BindingDB logo
myBDB logout

Search by PubMed Identification


PubMed Identification:

Starting with   __   _1   _2   _3   _4   _5   _6   _7   _8   _9   10   11   12   13   14   15   16   17   18   19   20   21   22   23   24   25   26   27   28

PMIDDataArticle TitleCitationOrganizationSD Files Download
6993683 8 N-(alpha-Hydroxyalkanoyl) derivatives of Leu-Val-Phe-OCH3 as inhibitors of renin.EBI J Med Chem 23: 666-9 (1980) TBA 2D 3D TSV
6991695 30 2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 4. 6-Substituted trimethoprim derivatives from phenolic Mannich intermediates. Application to the synthesis of trimethoprim and 3,5-dialkylbenzyl analogues.EBI J Med Chem 23: 535-41 (1980) TBA 2D 3D TSV
6991693 9 2,4-Diamino-5-benzylpyrimidines and analogues as antibacterial agents. 3. C-Benzylation of aminopyridines with phenolic Mannich bases. Synthesis of 1- and 3-deaza analogues of trimethoprim.EBI J Med Chem 23: 384-91 (1980) TBA 2D 3D TSV
6991692 12 2,4-Diamino-5-benzylpyrimidines and analogues as antibacterial agents. 2. C-Alkylation of pyrimidines with Mannich bases and application to the synthesis of trimethoprim and analogues.EBI J Med Chem 23: 379-84 (1980) TBA 2D 3D TSV
6980283 7 Absolute stereochemistry and dopaminergic activity of enantiomers of 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine.EBI J Med Chem 25: 697-703 (1982) TBA 2D 3D TSV
6965728 5 Binding specificities of adenosine aminohydrolase from calf intestinal mucosa with dialdehydes derived from hexofuranosyladenine nucleosides.EBI J Med Chem 23: 39-42 (1980) TBA 2D 3D TSV
6965727 1 Basic antiinflammatory compounds. N,N',N''-Trisubstituted guanidines.EBI J Med Chem 23: 13-20 (1980) TBA 2D 3D TSV
6876078 12 Resolution and absolute configuration of an ergoline-related dopamine agonist, trans-4,4a,5,6,7,8,8a,9-Octahydro-5-propyl-1H(or 2H)-pyrazolo[3,4-g]quinoline.EBI J Med Chem 26: 1112-6 (1983) TBA 2D 3D TSV
6864731 38 Synthesis and monoamine oxidase inhibitory activities of alpha-allenic amines in vivo and in vitro. Different activities of two enantiomeric allenes.EBI J Med Chem 26: 1036-42 (1983) TBA 2D 3D TSV
6834389 8 Preparation of 2-amino-4(3H)-oxopyrimido[5,4-b] [1,4]thiazines (5-thiapterins) and their evaluation as cofactors for phenylalanine hydroxylase.EBI J Med Chem 26: 559-63 (1983) TBA 2D 3D TSV
6834383 16 Synthesis and central dopaminergic activities of (+/-)-hexahydro-7H-indolo[3,4-gh][1,4]benzoxazine derivatives [(+/-)-9-oxaergolines].EBI J Med Chem 26: 522-7 (1983) TBA 2D 3D TSV
6827533 8 Some adenine and adenosine methylene-bridged estrogens.EBI J Med Chem 26: 162-6 (1983) TBA 2D 3D TSV
6827532 2 In vitro and in vivo protection of acetylcholinesterase against organophosphate poisoning by pretreatment with a novel derivative of 1,3,2-dioxaphosphorinane 2-oxide.EBI J Med Chem 26: 145-52 (1983) TBA 2D 3D TSV
6827528 1 Analogues of aminoglutethimide: selective inhibition of cholesterol side-chain cleavage.EBI J Med Chem 26: 50-4 (1983) TBA 2D 3D TSV
6818344 15 Spiro oxazolidinedione aldose reductase inhibitors.EBI J Med Chem 25: 1451-4 (1983) TBA 2D 3D TSV
6809942 8 Synthesis of analogues of the carboxyl protease inhibitor pepstatin. Effect of structure in subsite P3 on inhibition of pepsin.EBI J Med Chem 25: 791-5 (1982) TBA 2D 3D TSV
6809941 88 Comparison of the inhibition of Escherichia coli and Lactobacillus casei dihydrofolate reductase by 2,4-diamino-5-(substituted-benzyl)pyrimidines: quantitative structure-activity relationships, X-ray crystallography, and computer graphics in structure-activity analysis.EBI J Med Chem 25: 777-84 (1982) TBA 2D 3D TSV
6808133 26 Alkaline phosphatase inhibition by a series of pyrido[2,1-b]quinazolines: A possible relationship with cromolyn-like antiallergy activity.EBI J Med Chem 25: 742-5 (1982) TBA 2D 3D TSV
6802974 13 Antiinflammatory agents. 2. Syntheses and antiinflammatory activity of substituted 2-aminophenylacetic acid derivatives.EBI J Med Chem 25: 446-51 (1982) TBA 2D 3D TSV
6796692 1 Interaction of 5-ethynyl-2'-deoxyuridylate with thymidylate synthetase.EBI J Med Chem 24: 1537-40 (1982) TBA 2D 3D TSV
6796688 44 Comparison of the inhibition of methotrexate-sensitive and -resistant Lactobacillus casei cell cultures with purified Lactobacillus casei dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(3-substituted-phenyl)-s-triazines. Use of quantitative structure-activity relationships in makiEBI J Med Chem 24: 1422-9 (1981) TBA 2D 3D TSV
