26 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
PMID
Data
Article Title
Organization
Modulating the selectivity of matriptase-2 inhibitors with unnatural amino acids.
Universit£
Design and Synthesis of Nonpeptide Inhibitors of Hepatocyte Growth Factor Activation.
Southern Research
Structure-guided discovery of 2-aryl/pyridin-2-yl-1H-indole derivatives as potent and selective hepsin inhibitors.
Aurigene Discovery Technologies
Structure-based discovery of small molecule hepsin and HGFA protease inhibitors: Evaluation of potency and selectivity derived from distinct binding pockets.
Washington University
Inhibitors of HGFA, Matriptase, and Hepsin Serine Proteases: A Nonkinase Strategy to Block Cell Signaling in Cancer.
Washington University
Analysis of subpocket selectivity and identification of potent selective inhibitors for matriptase and matriptase-2.
Universit£
Structure-guided discovery of 1,3,5 tri-substituted benzenes as potent and selective matriptase inhibitors exhibiting in vivo antitumor efficacy.
Aurigene Discovery Technologies
Identification by in silico and in vitro screenings of small organic molecules acting as reversible inhibitors of kallikreins.
Universit£
Discovery of Pyridyl Bis(oxy)dibenzimidamide Derivatives as Selective Matriptase Inhibitors.
Aurigene Discovery Technologies
1,2,4-Triazole derivatives as transient inactivators of kallikreins involved in skin diseases.
Universit£
Targeting zymogen activation to control the matriptase-prostasin proteolytic cascade.
University Of Maryland
Development of substrate analogue inhibitors for the human airway trypsin-like protease HAT.
Philipps University Marburg
Identification of the first low-molecular-weight inhibitors of matriptase-2.
University Of Bonn
Substrate specificity and inhibitory study of human airway trypsin-like protease.
Faculty Of Chemistry Gdansk University
Incorporation of neutral C-terminal residues in 3-amidinophenylalanine-derived matriptase inhibitors.
The Medicines Company (Leipzig)
Modification of the N-terminal sulfonyl residue in 3-amidinophenylalanine-based matriptase inhibitors.
Curacyte Discovery
Synthesis and evaluation of the sunflower derived trypsin inhibitor as a potent inhibitor of the type II transmembrane serine protease, matriptase.
National Cancer Institute-Frederick
Structure-based approach for the discovery of bis-benzamidines as novel inhibitors of matriptase.
Georgetown University Medical Center
Design of Specific Serine Protease Inhibitors Based on a Versatile Peptide Scaffold: Conversion of a Urokinase Inhibitor to a Plasma Kallikrein Inhibitor.
Aarhus University
Engineering potent mesotrypsin inhibitors based on the plant-derived cyclic peptide, sunflower trypsin inhibitor-1.
The University Of Queensland
Stable and Long-Lasting, Novel Bicyclic Peptide Plasma Kallikrein Inhibitors for the Treatment of Diabetic Macular Edema.
Bicycle Therapeutics