The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 2.8M data for 1.2M Compounds and 9.2K Targets. Of those, 1,339K data for 617K Compounds and 4.5K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

If BindingDB was of value to your research, please take a moment to donate to this nonprofit project. Your donation will let us provide you with more data and improved service.

Advanced Search

181 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Synthesis of new thiazolo-celecoxib analogues as dual cyclooxygenase-2/15-lipoxygenase inhibitors: Determination of regio-specific different pyrazole cyclization by 2D NMR.EBI
Beni-Suef University
Isomeric iodinated analogs of nimesulide: Synthesis, physicochemical characterization, cyclooxygenase-2 inhibitory activity, and transport across Caco-2 cells.EBI
Tohoku Medical And Pharmaceutical University
Design, synthesis of 2,3-disubstitued 4(3H)-quinazolinone derivatives as anti-inflammatory and analgesic agents: COX-1/2 inhibitory activities and molecular docking studies.EBI
King Saud University
Rational Design of Small Peptides for Optimal Inhibition of Cyclooxygenase-2: Development of a Highly Effective Anti-Inflammatory Agent.EBI
Guru Nanak Dev University
Synthesis, anti-inflammatory, analgesic and COX-1/2 inhibition activities of anilides based on 5,5-diphenylimidazolidine-2,4-dione scaffold: Molecular docking studies.EBI
King Saud University
Design and synthesis of [(125)I]Pyricoxib: A novel (125)I-labeled cyclooxygenase-2 (COX-2) inhibitors.EBI
University Of Alberta
Potent multitarget FAAH-COX inhibitors: Design and structure-activity relationship studies.EBI
Fondazione Istituto Italiano Di Tecnologia
Synthesis, anti-inflammatory, analgesic, COX-1/2 inhibition activities and molecular docking study of pyrazoline derivatives.EBI
University Of Mansoura
Anti-inflammatory and antioxidant properties of a novel resveratrol-salicylate hybrid analog.EBI
University Of Alberta
Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of new 1,3,5-triarylpyrazoline and 1,5-diarylpyrazole derivatives as selective COX-2 inhibitors.EBI
Beni-Suef University
Isomeric methoxy analogs of nimesulide for development of brain cyclooxygense-2 (COX-2)-targeted imaging agents: Synthesis, in vitro COX-2-inhibitory potency, and cellular transport properties.EBI
Tohoku Pharmaceutical University
Dicarabrol, a new dimeric sesquiterpene from Carpesium abrotanoides L.EBI
Hunan University Of Chinese Medicine
Synthesis, characterization, evaluation and molecular dynamics studies of 5, 6-diphenyl-1,2,4-triazin-3(2H)-one derivatives bearing 5-substituted 1,3,4-oxadiazole as potential anti-inflammatory and analgesic agents.EBI
Indian Institute Of Technology (Banaras Hindu University)
Novel (pyrazolyl)benzenesulfonamides with a nitric oxide-releasing moiety as selective cyclooxygenase-2 inhibitors.EBI
Technische Universitat Dresden
Indole based peptidomimetics as anti-inflammatory and anti-hyperalgesic agents: Dual inhibition of 5-LOX and COX-2 enzymes.EBI
Guru Nanak Dev University
General role of the amino and methylsulfamoyl groups in selective cyclooxygenase(COX)-1 inhibition by 1,4-diaryl-1,2,3-triazoles and validation of a predictive pharmacometric PLS model.EBI
Universit£
Compounds from the insect Blaps japanensis with COX-1 and COX-2 inhibitory activities.EBI
Chinese Academy Of Sciences
Structure-based design of phthalimide derivatives as potential cyclooxygenase-2 (COX-2) inhibitors: anti-inflammatory and analgesic activities.EBI
King Saud University
Novel thiazolo[3,2-b]-1,2,4-triazoles derived from naproxen with analgesic/anti-inflammatory properties: Synthesis, biological evaluation and molecular modeling studies.EBI