6796687 6 Inhibition of thymidylate synthetase by 5-alkynyl-2'-deoxyuridylates.EBI J Med Chem 24: 1385-8 (1982) TBA 2D 3D TSV
6793726 7 Folate analogues altered in the C9-N10 bridge region. 18. Synthesis and antitumor evaluation of 11-oxahomoaminopterin and related compounds.EBI J Med Chem 24: 1068-73 (1981) TBA 2D 3D TSV
6779009 1 Synthesis and aldose reductase inhibitory activity of 7-sulfamoylxanthone-2-carboxylic acids.EBI J Med Chem 23: 1264-7 (1981) TBA 2D 3D TSV
6772788 8 Folate analogues altered in the C9-N10 bridge region. 16. Synthesis and antifolate activity of 11-thiohomoaminopterin.EBI J Med Chem 23: 899-903 (1980) TBA 2D 3D TSV
6772786 3 Synthesis and antiinflammatory activity of some 2-(substituted-pyridinyl)benzimidazoles.EBI J Med Chem 23: 734-8 (1980) TBA 2D 3D TSV
6767030 65 Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(alkylamino)uracils.EBI J Med Chem 23: 34-8 (1980) TBA 2D 3D TSV
6767029 14 Synthesis of analogues of the carboxyl protease inhibitor pepstatin. Effects of structure on inhibition of pepsin and renin.EBI J Med Chem 23: 27-33 (1980) TBA 2D 3D TSV
6754932 12 Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogues.EBI J Med Chem 25: 1120-2 (1983) TBA 2D 3D TSV
6747997 24 cis-1,3,4,6,7,11b-Hexahydro-2-methyl-7-phenyl-2H-pyrazino[2,1-a] isoquinoline: a new atypical antidepressant.EBI J Med Chem 27: 995-1003 (1984) TBA 2D 3D TSV
6747993 69 Pyrroloisoquinoline antidepressants. Potent, enantioselective inhibition of tetrabenazine-induced ptosis and neuronal uptake of norepinephrine, dopamine, and serotonin.EBI J Med Chem 27: 943-6 (1984) TBA 2D 3D TSV
6737432 4 Methotrexate analogues. 23. Synthesis, dihydrofolate reductase affinity, cytotoxicity, and in vivo antitumor activity of some putative degradation products of methotrexate-poly(L-lysine) conjugates.EBI J Med Chem 27: 888-93 (1984) TBA 2D 3D TSV
6737423 6 Aporphines. 58. N-(2-chloroethyl) [8,9-2H]norapomorphine, an irreversible ligand for dopamine receptors: synthesis and application.EBI J Med Chem 27: 806-10 (1984) TBA 2D 3D TSV
6716399 2 Synthesis and central nervous system properties of 2-[(alkoxycarbonyl)amino]-4(5)-phenyl-2-imidazolines.EBI J Med Chem 27: 616-27 (1984) TBA 2D 3D TSV
6699873 10 Adenosine deaminase inhibitors. Synthesis of deaza analogues of erythro-9-(2-hydroxy-3-nonyl)adenine.EBI J Med Chem 27: 274-8 (1984) TBA 2D 3D TSV
6694166 5 Synthesis and characterization of N2-(p-n-butylphenyl)-2'-deoxyguanosine and its 5'-triphosphate and their inhibition of HeLa DNA polymerase alpha.EBI J Med Chem 27: 175-81 (1984) TBA 2D 3D TSV
6694162 38 Inhibition of human dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazine s. A quantitative structure-activity relationship analysis.EBI J Med Chem 27: 144-9 (1984) TBA 2D 3D TSV
6682147 9 Aporphines. 48. Enantioselectivity of (R)-(-)- and (S)-(+)-N-n-propylnorapomorphine on dopamine receptors.EBI J Med Chem 26: 516-21 (1983) TBA 2D 3D TSV
6655559 46 Comparison of dopamine receptor sites labeled by [3H]-S-sulpiride and [3H]-spiperone in striatum.BDB J Pharmacol Exp Ther 227: 592-9 (1983) University of California 2D 3D TSV
6645787 26 pH-dependent modulation of agonist interactions with [3H]-ketanserin-labelled S2 serotonin receptors.BDB Life Sci 33: 2011-6 (1983) University of Toronto 2D 3D TSV
6644749 1 S-carbobenzoxyglutathione: a competitive inhibitor of mammalian glyoxalase II.EBI J Med Chem 26: 1784-5 (1984) TBA 2D 3D TSV
6631913 10 alpha-(Fluoromethyl)dehydroornithine and alpha-(fluoromethyl)dehydroputrescine analogues as irreversible inhibitors of ornithine decarboxylase.EBI J Med Chem 26: 1551-6 (1983) TBA 2D 3D TSV
6620311 9 Optical resolution, absolute configuration, and activity of the enantiomers of proxyphylline.EBI J Med Chem 26: 1514-8 (1983) TBA 2D 3D TSV
6620306 4 Multisubstrate adducts as potential inhibitors of S-adenosylmethionine dependent methylases: inhibition of indole N-methyltransferase by (5'-deoxyadenosyl)[3-(3-indolyl)prop-1-yl]methylsulfonium and (5'-deoxyadenosyl)[4-(3-indolyl)but-1-yl]methylsulfonium salts.EBI J Med Chem 26: 1470-7 (1983) TBA 2D 3D TSV
6606707 15 Structure-activity relationship study of the inhibition of adrenal cortical 11 beta-hydroxylase by new metyrapone analogues.EBI J Med Chem 27: 15-9 (1984) TBA 2D 3D TSV
6604819 5 Adenosine deaminase inhibitors. Synthesis and biological evaluation of (+/-)-3,6,7,8-tetrahydro-3-[(2-hydroxyethoxy)methyl]imidazo[4,5-d] [1,3]diazepin-8-ol and some selected C-5 homologues of pentostatin.EBI J Med Chem 26: 1478-82 (1983) TBA 2D 3D TSV
