PMID

Data

Article Title

Organization

Novel acetamidothiazole derivatives: synthesis and in vitro anticancer evaluation.

University Of Mansoura

Identification of benzofuran central cores for the inhibition of leukotriene A(4) hydrolase.

Janssen Research And Development

Optimization of 5-hydroxytryptamines as dual function inhibitors targeting phospholipase A2 and leukotriene A4 hydrolase.

Peking University

Azabenzthiazole inhibitors of leukotriene A4 hydrolase.

Janssen Research And Development

Rapid and efficient synthesis of a novel series of substituted aminobenzosuberone derivatives as potent, selective, non-peptidic neutral aminopeptidase inhibitors.

Universit£

Synthesis of potent leukotriene A(4) hydrolase inhibitors. Identification of 3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid.

Pfizer

Structure-activity relationship studies on 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a potent inhibitor of leukotriene A(4) (LTA(4)) hydrolase.

Searle Research And Development

 

Kelatorphan and related analogs: potent and selective inhibitors of leukotriene A4 hydrolase

TBA

 

Probing the inhibition of leukotriene A4 hydrolase based on its aminopeptidase activity

TBA

5-Lipoxygenase-activating protein (FLAP) inhibitors. Part 4: development of 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid (AM803), a potent, oral, once daily FLAP inhibitor.

Amira Pharmaceuticals

Discovery of dual target inhibitors against cyclooxygenases and leukotriene A4 hydrolyase.

Peking University

Pharmacophore-based virtual screening and Bayesian model for the identification of potential human leukotriene A4 hydrolase inhibitors.

Gyeongsang National University (Gnu)

Amino-benzosuberone: a novel warhead for selective inhibition of human aminopeptidase-N/CD13.

Merck Sharpe And Dohme

Discovery of novel leukotriene A4 hydrolase inhibitors based on piperidine and piperazine scaffolds.

Decode Chemistry

Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis.

Decode Chemistry

Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography.

Decode Biostructures

Isolation and structure of leukotriene-A4 hydrolase inhibitor: 8(S)-amino-2(R)-methyl-7-oxononanoic acid produced by Streptomyces diastaticus.

Searle Research And Development

Discovery of multitarget inhibitors by combining molecular docking with common pharmacophore matching.

Peking University

Activation and inhibition of leukotriene A4 hydrolase aminopeptidase activity by diphenyl ether and derivatives.

Peking University

Synthesis and biological evaluation of N-mercaptoacylproline and N-mercaptoacylthiazolidine-4-carboxylic acid derivatives as leukotriene A4 hydrolase inhibitors.

Santen Pharmaceutical

Discovery of novel and potent aryl diamines as leukotriene A4 hydrolase inhibitors.

Berlex Biosciences

Synthesis of N-alkyl glycine amides as potent inhibitors of leukotriene A4 hydrolase.

Berlex Biosciences

Synthesis of imidazopyridines and purines as potent inhibitors of leukotriene A4 hydrolase.

Pfizer

Pyrrolidine and piperidine analogues of SC-57461A as potent, orally active inhibitors of leukotriene A(4) hydrolase.

Pharmacia

Development of selective tight-binding inhibitors of leukotriene A4 hydrolase.

Scripps Research Institute