Hacettepe University
Five new phorbol esters with cytotoxic and selective anti-inflammatory activities from Croton tiglium.EBI
Hunan University Of Chinese Medicine
SAR-studies of¿-secretase modulators with PPAR¿-agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer's disease.EBI
Goethe-University Frankfurt
Design, synthesis and molecular docking study of novel quinoxalin-2(1H)-ones as anti-tumor active agents with inhibition of tyrosine kinase receptor and studying their cyclooxygenase-2 activity.EBI
Dokki
Potent, orally available, selective COX-2 inhibitors based on 2-imidazoline core.EBI
Griffith University
Pharmacological evaluation and docking studies ofa,ß-unsaturated carbonyl based synthetic compounds as inhibitors of secretory phospholipase A2, cyclooxygenases, lipoxygenase and proinflammatory cytokines.EBI
Universiti Kebangsaan Malaysia
Rational design, synthesis and evaluation of chromone-indole and chromone-pyrazole based conjugates: identification of a lead for anti-inflammatory drug.EBI
Guru Nanak Dev University
Part I. Synthesis, biological evaluation and docking studies of new 2-furylbenzimidazoles as antiangiogenic agents.EBI
National Research Centre, Dokki
Synthesis and evaluation of new indole-based chalcones as potential antiinflammatory agents.EBI
Anadolu University
Synthesis of novel pyrazole?thiadiazole hybrid as potential potent and selective cyclooxygenase-2 (COX-2) inhibitors.EBI
Kle University
Design of Fluorine-Containing 3,4-Diarylfuran-2(5H)-ones as Selective COX-1 Inhibitors.EBI
Vanderbilt University School Of Medicine
Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors.EBI
Minia University
Synthesis, biological evaluation and docking analysis of 3-methyl-1-phenylchromeno[4,3-c]pyrazol-4(1H)-ones as potential cyclooxygenase-2 (COX-2) inhibitors.EBI
National Institute Of Pharmaceutical Education And Research
Novel 1-[4-(Aminosulfonyl)phenyl]-1H-1,2,4-triazole derivatives with remarkable selective COX-2 inhibition: design, synthesis, molecular docking, anti-inflammatory and ulcerogenicity studies.EBI
Minia University
2-(2-Arylphenyl)benzoxazole As a Novel Anti-Inflammatory Scaffold: Synthesis and Biological Evaluation.EBI
National Institute Of Pharmaceutical Education And Research (Niper)
Tetra- and pentacyclic triterpene acids from the ancient anti-inflammatory remedy frankincense as inhibitors of microsomal prostaglandin E(2) synthase-1.EBI
University Of Tuebingen
Design and synthesis of novel 2-phenyl-5-(1,3-diphenyl-1H-pyrazol-4-yl)-1,3,4-oxadiazoles as selective COX-2 inhibitors with potent anti-inflammatory activity.EBI
Shoolini University
Synthesis, biological evaluation, molecular docking and theoretical evaluation of ADMET properties of nepodin and chrysophanol derivatives as potential cyclooxygenase (COX-1, COX-2) inhibitors.EBI
National Institute Of Pharmaceutical Education And Research
Synthesis, pharmacological screening and in silico studies of new class of Diclofenac analogues as a promising anti-inflammatory agents.EBI
K.L.E.U'S College Of Pharmacy
Synthesis, biological evaluation, and docking analysis of a novel family of 1-methyl-1H-pyrrole-2,5-diones as highly potent and selective cyclooxygenase-2 (COX-2) inhibitors.EBI
Kyung Hee University
Structure-activity relationship of celecoxib and rofecoxib for the membrane permeabilizing activity.EBI
Keio University
1-(4-Methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazole-3-carboxamides: synthesis, molecular modeling, evaluation of their anti-inflammatory activity and ulcerogenicity.EBI
Minia University
Synthesis and biological evaluation of new pyrazolone-pyridazine conjugates as anti-inflammatory and analgesic agents.EBI