6600791 32 Synthesis and pharmacological studies of 4,4-disubstituted piperidines: a new class of compounds with potent analgesic properties.EBI J Med Chem 26: 42-50 (1983) TBA 2D 3D TSV
6585550 9 Methotrexate analogues. 21. Divergent influence of alkyl chain length on the dihydrofolate reductase affinity and cytotoxicity of methotrexate monoesters.EBI J Med Chem 27: 605-9 (1984) TBA 2D 3D TSV
6581313 2 Synthesis and evaluation of a novel series of N,N-dimethylisotryptamines.EBI J Med Chem 27: 41-5 (1984) TBA 2D 3D TSV
6547745 4 Isomeric N-methyl-7-deazaguanines: synthesis, structural assignment, and inhibitory activity on xanthine oxidase.EBI J Med Chem 27: 981-5 (1984) TBA 2D 3D TSV
6547487 3 Vinylogous amino acid esters: a new class of inactivators for thiol proteases.EBI J Med Chem 27: 711-2 (1984) TBA 2D 3D TSV
6546949 4 Methotrexate analogues. 19. Replacement of the glutamate side chain in classical antifolates by L-homocysteic acid and L-cysteic acid: effect on enzyme inhibition and antitumor activity.EBI J Med Chem 27: 600-4 (1984) TBA 2D 3D TSV
6502602 9 A potent multisubstrate analogue inhibitor of human thymidylate synthetase.EBI J Med Chem 27: 1710-7 (1985) TBA 2D 3D TSV
6502598 1 Bulky amine analogues of ketoprofen: potent antiinflammatory agents.EBI J Med Chem 27: 1682-90 (1984) TBA 2D 3D TSV
6492080 195 Nontricyclic antidepressant agents derived from cis- and trans-1-amino-4-aryltetralins.EBI J Med Chem 27: 1508-15 (1984) TBA 2D 3D TSV
6492073 1 Structure-activity relationships for reactivators of organophosphorus-inhibited acetylcholinesterase: quaternary salts of 2-[(hydroxyimino)methyl]imidazole.EBI J Med Chem 27: 1431-8 (1984) TBA 2D 3D TSV
6481772 1 Carbocyclic analogues of xylofuranosylpurine nucleosides. Synthesis and antitumor activity.EBI J Med Chem 27: 1358-60 (1984) TBA 2D 3D TSV
6481768 7 Antiinflammatory activity of N-(2-benzoylphenyl)alanine derivatives.EBI J Med Chem 27: 1317-21 (1984) TBA 2D 3D TSV
6481761 17 N-allyl analogues of phencyclidine: chemical synthesis and pharmacological properties.EBI J Med Chem 27: 1267-71 (1984) TBA 2D 3D TSV
6471073 1 Nonquaternary cholinesterase reactivators. 2. Alpha-heteroaromatic aldoximes and thiohydroximates as reactivators of ethyl methylphosphonyl-acetylcholinesterase in vitro.EBI J Med Chem 27: 1201-11 (1984) TBA 2D 3D TSV
6471068 7 Steroids. 2. Synthesis of C-18 functionalized steroids via the Smith-Hughes route.EBI J Med Chem 27: 1131-7 (1984) TBA 2D 3D TSV
6471063 10 Cardiotonic agents. 1. 4,5-Dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3 (2H)-pyridazinones: novel positive inotropic agents for the treatment of congestive heart failure.EBI J Med Chem 27: 1099-101 (1984) TBA 2D 3D TSV
6458703 72 Synthesis of pyridylallylamines related to zimelidine and their inhibition of neuronal monoamine uptake.EBI J Med Chem 24: 1499-507 (1982) TBA 2D 3D TSV
6438320 10 A 1H NMR study of the interactions and conformations of rationally designed brodimoprim analogues in complexes with Lactobacillus casei dihydrofolate reductase.EBI J Med Chem 27: 1672-6 (1985) TBA 2D 3D TSV
6436487 49 Antiinflammatory agents. 3. Synthesis and pharmacological evaluation of 2-amino-3-benzoylphenylacetic acid and analogues.EBI J Med Chem 27: 1379-88 (1984) TBA 2D 3D TSV
6434741 2 Interaction of N4-hydroxy-2'-deoxycytidylic acid with thymidylate synthetase.EBI J Med Chem 27: 1259-62 (1984) TBA 2D 3D TSV
6429331 22 Inhibition of arabinose 5-phosphate isomerase. An approach to the inhibition of bacterial lipopolysaccharide biosynthesis.EBI J Med Chem 27: 717-26 (1984) TBA 2D 3D TSV
6422042 3 N-[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]- N-methylglycine (Tolrestat), a potent, orally active aldose reductase inhibitor.EBI J Med Chem 27: 255-6 (1984) TBA 2D 3D TSV
6420570 74 Quantitative structure-activity relationships of 6-anilinouracils as inhibitors of Bacillus subtilis DNA polymerase III.EBI J Med Chem 27: 181-5 (1984) TBA 2D 3D TSV
6420569 189 Crystallography, quantitative structure-activity relationships, and molecular graphics in a comparative analysis of the inhibition of dihydrofolate reductase from chicken liver and Lactobacillus casei by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazine s.EBI J Med Chem 27: 129-43 (1984) TBA 2D 3D TSV
6408258 4 5-p-benzoquinonyl-2'-deoxyuridine 5'-phosphate: a possible mechanism-based inhibitor of thymidylate synthetase.EBI J Med Chem 26: 1028-36 (1983) TBA 2D 3D TSV
