 44: 3302-10 (2001) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
11563928 2 Synthesis and biological evaluation of sialylmimetics as rotavirus inhibitors.EBI J Med Chem 44: 3292-301 (2001) Griffith University (Gold Coast Campus) 2D 3D TSV
11563927 75 1-[2-methoxy-5-(3-phenylpropyl)]-2-aminopropane unexpectedly shows 5-HT(2A) serotonin receptor affinity and antagonist character.EBI J Med Chem 44: 3283-91 (2001) Virginia Commonwealth University 2D 3D TSV
11563922 147 Structure-based design and synthesis of potent matrix metalloproteinase inhibitors derived from a 6H-1,3,4-thiadiazine scaffold.EBI J Med Chem 44: 3231-43 (2001) Universität Bielefeld 2D 3D TSV
11563921 305 Three-dimensional quantitative structure-activity relationships of cyclo-oxygenase-2 (COX-2) inhibitors: a comparative molecular field analysis.EBI J Med Chem 44: 3223-30 (2001) Universit£ de Lille 2 2D 3D TSV
11563920 64 Synthesis of a tetronic acid library focused on inhibitors of tyrosine and dual-specificity protein phosphatases and its evaluation regarding VHR and cdc25B inhibition.EBI J Med Chem 44: 3216-22 (2001) Tohoku University 2D 3D TSV
11563919 20 A structure-based design approach to the development of novel, reversible AChE inhibitors.BDB J Med Chem 44: 3203-15 (2001) Syngenta 2D 3D TSV
11561088 2 Multispecific substrate recognition of kidney-specific organic anion transporters OAT-K1 and OAT-K2.EBI J Pharmacol Exp Ther 299: 261-7 (2001) Kyoto University Hospital 2D 3D TSV
11557132 5 Troglitazone-induced intrahepatic cholestasis by an interference with the hepatobiliary export of bile acids in male and female rats. Correlation with the gender difference in troglitazone sulfate formation and the inhibition of the canalicular bile salt export pump (Bsep) by troglitazone and troglEBI Toxicology 167: 83-98 (2001) F. Hoffmann-La Roche Ltd. 2D 3D TSV
11551771 16 Antiprotozoal and cytotoxicity evaluation of sulfonamide and urea analogues of quinacrine.EBI Bioorg Med Chem Lett 11: 2655-7 (2001) University of Cape Town 2D 3D TSV
11551770 40 Selective heterocyclic amidine inhibitors of human inducible nitric oxide synthase.EBI Bioorg Med Chem Lett 11: 2651-3 (2001) Pharmacia 2D 3D TSV
11551769 2 Synthesis of a reported calpain inhibitor isolated from Streptomyces griseus.EBI Bioorg Med Chem Lett 11: 2647-9 (2001) The University of Tennessee Health Science Center 2D 3D TSV
11551767 54 New inhibitors of the thioredoxin-thioredoxin reductase system based on a naphthoquinone spiroketal natural product lead.EBI Bioorg Med Chem Lett 11: 2637-41 (2001) University of Pittsburgh 2D 3D TSV
11551765 7 Synthesis and acetylcholinesterase inhibition of 5-desamino huperzine A derivatives.EBI Bioorg Med Chem Lett 11: 2627-30 (2001) Universit£t Wien 2D 3D TSV
11551763 25 1,2,4-triazolo[3,4-a]pyridine as a novel, constrained template for fibrinogen receptor (GPIIb/IIIa) antagonists.EBI Bioorg Med Chem Lett 11: 2619-22 (2001) The R. W. Johnson Pharmaceutical Research Institute 2D 3D TSV
11551762 16 Potent peptide alpha-ketohydroxamate inhibitors of recombinant human calpain I.EBI Bioorg Med Chem Lett 11: 2615-7 (2001) Cephalon, Inc. 2D 3D TSV
11551758 58 Orally bioavailable, indole-based nonpeptide GnRH receptor antagonists with high potency and functional activity.EBI Bioorg Med Chem Lett 11: 2597-602 (2001) Merck Research Laboratories 2D 3D TSV
11551757 29 Isoxazolyl, oxazolyl, and thiazolylpropionic acid derivatives as potent alpha(4)beta(1) integrin antagonists.EBI Bioorg Med Chem Lett 11: 2593-6 (2001) Pfizer Inc. 2D 3D TSV
11551756 26 Synthesis and in vitro evaluation of a series of diketopiperazine inhibitors of plasminogen activator inhibitor-1.EBI Bioorg Med Chem Lett 11: 2589-92 (2001) Xenova Limited 2D 3D TSV
11551755 18 Asymmetric synthesis of BB-3497--a potent peptide deformylase inhibitor.EBI Bioorg Med Chem Lett 11: 2585-8 (2001) British Biotech Pharmaceuticals Limited 2D 3D TSV
11551754 43 Solid-Phase synthesis of a library constructed of aromatic phosphate, long alkyl chains and tryptophane components, and identification of potent dipeptide telomerase inhibitors.EBI Bioorg Med Chem Lett 11: 2581-4 (2001) Kyushu University 2D 3D TSV
11551751 18 Novel 3-dodecanoylindole-2-carboxylic acid inhibitors of cytosolic phospholipase A(2).EBI Bioorg Med Chem Lett 11: 2569-72 (2001) University of Münster 2D 3D TSV
11551750 6 Combinatorial synthesis of SSAO inhibitors using sonogashira coupling: SAR of aryl propargylic amines.EBI Bioorg Med Chem Lett 11: 2565-8 (2001) University of Technology 2D 3D TSV
11549469 38 Glutamyl-gamma-boronate inhibitors of bacterial Glu-tRNA(Gln) amidotransferase.EBI Bioorg Med Chem Lett 11: 2561-4 (2001) DuPont Pharmaceuticals Company 2D 3D TSV
11549468 54 New leads for selective inhibitors of alpha-L-fucosidases. Synthesis and glycosidase inhibitory activities of [(2R,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]furan derivatives.EBI Bioorg Med Chem Lett 11: 2555-9 (2001) Universidad de Sevilla 2D 3D TSV
11549467 85 Substituted imidazoles as glucagon receptor antagonists.EBI Bioorg Med Chem Lett 11: 2549-53 (2001) Merck Research Laboratories 2D 3D TSV
11549463 72 Benzamide bioisosteres incorporating dihydroheteroazole substructures: EPC synthesis and SAR leading to a selective dopamine D4 receptor partial agonist (FAUC 179).EBI Bioorg Med Chem Lett 11: 2533-6 (2001) Friedrich-Alexander University 2D 3D TSV
11549462 11 Synthesis and biological data of 4-amino-1-(2-chloro-2-phenylethyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl esters, a new series of A1-adenosine receptor (A1AR) ligands.EBI Bioorg Med Chem Lett 11: 2529-31 (2001) Facoltà di Farmacia dell'Università degli Studi di Genova 2D 3D TSV
11549461 13 Hydrophobicity, a physicochemical factor in the inhibition of the enzyme estrone sulfatase (ES).EBI Bioorg Med Chem Lett 11: 2525-8 (2001) Kingston University 2D 3D TSV
11549460 16 Furans with basic side chains: synthesis and biological evaluation of a novel series of antagonists with selectivity for the estrogen receptor alpha.EBI Bioorg Med Chem Lett 11: 2521-4 (2001) University of Illinois 2D 3D TSV
11549459 5 Synthesis and evaluation of the sunflower derived trypsin inhibitor as a potent inhibitor of the type II transmembrane serine protease, matriptase.EBI Bioorg Med Chem Lett 11: 2515-9 (2001) National Cancer Institute 2D 3D TSV
11549455 6 Inhibitors of bacterial tyrosyl tRNA synthetase: synthesis of carbocyclic analogues of the natural product SB-219383.EBI Bioorg Med Chem Lett 11: 2499-502 (2001) GlaxoSmithKline Pharmaceuticals 2D 3D TSV
11549453 77 Derivatives of (2R,3R,4S)-2-aminomethylpyrrolidine-3,4-diol are selective alpha-mannosidase inhibitors.EBI Bioorg Med Chem Lett 11: 2489-93 (2001) Section de Chimie de l'Universit£ de Lausanne 2D 3D TSV
11549450 55 Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 4: synthesis and structure-activity relationships for 1-[N-(methyl)-N-(phenylsulfonyl)amino]-2-(phenyl)-4-(4-(N-(alkyl)-N-(benzyloxycarbonyl)amino)piperidin-1-yl)butanes.EBI Bioorg Med Chem Lett 11: 2475-9 (2001) Merck Research Laboratories 2D 3D TSV
11549449 28 Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 3: a proposed pharmacophore model for 1-[N-(methyl)-N-(phenylsulfonyl)amino]-2-(phenyl)-4-[4-(substituted)piperidin-1-yl]butanes.EBI Bioorg Med Chem Lett 11: 2469-73 (2001) Merck Research Laboratories 2D 3D TSV
11549448 2 Design and synthesis of new inhibitors of HIV-1 protease dimerization with conformationally constrained templates.EBI Bioorg Med Chem Lett 11: 2465-8 (2001) Kyoto Pharmaceutical University 2D 3D TSV
11549447 6 The discovery of novel, potent and selective PDE5 inhibitors.EBI Bioorg Med Chem Lett 11: 2461-4 (2001) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
11549442 6 Alpha-ketoester-based photobiological switches: synthesis, peptide chain extension and assay against alpha-chymotrypsin.EBI Bioorg Med Chem Lett 11: 2441-4 (2001) University of Canterbury 2D 3D TSV
11549437 17 Synthesis and biological evaluation of clitocine analogues as adenosine kinase inhibitors.EBI Bioorg Med Chem Lett 11: 2419-22 (2001) Abbott Laboratories 2D 3D TSV
11546835 55 The molecular and behavioral pharmacology of the orphanin FQ/nociceptin peptide and receptor family.BDB Pharmacol Rev 53: 381-415 (2001) McGill University 2D 3D TSV
11543689 34 Coumarins derivatives as dual inhibitors of acetylcholinesterase and monoamine oxidase.EBI J Med Chem 44: 3195-8 (2001) Universit£ de Lausanne 2D 3D TSV
11543687 92 Design and synthesis of [(2,3-dichlorophenyl)piperazin-1-yl]alkylfluorenylcarboxamides as novel ligands selective for the dopamine D3 receptor subtype.EBI J Med Chem 44: 3175-86 (2001) National Institute on Drug Abuse-Intramural Research Program 2D 3D TSV
11543683 42 Identification of alkylidene hydrazides as glucagon receptor antagonists.EBI J Med Chem 44: 3141-9 (2001) Pfizer Global Research and Development 2D 3D TSV
11543680 17 Exploration of novel aryl binding sites of farnesyltransferase using molecular modeling and benzophenone-based farnesyltransferase inhibitors.EBI J Med Chem 44: 3117-24 (2001) Philipps-Universität Marburg 2D 3D TSV
11543679 15 A new approach to search for the bioactive conformation of glucagon: positional cyclization scanning.EBI J Med Chem 44: 3109-16 (2001) University of Arizona 2D 3D TSV
11543678 18 Acyclic and cyclopropyl analogues of adenosine bisphosphate antagonists of the P2Y1 receptor: structure-activity relationships and receptor docking.EBI J Med Chem 44: 3092-108 (2001) National Institute of Diabetes 2D 3D TSV
11543677 20 Design and synthesis of potent C(2)-symmetric diol-based HIV-1 protease inhibitors: effects of fluoro substitution.BDB J Med Chem 44: 3083-91 (2001) Linkoping University 2D 3D TSV
11543676 45 Design and synthesis of matrix metalloproteinase inhibitors guided by molecular modeling. Picking the S(1) pocket using conformationally constrained inhibitors.EBI J Med Chem 44: 3074-82 (2001) Université de Montréal 2D 3D TSV
11543675 104 N-Aryl sulfonyl homocysteine hydroxamate inhibitors of matrix metalloproteinases: further probing of the S(1), S(1)', and S(2)' pockets.EBI J Med Chem 44: 3066-73 (2001) Université de Montréal 2D 3D TSV
11543674 3 Determination of the binding specificity of an integral membrane protein by saturation transfer difference NMR: RGD peptide ligands binding to integrin alphaIIbbeta3.EBI J Med Chem 44: 3059-65 (2001) University of Hamburg 2D 3D TSV
11543672 24 [2',6'-Dimethyltyrosine]dynorphin A(1-11)-NH2 analogues lacking an N-terminal amino group: potent and selective kappa opioid antagonists.EBI J Med Chem 44: 3048-53 (2001) Clinical Research Institute of Montreal 2D 3D TSV
11527737 70 Identification of a series of oxadiazole-substituted alpha-isopropoxy phenylpropanoic acids with activity on PPARalpha, PPARgamma, and PPARdelta.EBI Bioorg Med Chem Lett 11: 2385-8 (2001) GlaxoSmithKline 2D 3D TSV
11527732 1 Drug design, synthesis, and evaluation of a non-sugar-based selectin antagonist.EBI Bioorg Med Chem Lett 11: 2365-7 (2001) Organon K.K. 2D 3D TSV
11527731 25 A novel class of inhibitors for steroid 5alpha-reductase: synthesis and evaluation of umbelliferone derivatives.EBI Bioorg Med Chem Lett 11: 2361-3 (2001) Seoul National University 2D 3D TSV
11527730 27 Structure-activity relationship studies of a bisbenzimidazole-based, Zn(2+)-dependent inhibitor of HCV NS3 serine protease.EBI Bioorg Med Chem Lett 11: 2355-9 (2001) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
11527728 56 New 1-aryl-4-(biarylmethylene)piperazines as potential atypical antipsychotics sharing dopamine D(2)-receptor and serotonin 5-HT(1A)-receptor affinities.EBI Bioorg Med Chem Lett 11: 2345-9 (2001) Solvay Pharma 2D 3D TSV
11527727 8 The synthesis and tubulin binding activity of thiophene-based analogues of combretastatin A-4.EBI Bioorg Med Chem Lett 11: 2341-3 (2001) Australian National University 2D 3D TSV
11527726 15 Rational design and synthesis of novel 2,5-disubstituted cis- and trans-piperidine derivatives exhibiting differential activity for the dopamine transporter.EBI Bioorg Med Chem Lett 11: 2337-40 (2001) Wayne State University 2D 3D TSV
11527724 30 Monocharged inhibitors of mast cell tryptase derived from potent and selective dibasic inhibitors.EBI Bioorg Med Chem Lett 11: 2325-30 (2001) Axys Pharmaceuticals, Inc. 2D 3D TSV
11527723 32 A novel phosphotyrosine mimetic 4'-carboxymethyloxy-3'-phosphonophenylalanine (Cpp): exploitation in the design of nonpeptide inhibitors of pp60(Src) SH2 domain.EBI Bioorg Med Chem Lett 11: 2319-23 (2001) ARIAD Pharmaceuticals, Inc. 2D 3D TSV
11527721 12 Metabolic stabilization of benzylidene ketal M(2) muscarinic receptor antagonists via halonaphthoic acid substitution.EBI Bioorg Med Chem Lett 11: 2311-4 (2001) Schering-Plough Research Institute 2D 3D TSV
11527718 9 Synthesis and purine receptor affinity of 6-oxopurine nucleosides and nucleotides containing (N)-methanocarba-pseudoribose rings.EBI Bioorg Med Chem Lett 11: 2295-300 (2001) NIDDK 2D 3D TSV
11527716 29 Pyrazolecarboxamide human neuropeptide Y5 receptor ligands with in vivo antifeedant activity.EBI Bioorg Med Chem Lett 11: 2287-90 (2001) The R. W. Johnson Pharmaceutical Research Institute 2D 3D TSV
11527715 33 Aminopyrazoles with high affinity for the human neuropeptide Y5 receptor.EBI Bioorg Med Chem Lett 11: 2283-6 (2001) The R. W. Johnson Pharmaceutical Research Institute 2D 3D TSV
11527714 66 Design and synthesis of glycolic and mandelic acid derivatives as factor Xa inhibitors.EBI Bioorg Med Chem Lett 11: 2279-82 (2001) COR Therapeutics, Inc. 2D 3D TSV
11527709 19 Optimization of a screening lead for factor VIIa/TF.EBI Bioorg Med Chem Lett 11: 2253-6 (2001) Axys Pharmaceuticals, Inc. 2D 3D TSV
11527706 65 Inhibitors of bacterial enoyl acyl carrier protein reductase (FabI): 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4-b]indoles as potential antibacterial agents.BDB Bioorg Med Chem Lett 11: 2241-4 (2001) GlaxoSmithKline 2D 3D TSV
11520216 41 Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase.EBI J Nat Prod 64: 1010-4 (2001) University of Shizuoka 2D 3D TSV
11520213 12 Design and synthesis of celecoxib and rofecoxib analogues as selective cyclooxygenase-2 (COX-2) inhibitors: replacement of sulfonamide and methylsulfonyl pharmacophores by an azido bioisostere.EBI J Med Chem 44: 3039-42 (2001) University of Alberta 2D 3D TSV
11520212 3 S(+)-4-(1-Phenylethylamino)quinazolines as inhibitors of human immunoglobulin E synthesis: potency is dictated by stereochemistry and atomic point charges at N-1.EBI J Med Chem 44: 3031-8 (2001) Novartis Forschungsinstitut 2D 3D TSV
11520211 7 Design, synthesis and pharmacological characterization of a potent radioiodinated and photoactivatable peptidic oxytocin antagonist.EBI J Med Chem 44: 3022-30 (2001) INSERM 2D 3D TSV
11520208 45 Identification of potent non-peptide somatostatin antagonists with sst(3) selectivity.EBI J Med Chem 44: 2990-3000 (2001) Institut Henri Beaufour 2D 3D TSV
11520205 4 5'-O-alkyl ethers of N,2-substituted adenosine derivatives: partial agonists for the adenosine A1 and A3 receptors.EBI J Med Chem 44: 2966-75 (2001) Leiden/Amsterdam Center for Drug Research 2D 3D TSV
11520202 130 Design and biological activity of (S)-4-(5-([1-(3-chlorobenzyl)-2-oxopyrrolidin-3-ylamino]methyl)imidazol-1-ylmethyl)benzonitrile, a 3-aminopyrrolidinone farnesyltransferase inhibitor with excellent cell potency.EBI J Med Chem 44: 2933-49 (2001) Merck Research Laboratories 2D 3D TSV
11520201 10 X-Ray crystal structures of Candida albicans dihydrofolate reductase: high resolution ternary complexes in which the dihydronicotinamide moiety of NADPH is displaced by an inhibitor.BDB J Med Chem 44: 2928-32 (2001) GSK 2D 3D TSV
11520200 17 Design and synthesis of 4,5-diphenyl-4-isoxazolines: novel inhibitors of cyclooxygenase-2 with analgesic and antiinflammatory activity.EBI J Med Chem 44: 2921-7 (2001) University of Alberta 2D 3D TSV
11520199 25 Discovery of potent antagonists of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction. 3. Amide (C-ring) structure-activity relationship and improvement of overall properties of arylthio cinnamides.EBI J Med Chem 44: 2913-20 (2001) Abbott Laboratories 2D 3D TSV
11520197 32 Synthesis, molecular modeling, and structure-activity relationship of benzophenone-based CAAX-peptidomimetic farnesyltransferase inhibitors.EBI J Med Chem 44: 2886-99 (2001) Philipps-Universität Marburg 2D 3D TSV
11520196 81 Synthesis and characterization of non-steroidal ligands for the glucocorticoid receptor: selective quinoline derivatives with prednisolone-equivalent functional activity.EBI J Med Chem 44: 2879-85 (2001) Abbott Laboratories 2D 3D TSV
11520195 19 Utilization of a peptide lead for the discovery of a novel PTP1B-binding motif.EBI J Med Chem 44: 2869-78 (2001) National Cancer Institute 2D 3D TSV