Cairo University
Synthesis and biological evaluation of some 5-arylidene-2-(1,3-thiazol-2-ylimino)-1,3-thiazolidin-4-ones as dual anti-inflammatory/antimicrobial agents.EBI
Department Of Pharmaceutical Chemistry Of Aristotle University Of Thessaloniki
Hybrid fluorescent conjugates of COX-2 inhibitors: search for a COX-2 isozyme imaging cancer biomarker.EBI
University Of Alberta
Inhibitory mode of 1,5-diarylpyrazole derivatives against cyclooxygenase-2 and cyclooxygenase-1: molecular docking and 3D QSAR analyses.EBI
Chinese Academy Of Sciences
Identification and characterization of carprofen as a multitarget fatty acid amide hydrolase/cyclooxygenase inhibitor.EBI
Istituto Italiano Di Tecnologia
Design and synthesis of indomethacin analogues that inhibit P-glycoprotein and/or multidrug resistant protein without COX inhibitory activity.EBI
Hokkaido University
Synthesis and pharmacological evaluation of N-substituted 2-(2-oxo-2H-chromen-4-yloxy)propanamide as cyclooxygenase inhibitors.EBI
University Of Hyderabad Campus
Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro.EBI
University Of Innsbruck
Molecular modeling, synthesis and screening of some new 4-thiazolidinone derivatives with promising selective COX-2 inhibitory activity.EBI
Hacettepe University
Radiosynthesis of a¹8F-labeled 2,3-diarylsubstituted indole via McMurry coupling for functional characterization of cyclooxygenase-2 (COX-2) in vitro and in vivo.EBI
Helmholtz-Zentrum Dresden-Rossendorf
Binding of ibuprofen, ketorolac, and diclofenac to COX-1 and COX-2 studied by saturation transfer difference NMR.EBI
Faculdade De Ci�Ncias E Tecnologia-Unl
Synthesis, biological evaluation and molecular modeling study of pyrazole and pyrazoline derivatives as selective COX-2 inhibitors and anti-inflammatory agents. Part 2.EBI
University Of Mansoura
Synthesis and biological evaluation of isoxazolo[4,5-d]pyridazin-4-(5H)-one analogues as potent anti-inflammatory agents.EBI
University Of Hacettepe
Ethanesulfohydroxamic acid ester prodrugs of nonsteroidal anti-inflammatory drugs (NSAIDs): synthesis, nitric oxide and nitroxyl release, cyclooxygenase inhibition, anti-inflammatory, and ulcerogenicity index studies.EBI
University Of Alberta
[I]-Celecoxib Analogues as SPECT Tracers of Cyclooxygenase-2 in Inflammation.EBI
TBA
In silico search for multi-target anti-inflammatories in Chinese herbs and formulas.EBI
King'S College London
COX, LOX and platelet aggregation inhibitory properties of Lauraceae neolignans.EBI
Universidad Nacional De Colombia
Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-carboxymethylphenyl)-1-(4-methanesulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its aminosulfonyl analog: Synthesis, biological evaluation and nitric oxide release studies.EBI
University Of Alberta
Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.EBI
Eberhard Karls University Tuebingen
Mechanism-based inactivation of COX-1 by red wine m-hydroquinones: a structure-activity relationship study.EBI
University Of Pennsylvania School Of Medicine
Design, synthesis, and biological evaluation of 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors.EBI
Temple University School Of Medicine
Molecular determinants for the selective inhibition of cyclooxygenase-2 by lumiracoxib.EBI
Vanderbilt Institute For Chemical Biology
Synthesis and cyclooxygenase inhibitory activities of linear 1-(methanesulfonylphenyl or benzenesulfonamido)-2-(pyridyl)acetylene regioisomers.EBI
University Of Alberta
Diazen-1-ium-1,2-diolated and nitrooxyethyl nitric oxide donor ester prodrugs of anti-inflammatory (E)-2-(aryl)-3-(4-methanesulfonylphenyl)acrylic acids: synthesis, cyclooxygenase inhibition, and nitric oxide release studies.EBI
