44 articles for thisTarget
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Article Title
Organization
Perspective: Tyrosine phosphatases as novel targets for antiplatelet therapy.
Sanford-Burnham Medical Research Institute
Substrate-based fragment identification for the development of selective, nonpeptidic inhibitors of striatal-enriched protein tyrosine phosphatase.
Yale University
Calix[4]arene methylenebisphosphonic acids as inhibitors of protein tyrosine phosphatase 1B.
National Academy Of Sciences Of Ukraine
Identification of cryptotanshinone as an inhibitor of oncogenic protein tyrosine phosphatase SHP2 (PTPN11).
Case Western Reserve University
A potent and selective small-molecule inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases.
Indiana University School Of Medicine
Discovery and evaluation of novel inhibitors of mycobacterium protein tyrosine phosphatase B from the 6-Hydroxy-benzofuran-5-carboxylic acid scaffold.
Indiana University School Of Medicine
Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells.
University Of Southern California
Novel thiophene derivatives as PTP1B inhibitors with selectivity and cellular activity.
Chinese Academy Of Sciences
Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases.
Indiana University School Of Medicine
Discovery of [(3-bromo-7-cyano-2-naphthyl)(difluoro)methyl]phosphonic acid, a potent and orally active small molecule PTP1B inhibitor.
Merck Frosst Centre For Therapeutic Research
Syntheses and biological activities of a novel group of steroidal derived inhibitors for human Cdc25A protein phosphatase.
Georgia Institute Of Technology
Structure of protein tyrosine phosphatase 1B in complex with inhibitors bearing two phosphotyrosine mimetics.
University Of Waterloo
Naphthalenebis[alpha,alpha-difluoromethylenephosphonates] as potent inhibitors of protein tyrosine phosphatases.
University Of Toronto
Small molecule receptor protein tyrosine phosphatase¿ (RPTP¿) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop.
Bristol-Myers Squibb Research And Development
Small molecule inhibitors of SHP2 tyrosine phosphatase discovered by virtual screening.
Indiana University
Inhibition of lymphoid tyrosine phosphatase by benzofuran salicylic acids.
Sanford-Burnham Medical Research Institute
A protected l-bromophosphonomethylphenylalanine amino acid derivative (BrPmp) for synthesis of irreversible protein tyrosine phosphatase inhibitors.
University Of Alberta
Fragment-based discovery of selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA.
University Of California
Isolation of the protein tyrosine phosphatase 1B inhibitory metabolite from the marine-derived fungus Cosmospora sp. SF-5060.
Silla University
Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2).
Indiana University School Of Medicine
Multidentate small-molecule inhibitors of vaccinia H1-related (VHR) phosphatase decrease proliferation of cervix cancer cells.
Institute For Medical Research
Knowledge-based characterization of similarity relationships in the human protein-tyrosine phosphatase family for rational inhibitor design.
University Of Miami
Illudalic acid as a potential LAR inhibitor: synthesis, SAR, and preliminary studies on the mechanism of action.
Chinese Academy Of Sciences
A highly efficient route to enantiomerically pure l-N-Bz-Pmp(t-Bu)2-OH and incorporation into a peptide-based protein tyrosine phosphatase inhibitor.
University Of Southern California
Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: from the active site to the second phosphotyrosine binding site.
Wyeth Research
Development of molecular probes for second-site screening and design of protein tyrosine phosphatase inhibitors.
Institute For Medical Research
Design and synthesis of potent, non-peptidic inhibitors of HPTPbeta.
Procter & Gamble Pharmaceuticals
PTP-1B inhibitors: cyclopenta[d][1,2]-oxazine derivatives.
Korea Research Institute Of Chemical Technology
Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors.
Merck Frosst Centre For Therapeutic Research
The development of potent non-peptidic PTP-1B inhibitors.
Merck Frosst Centre For Therapeutic Research
Discovery and SAR of novel, potent and selective protein tyrosine phosphatase 1B inhibitors.
Abbott Laboratories
Selective protein tyrosine phosphatase 1B inhibitors: targeting the second phosphotyrosine binding site with non-carboxylic acid-containing ligands.
Abbott Laboratories
Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B.
Novo Nordisk
Divalent and trivalent alpha-ketocarboxylic acids as inhibitors of protein tyrosine phosphatases.
Brown University
Synthesis and PTP1B inhibition of 1,2-naphthoquinone derivatives as potent anti-diabetic agents.
Korea Research Institute Of Chemical Technology
Potent reversible inhibitors of the protein tyrosine phosphatase CD45.
Astrazeneca Pharmaceuticals
Synthesis and characterization of a potent and selective protein tyrosine phosphatase inhibitor, 2.
Taisho Pharmaceutical
PTP1B inhibition and antihyperglycemic activity in the ob/ob mouse model of novel 11-arylbenzo[b]naphtho[2,3-d]furans and 11-arylbenzo[b]naphtho[2,3-d]thiophenes.
Wyeth-Ayerst Research