11520194 13 Structure-based design: potent inhibitors of human brain memapsin 2 (beta-secretase).BDB J Med Chem 44: 2865-8 (2001) University of Illinois at Chicago 2D 3D TSV
11514173 4 Novel 4-piperidinopyridine inhibitors of oxidosqualene cyclase-lanosterol synthase derived by consideration of inhibitor pK(a).EBI Bioorg Med Chem Lett 11: 2213-6 (2001) AstraZeneca 2D 3D TSV
11514172 20 Identification of selective inhibitors of cyclin dependent kinase 4.BDB Bioorg Med Chem Lett 11: 2209-11 (2001) DuPont Pharmaceuticals Company 2D 3D TSV
11514167 88 The discovery of anthranilic acid-based MMP inhibitors. Part 2: SAR of the 5-position and P1(1) groups.EBI Bioorg Med Chem Lett 11: 2189-92 (2001) Wyeth-Ayerst Research 2D 3D TSV
11514164 36 Conformationally restricted indolopiperidine derivatives as potent CCR2B receptor antagonists.EBI Bioorg Med Chem Lett 11: 2177-80 (2001) GlaxoSmithKline Pharmaceuticals 2D 3D TSV
11514163 14 Discovery of (R)-1-[2-hydroxy-3-(4-hydroxy-phenyl)-propyl]-4-(4-methyl-benzyl)-piperidin-4-ol: a novel NR1/2B subtype selective NMDA receptor antagonist.EBI Bioorg Med Chem Lett 11: 2173-6 (2001) F. Hoffmann-La Roche Ltd. 2D 3D TSV
11514161 23 N,N-dibenzyl-N'-benzylidenehydrazines: potent competitive glucose-6-phosphatase catalytic enzyme inhibitors.EBI Bioorg Med Chem Lett 11: 2165-7 (2001) Novo Nordisk A/S 2D 3D TSV
11514157 48 N-hydroxyformamide peptidomimetics as TACE/matrix metalloprotease inhibitors: oral activity via P1' isobutyl substitution.EBI Bioorg Med Chem Lett 11: 2147-51 (2001) GlaxoSmithKline Research and Development 2D 3D TSV
11514156 28 Piperazine-based CCR5 antagonists as HIV-1 inhibitors. I: 2(S)-methyl piperazine as a key pharmacophore element.EBI Bioorg Med Chem Lett 11: 2143-6 (2001) Schering-Plough Research Institute 2D 3D TSV
11514154 9 5-HT(3)R binding of lerisetron: an interdisciplinary approach to drug-Receptor interactions.EBI Bioorg Med Chem Lett 11: 2133-6 (2001) The University of Louisiana at Monroe 2D 3D TSV
11514153 45 Discovery of thioazepinone ligands for Src SH2: from non-specific to specific binding.EBI Bioorg Med Chem Lett 11: 2127-31 (2001) Aventis 2D 3D TSV
11514150 42 Stereoselective synthesis and antibacterial evaluation of 4-amido-isothiazolidinone oxides.EBI Bioorg Med Chem Lett 11: 2111-5 (2001) Procter& Gamble Pharmaceuticals 2D 3D TSV
11514149 86 Thrombin receptor (PAR-1) antagonists. Solid-phase synthesis of indole-based peptide mimetics by anchoring to a secondary amide.EBI Bioorg Med Chem Lett 11: 2105-9 (2001) The R. W. Johnson Pharmaceutical Research Institute 2D 3D TSV
11514144 51 Amino acid derived sulfonamide hydroxamates as inhibitors of procollagen C-proteinase: solid-phase synthesis of ornithine analogues.EBI Bioorg Med Chem Lett 11: 2085-8 (2001) Roche Bioscience 2D 3D TSV
11514143 71 Sar studies of piperidine-based analogues of cocaine. Part 3: oxadiazoles.EBI Bioorg Med Chem Lett 11: 2079-83 (2001) Georgetown University Medical Center 2D 3D TSV
11514142 4 Synthesis, antimalarial activity and inhibition of haem detoxification of novel bisquinolines.EBI Bioorg Med Chem Lett 11: 2075-7 (2001) La Trobe University 2D 3D TSV
11514141 16 Pyridopyrimidine analogues as novel adenosine kinase inhibitors.EBI Bioorg Med Chem Lett 11: 2071-4 (2001) Abbott Laboratories 2D 3D TSV
11514140 17 Structure-activity study and analgesic efficacy of amino acid derivatives as N-type calcium channel blockers.EBI Bioorg Med Chem Lett 11: 2067-70 (2001) no Pharmaceutical Co., Ltd. 2D 3D TSV
11514139 41 1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI).BDB Bioorg Med Chem Lett 11: 2061-5 (2001) GlaxoSmithKline 2D 3D TSV
11512051 80 The in vitro pharmacology of the beta-adrenergic receptor pet ligand (s)-fluorocarazolol reveals high affinity for cloned beta-adrenergic receptors and moderate affinity for the human 5-HT1A receptor.BDB Psychopharmacology (Berl) 157: 111-4 (2001) Case Western Reserve University 2D 3D TSV
11504829 16 Synthesis and pharmacological evaluation of dimeric muscarinic acetylcholine receptor agonists.BDB J Pharmacol Exp Ther 298: 1260-8 (2001) University of Melbourne 2D 3D TSV
11502885 35 Identification of potent and selective neuropeptide Y Y(1) receptor agonists with orexigenic activity in vivo.BDB Mol Pharmacol 60: 534-40 (2001) Schering-Plough Research Institute 2D 3D TSV
11502595 26 Interaction of cations, anions, and weak base quinine with rat renal cation transporter rOCT2 compared with rOCT1.EBI Am J Physiol Renal Physiol 281: 454-68 (2001) Institute of Anatomy of the Bayerische Julius-Maximilians-Universit£t 2D 3D TSV
11496833 15 Inhibitors of human and rat testes microsomal 17beta-hydroxysteroid dehydrogenase (17beta-HSD) as potential agents for prostatic cancer.BDB J Enzym Inhib 16: 35-45 (2001) Cardiff University 2D 3D TSV
11496832 7 Potential of pyrazolooxadiazinone derivatives as serine protease inhibitors.BDB J Enzym Inhib 16: 15-34 (2001) Università di Ferrara 2D 3D TSV
11495596 16 Synthesis and evaluation of 4-fluoro-8-substituted-2,3,4,5-tetrahydro-1H-2-benzazapines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.EBI J Med Chem 44: 2849-56 (2001) University of Kansas 2D 3D TSV
11495595 24 Synthesis of and a comparative study on the inhibition of muscle and liver glycogen phosphorylases by epimeric pairs of d-gluco- and d-xylopyranosylidene-spiro-(thio)hydantoins and N-(d-glucopyranosyl) amides.EBI J Med Chem 44: 2843-8 (2001) University of Debrecen 2D 3D TSV
11495592 12 Methylated analogues of methyl (R)-4-(3,4-dichlorophenylacetyl)- 3-(pyrrolidin-1-ylmethyl)piperazine-1-carboxylate (GR-89,696) as highly potent kappa-receptor agonists: stereoselective synthesis, opioid-receptor affinity, receptor selectivity, and functional studies.EBI J Med Chem 44: 2814-26 (2001) Pharmazeutisches Institut der Universit£t Freiburg 2D 3D TSV
11495587 198 Development of serine protease inhibitors displaying a multicentered short (<2.3 A) hydrogen bond binding mode: inhibitors of urokinase-type plasminogen activator and factor Xa.EBI J Med Chem 44: 2753-71 (2001) Axys Pharmaceuticals Inc. 2D 3D TSV
11495586 3 Synthesis, mechanism of action, and antiviral activity of a new series of covalent mechanism-based inhibitors of S-adenosyl-L-homocysteine hydrolase.EBI J Med Chem 44: 2743-52 (2001) Universit£ de Reims Champagne-Ardenne 2D 3D TSV
11495585 16 Fluorosulfonyl- and bis-(beta-chloroethyl)amino-phenylamino functionalized pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives: irreversible antagonists at the human A3 adenosine receptor and molecular modeling studies.EBI J Med Chem 44: 2735-42 (2001) Università degli Studi di Ferrara 2D 3D TSV
11495584 76 6-Substituted-4-(3-bromophenylamino)quinazolines as putative irreversible inhibitors of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor (HER-2) tyrosine kinases with enhanced antitumor activity.BDB J Med Chem 44: 2719-34 (2001) Wyeth-Ayerst Research 2D 3D TSV
11495583 62 Design, synthesis, and structure-activity relationships of a series of 3-[2-(1-benzylpiperidin-4-yl)ethylamino]pyridazine derivatives as acetylcholinesterase inhibitors.EBI J Med Chem 44: 2707-18 (2001) Universit£ Louis Pasteur 2D 3D TSV
11495581 4 Sorbitol dehydrogenase inhibitors (SDIs): a new potent, enantiomeric SDI, 4-[2-1R-hydroxy-ethyl)-pyrimidin-4-yl]piperazine-1-sulfonic acid dimethylamide.EBI J Med Chem 44: 2695-700 (2001) Pfizer Global Research & Development 2D 3D TSV
11495580 35 Rationally based efficacy tuning of selective dopamine d4 receptor ligands leading to the complete antagonist 2-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 213).EBI J Med Chem 44: 2691-4 (2001) Friedrich-Alexander University 2D 3D TSV
11495579 24 Identification of the first trans-(3R,4R)- dimethyl-4-(3-hydroxyphenyl)piperidine derivative to possess highly potent and selective opioid kappa receptor antagonist activity.EBI J Med Chem 44: 2687-90 (2001) Research Triangle Institute 2D 3D TSV
11495578 12 Discovery of estrogen sulfotransferase inhibitors from a purine library screen.EBI J Med Chem 44: 2683-6 (2001) University of California 2D 3D TSV
11495577 16 The first potent and selective inhibitors of the glycine transporter type 2.EBI J Med Chem 44: 2679-82 (2001) Organon Laboratories Ltd. 2D 3D TSV
11485475 42 Synthesis of natural flutimide and analogous fully substituted pyrazine-2,6-diones, endonuclease inhibitors of influenza virus.EBI J Org Chem 66: 5504-16 (2001) Merck Research Laboratories 2D 3D TSV
11474784 6 HMG-CoA reductase inhibitors (statins) characterized as direct inhibitors of P-glycoprotein.EBI Pharm Res 18: 800-6 (2001) Schering-Plough Research Institute 2D 3D TSV
11472219 27 Reduced amide bond peptidomimetics. (4S)-N-(4-amino-5-[aminoakyl]aminopentyl)-N'-nitroguanidines, potent and highly selective inhibitors of neuronal nitric oxide synthase.EBI J Med Chem 44: 2667-70 (2001) Northwestern University 2D 3D TSV
11472217 157 Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo.EBI J Med Chem 44: 2636-60 (2001) DuPont Pharmaceuticals Company 2D 3D TSV
11472216 89 Synthesis of 6- and 7- hydroxy-8-azabicyclo[3.2.1]octanes and their binding affinity for the dopamine and serotonin transporters.EBI J Med Chem 44: 2619-35 (2001) Organix Inc. 2D 3D TSV
11472213 12 Structure-activity studies of ground- and transition-state analogue inhibitors of cyclophilin.EBI J Med Chem 44: 2593-600 (2001) Southern Methodist University 2D 3D TSV
11472212 6 Design and synthesis of potent and selective alpha(4)beta(7) integrin antagonists.EBI J Med Chem 44: 2586-92 (2001) Technische Universität München 2D 3D TSV
11472210 9 Disabling erbB receptors with rationally designed exocyclic mimetics of antibodies: structure-function analysis.EBI J Med Chem 44: 2565-74 (2001) University of Pennsylvania School of Medicine 2D 3D TSV
11472209 72 Structural studies on bioactive compounds. 34. Design, synthesis, and biological evaluation of triazenyl-substituted pyrimethamine inhibitors of Pneumocystis carinii dihydrofolate reductase.EBI J Med Chem 44: 2555-64 (2001) University of Nottingham 2D 3D TSV
11472208 24 Structure-based design, synthesis, and biological evaluation of conformationally restricted novel 2-alkylthio-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as non-nucleoside inhibitors of HIV-1 reverse transcriptase.BDB J Med Chem 44: 2544-54 (2001) Universita degli Studi di Roma La Sapienza 2D 3D TSV
11472204 6 A rational approach to the design of selective substrates and potent nontransportable inhibitors of the excitatory amino acid transporter EAAC1 (EAAT3). new glutamate and aspartate analogues as potential neuroprotective agents.EBI J Med Chem 44: 2507-10 (2001) TBA 2D 3D TSV
11472202 143 Potent and selective carboxylic acid-based inhibitors of matrix metalloproteinases.EBI J Med Chem 44: 2499-502 (2001) TBA 2D 3D TSV
11462984 64 GnRH antagonists: a new generation of long acting analogues incorporating p-ureido-phenylalanines at positions 5 and 6.EBI J Med Chem 44: 453-67 (2001) Ferring Research Institute Inc. 2D 3D TSV
11462983 50 Design, synthesis, and biological evaluation of a series of lavendustin A analogues that inhibit EGFR and Syk tyrosine kinases, as well as tubulin polymerization.EBI J Med Chem 44: 441-52 (2001) Purdue University 2D 3D TSV
11462982 33 Tyrosine kinase inhibitors. 18. 6-Substituted 4-anilinoquinazolines and 4-anilinopyrido[3,4-d]pyrimidines as soluble, irreversible inhibitors of the epidermal growth factor receptor.BDB J Med Chem 44: 429-40 (2001) University of Auckland 2D 3D TSV
11462981 184 New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants.EBI J Med Chem 44: 418-28 (2001) Universidad de Navarra 2D 3D TSV
11462978 16 Behavioral approach to nondyskinetic dopamine antagonists: identification of seroquel.EBI J Med Chem 44: 372-89 (2001) AstraZeneca Pharmaceuticals LP 2D 3D TSV
11462977 21 Analogues of prazosin that bear a benextramine-related polyamine backbone exhibit different antagonism toward alpha1-adrenoreceptor subtypes.EBI J Med Chem 44: 362-71 (2001) University of Bologna 2D 3D TSV
11462976 20 Synthesis and SAR of a new series of COX-2-selective inhibitors: pyrazolo[1,5-a]pyrimidines.EBI J Med Chem 44: 350-61 (2001) J. Uriach & Cía. S.A. 2D 3D TSV
11462975 50 Structure-activity relationships of pyridoxal phosphate derivatives as potent and selective antagonists of P2X1 receptors.EBI J Med Chem 44: 340-9 (2001) National Institute of Diabetes and Digestive and Kidney Diseases 2D 3D TSV
11462973 47 3-Aryl[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-ones: a new class of selective A1 adenosine receptor antagonists.EBI J Med Chem 44: 316-27 (2001) Universit£ di Pisa 2D 3D TSV
11462972 93 Quinoxalinylethylpyridylthioureas (QXPTs) as potent non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors. Further SAR studies and identification of a novel orally bioavailable hydrazine-based antiviral agent.EBI J Med Chem 44: 305-15 (2001) Universita' degli Studi di Salerno 2D 3D TSV
11462970 9 Design of remarkably simple, yet potent urea-based inhibitors of glutamate carboxypeptidase II (NAALADase).EBI J Med Chem 44: 298-301 (2001) TBA 2D 3D TSV
11462969 7 New dermatological agents for the treatment of psoriasis.EBI J Med Chem 44: 281-97 (2001) Allergan Inc. 2D 3D TSV
11459929 7 Trace amines: identification of a family of mammalian G protein-coupled receptors.BDB Proc Natl Acad Sci U S A 98: 8966-71 (2001) Synaptic Pharmaceutical Corporation 2D 3D TSV
11459670 30 Cyclic imides as potent and selective alpha-1A adrenergic receptor antagonists.EBI Bioorg Med Chem Lett 11: 1959-62 (2001) Merck & Co. 2D 3D TSV
11459669 20 Spiro(indoline-3,4'-piperidine) growth hormone secretagogues as ghrelin mimetics.EBI Bioorg Med Chem Lett 11: 1955-7 (2001) Merck Research Laboratories 2D 3D TSV
11459668 16 Nicotinamide N-oxides as CXCR2 antagonists.EBI Bioorg Med Chem Lett 11: 1951-4 (2001) Celltech R&D 2D 3D TSV
11459667 13 Selectivity enhancement induced by substitution of non-natural analogues of arginine and lysine in arginine-based thrombin inhibitors.EBI Bioorg Med Chem Lett 11: 1947-50 (2001) Medical University of South Carolina 2D 3D TSV
11459666 20 Synthesis and evaluation of novel quinolinones as HIV-1 reverse transcriptase inhibitors.BDB Bioorg Med Chem Lett 11: 1943-5 (2001) DuPont Pharmaceuticals Company 2D 3D TSV
11459665 36 2-Amino-4,6-diarylpyridines as novel ligands for the estrogen receptor.EBI Bioorg Med Chem Lett 11: 1939-42 (2001) Glaxo Wellcome Research and Development 2D 3D TSV
11459664 21 alpha-Ketocarboxylic acid-based inhibitors of protein tyrosine phosphatases.EBI Bioorg Med Chem Lett 11: 1935-8 (2001) Brown University 2D 3D TSV
11459663 19 Introduction of alkynyl chains on C-8 of adenosine led to very selective antagonists of the A(3) adenosine receptor.EBI Bioorg Med Chem Lett 11: 1931-4 (2001) Universit£ di Camerino 2D 3D TSV
11459662 41 1-(Arylpiperazinylamidoalkyl)-pyrimidones: orally active inhibitors of lipoprotein-associated phospholipase A(2).EBI Bioorg Med Chem Lett 11: 1925-9 (2001) GlaxoSmithKline 2D 3D TSV
11459661 41 Synthesis of N(1)-substituted analogues of (2R,4R)-4-amino-pyrrolidine-2,4-dicarboxylic acid as agonists, partial agonists, and antagonists of group II metabotropic glutamate receptors.EBI Bioorg Med Chem Lett 11: 1919-24 (2001) Georgetown University Medical Center 2D 3D TSV
11459659 28 Studies leading to the identification of ZD1839 (IRESSA): an orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor targeted to the treatment of cancer.EBI Bioorg Med Chem Lett 11: 1911-4 (2001) AstraZeneca 2D 3D TSV
11459658 18 1,3-Biarylureas as selective non-peptide antagonists of the orexin-1 receptor.EBI Bioorg Med Chem Lett 11: 1907-10 (2001) GlaxoSmithKline Pharmaceuticals 2D 3D TSV
11459657 20 3-Arylpiperidines as potentiators of existing antibacterial agents.EBI Bioorg Med Chem Lett 11: 1903-6 (2001) Pharmacia 2D 3D TSV
11459656 27 Development of specific CXCR4 inhibitors possessing high selectivity indexes as well as complete stability in serum based on an anti-HIV peptide T140.EBI Bioorg Med Chem Lett 11: 1897-902 (2001) Kyoto University 2D 3D TSV
11459654 4 Macrocyclization in the design of a conformationally constrained Grb2 SH2 domain inhibitor.EBI Bioorg Med Chem Lett 11: 1889-92 (2001) National Institutes of Health 2D 3D TSV
11459653 31 Studies towards the next generation of antidepressants. Part 1: Indolylcyclohexylamines as potent serotonin reuptake inhibitors.EBI Bioorg Med Chem Lett 11: 1885-8 (2001) Wyeth-Ayerst Research Laboratories 2D 3D TSV
11459643 20 Phytoestrogens from the roots of Polygonum cuspidatum (Polygonaceae): structure-requirement of hydroxyanthraquinones for estrogenic activity.EBI Bioorg Med Chem Lett 11: 1839-42 (2001) Kyoto Pharmaceutical University 2D 3D TSV
11459642 39 Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 1.EBI Bioorg Med Chem Lett 11: 1833-7 (2001) Nippon Roche Research Center 2D 3D TSV
