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58 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Discovery of novel, high potent, ABC type PTP1B inhibitors with TCPTP selectivity and cellular activity.EBI
Qilu University Of Technology
Design, synthesis and in vitro activity of phidianidine B derivatives as novel PTP1B inhibitors with specific selectivity.EBI
Shanghai Institute Of Materia Medica
Novel, potent, selective and cellular active ABC type PTP1B inhibitors containing (methanesulfonyl-phenyl-amino)-acetic acid methyl ester phosphotyrosine mimetic.EBI
Qilu University Of Technology
Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors.EBI
Indiana University School Of Medicine
Discovery of novel, potent, selective and cellular active ADC type PTP1B inhibitors via fragment-docking-oriented de novel design.EBI
Qilu University Of Technology
Perspective: Tyrosine phosphatases as novel targets for antiplatelet therapy.EBI
Sanford-Burnham Medical Research Institute
A potent and selective inhibitor for the UBLCP1 proteasome phosphatase.EBI
Indiana University
Synthesis and biological evaluation of novel thiadiazole amides as potent Cdc25B and PTP1B inhibitors.EBI
Liaoning Normal University
Bioactive constituents from the green alga Caulerpa racemosa.EBI
Nanchang University
Design, synthesis, and biological evaluation of novel 2-ethyl-5-phenylthiazole-4-carboxamide derivatives as protein tyrosine phosphatase 1B inhibitors with improved cellular efficacy.EBI
Chinese Academy Of Sciences
Substrate-based fragment identification for the development of selective, nonpeptidic inhibitors of striatal-enriched protein tyrosine phosphatase.EBI
Yale University
Calix[4]arene methylenebisphosphonic acids as inhibitors of protein tyrosine phosphatase 1B.EBI
National Academy Of Sciences Of Ukraine
Identification of cryptotanshinone as an inhibitor of oncogenic protein tyrosine phosphatase SHP2 (PTPN11).EBI
Case Western Reserve University
The first synthesis of natural disulfide bruguiesulfurol and biological evaluation of its derivatives as a novel scaffold for PTP1B inhibitors.EBI
Chinese Academy Of Sciences
Discovery and evaluation of novel inhibitors of mycobacterium protein tyrosine phosphatase B from the 6-Hydroxy-benzofuran-5-carboxylic acid scaffold.EBI
Indiana University School Of Medicine
Discovery of di-indolinone as a novel scaffold for protein tyrosine phosphatase 1B inhibitors.EBI
East China University Of Science And Technology
Antidiabetic activity of some pentacyclic acid triterpenoids, role of PTP-1B: in vitro, in silico, and in vivo approaches.EBI
Universidad Aut£Noma Del Estado De Morelos
Bromophenols as inhibitors of protein tyrosine phosphatase 1B with antidiabetic properties.EBI
Chinese Academy Of Sciences
Identification and characterization of novel inhibitors of mPTPB, an essential virulent phosphatase from Mycobacterium tuberculosis.EBI
Indiana University School Of Medicine
Novel thiophene derivatives as PTP1B inhibitors with selectivity and cellular activity.EBI
Chinese Academy Of Sciences
5-Arylidene-2,4-thiazolidinediones as inhibitors of protein tyrosine phosphatases.EBI
Universit£
Click to a focused library of benzyl 6-triazolo(hydroxy)benzoic glucosides: novel construction of PTP1B inhibitors on a sugar scaffold.EBI
East China University Of Science And Technology
Novel thiazolidinedione derivatives with anti-obesity effects: dual action as PTP1B inhibitors and PPAR-¿ activators.EBI
Inha University
Small molecule inhibitors of SHP2 tyrosine phosphatase discovered by virtual screening.EBI
Indiana University
Facile fabrication of promising protein tyrosine phosphatase (PTP) inhibitor entities based on 'clicked' serine/threonine-monosaccharide hybrids.EBI
East China University Of Science And Technology
Utilization of nitrophenylphosphates and oxime-based ligation for the development of nanomolar affinity inhibitors of the Yersinia pestis outer protein H (YopH) phosphatase.EBI
