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31 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
 
Non-glycosidic/non-aminoalkyl-substituted indolocarbazoles as inhibitors of protein kinase CEBI
TBA
Hexosaminidase inhibitors as new drug candidates for the therapy of osteoarthritis.BDB
The Scripps Research Institute
Structure-based discovery and in-parallel optimization of novel competitive inhibitors of thymidylate synthase.BDB
Northwestern University
Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy.BDB
University Of Michigan
Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction.BDB
University Of Michigan
Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases.BDB
Medical University Of South Carolina
Benzopyrans as selective estrogen receptor beta agonists (SERBAs). Part 3: synthesis of cyclopentanone and cyclohexanone intermediates for C-ring modification.BDB
Eli Lilly
Crystal structure of Staphylococcus aureus tyrosyl-tRNA synthetase in complex with a class of potent and specific inhibitors.BDB
Gsk
Synthesis of beta-ketophosphonate analogs of glutamyl and glutaminyl adenylate, and selective inhibition of the corresponding bacterial aminoacyl-tRNA synthetases.BDB
Crefsip
Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structure-based optimization.BDB
Schering-Plough Research Institute
Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.BDB
The Procter & Gamble Pharmaceuticals
Design and Synthesis of HIV-1 Protease Inhibitors Incorporating Oxazolidinones as P2/P2' Ligands in Pseudosymmetric Dipeptide Isosteres.BDB
University Of Massachusetts Medical School
Selection of a 2-azabicyclo[2.2.2]octane-based alpha4beta1 integrin antagonist as an inhaled anti-asthmatic agent.BDB
Johnson & Johnson Pharmaceutical
Arylsulfonamides: a study of the relationship between activity and conformational preferences for a series of factor Xa inhibitors.BDB
Glaxosmithkline
Synthesis, molecular modeling studies, and selective inhibitory activity against monoamine oxidase of 1-thiocarbamoyl-3,5-diaryl-4,5-dihydro-(1H)- pyrazole derivatives.BDB
Sapienza University Of Rome
Bis-huperzine B: highly potent and selective acetylcholinesterase inhibitors.BDB
Shanghai Institute Of Materia Medica
Crystal structure of pyridoxal kinase in complex with roscovitine and derivatives.BDB
Chinese Academy Of Sciences
Specificity and affinity of natural product cyclopentapeptide inhibitors against A. fumigatus, human, and bacterial chitinases.BDB
University Of Dundee
Lipophilic versus hydrogen-bonding effect in P3 on potency and selectivity of valine aspartyl ketones as caspase 3 inhibitors.BDB
Merck Frosst Canada
First dual aromatase-steroid sulfatase inhibitors.BDB
University Of Bath
Synthesis and structure-activity relationships of 6-substituted androst-4-ene analogs as aromatase inhibitors.BDB
Tohoku College Of Pharmacy
Synthesis and characterization of azole isoflavone inhibitors of aromatase.BDB
Ohio State University