11459640 30 Nitrobenzene compounds inhibit expression of VCAM-1.EBI Bioorg Med Chem Lett 11: 1823-7 (2001) AtheroGenics, Inc. 2D 3D TSV
11459639 74 Evaluation of amino acid-based linkers in potent macrocyclic inhibitors of farnesyl-protein transferase.EBI Bioorg Med Chem Lett 11: 1817-21 (2001) Merck Research Laboratories 2D 3D TSV
11459637 5 Inhibition of fucosyltransferase V by a GDP-Azasugar.EBI Bioorg Med Chem Lett 11: 1809-11 (2001) Technische Universit£t Berlin 2D 3D TSV
11459636 16 Novel tricyclic benzothiazolo[2,3-c]thiadiazine antagonists of the platelet ADP receptor (P2Y(12)).EBI Bioorg Med Chem Lett 11: 1805-8 (2001) COR Therapeutics, Inc. 2D 3D TSV
11459634 94 Development of potent and selective factor Xa inhibitors.EBI Bioorg Med Chem Lett 11: 1797-800 (2001) Axys Pharmaceuticals, Inc. 2D 3D TSV
11454940 13 SL651498: an anxioselective compound with functional selectivity for alpha2- and alpha3-containing gamma-aminobutyric acid(A) (GABA(A)) receptors.BDB J Pharmacol Exp Ther 298: 753-68 (2001) Sanofi Synthelabo 2D 3D TSV
11454918 90 S33005, a novel ligand at both serotonin and norepinephrine transporters: I. Receptor binding, electrophysiological, and neurochemical profile in comparison with venlafaxine, reboxetine, citalopram, and clomipramine.BDB J Pharmacol Exp Ther 298: 565-80 (2001) Institut de Recherches Servier 2D 3D TSV
11454905 22 [3H]LY341495 binding to group II metabotropic glutamate receptors in rat brain.BDB J Pharmacol Exp Ther 298: 453-60 (2001) Eli Lilly and Company 2D 3D TSV
11454901 7 Prevention of allergic inflammation by a novel prostaglandin receptor antagonist, S-5751.BDB J Pharmacol Exp Ther 298: 411-9 (2001) Shionogi & Co. 2D 3D TSV
11454724 3 Evaluation of the interaction of loratadine and desloratadine with P-glycoprotein.EBI Drug Metab Dispos 29: 1080-3 (2001) Schering-Plough Research Institute 2D 3D TSV
11454474 84 Design and synthesis of a highly selective EP4-receptor agonist. Part 2: 5-thia and 9beta-haloPG derivatives with improved stability.EBI Bioorg Med Chem Lett 11: 2033-5 (2001) Minase Research Institute 2D 3D TSV
11454473 119 Design and synthesis of a highly selective EP4-receptor agonist. Part 1: 3,7-dithiaPG derivatives with high selectivity.EBI Bioorg Med Chem Lett 11: 2029-31 (2001) Minase Research Institute 2D 3D TSV
11454472 107 Design and synthesis of a highly selective EP2-receptor agonist.EBI Bioorg Med Chem Lett 11: 2025-8 (2001) Minase Research Institute 2D 3D TSV
11454470 17 Substituted 4-phenyl-2-(phenylcarboxamido)-1,3-thiazole derivatives as antagonists for the adenosine A(1) receptor.EBI Bioorg Med Chem Lett 11: 2017-9 (2001) Leiden/Amsterdam Center for Drug Research 2D 3D TSV
11454469 95 alpha(v)beta(3) Antagonists based on a central thiophene scaffold.EBI Bioorg Med Chem Lett 11: 2011-5 (2001) Aventis Pharma Deutschland GmbH 2D 3D TSV
11454468 35 Discovery and SAR of org 24598-a selective glycine uptake inhibitor.EBI Bioorg Med Chem Lett 11: 2007-9 (2001) Organon Research and Development Group 2D 3D TSV
11454465 4 Synthesis of N-alkyl substituted indolocarbazoles as potent inhibitors of human cytomegalovirus replication.EBI Bioorg Med Chem Lett 11: 1993-5 (2001) GlaxoSmithKline Medicines Research Centre 2D 3D TSV
11454461 111 The development of new carboxylic acid-based MMP inhibitors derived from a cyclohexylglycine scaffold.EBI Bioorg Med Chem Lett 11: 1975-9 (2001) Procter and Gamble Pharmaceuticals 2D 3D TSV
11452702 1 P-glycoprotein interactions of nefazodone and trazodone in cell culture.EBI J Clin Pharmacol 41: 708-14 (2001) Tufts University School of Medicine 2D 3D TSV
11451670 11 Hexosaminidase inhibitors as new drug candidates for the therapy of osteoarthritis.BDB Chem Biol 8: 701-11 (2001) The Scripps Research Institute 2D 3D TSV
11448230 14 Bisubstrate ketone analogues as serotonin N-acetyltransferase inhibitors.EBI J Med Chem 44: 2479-85 (2001) Johns Hopkins University School of Medicine 2D 3D TSV
11448224 9 Nonpeptidic, monocharged, cell permeable ligands for the p56lck SH2 domain.EBI J Med Chem 44: 2421-31 (2001) Boehringer Ingelheim (Canada) Ltd. 2D 3D TSV
11448222 80 Phenylpiperazinylalkylamino substituted pyridazinones as potent alpha(1) adrenoceptor antagonists.EBI J Med Chem 44: 2403-10 (2001) Istituto Chimico Farmaceutico e Tossicologico 2D 3D TSV
11448221 60 Design, synthesis, computational prediction, and biological evaluation of ester soft drugs as inhibitors of dihydrofolate reductase from Pneumocystis carinii.EBI J Med Chem 44: 2391-402 (2001) Uppsala University 2D 3D TSV
11448220 93 Novel C-terminus modifications of the Dmt-Tic motif: a new class of dipeptide analogues showing altered pharmacological profiles toward the opioid receptors.EBI J Med Chem 44: 2387-90 (2001) AstraZeneca R&D Montreal 2D 3D TSV
11448219 29 Reversible carnitine palmitoyltransferase inhibitors with broad chemical diversity as potential antidiabetic agents.EBI J Med Chem 44: 2383-6 (2001) Sigma Tau Pharmaceutical Industries S.p.A. 2D 3D TSV
11438309 51 The in vitro pharmacological profile of prucalopride, a novel enterokinetic compound.BDB Eur J Pharmacol 423: 71-83 (2001) Janssen Research Foundation 2D 3D TSV
11437380 2 Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells.EBI Biochem Biophys Res Commun 285: 111-7 (2001) Hungarian Academy of Sciences 2D 3D TSV
11430001 72 Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonospora alba.EBI J Nat Prod 64: 204-7 (2001) Kumamoto University 2D 3D TSV
11428928 70 Synthesis and structure-activity relationships of trisubstituted phenyl urea derivatives as neuropeptide Y5 receptor antagonists.EBI J Med Chem 44: 2344-56 (2001) Amgen Inc. 2D 3D TSV
11428927 117 A new concept for multidimensional selection of ligand conformations (MultiSelect) and multidimensional scoring (MultiScore) of protein-ligand binding affinities.EBI J Med Chem 44: 2333-43 (2001) The Royal Danish School of Pharmacy 2D 3D TSV
11428926 37 4-Hydroxy-5,6-dihydropyrones as inhibitors of HIV protease: the effect of heterocyclic substituents at C-6 on antiviral potency and pharmacokinetic parameters.EBI J Med Chem 44: 2319-32 (2001) Pfizer Global Research and Development 2D 3D TSV
11428923 39 Enantioselective syntheses of potent retinoid X receptor ligands: differential biological activities of individual antipodes.EBI J Med Chem 44: 2298-303 (2001) Allergan Inc. 2D 3D TSV
11428922 21 Novel N-(arylalkyl)indol-3-ylglyoxylylamides targeted as ligands of the benzodiazepine receptor: synthesis, biological evaluation, and molecular modeling analysis of the structure-activity relationships.EBI J Med Chem 44: 2286-97 (2001) Università di Pisa 2D 3D TSV
11428921 9 Utilization of an intramolecular hydrogen bond to increase the CNS penetration of an NK(1) receptor antagonist.EBI J Med Chem 44: 2276-85 (2001) Cambridge University Forvie Site 2D 3D TSV
11428920 6 Isomerization of (Z,Z) to (E,E)1-bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene in strong base: probes for amyloid plaques in the brain.EBI J Med Chem 44: 2270-5 (2001) University of Pennsylvania 2D 3D TSV
11426832 8 Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transporters.EBI Eur J Pharmacol 419: 113-20 (2001) Kyorin University School of Medicine 2D 3D TSV
11425561 197 Carbonic anhydrase inhibitors: 4-sulfamoyl-benzenecarboxamides and 4-chloro-3-sulfamoyl-benzenecarboxamides with strong topical antiglaucoma properties.EBI Bioorg Med Chem Lett 11: 1787-91 (2001) Universit£ degli Studi 2D 3D TSV
11425559 24 Novel and potent tacrine-related hetero- and homobivalent ligands for acetylcholinesterase and butyrylcholinesterase.BDB Bioorg Med Chem Lett 11: 1779-82 (2001) Universita degli Studi di Siena 2D 3D TSV
11425553 9 Significance of hydrogen bonding at the S(1)' subsite of calpain I.EBI Bioorg Med Chem Lett 11: 1753-5 (2001) The University of Tennessee 2D 3D TSV
11425550 62 Piperazinyl benzamidines: synthesis and affinity for the delta opioid receptor.EBI Bioorg Med Chem Lett 11: 1741-3 (2001) R. W. Johnson Pharmaceutical Research Institute 2D 3D TSV
11425549 30 Isoindolines: a new series of potent and selective endothelin-A receptor antagonists.EBI Bioorg Med Chem Lett 11: 1737-40 (2001) Novartis Institute for Biomedical Research 2D 3D TSV
11425547 137 Potent nonpeptide GnRH receptor antagonists derived from substituted indole-5-carboxamides and -acetamides bearing a pyridine side-chain terminus.EBI Bioorg Med Chem Lett 11: 1727-31 (2001) Merck Research Laboratories 2D 3D TSV
11425546 89 Substituted indole-5-carboxamides and -acetamides as potent nonpeptide GnRH receptor antagonists.EBI Bioorg Med Chem Lett 11: 1723-6 (2001) Merck Research Laboratories 2D 3D TSV
11425545 22 3-Carboxamido analogues of morphine and naltrexone. synthesis and opioid receptor binding properties.EBI Bioorg Med Chem Lett 11: 1717-21 (2001) Pharmacia 2D 3D TSV
11425544 14 Biphenyls as surrogates of the steroidal backbone. Part 2: discovery of a novel family of non-steroidal 5-alpha-reductase inhibitors.EBI Bioorg Med Chem Lett 11: 1713-6 (2001) Aventis 2D 3D TSV
11425540 6 Total synthesis of human chymase inhibitor methyllinderone and structure--activity relationships of its derivatives.EBI Bioorg Med Chem Lett 11: 1695-7 (2001) Shionogi & Co., Ltd. 2D 3D TSV
11425539 23 Inhibition of serine proteases: activity of 1,3-diazetidine-2,4-diones.EBI Bioorg Med Chem Lett 11: 1691-4 (2001) Shionogi & Co., Ltd. 2D 3D TSV
11425538 29 Synthesis of substituted 5[H]phenanthridin-6-ones as potent poly(ADP-ribose)polymerase-1 (PARP1) inhibitors.EBI Bioorg Med Chem Lett 11: 1687-90 (2001) Guilford Pharmaceuticals Inc. 2D 3D TSV
11425534 5 Novel sulfonate derivatives: potent antimitotic agents.EBI Bioorg Med Chem Lett 11: 1671-3 (2001) Abbott Laboratories 2D 3D TSV
11425533 13 Selective inhibition of Src SH2 by a novel thiol-targeting tricarbonyl-modified inhibitor and mechanistic analysis by (1)H/(13)C NMR spectroscopy.EBI Bioorg Med Chem Lett 11: 1665-9 (2001) ARIAD Pharmaceuticals, Inc. 2D 3D TSV
11425531 2 [3H]MFZ 2-12: a novel radioligand for the dopamine transporter.EBI Bioorg Med Chem Lett 11: 1659-61 (2001) National Institute on Drug Abuse-Intramural Research Program 2D 3D TSV
11425530 64 Nucleoside analogues as highly potent and selective inhibitors of herpes simplex virus thymidine kinase.EBI Bioorg Med Chem Lett 11: 1655-8 (2001) Roche Discovery Welwyn 2D 3D TSV
11425527 16 Expedited discovery of second generation NK-1 antagonists: identification of a nonbasic aryloxy substituent.EBI Bioorg Med Chem Lett 11: 1643-6 (2001) Lilly Research Laboratories 2D 3D TSV
11425526 3 Quinoline-4-acetamides as sPLA(2) inhibitors.EBI Bioorg Med Chem Lett 11: 1639-41 (2001) Peking University 2D 3D TSV
11425524 62 Dibasic inhibitors of human mast cell tryptase. Part 3: identification of a series of potent and selective inhibitors containing the benzamidine functionality.EBI Bioorg Med Chem Lett 11: 1629-33 (2001) Axys Pharmaceuticals, Inc. 2D 3D TSV
11425523 20 Novel heteroaryl replacements of aromatic 3-tetrafluoroethoxy substituents in trifluoro-3-(tertiaryamino)-2-propanols as potent inhibitors of cholesteryl ester transfer protein.EBI Bioorg Med Chem Lett 11: 1625-8 (2001) Pharmacia 2D 3D TSV
11421762 6 Steroidal alkaloids from the leaves of Sarcococca coriacea of Nepalese origin.EBI J Nat Prod 64: 842-4 (2001) Tribhuvan University 2D 3D TSV
11421736 31 Cox-2 inhibitory effects of naturally occurring and modified fatty acids.EBI J Nat Prod 64: 745-9 (2001) Uppsala University 2D 3D TSV
11412991 8 Synthesis of derivatives of the novel cyclophilin-binding immunosuppressant sanglifehrin A with reduced numbers of polar functions.EBI Bioorg Med Chem Lett 11: 1609-12 (2001) Novartis Pharma AG 2D 3D TSV
11412990 2 Synthesis and evaluation of GGPP geometric isomers: divergent substrate specificities of FTase and GGTase I.EBI Bioorg Med Chem Lett 11: 1605-8 (2001) Wayne State University 2D 3D TSV
11412987 2 Synthesis of novel sialylmimetics as biological probes.EBI Bioorg Med Chem Lett 11: 1587-90 (2001) Monash University (Parkville Campus) 2D 3D TSV
11412986 3 An unhydrolyzable analogue of N-(4-hydroxyphenyl)retinamide. synthesis and preliminary biological studies.EBI Bioorg Med Chem Lett 11: 1583-6 (2001) The Ohio State University 2D 3D TSV
11412985 62 Phenylethanolamine N-methyltransferase kinetics: bovine versus recombinant human enzyme.EBI Bioorg Med Chem Lett 11: 1579-82 (2001) University of Kansas 2D 3D TSV
11412984 66 Bioisosteric determinants for subtype selectivity of ligands for heteromeric GABA(A) receptors.EBI Bioorg Med Chem Lett 11: 1573-7 (2001) The Royal Danish School of Pharmacy 2D 3D TSV
11412983 9 New probes of the agonist binding site of metabotropic glutamate receptors.EBI Bioorg Med Chem Lett 11: 1569-72 (2001) Universit£ Ren£ Descartes 2D 3D TSV
11412982 2 Cyclooxygenase-inhibitory and antioxidant constituents of the aerial parts of Antirhea acutata.EBI Bioorg Med Chem Lett 11: 1565-8 (2001) University of Illinois at Chicago 2D 3D TSV
11412980 48 Discovery and characterization of the potent, selective and orally bioavailable MMP inhibitor ABT-770.EBI Bioorg Med Chem Lett 11: 1557-60 (2001) Abbott Laboratories 2D 3D TSV
11412979 67 Biaryl ether retrohydroxamates as potent, long-lived, orally bioavailable MMP inhibitors.EBI Bioorg Med Chem Lett 11: 1553-6 (2001) Abbott Laboratories 2D 3D TSV
11412977 23 Amidino benzimidazole inhibitors of bacterial two-component systems.EBI Bioorg Med Chem Lett 11: 1545-8 (2001) The R. W. Johnson Pharmaceutical Research Institute 2D 3D TSV
11412972 13 alpha-Keto heterocycle inhibitors of fatty acid amide hydrolase: carbonyl group modification and alpha-substitution.EBI Bioorg Med Chem Lett 11: 1517-20 (2001) The Scripps Research Institute 2D 3D TSV
11412967 10 Aromatic inhibitors of dehydroquinate synthase: synthesis, evaluation and implications for gallic acid biosynthesis.EBI Bioorg Med Chem Lett 11: 1493-6 (2001) Michigan State University 2D 3D TSV
11410378 50 Structure-based design and in-parallel synthesis of inhibitors of AmpC beta-lactamase.BDB Chem Biol 8: 593-611 (2001) Northwestern University 2D 3D TSV
11408610 18 Evidence for a new G protein-coupled cannabinoid receptor in mouse brain.BDB Mol Pharmacol 60: 155-63 (2001) Virginia Commonwealth University 2D 3D TSV
11408607 25 The peptide YY-preferring receptor mediating inhibition of small intestinal secretion is a peripheral Y(2) receptor: pharmacological evidence and molecular cloning.BDB Mol Pharmacol 60: 124-34 (2001) U410 2D 3D TSV
11408557 10 Characterization of the efflux transport of 17beta-estradiol-D-17beta-glucuronide from the brain across the blood-brain barrier.EBI J Pharmacol Exp Ther 298: 316-22 (2001) The University of Tokyo 2D 3D TSV
11408556 2 Pharmacological characterization of ZD6021: a novel, orally active antagonist of the tachykinin receptors.BDB J Pharmacol Exp Ther 298: 307-15 (2001) AstraZeneca Pharmaceuticals 2D 3D TSV
11408545 55 Rabbit alpha2-adrenoceptors: both platelets and adipocytes have alpha2A-pharmacology.BDB J Pharmacol Exp Ther 298: 219-25 (2001) Glaxo SmithKline Pharmaceuticals 2D 3D TSV
11408360 1 Methadone inhibits rhodamine123 transport in Caco-2 cells.EBI Drug Metab Dispos 29: 954-6 (2001) Tufts University School of Medicine 2D 3D TSV
11405662 100 Protease inhibitors: synthesis of a series of bacterial collagenase inhibitors of the sulfonyl amino acyl hydroxamate type.EBI J Med Chem 44: 2253-8 (2001) The University of Western Australia 2D 3D TSV
11405661 61 Characterization of melanocortin NDP-MSH agonist peptide fragments at the mouse central and peripheral melanocortin receptors.EBI J Med Chem 44: 2247-52 (2001) University of Florida 2D 3D TSV
11405660 155 Potent somatostatin undecapeptide agonists selective for somatostatin receptor 1 (sst1).EBI J Med Chem 44: 2238-46 (2001) Salk Institute 2D 3D TSV
11405659 22 Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2-exo-2-(2'-substituted 5'-pyridinyl)-7-azabicyclo[2.2.1]heptanes. Epibatidine analogues.EBI J Med Chem 44: 2229-37 (2001) Research Triangle Institute 2D 3D TSV
11405658 12 5-(Tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-based potent and selective CCK(1)receptor antagonists: structure-activity relationship studies on the substituent at N2-position.EBI J Med Chem 44: 2219-28 (2001) Instituto de Qu£mica M£dica (CSIC) 2D 3D TSV
11405657 123 Novel, potent, and selective phosphodiesterase 5 inhibitors: synthesis and biological activities of a series of 4-aryl-1-isoquinolinone derivatives.EBI J Med Chem 44: 2204-18 (2001) Tanabe Seiyaku Co., Ltd. 2D 3D TSV
11405650 42 Discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor..EBI J Med Chem 44: 2133-8 (2001) Abbott Laboratories 2D 3D TSV
11405647 24 Development of potent non-carbohydrate imidazole-based small molecule selectin inhibitors with antiinflammatory activity.EBI J Med Chem 44: 2094-107 (2001) Ontogen Corporation 2D 3D TSV