University Of Alberta
Synthesis and biological evaluation of 1,3-diphenylprop-2-yn-1-ones as dual inhibitors of cyclooxygenases and lipoxygenases.EBI
University Of Alberta
Design, synthesis, biological evaluation and molecular docking of curcumin analogues as antioxidant, cyclooxygenase inhibitory and anti-inflammatory agents.EBI
National Institute Of Pharmaceutical Education And Research (Niper)
Design, synthesis, and biological evaluation of 6-substituted-3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors.EBI
University Of Alberta
1-substituted 4-aryl-5-pyridinylimidazoles: a new class of cytokine suppressive drugs with low 5-lipoxygenase and cyclooxygenase inhibitory potency.EBI
Smithkline Beecham Pharmaceuticals
Antiinflammatory 4,5-diarylpyrroles. 2. Activity as a function of cyclooxygenase-2 inhibition.EBI
Dupont Pharmaceuticals
Synthesis and evaluation of fluorobenzoylated di- and tripeptides as inhibitors of cyclooxygenase-2 (COX-2).EBI
University Of Alberta
N-1 and C-3 substituted indole Schiff bases as selective COX-2 inhibitors: synthesis and biological evaluation.EBI
University Of Alberta
Novel 5-substituted 1H-tetrazoles as cyclooxygenase-2 (COX-2) inhibitors.EBI
University Of Alberta
Nitric oxide release is not required to decrease the ulcerogenic profile of nonsteroidal anti-inflammatory drugs.EBI
University Of Alberta
Fragment-based design, docking, synthesis, biological evaluation and structure-activity relationships of 2-benzo/benzisothiazolimino-5-aryliden-4-thiazolidinones as cycloxygenase/lipoxygenase inhibitors.EBI
Alexander Technological Education Institute Of Thessaloniki
Isomeric acetoxy analogs of celecoxib and their evaluation as cyclooxygenase inhibitors.EBI
University Of Alberta
Inhibition of COX-1 activity and COX-2 expression by 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans propenoic acid and its semi-synthetic derivatives.EBI
Universit£
SAR studies of acidic dual¿-secretase/PPAR¿ modulators.EBI
Goethe-University Frankfurt
Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.EBI
National Human Genome Research Institute
A diazen-1-ium-1,2-diolated nitric oxide donor ester prodrug of 3-(4-hydroxymethylphenyl)-4-(4-methanesulfonylphenyl)-5H-furan-2-one: synthesis, biological evaluation and nitric oxide release studies.EBI
University Of Alberta
Design and synthesis of 3-alkyl-2-aryl-1,3-thiazinan-4-one derivatives as selective cyclooxygenase (COX-2) inhibitors.EBI
Shahid Beheshti University (M.C)
Design, synthesis, and biological evaluation of substituted hydrazone and pyrazole derivatives as selective COX-2 inhibitors: Molecular docking study.EBI
University Of Mansoura
Synthesis and evaluation of carbaborane derivatives of indomethacin as cyclooxygenase inhibitors.EBI
Universit£T Leipzig
Natural compound cudraflavone B shows promising anti-inflammatory properties in vitro.EBI
University Of Veterinary And Pharmaceutical Sciences Brno
Synthesis, anti-inflammatory activity and COX-1/COX-2 inhibition of novel substituted cyclic imides. Part 1: Molecular docking study.EBI
King Saud University
Syntheses and characterization of nimesulide derivatives for dual enzyme inhibitors of both cyclooxygenase-1/2 and 5-lipoxygenase.EBI
Sun Yat-Sen University
Synthesis and evaluation of 1,5-diaryl-substituted tetrazoles as novel selective cyclooxygenase-2 (COX-2) inhibitors.EBI
University Of Alberta
Design of novel N-phenylnicotinamides as selective cyclooxygenase-1 inhibitors.EBI
Nanjing University
Ipomotaosides A-D, resin glycosides from the aerial parts of Ipomoea batatas and their inhibitory activity against COX-1 and COX-2.EBI
Tokushima Bunri University
