The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 2.8M data for 1.2M Compounds and 9.2K Targets. Of those, 1,339K data for 617K Compounds and 4.5K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

If BindingDB was of value to your research, please take a moment to donate to this nonprofit project. Your donation will let us provide you with more data and improved service.

Advanced Search

52 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Inhibition of Lactobacillus casei thymidylate synthetase by 5-substituted 2'-deoxyuridylates. Preliminary quantitative structure-activity relationship.EBI
TBA
Methotrexate analogues. 9. Synthesis and biological properties of some 8-alkyl-7,8-dihydro analogues.EBI
TBA
5-Cyano-2'-deoxyuridine 5'-phosphate: a potent competitive inhibitor of thymidylate synthetase.EBI
TBA
Methotrexate analogues. 12. Synthesis and biological properties of some aza homologues.EBI
TBA
Phosphonate analogue of 2'-deoxy-5-fluorouridylic acid.EBI
TBA
Synthesis of 5-selenium-substituted uracil derivatives. Inhibition of thymidylate synthetase by 5-hydroseleno-2'-deoxyuridylate.EBI
TBA
Enzyme affinity of the 5,6-dihydro derivatives of the substrate and product of thymidylate synthetase catalysis.EBI
TBA
2'-Deoxyuridine 5'-monophosphate substrate displacement in thymidylate synthase through 6-hydroxy-2H-naphtho[1,8-bc]furan-2-one derivatives.EBI
University Of Modena And Reggio Emilia
Folate analogues altered in the C9-N10 bridge region. 16. Synthesis and antifolate activity of 11-thiohomoaminopterin.EBI
TBA
Synthesis of classical, three-carbon-bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates.EBI
Duquesne University
Synthesis of classical, four-carbon bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates.EBI
Duquesne University
Fragment-based drug discovery.EBI
Sunesis Pharmaceuticals
Synthesis and antitumor activities of novel 6-5 fused ring heterocycle antifolates: N-[4-[omega-(2-amino-4-substituted-6,7-dihydrocyclopenta [d]pyrimidin-5-yl)alkyl]benzoyl]-L-glutamic acids.EBI
Eisai
Linear free energy relationship studies of enzyme active site binding: thymidylate synthase.EBI
University Of Kansas
Synthesis and biological evaluation of 8-deazahomofolic acid and its tetrahydro derivative.EBI
Sri International
Folate analogues as inhibitors of thymidylate synthase.EBI
TBA
Folate analogues. 26. Syntheses and antifolate activity of 10-substituted derivatives of 5,8-dideazafolic acid and of the poly-gamma-glutamyl metabolites of N10-propargyl-5,8-dideazafolic acid (PDDF).EBI
TBA
Folate analogues. 25. Synthesis and biological evaluation of N10-propargylfolic acid and its reduced derivatives.EBI
TBA
Spin probes as mechanistic inhibitors and active site probes of thymidylate synthetase.EBI
TBA
Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin.EBI
TBA
10-Propargylaminopterin and alkyl homologues of methotrexate as inhibitors of folate metabolism.EBI
TBA
Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening.EBI
Universita Degli Studi Di Modena E Reggio Emilia
Synthesis of N-(5,7-diamino-3-phenyl-quinoxalin-2-yl)-3,4,5-substituted anilines and N-[4[(5,7-diamino-3-phenylquinoxalin-2-yl)amino]benzoyl]-l-glutamic acid diethyl ester: evaluation of in vitro anti-cancer and anti-folate activities.EBI
Università
Improving specificity vs bacterial thymidylate synthases through N-dansyl modulation of didansyltyrosine.EBI
Università
Design and synthesis of Cyclopenta[g]quinazoline-based antifolates as inhibitors of thymidylate synthase and potential antitumor agents(,).EBI
The Institute Of Cancer Research
Mechanism-based inactivation of thymidylate synthase by 5-(3-fluoropropyn-1-yl)-2'-deoxyuridine 5'-phosphate.EBI
State University Of New York
Classical and nonclassical furo[2,3-d]pyrimidines as novel antifolates: synthesis and biological activities.EBI
Duquesne University
Effect of bridge region variation on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines.EBI
Duquesne University
5-Arylthio-substituted 2-amino-4-oxo-6-methylpyrrolo[2,3-d]pyrimidine antifolates as thymidylate synthase inhibitors and antitumor agents.EBI
Duquesne University
Interaction of 5-ethynyl-2'-deoxyuridylate with thymidylate synthetase.EBI
TBA
Inhibition of thymidylate synthetase by 5-alkynyl-2'-deoxyuridylates.EBI
TBA
Interaction of N4-hydroxy-2'-deoxycytidylic acid with thymidylate synthetase.EBI
TBA
5-p-benzoquinonyl-2'-deoxyuridine 5'-phosphate: a possible mechanism-based inhibitor of thymidylate synthetase.EBI
TBA
Kinetics and mechanism of interaction of 10-propargyl-5,8-dideazafolate with thymidylate synthase.EBI
TBA
Inactivation of thymidylate synthase at an alternate high-affinity binding site.EBI
University Of Kansas
Folate analogues. 30. Synthesis and biological evaluation of N10-propargyl-5,8-dideaza-5,6,7,8-tetrahydrofolic acid and related compounds.EBI
TBA
Synthesis and antifolate activity of 5-methyl-5,10-dideaza analogues of aminopterin and folic acid and an alternative synthesis of 5,10-dideazatetrahydrofolic acid, a potent inhibitor of glycinamide ribonucleotide formyltransferase.EBI
Southern Research Institute
Synthesis and antifolate properties of 5,10-methylenetetrahydro-8,10-dideazaminopterin.EBI
TBA
5-Quinone derivatives of 2'-deoxyuridine 5'-phosphate: inhibition and inactivation of thymidylate synthase, antitumor cell, and antiviral studies.EBI
TBA
Quinazoline antifolates inhibiting thymidylate synthase: 2-desamino derivatives with enhanced solubility and potency.EBI
Institute Of Cancer Research
Folate analogues. 32. Synthesis and biological evaluation of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid and related compounds.EBI
University Of South Alabama
Methotrexate analogues. 29. Effect of gamma-aminobutyric acid spacers between the pteroyl and glutamate moieties on enzyme binding and cell growth inhibition.EBI
TBA
Synthesis and antifolate properties of 9-alkyl-10-deazaminopterins.EBI
Sri International
Synthesis and biological activity of 5,11-methylenetetrahydro-5- deazahomofolic acid.EBI
Duquesne University
Synthesis and antifolate evaluation of the 10-propargyl derivatives of 5-deazafolic acid, 5-deazaaminopterin, and 5-methyl-5-deazaaminopterin.EBI
Southern Research Institute
5,10-Methylenetetrahydro-5-deazafolic acid and analogues: synthesis and biological activities.EBI
Duquesne University
Design, synthesis, biological evaluation, and molecular docking of novel benzopyran and phenylpyrazole derivatives as Akt inhibitors.BDB
Zhejiang University
Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen.BDB
Boston College