11405646 95 Adenosine analogues as selective inhibitors of glyceraldehyde-3-phosphate dehydrogenase of Trypanosomatidae via structure-based drug design.EBI J Med Chem 44: 2080-93 (2001) University of Washington 2D 3D TSV
11405645 13 Transformation of a kappa-opioid receptor antagonist to a kappa-agonist by transfer of a guanidinium group from the 5'- to 6'-position of naltrindole.EBI J Med Chem 44: 2073-9 (2001) University of Minnesota 2D 3D TSV
11405644 12 3-(4-aroyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides, a new class of synthetic histone deacetylase inhibitors.EBI J Med Chem 44: 2069-72 (2001) Università degli Studi di Siena 2D 3D TSV
11405642 33 Design and synthesis of 2-methyl-2-[4-(2-[5-methyl-2-aryloxazol-4-yl]ethoxy)phenoxy]propionic acids: a new class of dual PPARalpha/gamma agonists.EBI J Med Chem 44: 2061-4 (2001) Lilly Research Laboratories 2D 3D TSV
11405641 8 Secretase targets for Alzheimer's disease: identification and therapeutic potential.EBI J Med Chem 44: 2039-60 (2001) Harvard Medical School 2D 3D TSV
11404457 5 Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R.BDB Proc Natl Acad Sci U S A 98: 7564-9 (2001) Merck Research Laboratories 2D 3D TSV
11392550 5 Powerful probes for glycosidases: novel, fluorescently tagged glycosidase inhibitors.EBI Bioorg Med Chem Lett 11: 1339-42 (2001) Institut für Biochemie der Technischen Universität Graz 2D 3D TSV
11392549 45 Ring-Constrained (N)-methanocarba nucleosides as adenosine receptor agonists: independent 5'-uronamide and 2'-deoxy modifications.EBI Bioorg Med Chem Lett 11: 1333-7 (2001) NIDDK 2D 3D TSV
11392548 59 Design, synthesis and enzymatic activity of highly selective human mitochondrial thymidine kinase inhibitors.EBI Bioorg Med Chem Lett 11: 1329-32 (2001) Universit£ di Ferrara 2D 3D TSV
11392547 15 Thiazole analogues of the NSAID indomethacin as selective COX-2 inhibitors.EBI Bioorg Med Chem Lett 11: 1325-8 (2001) Abbott Laboratories 2D 3D TSV
11392544 11 Pharmacological evaluation of a diarylmethylene-piperidine derivative: a new potent atypical antipsychotic?EBI Bioorg Med Chem Lett 11: 1313-6 (2001) UCB SA 2D 3D TSV
11392542 25 Structure-activity relationship investigations of a potent and selective benzodiazepine oxytocin antagonist.EBI Bioorg Med Chem Lett 11: 1301-5 (2001) GlaxoSmithKline 2D 3D TSV
11392541 2 Identification of a potent and selective oxytocin antagonist, from screening a fully encoded differential release combinatorial chemical library.EBI Bioorg Med Chem Lett 11: 1297-300 (2001) GlaxoSmithKline Medicines Research Centre 2D 3D TSV
11392540 23 Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 2: design of potent antagonists containing the 3-azaspiro[5.5]undecanes.EBI Bioorg Med Chem Lett 11: 1293-6 (2001) COR Therapeutics, Inc 2D 3D TSV
11392539 34 Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 1: design of potent and specific 3,9-diazaspiro[5.5]undecanes.EBI Bioorg Med Chem Lett 11: 1289-92 (2001) COR Therapeutics, Inc 2D 3D TSV
11392538 2 Synthesis and biological evaluations of condensed pyridine and condensed pyrimidine-based HMG-CoA reductase inhibitors.EBI Bioorg Med Chem Lett 11: 1285-8 (2001) Central Research Institute 2D 3D TSV
11392536 2 Synthesis and evaluation of a difluoromethylene analogue of sphingomyelin as an inhibitor of sphingomyelinase.EBI Bioorg Med Chem Lett 11: 1277-80 (2001) Tokyo University of Pharmacy & Life Science 2D 3D TSV
11392535 12 Synthesis and antifungal activities of novel 1,3-beta-D-glucan synthase inhibitors. Part 2.EBI Bioorg Med Chem Lett 11: 1273-6 (2001) Nippon Roche Research Center 2D 3D TSV
11392531 79 Diaryl ether inhibitors of farnesyl-protein transferase.EBI Bioorg Med Chem Lett 11: 1257-60 (2001) Merck Research Laboratories 2D 3D TSV
11384246 86 Potent and selective nonpeptide inhibitors of caspases 3 and 7.BDB J Med Chem 44: 2015-26 (2001) GlaxoSmithKline 2D 3D TSV
11384244 61 Synthesis, antifolate, and antitumor activities of classical and nonclassical 2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines.EBI J Med Chem 44: 1993-2003 (2001) Duquesne University 2D 3D TSV
11384242 126 Structure-activity studies for a novel series of bicyclic substituted hexahydrobenz[e]isoindole alpha1A adrenoceptor antagonists as potential agents for the symptomatic treatment of benign prostatic hyperplasia.EBI J Med Chem 44: 1971-85 (2001) Abbott Laboratories 2D 3D TSV
11384239 82 Solid-phase synthesis of a nonpeptide RGD mimetic library: new selective alphavbeta3 integrin antagonists.EBI J Med Chem 44: 1938-50 (2001) Technische Universität München 2D 3D TSV
11384237 222 Soluble 2-substituted aminopyrido[2,3-d]pyrimidin-7-yl ureas. Structure-activity relationships against selected tyrosine kinases and exploration of in vitro and in vivo anticancer activity.BDB J Med Chem 44: 1915-26 (2001) Pfizer 2D 3D TSV
11384236 26 Radioiodinated styrylbenzenes and thioflavins as probes for amyloid aggregates.EBI J Med Chem 44: 1905-14 (2001) University of Pennsylvania 2D 3D TSV
11384235 21 An optimized protein kinase C activating diacylglycerol combining high binding affinity (Ki) with reduced lipophilicity (log P).EBI J Med Chem 44: 1892-904 (2001) National Cancer Institute at Frederick 2D 3D TSV
11384233 70 2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1.BDB J Med Chem 44: 1866-82 (2001) GlaxoSmithKline 2D 3D TSV
11384231 26 2-(2-Oxo-1,4-dihydro-2H-quinazolin-3-yl)- and 2-(2,2-dioxo-1,4-dihydro-2H-2lambda6-benzo[1,2,6]thiadiazin-3-yl)-N-hydroxy-acetamides as potent and selective peptide deformylase inhibitors.EBI J Med Chem 44: 1847-52 (2001) F. Hoffmann-La Roche Ltd. 2D 3D TSV
11378378 34 Arylsulphonyl hydroxamic acids: potent and selective matrix metalloproteinase inhibitors.EBI Bioorg Med Chem Lett 11: 1465-8 (2001) Celltech Chiroscience Ltd 2D 3D TSV
11378377 11 Fine Tuning of physico-chemical parameters to optimise a new series of novobiocin analogues.EBI Bioorg Med Chem Lett 11: 1461-4 (2001) Aventis Pharma 2D 3D TSV
11378374 39 Discovery of potent and selective phenylalanine derived CCR3 receptor antagonists. Part 2.EBI Bioorg Med Chem Lett 11: 1445-50 (2001) SmithKline Beecham Pharmaceuticals 2D 3D TSV
11378373 35 Discovery of potent and selective phenylalanine derived CCR3 antagonists. Part 1.EBI Bioorg Med Chem Lett 11: 1441-4 (2001) SmithKline Beecham Pharmaceuticals 2D 3D TSV
11378372 10 1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 1: discovery of the pyrrolidine scaffold and determination of its stereochemical requirements.EBI Bioorg Med Chem Lett 11: 1437-40 (2001) Merck Research Laboratories 2D 3D TSV
11378371 2 Discovery of a nuclease-resistant, non-natural dinucleotide that inhibits HIV-1 integrase.EBI Bioorg Med Chem Lett 11: 1433-5 (2001) The University of Iowa 2D 3D TSV
11378369 4 Effect of zinc ion on the inhibition of carboxypeptidase A by imidazole-bearing substrate analogues.EBI Bioorg Med Chem Lett 11: 1425-7 (2001) Pohang University of Science and Technology 2D 3D TSV
11378366 40 Aryloxy substituted N-arylpiperazinones as dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I.EBI Bioorg Med Chem Lett 11: 1411-5 (2001) Merck Research Laboratories 2D 3D TSV
11378365 52 MEK (MAPKK) inhibitors. Part 2: structure-activity relationships of 4-anilino-3-cyano-6,7-dialkoxyquinolines.EBI Bioorg Med Chem Lett 11: 1407-10 (2001) Wyeth-Ayerst Research 2D 3D TSV
11378364 34 Indazolylamino quinazolines and pyridopyrimidines as inhibitors of the EGFr and C-erbB-2.EBI Bioorg Med Chem Lett 11: 1401-5 (2001) Research Biomet. Glaxo Wellcome Medicines Research Centre 2D 3D TSV
11378362 11 Structure-activity relationships of phenylcyclohexene and biphenyl antitubulin compounds against plant and mammalian cells.EBI Bioorg Med Chem Lett 11: 1393-6 (2001) Rohm and Haas Company 2D 3D TSV
11378361 25 4,1-Benzoxazepinone analogues of efavirenz (Sustiva) as HIV-1 reverse transcriptase inhibitors.BDB Bioorg Med Chem Lett 11: 1389-92 (2001) DuPont Pharmaceuticals Company 2D 3D TSV
11378359 57 Structure-based design, synthesis and SAR of a novel series of thiopheneamidine urokinase plasminogen activator inhibitors.EBI Bioorg Med Chem Lett 11: 1379-82 (2001) 3-Dimensional Pharmaceuticals Inc. 2D 3D TSV
11378358 254 Synthesis of potent and selective dopamine D(4) antagonists as candidate radioligands.EBI Bioorg Med Chem Lett 11: 1375-7 (2001) Columbia University College of Physicians and Surgeons 2D 3D TSV
11378357 55 5,5-Diaryl-2-amino-4-pentenoates as novel, potent, and selective glycine transporter type-2 reuptake inhibitors.EBI Bioorg Med Chem Lett 11: 1371-3 (2001) NPS Pharmaceuticals Inc. 2D 3D TSV
11378353 14 Identification of novel potent hydroxamic acid inhibitors of peptidyl deformylase and the importance of the hydroxamic acid functionality on inhibition.EBI Bioorg Med Chem Lett 11: 1355-8 (2001) Pharmacia 2D 3D TSV
11378352 3 Synthesis and antiviral activities of the major metabolites of the HIV protease inhibitor ABT-378 (Lopinavir).EBI Bioorg Med Chem Lett 11: 1351-3 (2001) Abbott Laboratories 2D 3D TSV
11374978 12 Coumarins isolated from Angelica gigas inhibit acetylcholinesterase: structure-activity relationships.EBI J Nat Prod 64: 683-5 (2001) Seoul National University 2D 3D TSV
11374954 6 New sesquiterpene derivatives from the sponge Dysidea species with a selective inhibitor profile against human phospholipase A2 and other leukocyte functions.EBI J Nat Prod 64: 612-5 (2001) Università degli Studi di Napoli Federico II 2D 3D TSV
11356907 15 Antiparkinsonian agent piribedil displays antagonist properties at native, rat, and cloned, human alpha(2)-adrenoceptors: cellular and functional characterization.BDB J Pharmacol Exp Ther 297: 876-87 (2001) Institut de Recherches Servier 2D 3D TSV
11356115 108 Synthesis and structure-activity relationships of naphthamides as dopamine D3 receptor ligands.EBI J Med Chem 44: 1815-26 (2001) Wake Forest University School of Medicine 2D 3D TSV
11356113 18 Enantioselective syntheses of dopaminergic (R)- and (S)-benzyltetrahydroisoquinolines.EBI J Med Chem 44: 1794-801 (2001) Universidad de Valencia 2D 3D TSV
11356112 175 Potent reversible inhibitors of the protein tyrosine phosphatase CD45.EBI J Med Chem 44: 1777-93 (2001) AstraZeneca Pharmaceuticals 2D 3D TSV
11356110 2 Synthesis and biological evaluation of purine-containing butenolides.EBI J Med Chem 44: 1749-57 (2001) Institute of Chemistry 2D 3D TSV
11356108 3 Homology modeling using multiple molecular dynamics simulations and docking studies of the human androgen receptor ligand binding domain bound to testosterone and nonsteroidal ligands.EBI J Med Chem 44: 1729-40 (2001) The University of Tennessee-Health Science Center 2D 3D TSV
11356107 16 Discovery of novel aldose reductase inhibitors using a protein structure-based approach: 3D-database search followed by design and synthesis.EBI J Med Chem 44: 1718-28 (2001) Sankyo Co., Ltd. 2D 3D TSV
11356104 29 Structural basis of binding of high-affinity ligands to protein kinase C: prediction of the binding modes through a new molecular dynamics method and evaluation by site-directed mutagenesis.EBI J Med Chem 44: 1690-701 (2001) Georgetown University Medical Center 2D 3D TSV
11356103 61 Stepwise modulation of neurokinin-3 and neurokinin-2 receptor affinity and selectivity in quinoline tachykinin receptor antagonists.EBI J Med Chem 44: 1675-89 (2001) SmithKline Beecham Pharmaceuticals 2D 3D TSV
11356102 16 Development of a pharmacophore model for histamine H3 receptor antagonists, using the newly developed molecular modeling program SLATE.EBI J Med Chem 44: 1666-74 (2001) De Novo Pharmaceuticals 2D 3D TSV
11356100 15 Design, synthesis, and preclinical characterization of novel, highly selective indole estrogens.EBI J Med Chem 44: 1654-7 (2001) Wyeth-Ayerst Research 2D 3D TSV
11356099 20 Recent developments in the biology and medicinal chemistry of potassium channel modulators: update from a decade of progress.EBI J Med Chem 44: 1627-53 (2001) Abbott Laboratories 2D 3D TSV
11354387 20 Neuronal nicotinic acetylcholine receptor binding affinities of boron-containing nicotine analogues.EBI Bioorg Med Chem Lett 11: 1245-8 (2001) University of Kentucky 2D 3D TSV
11354386 90 Design and pharmacology of quinuclidine derivatives as M2-selective muscarinic receptor ligands.EBI Bioorg Med Chem Lett 11: 1241-3 (2001) University of Mainz 2D 3D TSV
11354385 27 2-Aryl indole NK1 receptor antagonists: optimisation of the 2-aryl ring and the indole nitrogen substituent.EBI Bioorg Med Chem Lett 11: 1237-40 (2001) Merck, Sharp and Dohme Research Laboratories 2D 3D TSV
11354384 27 2-Aryl indole NK1 receptor antagonists: optimisation of indole substitution.EBI Bioorg Med Chem Lett 11: 1233-6 (2001) The Neuroscience Research Centre 2D 3D TSV
11354383 24 Influence of the terminal amide fragment geometry in some 3-arylideneindolin-2(1H)-ones on their 5-HT1A/5-HT2A receptor activity.EBI Bioorg Med Chem Lett 11: 1229-31 (2001) Polish Academy of Sciences 2D 3D TSV
11354382 42 Identification of a subtype selective human PPARalpha agonist through parallel-array synthesis.EBI Bioorg Med Chem Lett 11: 1225-7 (2001) GlaxoSmithKline 2D 3D TSV
11354381 19 Discovery of a novel CCR3 selective antagonist.EBI Bioorg Med Chem Lett 11: 1219-23 (2001) Banyu Tsukuba Research Institute 2D 3D TSV
11354380 3 Syntheses and evaluation of quinoline derivatives as novel retinoic acid receptor alpha antagonists.EBI Bioorg Med Chem Lett 11: 1215-8 (2001) Eisai Co., Ltd. 2D 3D TSV
11354379 37 Design and synthesis of 2-oxo-imidazolidine-4-carboxylic acid hydroxyamides as potent matrix metalloproteinase-13 inhibitors.EBI Bioorg Med Chem Lett 11: 1211-3 (2001) Pfizer Global Research & Development 2D 3D TSV
11354377 8 Convergent synthesis of potent peptide inhibitors of the Grb2-SH2 domain by palladium catalyzed coupling of a terminal alkyne.EBI Bioorg Med Chem Lett 11: 1201-3 (2001) NOVARTIS Pharma AG 2D 3D TSV
11354366 81 Quinazolines as cyclin dependent kinase inhibitors.BDB Bioorg Med Chem Lett 11: 1157-60 (2001) DuPont Merck Pharmaceutical Company 2D 3D TSV
11354365 11 Inhibition of neuronal nitric oxide synthase by 7-methoxyindazole and related substituted indazoles.EBI Bioorg Med Chem Lett 11: 1153-6 (2001) Université de Caen 2D 3D TSV
11354362 18 Conformational analysis of tandospirone in aqueous solution: lead evolution of potent dopamine D4 receptor ligands.EBI Bioorg Med Chem Lett 11: 1141-4 (2001) Sumitomo Pharmaceuticals 2D 3D TSV
11354361 1 Glycosidase inhibition by cyclic sulfonium compounds.EBI Bioorg Med Chem Lett 11: 1137-9 (2001) Graduate School of Bioscience and Biotechnology 2D 3D TSV
11354359 6 Binding of dimeric aminoglycosides to the HIV-1 rev responsive element (RRE) RNA construct.EBI Bioorg Med Chem Lett 11: 1127-31 (2001) Purdue University 2D 3D TSV
11354358 53 Phenoxypyrimidine inhibitors of p38alpha kinase: synthesis and statistical evaluation of the p38 inhibitory potencies of a series of 1-(piperidin-4-yl)-4-(4-fluorophenyl)-5-(2-phenoxypyrimidin-4-yl) imidazoles.EBI Bioorg Med Chem Lett 11: 1123-6 (2001) GlaxoSmithKline Pharmaceuticals 2D 3D TSV
11354357 61 Two novel and potent 3-[(o-methoxyphenyl)piperazinylethyl]-5-phenylthien.EBI Bioorg Med Chem Lett 11: 1119-21 (2001) Abbott Laboratories 2D 3D TSV
11354356 42 Pharmacophore-based discovery of 3,4-disubstituted pyrrolidines as a novel class of monoamine transporter inhibitors.EBI Bioorg Med Chem Lett 11: 1113-8 (2001) Georgetown University Medical Center 2D 3D TSV
11354355 6 Design and synthesis of a new sialyl Lewis X mimetic: how selective are the selectin receptors?EBI Bioorg Med Chem Lett 11: 1109-12 (2001) Universit£ de Montr£al 2D 3D TSV
11342132 24 Structural basis for inhibition promiscuity of dual specific thrombin and factor Xa blood coagulation inhibitors.BDB Structure 9: 29-37 (2001) Boehringer Ingelheim Pharma KG 2D 3D TSV
11341829 9 Small molecule peptidomimetics containing a novel phosphotyrosine bioisostere inhibit protein tyrosine phosphatase 1B and augment insulin action.BDB Biochemistry 40: 5642-54 (2001) Pharmacia Corporation 2D 3D TSV
11334572 3 Combinatorial lead optimization of a neuropeptide FF antagonist.EBI J Med Chem 44: 1623-6 (2001) University of Florida 2D 3D TSV
11334571 79 Pharmacological and behavioral analysis of the effects of some bivalent ligand-based monoamine reuptake inhibitors.EBI J Med Chem 44: 1615-22 (2001) Georgetown University Medical Center 2D 3D TSV
11334570 103 3-(4-Fluoropiperidin-3-yl)-2-phenylindoles as high affinity, selective, and orally bioavailable h5-HT(2A) receptor antagonists.EBI J Med Chem 44: 1603-14 (2001) Merck Sharp and Dohme 2D 3D TSV
11334569 10 Synthesis and biological evaluation of novel A-ring modified hexacyclic camptothecin analogues.EBI J Med Chem 44: 1594-602 (2001) Life Science Research Center 2D 3D TSV
11334561 63 Synthesis of 2beta-acyl-3beta-(substituted naphthyl)-8-azabicyclo[3.2.1]octanes and their binding affinities at dopamine and serotonin transport sites.EBI J Med Chem 44: 1509-15 (2001) State University of New York 2D 3D TSV