6406670 17 Synthesis of analogues of pepstatin. Effect of structure in subsites P1', P2', and P2 on inhibition of porcine pepsin.EBI J Med Chem 26: 904-10 (1983) TBA 2D 3D TSV
6403710 6 Folate analogues. 21. Synthesis and antifolate and antitumor activities of N10-(cyanomethyl)-5,8-dideazafolic acid.EBI J Med Chem 26: 605-7 (1983) TBA 2D 3D TSV
6387355 50 Characterization of the binding of 3H-SCH 23390, a selective D-1 receptor antagonist ligand, in rat striatum.BDB Life Sci 35: 1885-93 (1984) Schering-Plough Corporation 2D 3D TSV
6384520 9 Inhibition of renin by substrate analogue inhibitors containing the olefinic amino acid 5(S)-amino-7-methyl-3(E)-octenoic acid.EBI J Med Chem 27: 1351-4 (1984) TBA 2D 3D TSV
6352942 10 Inhibition of renin by angiotensinogen peptide fragments containing the hydroxy amino acid residue 5-amino-3-hydroxy-7-methyloctanoic acid.EBI J Med Chem 26: 1457-62 (1983) TBA 2D 3D TSV
6348285 15 Inhibitors of glycolic acid oxidase. 4-substituted 2,4-dioxobutanoic acid derivatives.EBI J Med Chem 26: 1196-200 (1983) TBA 2D 3D TSV
6343601 36 Inhibition by carboxamides and sulfoxides of liver alcohol dehydrogenase and ethanol metabolism.EBI J Med Chem 26: 916-22 (1983) TBA 2D 3D TSV
6330361 6 Development of an affinity ligand for purification of alpha 2-adrenoceptors from human platelet membranes.EBI J Med Chem 27: 918-21 (1984) TBA 2D 3D TSV
6330358 6 The 3,4-catechol derivative of propranolol, a minor dihydroxylated metabolite.EBI J Med Chem 27: 857-61 (1984) TBA 2D 3D TSV
6330355 9 Bicyclic lactam inhibitors of angiotensin converting enzyme.EBI J Med Chem 27: 816-8 (1984) TBA 2D 3D TSV
6325601 52 Cholecystokinin receptors: biochemical demonstration and autoradiographical localization in rat brain and pancreas using [3H] cholecystokinin8 as radioligand.BDB J Neurosci 4: 1021-33 (1984) F. Hoffmann-La Roche & Co., Ltd. 2D 3D TSV
6319699 5 Replacement of the peptide-backbone amides connecting Tyr-Gly and Gly-Gly in leucine-enkephalin with ketomethylene groups: synthesis and biological activity.EBI J Med Chem 27: 115-20 (1984) TBA 2D 3D TSV
6317860 7 Synthesis, resolution, absolute stereochemistry, and enantioselectivity of 3',4'-dihydroxynomifensine.EBI J Med Chem 27: 28-35 (1984) TBA 2D 3D TSV
6317859 2 Parasite enzymes as potential targets for antiparasitic chemotherapy.EBI J Med Chem 27: 1-9 (1984) TBA 2D 3D TSV
6317122 20 Ligand binding to thromboxane receptors on human platelets: correlation with biological activity.BDB Br J Pharmacol 79: 953-64 (1983) University of Edinburgh 2D 3D TSV
6315939 2 14 beta-(2-bromoacetamido)morphine and 14 beta-(2-bromoacetamido)morphinone.EBI J Med Chem 26: 1775-7 (1983) TBA 2D 3D TSV
6315938 1 Neurotransmitter receptor binding and drug discovery.EBI J Med Chem 26: 1667-72 (1984) TBA 2D 3D TSV
6313921 10 Synthesis and pharmacological characterization of (+/-)-5,9 alpha-dimethyl-2-[2-(4-fluorophenyl)ethyl]-2'-hydroxy-6,7-benzomorphan (fluorophen), a ligand suitable for visualization of opiate receptors in vivo.EBI J Med Chem 26: 1643-5 (1983) TBA 2D 3D TSV
6313919 6 C4-substituted 1-beta-D-ribofuranosylpyrazolo[3,4-d]pyrimidines as adenosine agonist analogues.EBI J Med Chem 26: 1601-6 (1983) TBA 2D 3D TSV
6312042 7 Different receptor sites mediate opioid agonism and antagonism.EBI J Med Chem 26: 1341-3 (1983) TBA 2D 3D TSV
6310113 29 Angiotensin converting enzyme inhibitors: 1-glutarylindoline-2-carboxylic acids derivatives.EBI J Med Chem 26: 1277-82 (1983) TBA 2D 3D TSV
6310112 64 Angiotensin converting enzyme inhibitors: N-substituted monocyclic and bicyclic amino acid derivatives.EBI J Med Chem 26: 1267-77 (1983) TBA 2D 3D TSV
6310078 55 Sertraline, 1S,4S-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, a new uptake inhibitor with selectivity for serotonin.BDB J Pharmacol Exp Ther 226: 686-700 (1983) Pfizer Inc., 2D 3D TSV
6306238 4 4-(Aminoalkyl)-7-hydroxy-2(3H)-indolones, a novel class of potent presynaptic dopamine receptor agonists.EBI J Med Chem 26: 933-5 (1983) TBA 2D 3D TSV
6304315 8 4,5,6,7-Tetrahydroisothiazolo[5,4-c]pyridin-3-ol and related analogues of THIP. Synthesis and biological activity.EBI J Med Chem 26: 895-900 (1983) TBA 2D 3D TSV
6298429 31 (Mercaptopropanoyl)indoline-2-carboxylic acids and related compounds as potent angiotensin converting enzyme inhibitors and antihypertensive agents.EBI J Med Chem 26: 394-403 (1983) TBA 2D 3D TSV
