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58 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
A benzo[b]thiophene-based selective type 4 S1P receptor agonist.EBI
Harvard Medical School
Identification and Preclinical Pharmacology of BMS-986104: A Differentiated S1P1 Receptor Modulator in Clinical Trials.EBI
Bristol-Myers Squibb
Novel S1P1 receptor agonists - Part 4: Alkylaminomethyl substituted aryl head groups.EBI
Actelion Pharmaceuticals
Discovery of Tetrahydropyrazolopyridine as Sphingosine 1-Phosphate Receptor 3 (S1P3)-Sparing S1P1 Agonists Active at Low Oral Doses.EBI
Glaxosmithkline
Discovery of novel S1P2 antagonists, part 3: Improving the oral bioavailability of a series of 1,3-bis(aryloxy)benzene derivatives.EBI
Ono Pharmaceutical
Discovery of novel S1P2 antagonists. Part 2: Improving the profile of a series of 1,3-bis(aryloxy)benzene derivatives.EBI
Ono Pharmaceutical
Discovery of novel S1P2 antagonists. Part 1: discovery of 1,3-bis(aryloxy)benzene derivatives.EBI
Ono Pharmaceutical
Design and synthesis of new tricyclic indoles as potent modulators of the S1P1 receptor.EBI
Arena Pharmaceuticals
(7-Benzyloxy-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic Acids as S1P1 Functional Antagonists.EBI
Arena Pharmaceuticals
Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate-1 Receptor.EBI
Arena Pharmaceuticals
Discovery of a novel class of zwitterionic, potent, selective and orally active S1P1 direct agonists.EBI
RhôNe-Poulenc Rorer
An oral sphingosine 1-phosphate receptor 1 (S1P(1)) antagonist prodrug with efficacy in vivo: discovery, synthesis, and evaluation.EBI
Novartis Pharma
Fused tricyclic indoles as S1P1 agonists with robust efficacy in animal models of autoimmune disease.EBI
Arena Pharmaceuticals
4-Methoxy-N-[2-(trifluoromethyl)biphenyl-4-ylcarbamoyl]nicotinamide: A Potent and Selective Agonist of S1P1.EBI
TBA
Constrained azacyclic analogues of the immunomodulatory agent FTY720 as molecular probes for sphingosine 1-phosphate receptors.EBI
Universit£
Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1-phosphate and FTY720: discovery of potent S1P1 receptor agonists.EBI
University Of Virginia
Synthesis of benzimidazole based analogues of sphingosine-1-phosphate: discovery of potent, subtype-selective S1P4 receptor agonists.EBI
University Of Virginia
Design and synthesis of conformationally constrained 3-(N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors.EBI
Merck Research Laboratories
The discovery of 3-(N-alkyl)aminopropylphosphonic acids as potent S1P receptor agonists.EBI
Merck Research Laboratories
Synthesis of para-alkyl aryl amide analogues of sphingosine-1-phosphate: discovery of potent S1P receptor agonists.EBI
University Of Virginia
Synthesis and evaluation of CS-2100, a potent, orally active and S1P(3)- sparing S1P(1) agonist.EBI
Daiichi Sankyo
Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P4-R) agonists.EBI
The Scripps Research Institute
Novel immunomodulators based on an oxazolin-2-one-4-carboxamide scaffold.EBI
Institute Of Pharmacology & Toxicology
Discovery and characterization of potent and selective 4-oxo-4-(5-(5-phenyl-1,2,4-oxadiazol-3-yl)indolin-1-yl)butanoic acids as S1P¿? agonists.EBI
Arena Pharmaceuticals
Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotype.EBI
The Scripps Research Institute
Discovery of a brain-penetrant S1P3-sparing direct agonist of the S1P¿? and S1P5 receptors efficacious at low oral dose.EBI
Glaxosmithkline
SAR analysis of innovative selective small molecule antagonists of sphingosine-1-phosphate 4 (S1P4) receptor.EBI
The Scripps Research Institute
Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists.EBI
The Scripps Research Institute
2-imino-thiazolidin-4-one derivatives as potent, orally active S1P1 receptor agonists.EBI
Actelion Pharmaceuticals
Exploration of amino alcohol derivatives as novel, potent, and highly selective sphingosine-1-phosphate receptor subtype-1 agonists.EBI
Praecis Pharmaceuticals
Stereochemistry-activity relationship of orally active tetralin S1P agonist prodrugs.EBI
Biogen Idec
S1P receptor mediated activity of FTY720 phosphate mimics.EBI
Novartis Institutes For Biomedical Research
Pyrazole derived from (+)-3-carene; a novel potent, selective scaffold for sphingosine-1-phosphate (S1P(1)) receptor agonists.EBI
Novartis Institutes For Biomedical Research
Synthesis and evaluation of arylalkoxy- and biarylalkoxy-phenylamide and phenylimidazoles as potent and selective sphingosine-1-phosphate receptor subtype-1 agonists.EBI
Praecis Pharmaceuticals
Synthesis and evaluation of alkoxy-phenylamides and alkoxy-phenylimidazoles as potent sphingosine-1-phosphate receptor subtype-1 agonists.EBI
Praecis Pharmaceuticals
Synthesis and biological evaluation of gamma-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists.EBI
University Of Virginia
Discovery of 3-arylpropionic acids as potent agonists of sphingosine-1-phosphate receptor-1 (S1P1) with high selectivity against all other known S1P receptor subtypes.EBI
Merck Research Laboratories
2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors.EBI
Merck Research Laboratories
2,5-Disubstituted pyrrolidine carboxylates as potent, orally active sphingosine-1-phosphate (S1P) receptor agonists.EBI
Merck Research Laboratories
Novel immunomodulator FTY720 is phosphorylated in rats and humans to form a single stereoisomer. Identification, chemical proof, and biological characterization of the biologically active species and its enantiomer.EBI
Novartis Institutes For Biomedical Research
A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists.EBI
Merck Research Laboratories
Selecting against S1P3 enhances the acute cardiovascular tolerability of 3-(N-benzyl)aminopropylphosphonic acid S1P receptor agonists.EBI
Merck Research Laboratories
Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720.EBI
Merck Research Laboratories
Discovery of Clinical Candidate GSK1842799 As a Selective S1P1 Receptor Agonist (Prodrug) for Multiple Sclerosis.EBI
Praecis Pharmaceuticals
Discovery, design and synthesis of a selective S1P(3) receptor allosteric agonist.EBI
The Scripps Research Institute
Modulators of the Sphingosine 1-phosphate receptor 1.EBI
The Scripps Research Institute
NBD-labeled derivatives of the immunomodulatory drug FTY720 as tools for metabolism and mode of action studies.EBI
Novartis Institutes For Biomedical Research
Discovery of a 1-Methyl-3,4-dihydronaphthalene-Based Sphingosine-1-Phosphate (S1P) Receptor Agonist Ceralifimod (ONO-4641). A S1PEBI
Ono Pharmaceutical
Synthesis and biologic evaluation of substituted 5-methyl-2-phenyl-1H-pyrazol-3(2H)-one derivatives as selective COX-2 inhibitors: molecular docking study.BDB
Y.B. Chavan College Of Pharmacy
Decreased binding affinity of olanzapine and clozapine for human muscarinic receptors in intact clonal cells in physiological medium.BDB
Eli Lilly