11334560 18 Design, synthesis, and proposed active site binding analysis of monocyclic 2-azetidinone inhibitors of prostate specific antigen.EBI J Med Chem 44: 1491-508 (2001) University of Oxford 2D 3D TSV
11334558 42 Highly selective and potent neuropeptide Y (NPY) Y1 receptor antagonists based on [Pro(30), Tyr(32), Leu(34)]NPY(28-36)-NH2 (BW1911U90).EBI J Med Chem 44: 1479-82 (2001) University of Cincinnati and VA Medical Centers 2D 3D TSV
11327608 45 Allyl and propargyl substituted penam sulfones as versatile intermediates toward the syntheses of new beta-lactamase inhibitors.EBI Bioorg Med Chem Lett 11: 997-1000 (2001) Wyeth-Ayerst Research 2D 3D TSV
11327607 67 Novel non-peptide ligands for the somatostatin sst3 receptor.EBI Bioorg Med Chem Lett 11: 991-5 (2001) Institut Henri Beaufour 2D 3D TSV
11327605 27 New oxadiazolidinedione derivatives as potent and selective human beta3 agonists.EBI Bioorg Med Chem Lett 11: 981-4 (2001) Wyeth-Ayerst Research 2D 3D TSV
11327603 31 Discovery and SAR of diarylsulfide cyclopropylamide LFA-1/ICAM-1 interaction antagonists.EBI Bioorg Med Chem Lett 11: 973-6 (2001) Abbott Laboratories 2D 3D TSV
11327602 58 Novel 5,5-disubstitutedpyrimidine-2,4,6-triones as selective MMP inhibitors.EBI Bioorg Med Chem Lett 11: 969-72 (2001) Roche Research Center 2D 3D TSV
11327601 24 Vanilloid and isovanilloid analogues as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases.EBI Bioorg Med Chem Lett 11: 965-8 (2001) Seoul National University 2D 3D TSV
11327600 24 Ester and hydroxamate analogues of methionyl and isoleucyl adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases.EBI Bioorg Med Chem Lett 11: 961-4 (2001) Seoul National University 2D 3D TSV
11327599 25 Rational design, synthesis, and biological evaluation of rigid pyrrolidone analogues as potential inhibitors of prostate cancer cell growth.EBI Bioorg Med Chem Lett 11: 955-9 (2001) Georgetotwn University 2D 3D TSV
11327595 4 Synthesis and structure-activity relationships of guanine analogues as phosphodiesterase 7 (PDE7) inhibitors.EBI Bioorg Med Chem Lett 11: 1081-3 (2001) Celltech R& D 2D 3D TSV
11327594 26 Heterocyclic derivatives of 2-(3,5-dimethylphenyl)tryptamine as GnRH receptor antagonists.EBI Bioorg Med Chem Lett 11: 1077-80 (2001) Merck Research Laboratories 2D 3D TSV
11327593 16 2-(3,5-Dimethylphenyl)tryptamine derivatives that bind to the GnRH receptor.EBI Bioorg Med Chem Lett 11: 1073-6 (2001) Merck Research Laboratories 2D 3D TSV
11327592 9 1,2,5-Thiadiazole derivatives are potent and selective ligands at human 5-HT1A receptors.EBI Bioorg Med Chem Lett 11: 1069-71 (2001) Wyeth-Ayerst Research 2D 3D TSV
11327591 1 Design, synthesis and stability of N-acyloxymethyl- and N-aminocarbonyloxymethyl-2-azetidinones as human leukocyte elastase inhibitors.EBI Bioorg Med Chem Lett 11: 1065-8 (2001) INETI 2D 3D TSV
11327590 7 Novel, lipophilic derivatives of 2,5-dideoxy-2,5-imino-D-mannitol (DMDP) are powerful beta-glucosidase inhibitors.EBI Bioorg Med Chem Lett 11: 1063-4 (2001) Technische Universität Graz 2D 3D TSV
11327589 11 In vitro metabolism considerations, including activity testing of metabolites, in the discovery and selection of the COX-2 inhibitor etoricoxib (MK-0663).EBI Bioorg Med Chem Lett 11: 1059-62 (2001) Merck Frosst Centre for Therapeutic Research 2D 3D TSV
11327585 15 Synthesis and structure-activity studies of side-chain derivatized arylhydantoins for investigation as androgen receptor radioligands.EBI Bioorg Med Chem Lett 11: 1045-7 (2001) The University of Michigan Medical School 2D 3D TSV
11327582 23 2-Acylimino-3H-thiazoline derivatives: a novel template for platelet GPIIb/IIIa receptor antagonists.EBI Bioorg Med Chem Lett 11: 1031-5 (2001) Taisho Pharmaceutical Co. Ltd. 2D 3D TSV
11327581 44 Thienopyridines: nitric oxide synthase inhibitors with potent in vivo activity.EBI Bioorg Med Chem Lett 11: 1027-30 (2001) AstraZeneca R&D Charnwood 2D 3D TSV
11327580 73 3,4-Dihydro-1-isoquinolinamines: a novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potency.EBI Bioorg Med Chem Lett 11: 1023-6 (2001) AstraZeneca R&D Charnwood 2D 3D TSV
11327579 3 Structure determination and comparison of BM567, a sulfonylurea, with terbogrel, two compounds with dual action, thromboxane receptor antagonism and thromboxane synthase inhibition.EBI Bioorg Med Chem Lett 11: 1019-22 (2001) Facultés Universitaires N.-D. de la Paix 2D 3D TSV
11327577 86 Heterocycle-based MMP inhibitors with P2' substituents.EBI Bioorg Med Chem Lett 11: 1009-13 (2001) Procter and Gamble Pharmaceuticals 2D 3D TSV
11325241 2 Microxine, a new cdc2 kinase inhibitor from the Australian marine sponge Microxina species.EBI J Nat Prod 64: 525-6 (2001) Harbor Branch Oceanographic Institution, Inc. 2D 3D TSV
11312929 90 Highly potent and subtype selective ligands derived by N-methyl scan of a somatostatin antagonist.EBI J Med Chem 44: 1305-11 (2001) Tulane University Health Sciences Center 2D 3D TSV
11312928 62 Synthesis, structure-activity relationships, and pharmacokinetic profiles of nonpeptidic difluoromethylene ketones as novel inhibitors of human chymase.EBI J Med Chem 44: 1297-304 (2001) Welfide Corporation 2D 3D TSV
11312927 64 Synthesis, structure-activity relationships, and pharmacokinetic profiles of nonpeptidic alpha-keto heterocycles as novel inhibitors of human chymase.EBI J Med Chem 44: 1286-96 (2001) Welfide Corporation 2D 3D TSV
11312926 39 Development of orally active nonpeptidic inhibitors of human neutrophil elastase.EBI J Med Chem 44: 1268-85 (2001) Cortech, Inc. 2D 3D TSV
11312924 6 Angular methoxy-substituted furo- and pyranoquinolinones as blockers of the voltage-gated potassium channel Kv1.3.EBI J Med Chem 44: 1249-56 (2001) University of Kiel 2D 3D TSV
11312921 16 Acyl substitution at the ortho position of anilides enhances oral bioavailability of thiophene sulfonamides: TBC3214, an ETA selective endothelin antagonist.EBI J Med Chem 44: 1211-6 (2001) Texas Biotechnology Corporation 2D 3D TSV
11312920 23 Novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 2. Mechanism of inhibition and structure-based improvement of pharmaceutical properties.EBI J Med Chem 44: 1202-10 (2001) Abbott Laboratories 2D 3D TSV
11312919 22 Design, synthesis, and structural analysis of influenza neuraminidase inhibitors containing pyrrolidine cores.EBI J Med Chem 44: 1192-201 (2001) Abbott Laboratories 2D 3D TSV
11312916 2 Discovery of an orally active non-peptide fibrinogen receptor antagonist based on the hydantoin scaffold.EBI J Med Chem 44: 1158-76 (2001) Aventis Pharma AG 2D 3D TSV
11312914 53 Mapping and fitting the peripheral benzodiazepine receptor binding site by carboxamide derivatives. Comparison of different approaches to quantitative ligand-receptor interaction modeling.EBI J Med Chem 44: 1134-50 (2001) Universit£ degli Studi Magna Graecia di Catanzaro 2D 3D TSV
11311071 53 Effect of N-alkyl and N-alkenyl substituents in noroxymorphindole, 17-substituted-6,7-dehydro-4,5alpha-epoxy-3,14-dihydroxy-6,7:2',3'-indolomorphinans, on opioid receptor affinity, selectivity, and efficacy.EBI J Med Chem 44: 1471-4 (2001) National Institute of Diabetes and Digestive and Kidney Diseases 2D 3D TSV
11311069 64 (4-Piperidin-1-yl)phenyl amides: potent and selective human beta(3) agonists.EBI J Med Chem 44: 1456-66 (2001) Wyeth-Ayerst Research 2D 3D TSV
11311067 38 Discovery of novel N-phenylglycine derivatives as potent and selective beta(3)-adrenoceptor agonists for the treatment of frequent urination and urinary incontinence.EBI J Med Chem 44: 1436-45 (2001) Kissei Pharmaceutical Company Ltd. 2D 3D TSV
11311066 76 Design, synthesis, and discovery of a novel CCR1 antagonist.EBI J Med Chem 44: 1429-35 (2001) Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories 2D 3D TSV
11311064 84 N-Methyl scan of somatostatin octapeptide agonists produces interesting effects on receptor subtype specificity.EBI J Med Chem 44: 1416-21 (2001) Tulane University Health Sciences Center 2D 3D TSV
11311061 40 Azepanone-based inhibitors of human and rat cathepsin K.EBI J Med Chem 44: 1380-95 (2001) GlaxoSmithKline 2D 3D TSV
11311060 12 Development of potent truncated glucagon antagonists.EBI J Med Chem 44: 1372-9 (2001) University of Arizona 2D 3D TSV
11311057 15 Structure-based approach for the discovery of bis-benzamidines as novel inhibitors of matriptase.EBI J Med Chem 44: 1349-55 (2001) Georgetown University Medical Center 2D 3D TSV
11311055 42 Atropisomeric derivatives of 2',6'-disubstituted (R)-11-phenylaporphine: selective serotonin 5-HT(7) receptor antagonists.EBI J Med Chem 44: 1337-40 (2001) Uppsala University 2D 3D TSV
11311054 14 Indenopyrazoles as novel cyclin dependent kinase (CDK) inhibitors.BDB J Med Chem 44: 1334-6 (2001) DuPont Merck Pharmaceutical Company 2D 3D TSV
11306701 5 Modulation of multidrug resistance protein 1 (MRP1/ABCC1) transport and atpase activities by interaction with dietary flavonoids.EBI Mol Pharmacol 59: 1171-80 (2001) Queen's University 2D 3D TSV
11306677 6 BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity.BDB Mol Pharmacol 59: 965-73 (2001) UPR 9023 2D 3D TSV
11305907 3 The vnd/NK-2 homeodomain: thermodynamics of reversible unfolding and DNA binding for wild-type and with residue replacements H52R and H52R/T56W in helix III.BDB Biochemistry 40: 4923-31 (2001) National Institutes of Health 2D 3D TSV
11303071 22 Pharmacological properties of (2R)-N-[1-(6-aminopyridin-2-ylmethyl)piperidin-4-yl]-2-[(1R)-3,3-difluorocyclopentyl]-2-hydroxy-2-phenylacetamide: a novel mucarinic antagonist with M(2)-sparing antagonistic activity.BDB J Pharmacol Exp Ther 297: 790-7 (2001) Banyu Pharmaceutical Co., Ltd. 2D 3D TSV
11303063 11 Molecular and pharmacological characterization of muscarinic receptor subtypes in a rat parotid gland cell line: comparison with native parotid gland.BDB J Pharmacol Exp Ther 297: 718-26 (2001) Creighton University 2D 3D TSV
11303056 2 Pharmacological characterization of KUR-1246, a selective uterine relaxant.BDB J Pharmacol Exp Ther 297: 666-71 (2001) Kissei Pharmaceutical Co., Ltd. 2D 3D TSV
11300881 45 Enantiospecific synthesis and pharmacological evaluation of a series of super-potent, conformationally restricted 5-HT(2A/2C) receptor agonists.EBI J Med Chem 44: 1003-10 (2001) Purdue University 2D 3D TSV
11300880 168 Discovery of inhibitors of cell adhesion molecule expression in human endothelial cells. 1. Selective inhibition of ICAM-1 and E-selectin expression.EBI J Med Chem 44: 988-1002 (2001) Abbott Laboratories 2D 3D TSV
11300879 77 Factors influencing agonist potency and selectivity for the opioid delta receptor are revealed in structure-activity relationship studies of the 4-[(N-substituted-4-piperidinyl)arylamino]-N,N-diethylbenzamides.EBI J Med Chem 44: 972-87 (2001) Research Triangle Institute 2D 3D TSV
11300876 47 Structure-activity relationship studies of 4-[2-(diphenylmethoxy)ethyl]-1-benzylpiperidine derivatives and their N-analogues: evaluation of O-and N-analogues and their binding to monoamine transporters.EBI J Med Chem 44: 937-48 (2001) Wayne State University 2D 3D TSV
11300873 8 A potent, nonpeptidyl 1H-quinolone antagonist for the gonadotropin-releasing hormone receptor.EBI J Med Chem 44: 917-22 (2001) Merck Research Laboratories 2D 3D TSV
11300870 20 Pharmacophore analysis of the nuclear oxysterol receptor LXRalpha.BDB J Med Chem 44: 886-97 (2001) Dartmouth College 2D 3D TSV
11300868 37 Alpha(2) adrenoceptor agonists as potential analgesic agents. 3. Imidazolylmethylthiophenes.EBI J Med Chem 44: 863-72 (2001) The R. W. Johnson Pharmaceutical Research Institute 2D 3D TSV
11300867 32 Investigation of the selectivity of oxymorphone- and naltrexone-derived ligands via site-directed mutagenesis of opioid receptors: exploring the"address" recognition locus.EBI J Med Chem 44: 857-62 (2001) University of Minnesota 2D 3D TSV
11300866 14 A novel series of highly potent benzimidazole-based microsomal triglyceride transfer protein inhibitors.EBI J Med Chem 44: 851-6 (2001) The Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
11298663 8 Investigations into migraine pathogenesis: time course for effects of m-CPP, BW723C86 or glyceryl trinitrate on appearance of Fos-like immunoreactivity in rat trigeminal nucleus caudalis (TNC).BDB Cephalalgia 21: 46-52 (2001) Roche Bioscience 2D 3D TSV
11297453 173 Development of new carboxylic acid-based MMP inhibitors derived from functionalized propargylglycines.EBI J Med Chem 44: 1060-71 (2001) Procter and Gamble Pharmaceuticals 2D 3D TSV
11297451 21 Estimation of binding affinities for selective thrombin inhibitors via Monte Carlo simulations.EBI J Med Chem 44: 1043-50 (2001) Yale University 2D 3D TSV
11297449 3 Molecular models of N-benzyladriamycin-14-valerate (AD 198) in complex with the phorbol ester-binding C1b domain of protein kinase C-delta.EBI J Med Chem 44: 1028-34 (2001) University of Tennessee College of Medicine 2D 3D TSV
11297448 11 Substituted pyrazolopyridines as potent and selective PDE5 inhibitors: potential agents for treatment of erectile dysfunction.EBI J Med Chem 44: 1025-7 (2001) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
11297447 18 Discovery and optimization of a novel series of thrombin receptor (par-1) antagonists: potent, selective peptide mimetics based on indole and indazole templates.EBI J Med Chem 44: 1021-4 (2001) The R. W. Johnson Pharmaceutical Research Institute 2D 3D TSV
11297446 3 Covalently induced activation of the delta opioid receptor by a fluorogenic affinity label, 7'-(phthalaldehydecarboxamido)naltrindole (PNTI).EBI J Med Chem 44: 1017-20 (2001) University of Minnesota 2D 3D TSV
11294398 26 Different antagonist binding properties of human and rat histamine H3 receptors.EBI Bioorg Med Chem Lett 11: 951-4 (2001) Freie Universität Berlin 2D 3D TSV
11294396 57 Selective delta-opioid receptor ligands: potential PET ligands based on naltrindole.EBI Bioorg Med Chem Lett 11: 939-43 (2001) University of Bristol 2D 3D TSV
11294392 3 Synthesis and biological evaluation of a sialyl Lewis X mimic with significantly improved E-selectin inhibition.EBI Bioorg Med Chem Lett 11: 923-5 (2001) Novartis Pharma AG 2D 3D TSV
11294390 43 Synthesis of thiophene-2-carboxamidines containing 2-aminothiazoles and their biological evaluation as urokinase inhibitors.EBI Bioorg Med Chem Lett 11: 915-8 (2001) 3-Dimensional Pharmaceuticals, Inc. 2D 3D TSV
11294389 27 LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family.EBI Bioorg Med Chem Lett 11: 909-13 (2001) Department of Molecular Oncogenesis 2D 3D TSV
11294387 15 Acid dissociation constant, a potential physicochemical factor in the inhibition of the enzyme estrone sulfatase (ES).EBI Bioorg Med Chem Lett 11: 899-902 (2001) Kingston University 2D 3D TSV
11294386 5 The discovery of a potent, intracellular, orally bioavailable, long duration inhibitor of human neutrophil elastase--GW311616A a development candidate.EBI Bioorg Med Chem Lett 11: 895-8 (2001) GlaxoWellcome Medicines Research Centre 2D 3D TSV
11294385 21 Design and synthesis of ether analogues as potent and selective M2 muscarinic receptor antagonists.EBI Bioorg Med Chem Lett 11: 891-4 (2001) Schering-Plough Research Institute 2D 3D TSV
11294383 16 Cis- and trans-N-benzyl-octahydrobenzo[g]quinolines. Adrenergic and dopaminergic activity studies.EBI Bioorg Med Chem Lett 11: 883-6 (2001) University of Crete 2D 3D TSV
11294382 13 Synthesis and structure-activity relationships of 1-phenylpyrazoles as xanthine oxidase inhibitors.EBI Bioorg Med Chem Lett 11: 879-82 (2001) Welfide Corporation 2D 3D TSV
11294380 9 Novel sulfonate analogues of combretastatin A-4: potent antimitotic agents.EBI Bioorg Med Chem Lett 11: 871-4 (2001) Abbott Laboratories 2D 3D TSV
11294379 63 2-Arylindole-3-acetamides: FPP-competitive inhibitors of farnesyl protein transferase.EBI Bioorg Med Chem Lett 11: 865-9 (2001) Merck Research Laboratories 2D 3D TSV
11292354 48 A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site.BDB J Mol Biol 307: 1451-86 (2001) Axys Pharmaceuticals Corporation 2D 3D TSV
11278508 2 Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters.EBI J Biol Chem 276: 17221-8 (2001) Kyorin University School of Medicine 2D 3D TSV
11277743 8 Cheilanthane sesterterpenes, protein kinase inhibitors, from a marine sponge of the genus Ircinia.EBI J Nat Prod 64: 300-3 (2001) AstraZeneca R & D Griffith University 2D 3D TSV
11277536 130 7-Pyrrolidinyl- and 7-piperidinyl-5-aryl-pyrrolo[2,3-d]pyrimidines--potent inhibitors of the tyrosine kinase c-Src.EBI Bioorg Med Chem Lett 11: 853-6 (2001) Novartis Pharma Research 2D 3D TSV
11277535 80 7-Alkyl- and 7-cycloalkyl-5-aryl-pyrrolo[2,3-d]pyrimidines--potent inhibitors of the tyrosine kinase c-Src.EBI Bioorg Med Chem Lett 11: 849-52 (2001) Novartis Pharma Research 2D 3D TSV
