PMID

Data

Article Title

Organization

Synthesis and evaluation of methylsulfonylnitrobenzamides (MSNBAs) as inhibitors of the thyroid hormone receptor-coactivator interaction.

St. Jude Children'S Research Hospital

Development of silicon-containing bis-phenol derivatives as androgen receptor antagonists: selectivity switching by C/Si exchange.

The University Of Tokyo

Structure-activity relationship of benzodiazepine derivatives as LXXLL peptide mimetics that inhibit the interaction of vitamin D receptor with coactivators.

The University Of Tokyo

Synthesis and biological evaluation of halogenated curcumin analogs as potential nuclear receptor selective agonists.

Arizona State University

Further synthetic and biological studies on vitamin D hormone antagonists based on C24-alkylation and C2alpha-functionalization of 25-dehydro-1alpha-hydroxyvitamin D(3)-26,23-lactones.

Teikyo University

Practical synthesis and evaluation of the biological activities of 1alpha,25-dihydroxyvitamin D3 antagonists, 1alpha,25-dihydroxyvitamin D3-26,23-lactams. Designed on the basis of the helix 12-folding inhibition hypothesis.

University Of Tokyo

Synthesis and biological evaluation of 1a,25-dihydroxyvitamin D3 analogues with a long side chain at C12 and short C17 side chains.

Universidad De Santiago De Compostela

Structural basis for the accommodation of bis- and tris-aromatic derivatives in vitamin D nuclear receptor.

Institute Of Genetics And Molecular And Cellular Biology (Igbmc)

The many faces of the adamantyl group in drug design.

University Of Sydney

Discovery of the first irreversible small molecule inhibitors of the interaction between the vitamin D receptor and coactivators.

University Of Wisconsin-Milwaukee

Butyl pocket formation in the vitamin D receptor strongly affects the agonistic or antagonistic behavior of ligands.

Showa Pharmaceutical University

Novel selective anti-androgens with a diphenylpentane skeleton.

The University Of Tokyo

Vitamin D receptor agonist/histone deacetylase inhibitor molecular hybrids.

Mcgill University

2-Methylene 19-nor-25-dehydro-1alpha-hydroxyvitamin D3 26,23-lactones: synthesis, biological activities and molecular basis of passive antagonism.

Tokyo Medical And Dental University

(2S,2'R)-analogue of LG190178 is a major active isomer.

National Institute Of Health Sciences

22-Alkyl-20-epi-1alpha,25-dihydroxyvitamin D3 compounds of superagonistic activity: syntheses, biological activities and interaction with the receptor.

Tokyo Medical And Dental University

New dermatological agents for the treatment of psoriasis.

Allergan

Design, synthesis and X-ray crystallographic study of new nonsecosteroidal vitamin D receptor ligands.

National Institute Of Health Sciences

An o-aminoanilide analogue of 1a,25-dihydroxyvitamin D(3) functions as a strong vitamin D receptor antagonist.

Mcgill University

Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists.

Phenex Pharmaceuticals

LXXLL peptide mimetics as inhibitors of the interaction of vitamin D receptor with coactivators.

The University Of Tokyo

Synthesis and anti-inflammatory properties of 1alpha,25-dihydroxy-16-ene-20-cyclopropyl-24-oxo-vitamin D3, a hypocalcemic, stable metabolite of 1alpha,25-dihydroxy-16-ene-20-cyclopropyl-vitamin D3.

Bioxell

Crystal structures of rat vitamin D receptor bound to adamantyl vitamin D analogs: structural basis for vitamin D receptor antagonism and partial agonism.

Tokyo Medical And Dental University

Structure-activity relationship studies on vitamin D lactam derivatives as vitamin D receptor antagonist.

Tokyo University Of Agriculture And Technology

Low-calcemic, highly antiproliferative, 23-oxa ether analogs of the natural hormone 1 alpha,25-dihydroxyvitamin D3: design, synthesis, and preliminary biological evaluation.

The Johns Hopkins University

Low-calcemic, highly antiproliferative, 1-difluoromethyl hybrid analogs of the natural hormone 1alpha,25-dihydroxyvitamin D3: design, synthesis, and preliminary biological evaluation.

The University Of Texas

Structure-activity relationships of 19-norvitamin D analogs having a fluoroethylidene group at the C-2 position.

Tokyo Medical And Dental University

Vitamin D receptor: ligand recognition and allosteric network.

Tokyo Medical And Dental University

Crystal structures of the vitamin D nuclear receptor liganded with the vitamin D side chain analogues calcipotriol and seocalcitol, receptor agonists of clinical importance. Insights into a structural basis for the switching of calcipotriol to a receptor antagonist by further side chain modificatio

Institute Of Genetics And Molecular And Cellular Biology (Igbmc)

Bicyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors.

National Institutes Of Health