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33 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
ß-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease.EBI
F. Hoffmann-La Roche
Protease inhibitors: current status and future prospects.EBI
University Of Queensland
Non-peptide renin inhibitors containing 2-(((3-phenylpropyl)phosphoryl)oxy)alkanoic acid moieties as P2-P3 replacements.EBI
E. Merck Darmstadt
Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors.EBI
Parke-Davis Pharmaceutical Research Division Of Warner-Lambert
Renin inhibitors containing conformationally restricted P1-P1' dipeptide mimetics.EBI
Merck Sharp And Dohme Research Laboratories
Substrate analogue renin inhibitors containing replacements of histidine in P2 or isosteres of the amide bond between P3 and P2 sites.EBI
E. Merck Darmstadt
Orally potent human renin inhibitors derived from angiotensinogen transition state: design, synthesis, and mode of interaction.EBI
Kissei Pharmaceutical
Inhibition of cathepsin D by substrate analogues containing statine and by analogues of pepstatin.EBI
TBA
Design and synthesis of a potent and specific renin inhibitor with a prolonged duration of action in vivo.EBI
TBA
Design and synthesis of potent and specific renin inhibitors containing difluorostatine, difluorostatone, and related analogues.EBI
TBA
Renin inhibitors. Syntheses of subnanomolar, competitive, transition-state analogue inhibitors containing a novel analogue of statine.EBI
TBA
Difluorostatine- and difluorostatone-containing peptides as potent and specific renin inhibitors.EBI
TBA
The sulfonimidamide as a novel transition state analog for aspartic acid and metallo proteases.EBI
The University Of Kansas
 
Peptidomimetic inhibitors of human immunodeficiency virus protease (HIV-PR): Design, enzyme binding and selectivity, antiviral efficacy, and cell permeability propertiesEBI
TBA
 
Novel low molecular renin inhibitors which show good oral blood pressure lowering effects in marmosetsEBI
TBA
 
Novel pseudosymmetric inhibitors of HIV-1 proteaseEBI
TBA
 
MDL 74147, a novel selective and soluble inhibitor of human renin. Synthesis, structure-activity relationship, species and protease selectivities.EBI
TBA
Miraziridine A: natures blueprint towards protease class-spanning inhibitors.EBI
Institut FüR Biochemie
Designing non-peptide peptidomimetics in the 21st century: inhibitors targeting conformational ensembles.EBI
University Of Wisconsin-Madison
Simplified pepstatins: synthesis and evaluation of N-terminally modified analogues.EBI
Institute Of Pharmaceutical Chemistry And Institute Of Pharmaceutical Technology
Synthesis of analogues of the carboxyl protease inhibitor pepstatin. Effect of structure in subsite P3 on inhibition of pepsin.EBI
TBA
Synthesis of analogues of the carboxyl protease inhibitor pepstatin. Effects of structure on inhibition of pepsin and renin.EBI
TBA
Synthesis of analogues of pepstatin. Effect of structure in subsites P1', P2', and P2 on inhibition of porcine pepsin.EBI
TBA
Pepstatin-derived inhibitors of aspartic proteinases. A close look at an apparent transition-state analogue inhibitor.EBI
TBA
Renin inhibitors. Design and synthesis of a new class of conformationally restricted analogues of angiotensinogen.EBI
Abbott Laboratories
Inhibition of porcine pepsin by two substrate analogues containing statine. The effect of histidine at the P2 subsite on the inhibition of aspartic proteinases.EBI
University Of Wisconsin
Synthetic and enzyme inhibition studies of pepstatin analogues containing hydroxyethylene and ketomethylene dipeptide isosteres.EBI
TBA
Inhibition of aspartic proteinases by peptides containing lysine and ornithine side-chain analogues of statine.EBI
TBA
New pepstatin analogues: synthesis and pepsin inhibition.EBI
University Of Arkansas
Renin inhibitors containing new P1-P1' dipeptide mimetics with heterocycles in P1'.EBI
E. Merck Darmstadt
Kainate receptors are involved in synaptic plasticity.BDB
University Of Bristol