Synthesis and biological evaluation of indomethacin analogs possessing a N-difluoromethyl-1,2-dihydropyrid-2-one ring system: a search for novel cyclooxygenase and lipoxygenase inhibitors.EBI
University Of Alberta
Synthesis, anti-inflammatory activity, and in vitro antitumor effect of a novel class of cyclooxygenase inhibitors: 4-(aryloyl)phenyl methyl sulfones.EBI
Universitat De Barcelona
Design, synthesis and biological evaluation of new (E)- and (Z)-1,2,3-triaryl-2-propen-1-ones as selective COX-2 inhibitors.EBI
Shahid Beheshti University Of Medical Sciences
Synthesis, biological evaluation, and docking studies of novel heterocyclic diaryl compounds as selective COX-2 inhibitors.EBI
Gazi University
Triaryl (Z)-olefins suitable for radiolabeling with carbon-11 or fluorine-18 radionuclides for positron emission tomography imaging of cyclooxygenase-2 expression in pathological disease.EBI
University Of Alberta
Celecoxib prodrugs possessing a diazen-1-ium-1,2-diolate nitric oxide donor moiety: synthesis, biological evaluation and nitric oxide release studies.EBI
University Of Alberta
Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites.EBI
Purdue University
Design, synthesis, and biological evaluation of a novel class of gamma-secretase modulators with PPARgamma activity.EBI
Zafes/Liff/Goethe University Frankfurt
Mono-, di-, and triaryl substituted tetrahydropyrans as cyclooxygenase-2 and tumor growth inhibitors. Synthesis and biological evaluation.EBI
Guru Nanak Dev University
Derivatives of schisandrin with increased inhibitory potential on prostaglandin E(2) and leukotriene B(4) formation in vitro.EBI
University Of Graz
Synthesis and biological evaluation of N-difluoromethyl-1,2-dihydropyrid-2-one acetic acid regioisomers: dual inhibitors of cyclooxygenases and 5-lipoxygenase.EBI
University Of Alberta
Podophyllotoxin analogues active versus Trypanosoma brucei.EBI
Vanderbilt University School Of Medicine
Phenylacetic acid regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.EBI
University Of Alberta
Celecoxib analogs possessing a N-(4-nitrooxybutyl)piperidin-4-yl or N-(4-nitrooxybutyl)-1,2,3,6-tetrahydropyridin-4-yl nitric oxide donor moiety: synthesis, biological evaluation and nitric oxide release studies.EBI
University Of Alberta
Design, synthesis and biological evaluation of new 2,3-diarylquinoline derivatives as selective cyclooxygenase-2 inhibitors.EBI
Shahid Beheshti University Mc
Synthesis and biological evaluation of new 4-carboxyl quinoline derivatives as cyclooxygenase-2 inhibitors.EBI
Shahid Beheshti University (M.C)
Fenbufen based 3-[5-(substituted aryl)-1,3,4-oxadiazol-2-yl]-1-(biphenyl-4-yl)propan-1-ones as safer antiinflammatory and analgesic agents.EBI
Hamdard University
7-Azaindole-3-acetic acid derivatives: potent and selective CRTh2 receptor antagonists.EBI
Novartis Institutes Of Biomedical Research
Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4-formation.EBI
Karl-Franzens-Universit£T Graz
Design and synthesis of new 1,3-benzthiazinan-4-one derivatives as selective cyclooxygenase (COX-2) inhibitors.EBI
Shahid Beheshti University (M.C)
 
Chemistry and pharmacokinetics of diarylthiophenes and terphenyls as selective COX-2 inhibitorsEBI
TBA
Dinitroglyceryl and diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of aspirin, indomethacin and ibuprofen: synthesis, biological evaluation and nitric oxide release studies.EBI
University Of Alberta
Synthesis of 1-(methanesulfonyl- and aminosulfonylphenyl)acetylenes that possess a 2-(N-difluoromethyl-1,2-dihydropyridin-2-one) pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.EBI
University Of Alberta
Synthesis and biological evaluation of 4,5-diphenyloxazolone derivatives on route towards selective COX-2 inhibitors.EBI