6298428 28 Antihypertensive agents: angiotensin converting enzyme inhibitors. 1-[3-(Acylthio)-3-aroylpropionyl]-L-prolines.EBI J Med Chem 26: 381-93 (1983) TBA 2D 3D TSV
6298427 22 Synthesis of (7R)-7H-indolo[3,4-gh][1,4]benzoxazines, a new class of D-heteroergolines with dopamine agonist activity.EBI J Med Chem 26: 363-7 (1983) TBA 2D 3D TSV
6298425 55 Synthesis of esters of phosphonoformic acid and their antiherpes activity.EBI J Med Chem 26: 264-70 (1983) TBA 2D 3D TSV
6298421 10 Synthesis and 5-lipoxygenase inhibitory activities of eicosanoid compounds.EBI J Med Chem 26: 72-8 (1983) TBA 2D 3D TSV
6298420 17 New carboxyalkyl inhibitors of brain enkephalinase: synthesis, biological activity, and analgesic properties.EBI J Med Chem 26: 60-5 (1983) TBA 2D 3D TSV
6296388 68 Synthesis and pharmacological characterization in vitro of cyclic enkephalin analogues: effect of conformational constraints on opiate receptor selectivity.EBI J Med Chem 25: 1432-8 (1983) TBA 2D 3D TSV
6296387 15 alpha 2 adrenoceptors: classification, localization, mechanisms, and targets for drugs.EBI J Med Chem 25: 1389-401 (1982) TBA 2D 3D TSV
6292421 6 N-Methylnalorphine: definition of N-allyl conformation for antagonism at the opiate receptor.EBI J Med Chem 25: 1278-80 (1982) TBA 2D 3D TSV
6292420 6 Synthesis and pharmacology of metabolically stable tert-butyl ethers of morphine and levorphanol.EBI J Med Chem 25: 1264-6 (1982) TBA 2D 3D TSV
6292419 14 Pentasubstituted quercetin analogues as selective inhibitors of particulate 3':5'-cyclic-AMP phosphodiesterase from rat brain.EBI J Med Chem 25: 1192-8 (1983) TBA 2D 3D TSV
6292418 35 Species- or isozyme-specific enzyme inhibitors. 8. Synthesis of disubstituted two-substrate condensation products as inhibitors of rat adenylate kinases.EBI J Med Chem 25: 1179-84 (1983) TBA 2D 3D TSV
6292417 10 Hydroxy- and amino-substituted piperidinecarboxylic acids as gamma-aminobutyric acid agonists and uptake inhibitors.EBI J Med Chem 25: 1157-62 (1982) TBA 2D 3D TSV
6292197 11 Specific binding of prostaglandin D2 to rat brain synaptic membrane. Occurrence, properties, and distribution.BDB J Biol Chem 257: 13570-5 (1982) Kyoto University 2D 3D TSV
6288947 6 Angiotensin converting enzyme inhibitors: modifications of a tripeptide analogue.EBI J Med Chem 25: 996-9 (1982) TBA 2D 3D TSV
6288945 28 Potential affinity labels for the opiate receptor based on fentanyl and related compounds.EBI J Med Chem 25: 913-9 (1982) TBA 2D 3D TSV
6286970 54 Species- or isozyme-specific enzyme inhibitors. 7. Selective effects in inhibitions of rat adenylate kinase isozymes by adenosine 5'-phosphate derivatives.EBI J Med Chem 25: 806-12 (1982) TBA 2D 3D TSV
6284937 13 Species- or isozyme-specific enzyme inhibitors. 4. Design of a two-site inhibitor of adenylate kinase with isozyme selectivity.EBI J Med Chem 25: 638-44 (1982) TBA 2D 3D TSV
6283083 2 1-beta-D-arabinofuranosyl-1H-imidazo[4,5-c]pyridine (ara-3-deazaadenine).EBI J Med Chem 25: 96-8 (1982) TBA 2D 3D TSV
6283082 3 Stereochemical studies on medicinal agents. 25. Absolute configuration and analgetic potency of beta-1,2-dimethyl-2-phenyl-4-(propionyloxy)piperidine enantiomers.EBI J Med Chem 25: 9-12 (1982) TBA 2D 3D TSV
6279846 1 2-(Alkylthio)-1,2,4-triazolo[1,5-a]pyrimidines as adenosine cyclic 3',5'-monophosphate phosphodiesterase inhibitors with potential as new cardiovascular agents.EBI J Med Chem 25: 420-6 (1982) TBA 2D 3D TSV
6279845 15 Use of adenine nucleotide derivatives to assess the potential of exo-active-site-directed reagents as species- or isozyme-specific enzyme inactivators. 4. Interactions of adenosine 5'-triphosphate derivatives with adenylate kinases from Escherichia coli and rat tissues.EBI J Med Chem 25: 382-6 (1982) TBA 2D 3D TSV
6279844 2 Use of adenine nucleotide derivatives to assess the potential of exo-active-site-directed reagents as species- or isozyme-specific enzyme inactivators. 3. Synthesis of adenosine 5'-triphosphate derivatives with N6- or 8-substituents bearing iodoacetyl groups.EBI J Med Chem 25: 373-81 (1982) TBA 2D 3D TSV
6279843 27 Angiotensin-converting enzyme inhibitors: importance of the amide carbonyl of mercaptoacyl amino acids for hydrogen bonding to the enzyme.EBI J Med Chem 25: 250-8 (1982) TBA 2D 3D TSV
6279840 53 Adenosine receptors: targets for future drugs.EBI J Med Chem 25: 197-207 (1982) TBA 2D 3D TSV
6276546 12 Common anionic receptor site hypothesis: its relevance to the antagonist action of naloxone.EBI J Med Chem 25: 116-20 (1982) TBA 2D 3D TSV