National Cancer Institute-Frederick
A unique and rapid approach toward the efficient development of novel protein tyrosine phosphatase (PTP) inhibitors based on 'clicked' pseudo-glycopeptides.EBI
East China University Of Science And Technology
Inhibition of lymphoid tyrosine phosphatase by benzofuran salicylic acids.EBI
Sanford-Burnham Medical Research Institute
Synthesis and evaluation of some novel dibenzo[b,d]furan carboxylic acids as potential anti-diabetic agents.EBI
Glenmark Research Center
Fragment-based discovery of selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA.EBI
University Of California
Isolation of the protein tyrosine phosphatase 1B inhibitory metabolite from the marine-derived fungus Cosmospora sp. SF-5060.EBI
Silla University
Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2).EBI
Indiana University School Of Medicine
Synthesis and biological evaluation of heterocyclic ring-substituted maslinic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B.EBI
East China Normal University
Knowledge-based characterization of similarity relationships in the human protein-tyrosine phosphatase family for rational inhibitor design.EBI
University Of Miami
Thiazolidinedione derivatives as PTP1B inhibitors with antihyperglycemic and antiobesity effects.EBI
Inha University
Synthesis and evaluation of some novel isochroman carboxylic acid derivatives as potential anti-diabetic agents.EBI
Glenmark Research Center
Oleanolic acid and its derivatives: new inhibitor of protein tyrosine phosphatase 1B with cellular activities.EBI
Chinese Academy Of Sciences
Illudalic acid as a potential LAR inhibitor: synthesis, SAR, and preliminary studies on the mechanism of action.EBI
Chinese Academy Of Sciences
Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: from the active site to the second phosphotyrosine binding site.EBI
Wyeth Research
Design and synthesis of potent, non-peptidic inhibitors of HPTPbeta.EBI
Procter & Gamble Pharmaceuticals
PTP-1B inhibitors: cyclopenta[d][1,2]-oxazine derivatives.EBI
Korea Research Institute Of Chemical Technology
Identification of a novel class of orally active pyrimido[5,4-3][1,2,4]triazine-5,7-diamine-based hypoglycemic agents with protein tyrosine phosphatase inhibitory activity.EBI
Roche Research Center
Discovery and SAR of novel, potent and selective protein tyrosine phosphatase 1B inhibitors.EBI
Abbott Laboratories
Selective protein tyrosine phosphatase 1B inhibitors: targeting the second phosphotyrosine binding site with non-carboxylic acid-containing ligands.EBI
Abbott Laboratories
Formylchromone derivatives as a novel class of protein tyrosine phosphatase 1B inhibitors.EBI
Inha University
Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B.EBI
Novo Nordisk
Divalent and trivalent alpha-ketocarboxylic acids as inhibitors of protein tyrosine phosphatases.EBI
Brown University
Synthesis and PTP1B inhibition of 1,2-naphthoquinone derivatives as potent anti-diabetic agents.EBI
Korea Research Institute Of Chemical Technology
Novel benzofuran and benzothiophene biphenyls as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties.EBI
Wyeth-Ayerst Research
PTP1B inhibition and antihyperglycemic activity in the ob/ob mouse model of novel 11-arylbenzo[b]naphtho[2,3-d]furans and 11-arylbenzo[b]naphtho[2,3-d]thiophenes.EBI
Wyeth-Ayerst Research
Secondary/tertiary benzenesulfonamides with inhibitory action against the cytosolic human carbonic anhydrase isoforms I and II.BDB
Ataturk University
A Molecular Dynamics Investigation of Mycobacterium tuberculosis Prenyl Synthases: Conformational Flexibility and Implications for Computer-aided Drug Discovery.BDB
University Of California San Diego
[3H]SCH 23390 labels both dopamine-1 and 5-hydroxytryptamine1c receptors in the choroid plexus.BDB
University Of Pennsylvania