Gazi University
Synthesis of celecoxib analogs that possess a N-hydroxypyrid-2(1H)one 5-lipoxygenase pharmacophore: biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.EBI
University Of Alberta
Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-hydroxymethylphenyl)-1-(4-aminosulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its methanesulfonyl analog: synthesis, biological evaluation and nitric oxide release studies.EBI
University Of Alberta
Design, synthesis and evaluation of tetrahydropyran based COX-1/-2 inhibitors.EBI
Guru Nanak Dev University
Nitrogen-containing phorbol esters from Croton ciliatoglandulifer and their effects on cyclooxygenases-1 and -2.EBI
Centro De Investigaciones QuíMicas De La Universidad AutóNoma Del Estado De Morelos
Anti-inflammatory acylphloroglucinol derivatives from Hops (Humulus lupulus).EBI
Fr. 8.2 Pharmakognosie Und Analytische Phytochemie Der UniversitäT Des Saarlandes
Lanostane triterpenoids and triterpene glycosides from the fruit body of Fomitopsis pinicola and their inhibitory activity against COX-1 and COX-2.EBI
Tokushima Bunri University
Two new prenylated 3-benzoxepin derivatives as cyclooxygenase inhibitors from Perilla frutescens var. acuta.EBI
Columbia University
Design and synthesis of 1,3-diarylurea derivatives as selective cyclooxygenase (COX-2) inhibitors.EBI
Shaheed Beheshti University Of Medical Sciences
New celecoxib derivatives as anti-inflammatory agents.EBI
Gedeon Richter
1-Toluene-sulfonyl-3-[(3'-hydroxy-5'-substituted)-gamma-butyrolactone]-indoles: synthesis, COX-2 inhibition and anti-cancer activities.EBI
Guru Nanak Dev University
Synthesis and biological evaluation of 2-trifluoromethyl/sulfonamido-5,6-diaryl substituted imidazo[2,1-b]-1,3,4-thiadiazoles: a novel class of cyclooxygenase-2 inhibitors.EBI
The University Of The West Indies
Novel (E)-2-(aryl)-3-(4-methanesulfonylphenyl)acrylic ester prodrugs possessing a diazen-1-ium-1,2-diolate moiety: design, synthesis, cyclooxygenase inhibition, and nitric oxide release studies.EBI
University Of Alberta
'Bridged' stilbene derivatives as selective cyclooxygenase-1 inhibitors.EBI
University Of Vienna
O2-acetoxymethyl-protected diazeniumdiolate-based NSAIDs (NONO-NSAIDs): synthesis, nitric oxide release, and biological evaluation studies.EBI
National Cancer Institute At Frederick
Design, synthesis, and biological evaluation of substituted 2-alkylthio-1,5-diarylimidazoles as selective COX-2 inhibitors.EBI
Tehran University Of Medical Sciences
Analgesic agents without gastric damage: design and synthesis of structurally simple benzenesulfonanilide-type cyclooxygenase-1-selective inhibitors.EBI
Okayama University Graduate School Of Medicine
Synthesis and biological evaluation of methanesulfonamide analogues of rofecoxib: Replacement of methanesulfonyl by methanesulfonamido decreases cyclooxygenase-2 selectivity.EBI
University Of Alberta Edmonton
Design and synthesis of new water-soluble tetrazolide derivatives of celecoxib and rofecoxib as selective cyclooxygenase-2 (COX-2) inhibitors.EBI
Tehran University Of Medical Sciences
Novel nonsteroidal antiinflammatory drugs possessing a nitric oxide donor diazen-1-ium-1,2-diolate moiety: design, synthesis, biological evaluation, and nitric oxide release studies.EBI
University Of Alberta
Stereoselective binding of indomethacin ethanolamide derivatives to cyclooxygenase-1.EBI
Vanderbilt University
Design and synthesis of (E)-1,1,2-triarylethenes: novel inhibitors of the cyclooxygenase-2 (COX-2) isozyme.EBI
University Of Alberta
A new class of acyclic 2-alkyl-1,1,2-triaryl (Z)-olefins as selective cyclooxygenase-2 inhibitors.EBI
University Of Alberta