6276540 20 Evidence of the preferential involvement of mu receptors in analgesia using enkephalins highly selective for peripheral mu or delta receptors.EBI J Med Chem 24: 1119-24 (1982) TBA 2D 3D TSV
6273560 16 Preparation and analgesic properties of amino acid derivatives of (-)-5,9 alpha-diethyl-2'-hydroxybenzomorphan.EBI J Med Chem 24: 1297-9 (1981) TBA 2D 3D TSV
6271132 14 Prostacyclin receptors of a neuronal hybrid cell line. Divalent citations and ligand-receptor coupling.BDB Biochem Pharmacol 30: 2041-4 (1981) Royal Postgraduate Medical School 2D 3D TSV
6268789 22 Synthesis of analogues of acetylmethadol and methadol as potential narcotic antagonists.EBI J Med Chem 24: 903-6 (1981) TBA 2D 3D TSV
6268786 27 Opiate receptor interaction of compounds derived from or structurally related to fentanyl.EBI J Med Chem 24: 777-82 (1981) TBA 2D 3D TSV
6267277 15 Inhibition of the renin-angiotensin system. A new approach to the therapy of hypertension.EBI J Med Chem 24: 355-61 (1981) TBA 2D 3D TSV
6266565 14 The binding of [3H]-prostacyclin to membranes of a neuronal somatic hybrid.BDB Br J Pharmacol 72: 435-41 (1981) Royal Postgraduate Medical School 2D 3D TSV
6259353 4 Synthesis and antiviral activity of 1-(2-deoxy-beta-D-ribofuranosyl)-5-(methylmercapto)-2-pyrimidinone.EBI J Med Chem 24: 109-12 (1981) TBA 2D 3D TSV
6259352 8 Synthesis and angiotensin-converting enzyme inhibitory activity of 3-(Mercaptomethyl)-2-oxo-1-pyrrolidineacetic acids and 3-(Mercaptomethyl)-2-oxo-1-piperidineacetic acids.EBI J Med Chem 24: 104-9 (1981) TBA 2D 3D TSV
6252322 19 Novel analogues of enkephalin: indentification of functional groups required for biological activity.EBI J Med Chem 23: 1113-22 (1980) TBA 2D 3D TSV
6249933 12 Conformationally restricted tricyclic antidepressants. 1. Octahydrodibenzazepinonaphthyridines as rigid imipramine analogues.EBI J Med Chem 23: 865-73 (1980) TBA 2D 3D TSV
6249930 7 Synthesis and analgesic activity of some 5-(4-hydroxyphenyl)-2-azabicyclo[3.2.1]octanes.EBI J Med Chem 23: 726-9 (1980) TBA 2D 3D TSV
6248644 4 Some spiro analogues of the potent analgesic ketobemidone.EBI J Med Chem 23: 688-90 (1980) TBA 2D 3D TSV
6248642 38 Mammalian alkaloids. 8. Synthesis and biological effects of tetrahydropapaveroline related 1-benzyltetrahydroisoquinolines.EBI J Med Chem 23: 648-52 (1980) TBA 2D 3D TSV
6248635 48 Opioid binding properties of brain and peripheral tissues: evidence for heterogeneity in opioid ligand binding sites.BDB J Pharmacol Exp Ther 214: 395-402 (1980) Stanford University 2D 3D TSV
6228661 1 Synthesis and biological activity of 5-fluoro-2',3'-dideoxy-3'-fluorouridine and its 5'-phosphate.EBI J Med Chem 27: 11-4 (1984) TBA 2D 3D TSV
6225026 45 Identification of presynaptic serotonin autoreceptors using a new ligand: 3H-PAT.BDB Nature 305: 140-2 (1983) INSERM U. 114 2D 3D TSV
6219223 94 Aromatic amidines: comparison of their ability to block respiratory syncytial virus induced cell fusion and to inhibit plasmin, urokinase, thrombin, and trypsin.EBI J Med Chem 26: 294-8 (1983) TBA 2D 3D TSV
6209395 8 Diastereomeric 6-desoxy-6-spiro-alpha-methylene-gamma-butyrolactone derivatives of naltrexone and oxymorphone. Selective irreversible inhibition of naltrexone binding in an opioid receptor preparation by a conformationally restricted michael acceptor ligand.EBI J Med Chem 27: 1718-23 (1984) TBA 2D 3D TSV
6198519 54 Design, synthesis, and X-ray data of novel potential antipsychotic agents. Substituted 7-phenylquinolizidines: stereospecific, neuroleptic, and antinociceptive properties.EBI J Med Chem 27: 165-75 (1984) TBA 2D 3D TSV
6192241 15 Synthesis and biological properties of thiophene ring analogues of mianserin.EBI J Med Chem 26: 1116-22 (1983) TBA 2D 3D TSV
6173481 24 Novel synthesis of (S)-1-[5-(benzoylamino)-1,4-dioxo-6-phenylhexyl]-L-proline and analogues: potent angiotensin converting enzyme inhibitors.EBI J Med Chem 24: 964-9 (1982) TBA 2D 3D TSV
6161252 3 Substituted 6,7-dihydroimidazo[1,2-a]purin-9(4H)-ones.EBI J Med Chem 23: 1188-98 (1980) TBA 2D 3D TSV
6154141 57 Quantitative structure--activity correlations of rifamycins as inhibitors of viral RNA-directed DNA polymerase and mammalian alpha and beta DNA polymerases.EBI J Med Chem 23: 256-61 (1980) TBA 2D 3D TSV
6150112 24 Probes for narcotic receptor mediated phenomena. 7. Synthesis and pharmacological properties of irreversible ligands specific for mu or delta opiate receptors.EBI J Med Chem 27: 1570-4 (1985) TBA 2D 3D TSV