11277534 3 N-Aminoindoline derivatives as inhibitors of 5-lipoxygenase.EBI Bioorg Med Chem Lett 11: 845-8 (2001) Université de Lille 2 2D 3D TSV
11277533 13 Novel inhibitors of the enzyme estrone sulfatase (ES).EBI Bioorg Med Chem Lett 11: 841-4 (2001) Kingston University 2D 3D TSV
11277529 14 Effects of two-carbon bridge region methoxylation of benztropine: discovery of novel chiral ligands for the dopamine transporter.EBI Bioorg Med Chem Lett 11: 823-7 (2001) Universit£ di Ferrara 2D 3D TSV
11277528 7 Spatial requirements of the antagonist binding site of the NK2 receptor.EBI Bioorg Med Chem Lett 11: 819-22 (2001) University of Leeds 2D 3D TSV
11277527 2 Synthesis and use of FSCPX, an irreversible adenosine A1 antagonist, as a 'receptor knock-down' tool.EBI Bioorg Med Chem Lett 11: 815-8 (2001) Vrije Universiteit 2D 3D TSV
11277524 14 Discovery of zoniporide: a potent and selective sodium-hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubility.EBI Bioorg Med Chem Lett 11: 803-7 (2001) Pfizer Global Research and Development 2D 3D TSV
11277522 7 A novel fluorinated tryptamine with highly potent serotonin 5-HT1A receptor agonist properties.EBI Bioorg Med Chem Lett 11: 793-5 (2001) Purdue University 2D 3D TSV
11277515 51 Phenylcyclohexene and phenylcyclohexadiene substituted compounds having retinoid antagonist activity.EBI Bioorg Med Chem Lett 11: 765-8 (2001) Allergan Inc 2D 3D TSV
11277514 23 Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity.EBI Bioorg Med Chem Lett 11: 761-4 (2001) Yale University 2D 3D TSV
11277513 25 2,4-Thiazolidinediones as potent and selective human beta3 agonists.EBI Bioorg Med Chem Lett 11: 757-60 (2001) Wyeth-Ayerst Research 2D 3D TSV
11275272 4 A robust GTP-induced shift in alpha(2)-adrenoceptor agonist affinity in tissue sections from rat brain.BDB J Neurosci Methods 105: 159-66 (2001) University of Nebraska 2D 3D TSV
11270320 11 Dynorphin A analogs containing a conformationally constrained phenylalanine derivative in position 4: reversal of preferred stereochemistry for opioid receptor affinity and discrimination of kappa vs. delta receptors.BDB Chirality 13: 125-9 (2001) University of Maryland 2D 3D TSV
11266183 32 Structure-activity relationship on the human EP3 prostanoid receptor by use of solid-support chemistry.EBI Bioorg Med Chem Lett 11: 747-9 (2001) Merck Frosst Canada & Co. 2D 3D TSV
11266182 53 Synthesis of substituted imidazopyrazines as ligands for the human somatostatin receptor subtype 5.EBI Bioorg Med Chem Lett 11: 741-5 (2001) Institut Henri Beaufour 2D 3D TSV
11266181 3 Structure-activity analysis of truncated orexin-A analogues at the orexin-1 receptor.EBI Bioorg Med Chem Lett 11: 737-40 (2001) SmithKline Beecham Pharmaceuticals 2D 3D TSV
11266180 74 The design of phenylglycine containing benzamidine carboxamides as potent and selective inhibitors of factor Xa.EBI Bioorg Med Chem Lett 11: 733-6 (2001) Prosthetics Molecular Design 2D 3D TSV
11266178 39 The amide hydrogen of (-)-indolactam-V and benzolactam-V8's plays a critical role in protein kinase C binding and tumor-promoting activities.EBI Bioorg Med Chem Lett 11: 723-8 (2001) Kyoto University 2D 3D TSV
11266177 26 The C4 hydroxyl group of phorbol esters is not necessary for protein kinase C binding.EBI Bioorg Med Chem Lett 11: 719-22 (2001) Kyoto University 2D 3D TSV
11266176 5 Potent synthetic inhibitors of tyrosyl tRNA synthetase derived from C-pyranosyl analogues of SB-219383.EBI Bioorg Med Chem Lett 11: 715-8 (2001) GlaxoSmithKline 2D 3D TSV
11266175 4 Synthetic analogues of SB-219383. Novel C-glycosyl peptides as inhibitors of tyrosyl tRNA synthetase.EBI Bioorg Med Chem Lett 11: 711-4 (2001) GlaxoSmithKline 2D 3D TSV
11266174 51 Design of non-peptide CCK2 and NK1 peptidomimetics using 1-(2-nitrophenyl)thiosemicarbazide as a novel common scaffold.EBI Bioorg Med Chem Lett 11: 705-9 (2001) Novartis Institute for Medical Sciences 2D 3D TSV
11266173 1 The identification of a potent, water soluble inhibitor of lipoprotein-associated phospholipase A2.EBI Bioorg Med Chem Lett 11: 701-4 (2001) GlaxoSmithKline Pharmaceuticals 2D 3D TSV
11266171 4 RPR203494 a pyrimidine analogue of the p38 inhibitor RPR200765A with an improved in vitro potency.EBI Bioorg Med Chem Lett 11: 693-6 (2001) Aventis Pharma 2D 3D TSV
11266169 27 Design and synthesis of novel 2,3-dihydro-1H-isoindoles with high affinity and selectivity for the dopamine D3 receptor.EBI Bioorg Med Chem Lett 11: 685-8 (2001) SmithKline Beecham Pharmaceuticals 2D 3D TSV
11266168 14 Gamma-lactone-Functionalized antitumoral acetogenins are the most potent inhibitors of mitochondrial complex I.EBI Bioorg Med Chem Lett 11: 681-4 (2001) Universidad de Valencia 2D 3D TSV
11266166 36 Sialidase inhibitors related to zanamivir. Further SAR studies of 4-amino-4H-pyran-2-carboxylic acid-6-propylamides.EBI Bioorg Med Chem Lett 11: 669-73 (2001) Glaxo Wellcome Medicines Research Centre 2D 3D TSV
11266164 3 Synthesis, modelling and NK1 antagonist evaluation of a non-rigid cyclopropane-containing analogue of CP-99,994.EBI Bioorg Med Chem Lett 11: 659-61 (2001) Laboratoire de Chimie Thérapeutique associé au CNRS et à l'Université René Descartes (UMR 8638) 2D 3D TSV
11266163 26 Influence of chain length and N-alkylation on the selective serotonin receptor ligand 9-(aminomethyl)-9,10-dihydroanthracene.EBI Bioorg Med Chem Lett 11: 655-8 (2001) Virginia Commonwealth University 2D 3D TSV
11266161 6 Importance of the C28-C38 hydrophobic domain of okadaic acid for potent inhibition of protein serine-threonine phosphatases 1 and 2A.EBI Bioorg Med Chem Lett 11: 647-9 (2001) University of Minnesota 2D 3D TSV
11266160 57 Synthesis and SAR of benzamidine factor Xa inhibitors containing a vicinally-substituted heterocyclic core.EBI Bioorg Med Chem Lett 11: 641-5 (2001) DuPont Pharmaceuticals Company 2D 3D TSV
11266159 63 3-Anilino-4-arylmaleimides: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3).BDB Bioorg Med Chem Lett 11: 635-9 (2001) SmithKline Beecham Pharmaceuticals 2D 3D TSV
11266158 29 Synthesis and structure-activity relationships of 5-substituted pyridine analogues of 3.EBI Bioorg Med Chem Lett 11: 631-3 (2001) Abbott Laboratories 2D 3D TSV
11266157 12 Chemoenzymatic synthesis of functionalized cyclohexylglycines and alpha-methylcyclohexylglycines via Kazmaier-Claisen rearrangement.EBI Bioorg Med Chem Lett 11: 627-9 (2001) University of Florida 2D 3D TSV
11266156 42 8-Carboxamidocyclazocine analogues: redefining the structure-activity relationships of 2,6-methano-3-benzazocines.EBI Bioorg Med Chem Lett 11: 623-6 (2001) Rensselaer Polytechnic Institute 2D 3D TSV
11266155 7 Synthesis and biological activities of potential metabolites of the non-nucleoside reverse transcriptase inhibitor efavirenz.EBI Bioorg Med Chem Lett 11: 619-22 (2001) DuPont Pharmaceuticals Company 2D 3D TSV
11266153 32 Syntheses and evaluation of pyrido[2,3-dlpyrimidine-2,4-diones as PDE 4 inhibitors.EBI Bioorg Med Chem Lett 11: 611-4 (2001) Korea Institute of Science and Technology 2D 3D TSV
11262093 36 Syntheses and biological activities of a novel group of steroidal derived inhibitors for human Cdc25A protein phosphatase.EBI J Med Chem 44: 834-48 (2001) School of Chemistry and Biochemistry 2D 3D TSV
11262092 31 Synthesis and Src kinase inhibitory activity of a series of 4-phenylamino-3-quinolinecarbonitriles.BDB J Med Chem 44: 822-33 (2001) Wyeth-Ayerst Research 2D 3D TSV
11262085 92 Thiazole and thiadiazole analogues as a novel class of adenosine receptor antagonists.EBI J Med Chem 44: 749-62 (2001) Vrije Universiteit 2D 3D TSV
11262083 56 Cyclic ketone inhibitors of the cysteine protease cathepsin K.BDB J Med Chem 44: 725-36 (2001) GSK 2D 3D TSV
11262081 19 Correlation of anti-HIV activity with anion spacing in a series of cosalane analogues with extended polycarboxylate pharmacophores.EBI J Med Chem 44: 703-14 (2001) Purdue University 2D 3D TSV
11262078 19 A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase.EBI J Med Chem 44: 672-80 (2001) University of Bologna 2D 3D TSV
11262076 4 X-Ray structure of citrate bound to Src SH2 leads to a high-affinity, bone-targeted Src SH2 inhibitor.EBI J Med Chem 44: 660-3 (2001) ARIAD Pharmaceuticals, Inc. 2D 3D TSV
11262075 3 Perspectives in animal health: old targets and new opportunities.EBI J Med Chem 44: 641-59 (2001) Merck Research Laboratories 2D 3D TSV
11259544 7 Zebra finch CB1 cannabinoid receptor: pharmacology and in vivo and in vitro effects of activation.BDB J Pharmacol Exp Ther 297: 189-97 (2001) Florida State University 2D 3D TSV
11248200 4 Characterization of bile acid transport mediated by multidrug resistance associated protein 2 and bile salt export pump.EBI Biochim Biophys Acta 1511: 7-16 (2001) The University of Tokyo 2D 3D TSV
11231118 8 Inhibitory effects of CYP3A4 substrates and their metabolites on P-glycoprotein-mediated transport.EBI Eur J Pharm Sci 12: 505-13 (2001) Kanazawa University 2D 3D TSV
11229779 11 New 5-HT1A receptor agonists possessing 1,4-benzoxazepine scaffold exhibit highly potent anti-ischemic effects.EBI Bioorg Med Chem Lett 11: 595-8 (2001) Suntory Biomedical Research Limited 2D 3D TSV
11229778 14 Aminoglycoside antibiotics, neamine and its derivatives as potent inhibitors for the RNA-protein interactions derived from HIV-1 activators.EBI Bioorg Med Chem Lett 11: 591-4 (2001) Graduate School of Bioscience and Biotechnology 2D 3D TSV
11229777 5 Pyrrolidine inhibitors of human cytosolic phospholipase A2. Part 2: synthesis of potent and crystallized 4-triphenylmethylthio derivative 'pyrrophenone'.EBI Bioorg Med Chem Lett 11: 587-90 (2001) Shionogi & Co., Ltd. 2D 3D TSV
11229776 24 Development of novel telomerase inhibitors based on a bisindole unit.EBI Bioorg Med Chem Lett 11: 583-5 (2001) Kyushu University 2D 3D TSV
11229775 204 Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating dtpa tails and of their zinc complexes with powerful topical antiglaucoma properties.EBI Bioorg Med Chem Lett 11: 575-82 (2001) Universit£ degli Studi 2D 3D TSV
11229774 40 Discovery of potent and selective succinyl hydroxamate inhibitors of matrix metalloprotease-3 (stromelysin-1).EBI Bioorg Med Chem Lett 11: 571-4 (2001) Pfizer Global Research and Development 2D 3D TSV
11229773 73 Selectivity of inhibition of matrix metalloproteases MMP-3 and MMP-2 by succinyl hydroxamates and their carboxylic acid analogues is dependent on P3' group chirality.EBI Bioorg Med Chem Lett 11: 567-70 (2001) Pfizer Global Research and Development 2D 3D TSV
11229772 16 Exploring the relationship between binding modes of 9-(aminomethyl)-9,10-dihydroanthracene and cyproheptadine analogues at the 5-HT2A serotonin receptor.EBI Bioorg Med Chem Lett 11: 563-6 (2001) Virginia Commonwealth University 2D 3D TSV
11229771 38 Pimarane cyclooxygenase 2 (COX-2) inhibitor and its structure-activity relationship.EBI Bioorg Med Chem Lett 11: 559-62 (2001) Seoul National University 2D 3D TSV
11229770 28 Peptoids as endothelin receptor antagonists.EBI Bioorg Med Chem Lett 11: 555-7 (2001) Ranbaxy Laboratories Limited 2D 3D TSV
11229766 65 A series of quinoline analogues as potent inhibitors of C. albicans prolyl tRNA synthetase.EBI Bioorg Med Chem Lett 11: 541-4 (2001) Cubist Pharmaceuticals, Inc. 2D 3D TSV
11229765 16 Oxo-piperazine derivatives of N-arylpiperazinones as inhibitors of farnesyltransferase.EBI Bioorg Med Chem Lett 11: 537-40 (2001) Merck Research Laboratories 2D 3D TSV
11229763 14 Synthesis of analogues of the O-beta-D-ribofuranosyl nucleoside moiety of liposidomycins. Part 1: contribution of the amino group and the uracil moiety upon the inhibition of MraY.EBI Bioorg Med Chem Lett 11: 529-31 (2001) Aventis Pharma 2D 3D TSV
11229762 25 Anti-HIV activity of aromatic and heterocyclic thiazolyl thiourea compounds.EBI Bioorg Med Chem Lett 11: 523-8 (2001) Institute 2D 3D TSV
11229760 20 SAR studies of novel 5-substituted 2-arylindoles as nonpeptidyl GnRH receptor antagonists.EBI Bioorg Med Chem Lett 11: 515-7 (2001) Merck Research Laboratories 2D 3D TSV
11229759 40 Initial structure-activity relationship of a novel class of nonpeptidyl GnRH receptor antagonists: 2-arylindoles.EBI Bioorg Med Chem Lett 11: 509-13 (2001) Merck Research Laboratories 2D 3D TSV
11229757 5 Identification and characterization of a potential ischemia-selective N-methyl-D-aspartate (NMDA) receptor ion-channel blocker, CNS 5788.EBI Bioorg Med Chem Lett 11: 501-4 (2001) Cambridge NeuroScience, Inc. 2D 3D TSV
11229755 66 Synthesis of substituted 4(Z)-(methoxyimino)pentyl-1-piperidines as dual NK1/NK2 inhibitors.EBI Bioorg Med Chem Lett 11: 491-4 (2001) Schering-Plough Research Institute 2D 3D TSV
11229754 28 Synthesis and monoamine transporter affinity of 3beta-(4-(2-pyrrolyl)phenyl)-8-azabicycl.EBI Bioorg Med Chem Lett 11: 487-9 (2001) State University of New York 2D 3D TSV
11229749 1 Beta-D-glycosylamidines: potent, selective, and easily accessible 1-glycosidase inhibitors.EBI Bioorg Med Chem Lett 11: 467-70 (2001) Kyoto University 2D 3D TSV
11229747 10 Synthesis of sialyl Lewis(x) mimics. Modifications of the 6-position of galactose.EBI Bioorg Med Chem Lett 11: 459-62 (2001) Novartis Pharma AG 2D 3D TSV
11229746 6 First tricyclic oximino derivatives as 5-HT3 ligands.EBI Bioorg Med Chem Lett 11: 453-7 (2001) Universit£ de Caen 2D 3D TSV
11229744 7 Synthesis and biological evaluation of novel amides of polyunsaturated fatty acids with dopamine.EBI Bioorg Med Chem Lett 11: 447-9 (2001) Institute of Bioorganic Chemistry RAS 2D 3D TSV
11218067 19 5HT4(a) and 5-HT4(b) receptors have nearly identical pharmacology and are both expressed in human atrium and ventricle.BDB Naunyn Schmiedebergs Arch Pharmacol 363: 146-60 (2001) University of Oslo 2D 3D TSV
11212127 7 Non-peptidic, non-prenylic inhibitors of the prenyl protein-specific protease Rce1.EBI Bioorg Med Chem Lett 11: 425-7 (2001) Philipps-Universität Marburg 2D 3D TSV
11212124 41 Nipecotic and iso-nipecotic amides as potent and selective somatostatin subtype-2 receptor agonists.EBI Bioorg Med Chem Lett 11: 415-7 (2001) Merck Research Laboratories 2D 3D TSV
11212119 12 Synthesis and antifungal activities of novel 1,3-beta-D-glucan synthase inhibitors. Part 1.EBI Bioorg Med Chem Lett 11: 395-8 (2001) Nippon Roche Research Center 2D 3D TSV
11212115 72 Human beta3 adrenergic receptor agonists containing cyanoguanidine and nitroethylenediamine moieties.EBI Bioorg Med Chem Lett 11: 379-82 (2001) Merck Research Laboratories 2D 3D TSV
11212114 16 Synthesis and biological activity of novel potent endothelin-converting enzyme-1 inhibitors.EBI Bioorg Med Chem Lett 11: 375-8 (2001) Novartis Institute for Biomedical Research 2D 3D TSV
11212112 24 Serotonergic and dopaminergic activities of rigidified (R)-aporphine derivatives.EBI Bioorg Med Chem Lett 11: 367-70 (2001) Uppsala University 2D 3D TSV
11212110 1 Conformational study of a highly specific CXCR4 inhibitor, T140, disclosing the close proximity of its intrinsic pharmacophores associated with strong anti-HIV activity.EBI Bioorg Med Chem Lett 11: 359-62 (2001) Kyoto University 2D 3D TSV
11212109 14 The identification of alpha-ketoamides as potent inhibitors of hepatitis C virus NS3-4A proteinase.EBI Bioorg Med Chem Lett 11: 355-7 (2001) Roche Discover Welwyn 2D 3D TSV
11212103 4 The development of a potential single photon emission computed tomography (SPECT) imaging agent for the corticotropin-releasing hormone receptor type.EBI Bioorg Med Chem Lett 11: 331-3 (2001) NIDDK 2D 3D TSV
11212102 24 Enkephalin analogues with 2',6'-dimethylphenylalanine replacing phenylalanine in position 4.EBI Bioorg Med Chem Lett 11: 327-9 (2001) Tohoku Pharmaceutical University 2D 3D TSV
11212101 8 Stereospecific synthesis of (2S)-2-methyl-3-(2',6'-dimethyl-4'-hydroxyphenyl)-propionic acid (Mdp) and its incorporation into an opioid peptide.EBI Bioorg Med Chem Lett 11: 323-5 (2001) Clinical Research Institute of Montreal 2D 3D TSV
11212100 27 The 5-HT3 antagonist tropisetron (ICS 205-930) is a potent and selective alpha7 nicotinic receptor partial agonist.EBI Bioorg Med Chem Lett 11: 319-21 (2001) AstraZeneca 2D 3D TSV
11212099 107 Sulfonylated aminothiazoles as new small molecule inhibitors of protein phosphatases.EBI Bioorg Med Chem Lett 11: 313-7 (2001) University of Pittsburgh 2D 3D TSV
11212098 25 Trifluoromethyl-containing 3-alkoxymethyl- and 3-aryloxymethyl-2-pyridinones are potent inhibitors of HIV-1 non-nucleoside reverse transcriptase.EBI Bioorg Med Chem Lett 11: 309-12 (2001) DuPont Pharmaceuticals Company 2D 3D TSV
11212095 65 General synthesis of alpha-substituted 3-bisaryloxy propionic acid derivatives as specific MMP inhibitors.EBI Bioorg Med Chem Lett 11: 295-9 (2001) Institut de Recherches Servier 2D 3D TSV
11212093 21 Potent and selective bicyclic lactam inhibitors of thrombin. Part 4: transition state inhibitors.EBI Bioorg Med Chem Lett 11: 287-90 (2001) BioChem Pharma Inc. 2D 3D TSV
