33 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Article Title
Organization
ß-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease.
F. Hoffmann-La Roche
Non-peptide renin inhibitors containing 2-(((3-phenylpropyl)phosphoryl)oxy)alkanoic acid moieties as P2-P3 replacements.
E. Merck Darmstadt
Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors.
Parke-Davis Pharmaceutical Research Division Of Warner-Lambert
Renin inhibitors containing conformationally restricted P1-P1' dipeptide mimetics.
Merck Sharp And Dohme Research Laboratories
Substrate analogue renin inhibitors containing replacements of histidine in P2 or isosteres of the amide bond between P3 and P2 sites.
E. Merck Darmstadt
Orally potent human renin inhibitors derived from angiotensinogen transition state: design, synthesis, and mode of interaction.
Kissei Pharmaceutical
Inhibition of cathepsin D by substrate analogues containing statine and by analogues of pepstatin.
TBA
Design and synthesis of a potent and specific renin inhibitor with a prolonged duration of action in vivo.
TBA
Design and synthesis of potent and specific renin inhibitors containing difluorostatine, difluorostatone, and related analogues.
TBA
Renin inhibitors. Syntheses of subnanomolar, competitive, transition-state analogue inhibitors containing a novel analogue of statine.
TBA
Difluorostatine- and difluorostatone-containing peptides as potent and specific renin inhibitors.
TBA
The sulfonimidamide as a novel transition state analog for aspartic acid and metallo proteases.
The University Of Kansas
Peptidomimetic inhibitors of human immunodeficiency virus protease (HIV-PR): Design, enzyme binding and selectivity, antiviral efficacy, and cell permeability properties
TBA
Novel low molecular renin inhibitors which show good oral blood pressure lowering effects in marmosets
TBA
MDL 74147, a novel selective and soluble inhibitor of human renin. Synthesis, structure-activity relationship, species and protease selectivities.
TBA
Miraziridine A: natures blueprint towards protease class-spanning inhibitors.
Institut FüR Biochemie
Designing non-peptide peptidomimetics in the 21st century: inhibitors targeting conformational ensembles.
University Of Wisconsin-Madison
Simplified pepstatins: synthesis and evaluation of N-terminally modified analogues.
Institute Of Pharmaceutical Chemistry And Institute Of Pharmaceutical Technology
Synthesis of analogues of the carboxyl protease inhibitor pepstatin. Effect of structure in subsite P3 on inhibition of pepsin.
TBA
Synthesis of analogues of the carboxyl protease inhibitor pepstatin. Effects of structure on inhibition of pepsin and renin.
TBA
Synthesis of analogues of pepstatin. Effect of structure in subsites P1', P2', and P2 on inhibition of porcine pepsin.
TBA
Pepstatin-derived inhibitors of aspartic proteinases. A close look at an apparent transition-state analogue inhibitor.
TBA
Renin inhibitors. Design and synthesis of a new class of conformationally restricted analogues of angiotensinogen.
Abbott Laboratories
Inhibition of porcine pepsin by two substrate analogues containing statine. The effect of histidine at the P2 subsite on the inhibition of aspartic proteinases.
University Of Wisconsin
Synthetic and enzyme inhibition studies of pepstatin analogues containing hydroxyethylene and ketomethylene dipeptide isosteres.
TBA
Inhibition of aspartic proteinases by peptides containing lysine and ornithine side-chain analogues of statine.
TBA
Renin inhibitors containing new P1-P1' dipeptide mimetics with heterocycles in P1'.
E. Merck Darmstadt