6149136 83 Antagonism by neuroleptics of neurotransmitter receptors of normal human brain in vitro.BDB Eur J Pharmacol 103: 197-204 (1984) Mayo Clinic and Foundation 2D 3D TSV
6148422 36 Synthesis and beta-adrenergic blocking activity of new aliphatic and alicyclic oxime ethers.EBI J Med Chem 27: 1291-4 (1984) TBA 2D 3D TSV
6146381 35 Histamine H1 receptors in human brain labelled with [3H]doxepin.BDB Brain Res 304: 1-7 (1984) Mayo Foundation 2D 3D TSV
6144048 9 Comparison of the alpha-adrenoceptor antagonist profiles of idazoxan (RX 781094), yohimbine, rauwolscine and corynanthine.BDB Naunyn Schmiedebergs Arch Pharmacol 325: 136-44 (1984) TBA 2D 3D TSV
6142954 70 Quantitative relationships between alpha-adrenergic activity and binding affinity of alpha-adrenoceptor agonists and antagonists.EBI J Med Chem 27: 495-503 (1984) TBA 2D 3D TSV
6142953 5 Inhibitors of inosinic acid dehydrogenase. 2-Substituted inosinic acids.EBI J Med Chem 27: 429-32 (1984) TBA 2D 3D TSV
6142952 42 Inhibition of aminopeptidases by amastatin and bestatin derivatives. Effect of inhibitor structure on slow-binding processes.EBI J Med Chem 27: 417-22 (1984) TBA 2D 3D TSV
6141293 4 Design and synthesis of tetrahedral intermediate analogues as potential dihydroorotase inhibitors.EBI J Med Chem 27: 228-32 (1984) TBA 2D 3D TSV
6139481 32 alpha-Adrenergic activities of some substituted 2-(aminomethyl)imidazolines.EBI J Med Chem 26: 1769-72 (1984) TBA 2D 3D TSV
6139479 48 Pyridinylpiperazines, a new class of selective alpha 2-adrenoceptor antagonists.EBI J Med Chem 26: 1696-701 (1984) TBA 2D 3D TSV
6135157 11 Specific binding of 3H-tiotidine to histamine H2 receptors in guinea pig cerebral cortex.BDB Nature 304: 65-7 (1983) Hoechst Pharmaceutical Research Laboratories 2D 3D TSV
6134835 76 Synthesis and receptor binding studies relevant to the neuroleptic activities of some 1-methyl-4-piperidylidene-9-substituted-pyrrolo[2,1-b][3]benzazepine derivatives.EBI J Med Chem 26: 974-80 (1983) TBA 2D 3D TSV
6134834 54 Beta 1-selective adrenoceptor antagonists: examples of the 2-[4-[3-(substituted-amino)-2-hydroxypropoxy]phenyl]imidazole class.EBI J Med Chem 26: 950-7 (1983) TBA 2D 3D TSV
6134833 91 Neuroleptic activity and dopamine-uptake inhibition in 1-piperazino-3-phenylindans.EBI J Med Chem 26: 935-47 (1983) TBA 2D 3D TSV
6133954 6 Antihypertensive 9-substituted 1-oxa-4,9-diazaspiro[5.5]undecan-3-ones.EBI J Med Chem 26: 855-61 (1983) TBA 2D 3D TSV
6133953 2 alpha-adrenoreceptor reagents. 1. Synthesis of some 1,4-benzodioxans as selective presynaptic alpha 2-adrenoreceptor antagonists and potential antidepressants.EBI J Med Chem 26: 823-31 (1983) TBA 2D 3D TSV
6132009 10 Preparation of some 10-[3-(dimethylamino)-1-propyl]-10H-pyrazino[2,3-b][1,4] benzothiazines as potential neuroleptics.EBI J Med Chem 26: 564-9 (1983) TBA 2D 3D TSV
6131130 58 Buspirone analogues. 1. Structure-activity relationships in a series of N-aryl- and heteroarylpiperazine derivatives.EBI J Med Chem 26: 194-203 (1983) TBA 2D 3D TSV
6131129 10 Conformational requirements for histamine H2-receptor inhibitors: a structure-activity study of phenylene analogues related to cimetidine and tiotidine.EBI J Med Chem 26: 140-4 (1983) TBA 2D 3D TSV
6131128 30 beta-Adrenergic antagonists with multiple pharmacophores: persistent blockade of receptors.EBI J Med Chem 26: 7-11 (1983) TBA 2D 3D TSV
6130154 68 Ultra-short-acting beta-adrenergic receptor blocking agents. 2. (Aryloxy)propanolamines containing esters on the aryl function.EBI J Med Chem 25: 1408-12 (1983) TBA 2D 3D TSV
6130153 66 Ultra-short-acting beta-adrenergic receptor blocking agents. 1. (Aryloxy)propanolamines containing esters in the nitrogen substituent.EBI J Med Chem 25: 1402-7 (1983) TBA 2D 3D TSV
6128416 29 Effects of conformationally restricted 4-piperazinyl-10H-thienobenzodiazepine neuroleptics on central dopaminergic and cholinergic systems.EBI J Med Chem 25: 1133-40 (1982) TBA 2D 3D TSV
6126588 12 Use of (S)-(trifloxymethyl)oxirane in the synthesis of a chiral beta-adrenoceptor antagonist, (R)- and (S)-9-[[3-(tert-butylamino)-2-hydroxypropyl]oximino]fluorene.EBI J Med Chem 25: 931-6 (1982) TBA 2D 3D TSV
6124637 18 Syntheses and adrenergic agonist properties of ring-fluorinated isoproterenols.EBI J Med Chem 25: 680-4 (1982) TBA 2D 3D TSV