Novel cyclooxygenase-1 inhibitors discovered using affinity fingerprints.EBI
Telik
A new class of acyclic 2-alkyl-1,2-diaryl (E)-olefins as selective cyclooxygenase-2 (COX-2) inhibitors.EBI
University Of Alberta
Design, synthesis, and structure-activity relationship studies of 3,4,6-triphenylpyran-2-ones as selective cyclooxygenase-2 inhibitors.EBI
University Of Alberta
Sulfonamido, azidosulfonyl and N-acetylsulfonamido analogues of rofecoxib: 4-[4-(N-acetylsulfonamido)phenyl]-3-(4-methanesulfonylphenyl)-2(5H)furanone is a potent and selective cyclooxygenase-2 inhibitor.EBI
University Of Alberta
Design of acyclic triaryl olefins: a new class of potent and selective cyclooxygenase-2 (COX-2) inhibitors.EBI
University Of Alberta
Methanesulfonamide group at position-4 of the C-5-phenyl ring of 1,5-diarylpyrazole affords a potent class of cyclooxygenase-2 (COX-2) inhibitors.EBI
Discovery Research-Dr. Reddy'S Laboratories
Synthesis and evaluation of S-4-(3-thienyl)phenyl-alpha-methylacetic acid.EBI
National Institute Of Pharmaceutical Education And Research
Manipulation of kinetic profiles in 2-aryl propionic acid cyclooxygenase inhibitors.EBI
Drexel University College Of Medicine
Polar substitutions in the benzenesulfonamide ring of celecoxib afford a potent 1,5-diarylpyrazole class of COX-2 inhibitors.EBI
Discovery Research-Dr. Reddy'S Laboratories
1,2-Diaryl-1-ethanone and pyrazolo [4,3-c] quinoline-4-one as novel selective cyclooxygenase-2 inhibitors.EBI
Dr. Reddy'S Laboratories
Synthesis and cyclooxygenase-2 inhibiting property of 1,5-diarylpyrazoles with substituted benzenesulfonamide moiety as pharmacophore: Preparation of sodium salt for injectable formulation.EBI
Dr. Reddy'S Laboratories
6-Alkyl, alkoxy, or alkylthio-substituted 3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors.EBI
University Of Alberta
SAR of 2,6-diamino-3,5-difluoropyridinyl substituted heterocycles as novel p38MAP kinase inhibitors.EBI
Novartis Pharma
Enantiospecific, selective cyclooxygenase-2 inhibitors.EBI
Vanderbilt University School Of Medicine
Thalidomide and its analogues as cyclooxygenase inhibitors.EBI
The University Of Tokyo
Amide derivatives of meclofenamic acid as selective cyclooxygenase-2 inhibitors.EBI
Vanderbilt University School Of Medicine
Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors.EBI
Vanderbilt University School Of Medicine
SAR of 4-hydroxypiperidine and hydroxyalkyl substituted heterocycles as novel p38 map kinase inhibitors.EBI
Novartis Pharma
N-hydroxyurea and hydroxamic acid inhibitors of cyclooxygenase and 5-lipoxygenase.EBI
The R. W. Johnson Pharmaceutical Research Institute
Terphenyl cyclooxygenase-2 (COX-2) inhibitors: optimization of the central ring and o-biphenyl analogs.EBI
Dupont Pharmaceuticals
Structure-based design of COX-2 selectivity into flurbiprofen.EBI
Merck Frosst Canada
Covalent modification of cyclooxygenase-2 (COX-2) by 2-acetoxyphenyl alkyl sulfides, a new class of selective COX-2 inactivators.EBI
Center In Molecular Toxicology And The Vanderbilt Cancer Center
Design, synthesis, and biological evaluation of conformationally constrained aci-reductone mimics of arachidonic acid.EBI
Oxis International
Biotransformation of dehydroepiandrosterone with Macrophomina phaseolina and ß-glucuronidase inhibitory activity of transformed products.BDB
University Of Karachi
Effects of dopaminergic compounds on carbonic anhydrase isozymes I, II, and VI.BDB
Agri Ibrahim Cecen University
Synthesis, Biological Evaluation, and Molecular Docking of 8-imino-2-oxo-2H,8H-pyrano[2,3-f]chromene Analogs: New Dual AChE Inhibitors as Potential Drugs for the Treatment of Alzheimer's Disease.BDB
Yogi Vemana University