PMID

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Article Title

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Design and synthesis of a new series of 3,5-disubstituted isoxazoles active against Trypanosoma cruzi and Leishmania amazonensis.

Federal University Of Santa Catarina

Applications of Fluorine in Medicinal Chemistry.

Bristol-Myers Squibb Research And Development

Dibenzosuberyl substituted polyamines and analogs of clomipramine as effective inhibitors of trypanothione reductase; molecular docking, and assessment of trypanocidal activities.

Canisius College

Synthesis and evaluation of the antiparasitic activity of bis-(arylmethylidene) cycloalkanones.

Universidade Federal De Minas Gerais

Inhibitors of Trypanosoma cruzi trypanothione reductase revealed by virtual screening and parallel synthesis.

Universit£T Heidelberg

Use of an additional hydrophobic binding site, the Z site, in the rational drug design of a new class of stronger trypanothione reductase inhibitor, quaternary alkylammonium phenothiazines.

University Of Manchester

Optimising inhibitors of trypanothione reductase using solid-phase chemistry.

University Of Southamton

Dihydroquinazolines as a novel class of Trypanosoma brucei trypanothione reductase inhibitors: discovery, synthesis, and characterization of their binding mode by protein crystallography.

University Of Dundee

A fast virtual screening approach to identify structurally diverse inhibitors of trypanothione reductase.

Universit£

Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity.

Monash University (Parkville Campus)

Discovery of novel and potent benzhydryl-tropane trypanocides highly selective for Trypanosoma cruzi.

Institute Of Medical Research

Neglected tropical diseases: multi-target-directed ligands in the search for novel lead candidates against Trypanosoma and Leishmania.

University Of Bologna

Privileged structure-guided synthesis of quinazoline derivatives as inhibitors of trypanothione reductase.

Alma Mater Studiorum-Bologna University

 

Novel polyamine derivatives as potent competitive inhibitors of Trypanosoma cruzi trypanothione reductase

TBA

 

Synthesis of non reducible inhibitors for trypanothione reductase from Trypanosoma cruzi.

TBA

The use of natural product scaffolds as leads in the search for trypanothione reductase inhibitors.

Pontificia Universidad Catolica Del Peru

Novel alkylpolyaminoguanidines and alkylpolyaminobiguanides with potent antitrypanosomal activity.

Wayne State University

Antitrypanosomal, antileishmanial, and antimalarial activities of quaternary arylalkylammonium 2-amino-4-chlorophenyl phenyl sulfides, a new class of trypanothione reductase inhibitor, and of N-acyl derivatives of 2-amino-4-chlorophenyl phenyl sulfide.

University Of Manchester

Irreversible inactivation of trypanothione reductase by unsaturated Mannich bases: a divinyl ketone as key intermediate.

Biochemie-Zentrum Der UniversitäT Heidelberg

Antitrypanosomal activities and cytotoxicity of 5-nitro-2-furancarbohydrazides.

Université

Antiprotozoal and cytotoxicity evaluation of sulfonamide and urea analogues of quinacrine.

University Of Cape Town

Polyamines with N-(3-phenylpropyl) substituents are effective competitive inhibitors of trypanothione reductase and trypanocidal agents.

Indiana State University

2- and 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: synthesis and correlation between redox cycling activities and in vitro cytotoxicity.

Umr 8525 Cnrs - Université

Parallel synthesis of a library of 1,4-naphthoquinones and automated screening of potential inhibitors of trypanothione reductase from Trypanosoma cruzi.

Université

Inhibition of Trypanosoma cruzi trypanothione reductase by acridines: kinetic studies and structure-activity relationships.

Heidelberg University

Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design.

Bristol-Myers Squibb

Structure-activity relationships in 2-aminodiphenylsulfides against trypanothione reductase from Trypanosoma cruzi.

Ura Cnrs 1309

Phenothiazine inhibitors of trypanothione reductase as potential antitrypanosomal and antileishmanial drugs.

University Of Manchester

Synthesis and 2D-QSAR studies of neolignan-based diaryl-tetrahydrofuran and -furan analogues with remarkable activity against Trypanosoma cruzi and assessment of the trypanothione reductase activity.

University Of S£O Paulo

Crassiflorone derivatives that inhibit Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH) and Trypanosoma cruzi trypanothione reductase (TcTR) and display trypanocidal activity.

University Of Bologna

Bistacrines as potential antitrypanosomal agents.

Julius-Maximilians-University Of W£Rzburg

Rational design of nitrofuran derivatives: Synthesis and valuation as inhibitors of Trypanosoma cruzi trypanothione reductase.

Universidad Nacional Del Litoral

The molecular basis of inhibition of Golgi alpha-mannosidase II by mannostatin A.

University Of Toronto