11212092 1 Synthesis and preliminary pharmacological evaluation of coumestans with different patterns of oxygenation.EBI Bioorg Med Chem Lett 11: 283-6 (2001) Universidade Federal do Rio de Janeiro 2D 3D TSV
11206480 6 Synthesis of 7,8-disubstituted benzolactam-V8 and its binding to protein kinase C.EBI Bioorg Med Chem Lett 11: 99-101 (2001) Institute of Organic Chemistry 2D 3D TSV
11206479 14 A disubstituted NAD+ analogue is a nanomolar inhibitor of trypanosomal glyceraldehyde-3-phosphate dehydrogenase.EBI Bioorg Med Chem Lett 11: 95-8 (2001) University of Washington 2D 3D TSV
11206478 18 Arylalkylidene rhodanine with bulky and hydrophobic functional group as selective HCV NS3 protease inhibitor.EBI Bioorg Med Chem Lett 11: 91-4 (2001) Institute of Molecular and Cell Biology 2D 3D TSV
11206474 51 Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 2: structure-activity relationships for substituted 2-Aryl-1-[N-(methyl)-N-(phenylsulfonyl)amino]-4-(piperidin-1-yl)butanes.EBI Bioorg Med Chem Lett 11: 265-70 (2001) Merck Research Laboratories 2D 3D TSV
11206473 36 Antagonists of the human CCR5 receptor as anti-HIV-1 agents. part 1: discovery and initial structure-activity relationships for 1 -amino-2-phenyl-4-(piperidin-1-yl)butanes.EBI Bioorg Med Chem Lett 11: 259-64 (2001) Merck Research Laboratories 2D 3D TSV
11206471 11 Polyamines with N-(3-phenylpropyl) substituents are effective competitive inhibitors of trypanothione reductase and trypanocidal agents.EBI Bioorg Med Chem Lett 11: 251-4 (2001) Indiana State University 2D 3D TSV
11206469 14 Intracellular inhibition of human neutrophil elastase by orally active pyrrolidine-trans-lactams.EBI Bioorg Med Chem Lett 11: 243-6 (2001) Glaxo Wellcome Medicines Research Centre 2D 3D TSV
11206468 24 Heteroaryl and cycloalkyl sulfonamide hydroxamic acid inhibitors of matrix metalloproteinases.EBI Bioorg Med Chem Lett 11: 239-42 (2001) Wyeth-Ayerst Research 2D 3D TSV
11206467 44 The discovery of anthranilic acid-based MMP inhibitors. Part 1: SAR of the 3-position.EBI Bioorg Med Chem Lett 11: 235-8 (2001) Wyeth-Ayerst Research 2D 3D TSV
11206465 13 Solid-phase optimisation of achiral amidinobenzyl indoles as potent and selective factor Xa inhibitors.EBI Bioorg Med Chem Lett 11: 227-30 (2001) Aventis Pharma 2D 3D TSV
11206464 6 Synthesis and dopaminergic properties of the two enantiomers of 3-(3,4-dimethylphenyl)-1-propylpiperidine, a potent and selective dopamine D4 receptor ligand.EBI Bioorg Med Chem Lett 11: 223-6 (2001) Universit£ di Pisa 2D 3D TSV
11206463 44 Design, synthesis, and biological evaluation of HIV/FIV protease inhibitors incorporating a conformationally constrained macrocycle with a small P3' residue.EBI Bioorg Med Chem Lett 11: 219-22 (2001) The Scripps Research Institute 2D 3D TSV
11206461 10 3,3a-Dihydropyrano[4,3,2-de]quinazolin-2(1H)-ones are potent non-nucleoside reverse transcriptase inhibitors.EBI Bioorg Med Chem Lett 11: 211-4 (2001) DuPont Pharmaceuticals Company 2D 3D TSV
11206459 29 Inhibition of hepatitis C virus NS3 protease activity by product-based peptides is dependent on helicase domain.EBI Bioorg Med Chem Lett 11: 203-6 (2001) Uppsala University 2D 3D TSV
11206458 14 Diastereoselective synthesis, activity and chiral stability of cyclic alkoxyketone inhibitors of cathepsin K.EBI Bioorg Med Chem Lett 11: 199-202 (2001) SmithKline Beecham Pharmaceuticals 2D 3D TSV
11206457 29 Solid-phase synthesis of cyclic alkoxyketones, inhibitors of the cysteine protease cathepsin K.EBI Bioorg Med Chem Lett 11: 195-8 (2001) Smith Kline Beecham Pharmaceuticals 2D 3D TSV
11206456 7 High-pressure synthesis of enantiomerically pure C-6 substituted pyrazol.EBI Bioorg Med Chem Lett 11: 191-3 (2001) AstraZeneca R&D Griffith University 2D 3D TSV
11206452 14 3-Deoxy-3-substituted-D-myo-inositol imidazolyl ether lipid phosphates and carbonate as inhibitors of the phosphatidylinositol 3-kinase pathway and cancer cell growth.EBI Bioorg Med Chem Lett 11: 173-6 (2001) Georgetown University Medical Center 2D 3D TSV
11206450 36 2,2-Dimethyl-4,5-diaryl-3(2H)furanone derivatives as selective cyclo-oxygenase-2 inhibitors.EBI Bioorg Med Chem Lett 11: 165-8 (2001) Pacific Corporation R&D Center 2D 3D TSV
11206448 21 Synthesis and P2Y receptor activity of a series of uridine dinucleoside 5'-polyphosphates.EBI Bioorg Med Chem Lett 11: 157-60 (2001) Inspire Pharmaceuticals, Inc. 2D 3D TSV
11206447 12 Design and synthesis of sialyl Lewis x mimics as E-selectin inhibitors.EBI Bioorg Med Chem Lett 11: 151-5 (2001) Wyeth Research 2D 3D TSV
11206439 51 Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 2.EBI Bioorg Med Chem Lett 11: 113-7 (2001) Merck Research Laboratories 2D 3D TSV
11206438 48 Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 1.EBI Bioorg Med Chem Lett 11: 107-11 (2001) Merck Research Laboratories 2D 3D TSV
11196150 3 Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro.BDB Cancer Res 61: 131-7 (2001) Janssen Research Foundation 2D 3D TSV
11191840 25 Cloning of a chick A3 adenosine receptor: characterization of ligand binding and receptor-effector coupling of chick A1 and A3 adenosine receptors.BDB Naunyn Schmiedebergs Arch Pharmacol 363: 81-6 (2001) University of Illinois at Chicago 2D 3D TSV
11191835 3 Apical uptake of organic cations by human intestinal Caco-2 cells: putative involvement of ASF transporters.EBI Naunyn Schmiedebergs Arch Pharmacol 363: 40-9 (2001) Universidade do Porto 2D 3D TSV
11191833 15 Characterisation and comparison of novel ligands for the nociceptin/orphanin FQ receptor.BDB Naunyn Schmiedebergs Arch Pharmacol 363: 28-33 (2001) Leicester Royal Infirmary 2D 3D TSV
11182316 22 Energetic, structural, and antimicrobial analyses of beta-lactam side chain recognition by beta-lactamases.BDB Chem Biol 8: 17-31 (2001) Northwestern University 2D 3D TSV
11179436 9 Cloning, expression, and pharmacological characterization of a novel human histamine receptor.BDB Mol Pharmacol 59: 434-41 (2001) SmithKline Beecham Pharmaceuticals 2D 3D TSV
11179435 15 Discovery of a novel member of the histamine receptor family.BDB Mol Pharmacol 59: 427-33 (2001) The Centre for Addiction and Mental Health 2D 3D TSV
11179434 31 Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow.BDB Mol Pharmacol 59: 420-6 (2001) The R. W. Johnson Pharmaceutical Research Institute 2D 3D TSV
11171942 32 Antipsychotic drugs: importance of dopamine receptors for mechanisms of therapeutic actions and side effects.BDB Pharmacol Rev 53: 119-33 (2001) University of Reading 2D 3D TSV
11170689 6 Two new stilbene dimer glucosides from grape (Vitis vinifera) cell cultures.EBI J Nat Prod 64: 136-8 (2001) University of Illinois at Chicago 2D 3D TSV
11170654 72 Structure-activity relationships at monoamine transporters and muscarinic receptors for N-substituted-3alpha-(3'-chloro-, 4'-chloro-, and 4',4''-dichloro-substituted-diphenyl)methoxytropanes.EBI J Med Chem 44: 633-40 (2001) National Institute on Drug Abuse-Intramural Research Program 2D 3D TSV
11170651 47 AMP deaminase inhibitors. 5. Design, synthesis, and SAR of a highly potent inhibitor series.EBI J Med Chem 44: 613-8 (2001) Metabasis Therapeutics Inc. 2D 3D TSV
11170650 4 Novel glucocorticoid antedrugs possessing a 17beta-(gamma-lactone) ring.EBI J Med Chem 44: 602-12 (2001) Glaxo Wellcome Research and Development 2D 3D TSV
11170646 106 Discovery of 1-[3-(aminomethyl)phenyl]-N-3-fluoro-2'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a highly potent, selective, and orally bioavailable inhibitor of blood coagulation factor Xa.EBI J Med Chem 44: 566-78 (2001) DuPont Pharmaceuticals Company 2D 3D TSV
11170645 77 2- and 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: synthesis and correlation between redox cycling activities and in vitro cytotoxicity.EBI J Med Chem 44: 548-65 (2001) UMR 8525 CNRS - Université Lille II 2D 3D TSV
11170644 18 Coumarin and chromen-4-one analogues as tautomerase inhibitors of macrophage migration inhibitory factor: discovery and X-ray crystallography.EBI J Med Chem 44: 540-7 (2001) Yamanouchi Pharmaceutical Company Ltd. 2D 3D TSV
11170643 171 Design, synthesis, and evaluation of novel A2A adenosine receptor agonists.EBI J Med Chem 44: 531-9 (2001) University of Virginia 2D 3D TSV
11170642 12 Crystal structure of human cyclin-dependent kinase 2 in complex with the adenine-derived inhibitor H717.BDB J Med Chem 44: 524-30 (2001) Lawrence Berkeley National Laboratory 2D 3D TSV
11170639 73 Current and novel approaches to the drug treatment of schizophrenia.EBI J Med Chem 44: 477-501 (2001) Merck Sharp and Dohme 2D 3D TSV
11170630 46 Nucleosides and nucleotides. 200. Reinvestigation of 5'-N-ethylcarboxamidoadenosine derivatives: structure-activity relationships for P(3) purinoceptor-like proteins.EBI J Med Chem 44: 208-14 (2001) Hokkaido University 2D 3D TSV
11170629 35 Synthesis and structure-activity relationships of a new model of arylpiperazines. Study of the 5-HT(1a)/alpha(1)-adrenergic receptor affinity by classical hansch analysis, artificial neural networks, and computational simulation of ligand recognition.EBI J Med Chem 44: 198-207 (2001) Universidad Complutense 2D 3D TSV
11170628 37 Synthesis and structure-activity relationships of a new model of arylpiperazines. 5. Study of the physicochemical influence of the pharmacophore on 5-HT(1a)/alpha(1)-adrenergic receptor affinity: synthesis of a new derivative with mixed 5-HT(1a)/d(2) antagonist properties.EBI J Med Chem 44: 186-97 (2001) Universidad Complutense 2D 3D TSV
11170626 55 2-Alkynyl-8-aryl-9-methyladenines as novel adenosine receptor antagonists: their synthesis and structure-activity relationships toward hepatic glucose production induced via agonism of the A(2B) receptor.EBI J Med Chem 44: 170-9 (2001) Eisai Company, Ltd. 2D 3D TSV
11170625 25 Synthesis and comparative molecular field analysis (CoMFA) of symmetric and nonsymmetric cyclic sulfamide HIV-1 protease inhibitors.BDB J Med Chem 44: 155-69 (2001) Uppsala University 2D 3D TSV
11170624 40 Estimation of binding affinities for HEPT and nevirapine analogues with HIV-1 reverse transcriptase via Monte Carlo simulations.EBI J Med Chem 44: 145-54 (2001) Yale University 2D 3D TSV
11164381 20 Stereochemistry and molecular pharmacology of (S)-thio-ATPA, a new potent and selective GluR5 agonist.BDB Eur J Pharmacol 411: 245-53 (2001) The Royal Danish School of Pharmacy 2D 3D TSV
11160654 10 Pharmacological properties of the potent epileptogenic amino acid dysiherbaine, a novel glutamate receptor agonist isolated from the marine sponge Dysidea herbacea.BDB J Pharmacol Exp Ther 296: 650-8 (2001) Kitasato University 2D 3D TSV
11160644 46 Etoricoxib (MK-0663): preclinical profile and comparison with other agents that selectively inhibit cyclooxygenase-2.BDB J Pharmacol Exp Ther 296: 558-66 (2001) Merck Frosst Centre for Therapeutic Research 2D 3D TSV
11160626 23 In vitro and in vivo pharmacological characterization of JTE-907, a novel selective ligand for cannabinoid CB2 receptor.BDB J Pharmacol Exp Ther 296: 420-5 (2001) Japan Tobacco Inc. 2D 3D TSV
11150177 43 Extended TIP(P) analogues as precursors for labeled delta-opioid receptor ligands.EBI J Med Chem 43: 5050-4 (2001) University of Maryland 2D 3D TSV
11150176 9 Synthesis and evaluation of isothiocyanate-containing derivatives of the delta-opioid receptor antagonist Tyr-Tic-Phe-Phe (TIPP) as potential affinity labels for delta-opioid receptors.EBI J Med Chem 43: 5044-9 (2001) University of Maryland 2D 3D TSV
11150175 17 Optimization of substituted N-3-benzylimidazoquinazolinone sulfonamides as potent and selective PDE5 inhibitors.EBI J Med Chem 43: 5037-43 (2001) Bristol-Myers Squibb Pharmaceutical Research Institute 2D 3D TSV
11150174 84 Synthesis and in vitro and in vivo activity of (-)-(1R,5R,9R)- and (+)-(1S,5S,9S)-N-alkenyl-, -N-alkynyl-, and -N-cyanoalkyl-5, 9-dimethyl-2'-hydroxy-6,7-benzomorphan homologues.EBI J Med Chem 43: 5030-6 (2001) Virginia Commonwealth University 2D 3D TSV
11150173 120 A potent, long-acting, orally active (2R)-2-[(1R)-3, 3-difluorocyclopentyl]-2-hydroxy-2-phenylacetamide: novel muscarinic M(3) receptor antagonist with high selectivity for M(3) over M(2) receptors.EBI J Med Chem 43: 5017-29 (2001) Banyu Tsukuba Research Institute in collaboration with Merck Research Laboratories 2D 3D TSV
11150172 8 Synthesis and biological activity of a novel, highly potent progesterone receptor antagonist.EBI J Med Chem 43: 5010-6 (2001) Schering AG 2D 3D TSV
11150171 2 5-Azidoimidacloprid and an acyclic analogue as candidate photoaffinity probes for mammalian and insect nicotinic acetylcholine receptors.EBI J Med Chem 43: 5003-9 (2001) University of California 2D 3D TSV
11150170 30 D-Amino acid scan of gamma-melanocyte-stimulating hormone: importance of Trp(8) on human MC3 receptor selectivity.EBI J Med Chem 43: 4998-5002 (2001) University of Arizona 2D 3D TSV
11150168 165 Slow-onset, long-duration 3-(3',4'-dichlorophenyl)-1-indanamine monoamine reuptake blockers as potential medications to treat cocaine abuse.EBI J Med Chem 43: 4981-92 (2001) Pharm-Eco Laboratories 2D 3D TSV
11150167 28 Fluorosulfonyl-substituted xanthines as selective irreversible antagonists for the A(1)-adenosine receptor.EBI J Med Chem 43: 4973-80 (2001) Deakin University 2D 3D TSV
11150166 12 A novel series of 4-piperidinopyridine and 4-piperidinopyrimidine inhibitors of 2,3-oxidosqualene cyclase-lanosterol synthase.EBI J Med Chem 43: 4964-72 (2001) AstraZeneca 2D 3D TSV
11150165 228 Development of new hydroxamate matrix metalloproteinase inhibitors derived from functionalized 4-aminoprolines.EBI J Med Chem 43: 4948-63 (2001) Procter and Gamble Pharmaceuticals 2D 3D TSV
11150162 15 Design and synthesis of new orally active nonpeptidic inhibitors of human neutrophil elastase.EBI J Med Chem 43: 4927-9 (2001) Colorado State University 2D 3D TSV
11150161 19 4-Aryl-2,4-dioxobutanoic acid inhibitors of HIV-1 integrase and viral replication in cells.EBI J Med Chem 43: 4923-6 (2001) Merck Research Laboratories 2D 3D TSV
11148027 15 Chalcone derivatives antagonize interactions between the human oncoprotein MDM2 and p53.BDB Biochemistry 40: 336-44 (2001) Max Planck Institute 2D 3D TSV
11145223 7 Inhibitory potencies of 1,4-dihydropyridine calcium antagonists to P-glycoprotein-mediated transport: comparison with the effects on CYP3A4.EBI Pharm Res 17: 1189-97 (2000) Kanazawa University 2D 3D TSV
11141112 2 Three new arylobenzofurans from Onobrychis ebenoides and evaluation of their binding affinity for the estrogen receptor.EBI J Nat Prod 63: 1672-4 (2001) University of Athens 2D 3D TSV
11141093 20 Hexahydrochromeno[4,3-b]pyrrole derivatives as acetylcholinesterase inhibitors.EBI J Med Chem 44: 105-9 (2001) University of Bologna 2D 3D TSV
11141092 85 Novel, nonpeptidic cyanamides as potent and reversible inhibitors of human cathepsins K and L.EBI J Med Chem 44: 94-104 (2001) Merck Frosst Centre for Therapeutic Research 2D 3D TSV
11141084 7 Terminally alkylated polyamine analogues as chemotherapeutic agents.EBI J Med Chem 44: 1-26 (2001) Wayne State University 2D 3D TSV
11140741 43 p38 kinase inhibitors for the treatment of arthritis and osteoporosis: thienyl, furyl, and pyrrolyl ureas.EBI Bioorg Med Chem Lett 11: 9-12 (2001) Bayer Research Center 2D 3D TSV
11140740 65 Structure-activity studies of 5-substituted pyridopyrimidines as adenosine kinase inhibitors.EBI Bioorg Med Chem Lett 11: 83-6 (2001) Abbott Laboratories 2D 3D TSV
11140738 8 B-ring substituted 5,7-dihydroxyflavonols with high-affinity binding to P-glycoprotein responsible for cell multidrug resistance.EBI Bioorg Med Chem Lett 11: 75-7 (2001) Département de Pharmacochimie Moléculaire UMR-CNRS 5063 2D 3D TSV
11140734 8 Inhibition of RANTES/CCR1-mediated chemotaxis by cosalane and related compounds.EBI Bioorg Med Chem Lett 11: 59-62 (2001) National Cancer Istitute-Frederick Cancer Research and Development Center 2D 3D TSV
11140733 92 Phenyl benzenesulfonamides are novel and selective 5-HT6 antagonists: identification of N-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide (SB-357134).EBI Bioorg Med Chem Lett 11: 55-8 (2001) SmithKline Beecham Pharmaceuticals 2D 3D TSV
11140732 10 Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers.EBI Bioorg Med Chem Lett 11: 51-4 (2001) The University of Manchester 2D 3D TSV
11140727 31 Phthalazine PDE4 inhibitors. Part 2: the synthesis and biological evaluation of 6-methoxy-1,4-disubstituted derivatives.EBI Bioorg Med Chem Lett 11: 33-7 (2001) Zambon Group 2D 3D TSV
11140724 53 Allosteric inhibition of fructose-1,6-bisphosphatase by anilinoquinazolines.EBI Bioorg Med Chem Lett 11: 17-21 (2001) Pfizer Central Research 2D 3D TSV
11140722 24 Imide and lactam derivatives of N-benzylpyroglutamyl-L-phenylalanine as VCAM/VLA-4 antagonists.EBI Bioorg Med Chem Lett 11: 1-4 (2001) Hoffmann-La Roche Inc. 2D 3D TSV