6124636 7 Arylethanolamines derived from salicylamide with alpha- and beta-adrenoceptor blocking activities. Preparation of labetalol, its enantiomers, and related salicylamides.EBI J Med Chem 25: 670-9 (1982) TBA 2D 3D TSV
6123600 10 1-(alkylamino)isochromans: hypotensives with peripheral and central activities.EBI J Med Chem 25: 75-81 (1982) TBA 2D 3D TSV
6123599 4 Synthesis and pharmacological evaluation of conformationally restricted phenothiazine analogues.EBI J Med Chem 25: 5-9 (1982) TBA 2D 3D TSV
6123593 24 A new inhibitor of norepinephrine uptake devoid of affinity for receptors in rat brain.BDB J Pharmacol Exp Ther 222: 61-5 (1982) Eli Lilly and Company 2D 3D TSV
6121914 2 1,2,5-thiadiazole 1-oxide and 1,1-dioxide derivatives. A new class of potent histamine H2-receptor antagonists.EBI J Med Chem 25: 210-2 (1982) TBA 2D 3D TSV
6121913 5 Inhibitors of gastric acid secretion: 3,4-diamino-1,2,5-thiadiazole 1-oxides and 1,1-dioxides as urea equivalents in a series of histamine H2-receptor antagonists.EBI J Med Chem 25: 207-10 (1982) TBA 2D 3D TSV
6120237 15 2-Benzodioxinylaminoethanols: a new class of beta-adrenergic blocking and antihypertensive agents.EBI J Med Chem 24: 994-8 (1982) TBA 2D 3D TSV
6120233 43 beta-Adrenergic blocking agents. alpha- and gamma-methyl(aryloxy)propanolamines.EBI J Med Chem 24: 1211-4 (1981) TBA 2D 3D TSV
6120232 32 Inhibition of inosinic acid dehydrogenase by 8-substituted purine nucleotides.EBI J Med Chem 24: 1155-61 (1982) TBA 2D 3D TSV
6118438 12 Alpha-adrenergic agents. 1. Direct-acting alpha 1 agonists related to methoxamine.EBI J Med Chem 24: 1432-7 (1982) TBA 2D 3D TSV
6106064 20 Synthesis and biological activity of fluoroalkylamine derivatives of narcotic analgesics.EBI J Med Chem 23: 985-90 (1980) TBA 2D 3D TSV
6106063 34 Synthesis of 8-aryltetrahydroisoquinolines as dopamine antagonists and evaluation for potential neuroleptic activity.EBI J Med Chem 23: 977-80 (1980) TBA 2D 3D TSV
6106062 8 6-(Phenylthio)-substituted 2,3,4,5-tetrahydro-1H-3-benzazepines, a novel class of dopamine receptor antagonists and neuroleptics.EBI J Med Chem 23: 975-6 (1980) TBA 2D 3D TSV
6105221 1 Synthesis and anxiolytic activity of a series of pyrazino[1,2-a][1,4]benzodiazepine derivatives.EBI J Med Chem 23: 952-5 (1980) TBA 2D 3D TSV
6105220 5 4a,9b-trans-8-Fluoro-5-(4-fluorophenyl)-2-[4-(4-fluorophenyl)-4-hydroxybutyl]-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole hydrochloride, a new potent neuroleptic.EBI J Med Chem 23: 949-52 (1980) TBA 2D 3D TSV
6105219 4 Conformationally restricted phenothiazine neuroleptics. 1. 3-(Dimethylamino)-1,2,3,4-tetrahydroazepino[3,2,1-kl]phenothiazine.EBI J Med Chem 23: 938-41 (1980) TBA 2D 3D TSV
6104732 9 Neuroleptic activity in 5-aryltetrahydro-gamma-carbolines.EBI J Med Chem 23: 635-43 (1980) TBA 2D 3D TSV
6104730 47 Synthesis and beta-adrenergic blocking activity of new aliphatic oxime ethers.EBI J Med Chem 23: 620-4 (1980) TBA 2D 3D TSV
6094811 56 Synthesis of 4-substituted 2H-naphth[1,2-b]-1,4-oxazines, a new class of dopamine agonists.EBI J Med Chem 27: 1607-13 (1984) TBA 2D 3D TSV
6094810 6 Synthesis and biological activity of new peptide segments of gastrin exhibiting gastrin antagonist property.EBI J Med Chem 27: 1597-601 (1985) TBA 2D 3D TSV
6094809 32 Synthesis and biological evaluation of 14-alkoxymorphinans. 1. Highly potent opioid agonists in the series of (-)-14-methoxy-N-methylmorphinan-6-ones.EBI J Med Chem 27: 1575-9 (1984) TBA 2D 3D TSV
6094806 2 Cyclopentenyluridine and cyclopentenylcytidine analogues as inhibitors of uridine-cytidine kinase.EBI J Med Chem 27: 1536-8 (1985) TBA 2D 3D TSV
6090665 28 Mesoionic xanthine analogues: antagonists of adenosine receptors.EBI J Med Chem 27: 1364-7 (1984) TBA 2D 3D TSV
6090663 1 Design and synthesis of naltrexone-derived affinity labels with nonequilibrium opioid agonist and antagonist activities. Evidence for the existence of different mu receptor subtypes in different tissues.EBI J Med Chem 27: 1325-35 (1984) TBA 2D 3D TSV
6088771 5 Potential synthetic codeine substitutes: (-)-3-O-aryl-N-methylmorphinans.EBI J Med Chem 27: 1219-22 (1984) TBA 2D 3D TSV
6088770 13 Adrenoceptor and tetrabenazine antagonism activities of some pyridinyltetrahydropyridines.EBI J Med Chem 27: 1182-5 (1984) TBA 2D 3D TSV
6087359 69 Psychotomimetic opiate receptors labeled and visualized with (+)-[3H]3-(3-hydroxyphenyl)-N-(1-propyl)piperidine.BDB Proc Natl Acad Sci U S A 81: 4983-7 (1984) TBA 2D 3D TSV

BDB Curated by BindingDB
EBI Curated by ChEMBL