11133101 29 Synthesis and structure-activity relationships of 3-cyano-4-(phenoxyanilino)quinolines as MEK (MAPKK) inhibitors.EBI Bioorg Med Chem Lett 10: 2825-8 (2000) Wyeth-Ayerst Research 2D 3D TSV
11133099 43 Synthesis and activity of selective MMP inhibitors with an aryl backbone.EBI Bioorg Med Chem Lett 10: 2815-7 (2000) Pharmacia 2D 3D TSV
11133092 2 A novel pyridazinone derivative as a nonprostanoid PGI2 agonist.EBI Bioorg Med Chem Lett 10: 2787-90 (2000) Fujisawa Pharmaceutical Co., Ltd 2D 3D TSV
11133090 2 Evaluation of new L-thiocitrulline derivatives as inhibitors of nitric oxide synthase.EBI Bioorg Med Chem Lett 10: 2779-81 (2000) Wake Forest University 2D 3D TSV
11133089 28 Noncovalent thrombin inhibitors incorporating an imidazolylethynyl P1.EBI Bioorg Med Chem Lett 10: 2775-8 (2000) LG Chemical Ltd 2D 3D TSV
11133088 46 1H-pyrazole-1-carboxamidines: new inhibitors of nitric oxide synthase.EBI Bioorg Med Chem Lett 10: 2771-4 (2000) Northwestern University 2D 3D TSV
11133084 14 Synthesis and binding activity of endomorphin-1 analogues containing beta-amino acids.EBI Bioorg Med Chem Lett 10: 2755-8 (2000) Universit£ di Bologna 2D 3D TSV
11133082 32 Assessment of substitution in the second pharmacophore of Dmt-Tic analogues.EBI Bioorg Med Chem Lett 10: 2745-8 (2000) University of Naples 2D 3D TSV
11133081 33 A convenient procedure for the synthesis of nonsymmetrical bivalent selective serotonin reuptake inhibitors using polymer-supported reagents.EBI Bioorg Med Chem Lett 10: 2741-3 (2000) Georgetown University Medical Center 2D 3D TSV
11133079 10 Optimization of a somatostatin mimetic via constrained amino acid and backbone incorporation.EBI Bioorg Med Chem Lett 10: 2731-3 (2000) University of California 2D 3D TSV
11133078 20 Benzylidene ketal derivatives as M2 muscarinic receptor antagonists.EBI Bioorg Med Chem Lett 10: 2727-30 (2000) Schering-Plough Research Institute 2D 3D TSV
11133073 12 Determination of the relative and absolute stereochemistry of a potent and alpha1A-selective adrenoceptor antagonist.EBI Bioorg Med Chem Lett 10: 2705-7 (2000) Synaptic Pharmaceutical Corporation 2D 3D TSV
11133072 11 3-(4-Piperidinyl)- and 3-(8-aza-bicyclo[3.2.1]oct-3-yl)-2-phenyl-1H-indoles as bioavailable h5-HT2A antagonists.EBI Bioorg Med Chem Lett 10: 2701-3 (2000) Merck Sharp & Dohme Research Laboratories 2D 3D TSV
11133071 60 2-Aryl tryptamines: selective high-affinity antagonists for the h5-HT2A receptor.EBI Bioorg Med Chem Lett 10: 2697-9 (2000) Merck Sharp & Dohme Research Laboratories 2D 3D TSV
11133070 4 Solid-phase synthesis of 2,3-disubstituted indoles: discovery of a novel, high-affinity, selective h5-HT2A antagonist.EBI Bioorg Med Chem Lett 10: 2693-6 (2000) Merck Sharp & Dohme Research Laboratories 2D 3D TSV
11132243 125 Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds.BDB Life Sci 68: 29-39 (2000) Mayo Foundation for Medical Education and Research and Mayo Clinic 2D 3D TSV
11128651 18 Synthesis, characterization, and activity of metabolites derived from the cyclooxygenase-2 inhibitor rofecoxib (MK-0966, Vioxx).EBI Bioorg Med Chem Lett 10: 2683-6 (2000) Merck Frosst Centre for Therapeutic Research 2D 3D TSV
11128646 69 Synthesis and biological evaluation of 2,5-dihydropyrazol.EBI Bioorg Med Chem Lett 10: 2661-4 (2000) Rhône-Poulenc Rorer 2D 3D TSV
11128645 16 Synthesis and characterization of a potent and selective protein tyrosine phosphatase inhibitor, 2.EBI Bioorg Med Chem Lett 10: 2657-60 (2000) Taisho Pharmaceutical Co., Ltd 2D 3D TSV
11128643 4 (S)-Thiirancarboxylic acid as a reactive building block for a new class of cysteine protease inhibitors.EBI Bioorg Med Chem Lett 10: 2647-51 (2000) University of Würzburg 2D 3D TSV
11128642 5 Serotonin transporter inhibitors: synthesis and binding potency of 2'-methyl- and 3'-methyl-6-nitroquipazine.EBI Bioorg Med Chem Lett 10: 2643-6 (2000) Central Washington University 2D 3D TSV
11128640 22 Pharmacophore identification of a specific CXCR4 inhibitor, T140, leads to development of effective anti-HIV agents with very high selectivity indexes.EBI Bioorg Med Chem Lett 10: 2633-7 (2000) Kyoto University 2D 3D TSV
11128638 7 6-Hydroxy-1,3-dioxin-4-ones as non-peptidic HIV protease inhibitors.EBI Bioorg Med Chem Lett 10: 2625-7 (2000) Institute of Science & Technology 2D 3D TSV
11124001 5 Synthesis of apicidin-derived quinolone derivatives: parasite-selective histone deacetylase inhibitors and antiproliferative agents.EBI J Med Chem 43: 4919-22 (2000) Merck Research Laboratories 2D 3D TSV
11123999 42 Synthesis, SARs, and pharmacological characterization of 2-amino-3 or 6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as potent, selective, and orally active group II metabotropic glutamate receptor agonists.EBI J Med Chem 43: 4893-909 (2000) Taisho Pharmaceutical Co., Ltd. 2D 3D TSV
11123998 141 Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects.EBI J Med Chem 43: 4884-92 (2000) Universit£ degli Studi di Firenze 2D 3D TSV
11123996 21 Design, synthesis, and monoamine transporter binding site affinities of methoxy derivatives of indatraline.EBI J Med Chem 43: 4868-76 (2000) National Institute of Diabetes and Digestive and Kidney Diseases 2D 3D TSV
11123994 72 Synthesis and transporter binding properties of bridged piperazine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909).EBI J Med Chem 43: 4840-9 (2000) National Institute of Diabetes and Digestive and Kidney Diseases 2D 3D TSV
11123988 23 Semisynthesis of antitumoral acetogenins: SAR of functionalized alkyl-chain bis-tetrahydrofuranic acetogenins, specific inhibitors of mitochondrial complex I.EBI J Med Chem 43: 4793-800 (2000) Universidad de Valencia 2D 3D TSV
11123986 5 Design of adenosine kinase inhibitors from the NMR-based screening of fragments.EBI J Med Chem 43: 4781-6 (2000) Abbott Laboratories 2D 3D TSV
11123985 176 Pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists: influence of the chain at the N(8) pyrazole nitrogen.EBI J Med Chem 43: 4768-80 (2000) Università degli Studi di Ferrara 2D 3D TSV
11123983 112 Inhibition of monoamine oxidases by functionalized coumarin derivatives: biological activities, QSARs, and 3D-QSARs.EBI J Med Chem 43: 4747-58 (2000) Universit£ de Lausanne 2D 3D TSV
11121615 32 Synthesis and in vitro opioid activity profiles of DALDA analogues.BDB Eur J Med Chem 35: 895-901 (2000) Clinical Research Institute of Montreal 2D 3D TSV
11114395 7 Pharmacological profiles of the metabotropic glutamate receptor ligands.BDB Neuropharmacology 40: 170-7 (2001) University of Toronto 2D 3D TSV
11112523 7 Estimation of the hydrophobic effect in an antigen-antibody protein-protein interface.BDB Biochemistry 39: 15375-87 (2000) University of Maryland Biotechnology Institute 2D 3D TSV
11111828 16 Agonists and antagonists acting at P2X receptors: selectivity profiles and functional implications.BDB Naunyn Schmiedebergs Arch Pharmacol 362: 340-50 (2000) Biocentre Niederursel 2D 3D TSV
11104741 44 Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications.BDB Circulation 102: 2836-41 (2000) NIH 2D 3D TSV
11101361 37 Effect of ring fluorination on the pharmacology of hallucinogenic tryptamines.EBI J Med Chem 43: 4701-10 (2001) Purdue University 2D 3D TSV
11101360 14 Adenosine deaminase inhibitors: synthesis and biological evaluation of unsaturated, aromatic, and oxo derivatives of (+)-erythro-9-(2'S-hydroxy-3'R-nonyl)adenine [(+)-EHNA].EBI J Med Chem 43: 4694-700 (2001) University of Rhode Island 2D 3D TSV
11101359 9 Conformationally constrained butyrophenones with affinity for dopamine (D(1), D(2), D(4)) and serotonin (5-HT(2A), 5-HT(2B), 5-HT(2C)) receptors: synthesis of aminomethylbenzo[b]furanones and their evaluation as antipsychotics.EBI J Med Chem 43: 4678-93 (2001) Universidad de Santiago 2D 3D TSV
11101358 24 4-Aminoquinolines: novel nociceptin antagonists with analgesic activity.EBI J Med Chem 43: 4667-77 (2001) Central Pharmaceutical Research Institute 2D 3D TSV
11101357 84 New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease.EBI J Med Chem 43: 4657-66 (2001) Universitat de Barcelona 2D 3D TSV
11101356 23 5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity.EBI J Med Chem 43: 4647-56 (2001) Polish Academy of Sciences 2D 3D TSV
11101355 26 7-Deazaadenines bearing polar substituents: structure-activity relationships of new A(1) and A(3) adenosine receptor antagonists.EBI J Med Chem 43: 4636-46 (2001) University of Leipzig 2D 3D TSV
11101354 18 Chiral derivatives of 2-cyclohexylideneperhydro-4,7-methanoindenes, a novel class of nonsteroidal androgen receptor ligand: synthesis, X-ray analysis, and biological activity.EBI J Med Chem 43: 4629-35 (2001) The University of Sydney 2D 3D TSV
11101352 88 Pyrido[2,3-d]pyrimidin-7-one inhibitors of cyclin-dependent kinases.BDB J Med Chem 43: 4606-16 (2000) Parke-Davis Pharmaceutical Research 2D 3D TSV
11101350 72 1,3-Diaryl-4,5,6,7-tetrahydro-2H-isoindole derivatives: a new series of potent and selective COX-2 inhibitors in which a sulfonyl group is not a structural requisite.EBI J Med Chem 43: 4582-93 (2001) Institut de Recherche Servier 2D 3D TSV
11101348 22 Discovery of chiral N,N-disubstituted trifluoro-3-amino-2-propanols as potent inhibitors of cholesteryl ester transfer protein.EBI J Med Chem 43: 4575-8 (2001) Pharmacia Discovery Research 2D 3D TSV
11099697 4 Interaction between methotrexate and nonsteroidal anti-inflammatory drugs in organic anion transporter.EBI Eur J Pharmacol 409: 31-6 (2001) Kyoto University Hospital 2D 3D TSV
11095748 54 SST3-selective potent peptidic somatostatin receptor antagonists.BDB Proc Natl Acad Sci U S A 97: 13973-8 (2000) University of Berne 2D 3D TSV
11093801 7 Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist.BDB Mol Pharmacol 58: 1601-8 (2000) University of California at Irvine 2D 3D TSV
11093791 20 Synthetic modification of prostaglandin f(2alpha) indicates different structural determinants for binding to the prostaglandin F receptor versus the prostaglandin transporter.BDB Mol Pharmacol 58: 1511-6 (2000) Albert Einstein College of Medicine 2D 3D TSV
11093776 5 Correlation of the apparent affinities and efficacies of gamma-aminobutyric acid(C) receptor agonists.BDB Mol Pharmacol 58: 1375-80 (2000) University of Alabama at Birmingham 2D 3D TSV
11093768 5 Characterization of the binding site for a novel class of noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonists.BDB Mol Pharmacol 58: 1310-7 (2000) Pfizer Inc. 2D 3D TSV
11090628 5 Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine.BDB Mol Cell 6: 909-19 (2000) MRC 2D 3D TSV
11087581 72 Cyanoindole derivatives as highly selective dopamine D(4) receptor partial agonists: solid-phase synthesis, binding assays, and functional experiments.EBI J Med Chem 43: 4563-9 (2000) Friedrich-Alexander University 2D 3D TSV
11087579 465 Carbonic anhydrase inhibitors: perfluoroalkyl/aryl-substituted derivatives of aromatic/heterocyclic sulfonamides as topical intraocular pressure-lowering agents with prolonged duration of action.EBI J Med Chem 43: 4542-51 (2000) Universit£ degli Studi di Firenze 2D 3D TSV
11087576 33 Syntheses of 4'-C-ethynyl-beta-D-arabino- and 4'-C-ethynyl-2'-deoxy-beta-D-ribo-pentofuranosylpyrimidines and -purines and evaluation of their anti-HIV activity.EBI J Med Chem 43: 4516-25 (2000) Tohoku University 2D 3D TSV
11087571 35 Structure-activity relationships of 17alpha-derivatives of estradiol as inhibitors of steroid sulfatase.EBI J Med Chem 43: 4465-78 (2000) Laval University Medical Center (CHUL) 2D 3D TSV
11087570 14 Design and synthesis of pyrrolidine-5,5-trans-lactams (5-oxo-hexahydro-pyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 1. The alpha-methyl-trans-lactam template.EBI J Med Chem 43: 4452-64 (2000) Glaxo Wellcome Research and Development 2D 3D TSV
11087569 37 Computational studies on HIV-1 protease inhibitors: influence of calculated inhibitor-enzyme binding affinities on the statistical quality of 3D-QSAR CoMFA models.EBI J Med Chem 43: 4446-51 (2000) University of Missouri-St. Louis 2D 3D TSV
11087568 55 Synthesis and evaluation of 17-aliphatic heterocycle-substituted steroidal inhibitors of 17alpha-hydroxylase/C17-20-lyase (P450 17).EBI J Med Chem 43: 4437-45 (2000) University of the Saarland 2D 3D TSV
11087567 6 Chiral resolution, pharmacological characterization, and receptor docking of the noncompetitive mGlu1 receptor antagonist (+/-)-2-hydroxyimino- 1a, 2-dihydro-1H-7-oxacyclopropa[b]naphthalene-7a-carboxylic acid ethyl ester.EBI J Med Chem 43: 4428-36 (2000) Novartis Pharma AG 2D 3D TSV
11087566 69 Multiple-conformation and protonation-state representation in 4D-QSAR: the neurokinin-1 receptor system.EBI J Med Chem 43: 4416-27 (2000) Biographics Laboratory 3R 2D 3D TSV
11087565 86 Design, synthesis, and biological evaluation of potent and selective amidino bicyclic factor Xa inhibitors.EBI J Med Chem 43: 4398-415 (2000) DuPont Pharmaceuticals Company 2D 3D TSV
11087564 30 Novel design of nonpeptide AVP V(2) receptor agonists: structural requirements for an agonist having 1-(4-aminobenzoyl)-2,3,4, 5-tetrahydro-1H-1-benzazepine as a template.EBI J Med Chem 43: 4388-97 (2000) Otsuka Pharmaceutical Company 2D 3D TSV
11087562 27 Structure-function studies on the new growth hormone-releasing peptide, ghrelin: minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a.EBI J Med Chem 43: 4370-6 (2000) Merck Research Laboratories 2D 3D TSV
11087559 7 Design, radiosynthesis, and biodistribution of a new potent and selective ligand for in vivo imaging of the adenosine A(2A) receptor system using positron emission tomography.EBI J Med Chem 43: 4359-62 (2000) University of Milano-Bicocca 2D 3D TSV
11087558 29 Biarylpropylsulfonamides as novel, potent potentiators of 2-amino-3- (5-methyl-3-hydroxyisoxazol-4-yl)- propanoic acid (AMPA) receptors.EBI J Med Chem 43: 4354-8 (2000) NPS Allelix Corporation 2D 3D TSV
11086733 56 Potent nonpeptide endothelin antagonists: synthesis and structure-activity relationships of pyrazole-5-carboxylic acids.EBI Bioorg Med Chem Lett 10: 2575-8 (2001) Hoechst Marion Roussel 2D 3D TSV
11086732 10 Synthesis of the novel analogues of dysidiolide and their structure-activity relationship.EBI Bioorg Med Chem Lett 10: 2571-4 (2001) The University of Tokyo 2D 3D TSV
11086731 16 Arylacetamides as peripherally restricted kappa opioid receptor agonists.EBI Bioorg Med Chem Lett 10: 2567-70 (2001) Adolor Corporation 2D 3D TSV
11086729 51 N-1 substituted pyrimidin-4-ones: novel, orally active inhibitors of lipoprotein-associated phospholipase A2.EBI Bioorg Med Chem Lett 10: 2557-61 (2001) SmithKline Beecham Pharmaceuticals 2D 3D TSV
11086728 30 Novel 2,3,4,5-tetrahydro-1H-3-benzazepines with high affinity and selectivity for the dopamine D3 receptor.EBI Bioorg Med Chem Lett 10: 2553-5 (2000) SmithKline Beecham Pharmaceuticals 2D 3D TSV
11086723 12 Androsterone 3beta-substituted derivatives as inhibitors of type 3 17beta-hydroxysteroid dehydrogenase.EBI Bioorg Med Chem Lett 10: 2533-6 (2001) Laval University Medical Center (CHUL) and Laval University 2D 3D TSV
11086722 12 Bisquaternary caracurine V derivatives as allosteric modulators of ligand binding to M2 acetylcholine receptors.EBI Bioorg Med Chem Lett 10: 2529-32 (2001) University of Würzburg 2D 3D TSV
11086721 10 Inhibition of vertebrate squalene epoxidase by isoprenyl gallates and phenylalkyl gallates.EBI Bioorg Med Chem Lett 10: 2525-8 (2001) University of Shizuoka 2D 3D TSV
11086718 65 Solid-phase synthesis of di- and tripeptidic hydroxamic acids as inhibitors of procollagen C-proteinase.EBI Bioorg Med Chem Lett 10: 2513-6 (2001) Roche Bioscience 2D 3D TSV
11086714 10 Synthesis and calpain inhibitory activity of alpha-ketoamides with 2,3-methanoleucine stereoisomers at the P2 position.EBI Bioorg Med Chem Lett 10: 2497-500 (2001) The University of Tennessee Health Science Center 2D 3D TSV
11082457 63 S18616, a highly potent, spiroimidazoline agonist at alpha(2)-adrenoceptors: I. Receptor profile, antinociceptive and hypothermic actions in comparison with dexmedetomidine and clonidine.BDB J Pharmacol Exp Ther 295: 1192-205 (2000) Centre de Recherches de Croissy 2D 3D TSV
11082453 77 ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholinopyridin-3-yl)pyrido[2, 3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties: I. In vitro characterization and acute antinociceptive effects in the mouse.BDB J Pharmacol Exp Ther 295: 1156-64 (2000) Abbott Laboratories 2D 3D TSV
11080213 35 Characterization of [(3)H]Quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections.BDB J Neurochem 75: 2590-601 (2000) F. Hoffmann-La Roche 2D 3D TSV
11078204 19 Inhibitors of src tyrosine kinase: the preparation and structure-activity relationship of 4-anilino-3-cyanoquinolines and 4-anilinoquinazolines.BDB Bioorg Med Chem Lett 10: 2477-80 (2000) Wyeth-Ayerst Research 2D 3D TSV
11078202 4 Synthesis, chiral chromatographic separation, and biological activities of the enantiomers of 10,10-dimethylhuperzine A.