PMID

Data

Article Title

Organization

10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acids are selective inhibitors of DYRK1A.

Technische Universit£T Braunschweig

Acridone alkaloids from Glycosmis chlorosperma as DYRK1A inhibitors.

Institut De Chimie Des Substances Naturelles

Synthesis, biological evaluation and molecular docking studies of pyrazole derivatives coupling with a thiourea moiety as novel CDKs inhibitors.

Nanjing University

Selectivity data: assessment, predictions, concordance, and implications.

Eli Lilly

Structure-based optimization of oxadiazole-based GSK-3 inhibitors.

Technische Universit£T Darmstadt

Novel Inverse Binding Mode of Indirubin Derivatives Yields Improved Selectivity for DYRK Kinases.

University Of Athens

Evidence for a new binding mode to GSK-3: allosteric regulation by the marine compound palinurin.

Universitat De Barcelona

Hit to Lead optimization of a novel class of squarate-containing polo-like kinases inhibitors.

Abbott Laboratories

Discovery of 5-(2-amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-(tert-butyl)pyridine-3-sulfonamide (CZC24758), as a potent, orally bioavailable and selective inhibitor of PI3K for the treatment of inflammatory disease.

Cellzome

Exploring aigialomycin d and its analogues as protein kinase inhibitors for cancer targets.

TBA

Selectivity and potency of cyclin-dependent kinase inhibitors.

Georgetown University

Pharmacological inhibitors of glycogen synthase kinase 3.

The Rockefeller University

A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity.

Nerviano Medical Sciences Oncology

Discovery of potent and bioavailable GSK-3beta inhibitors.

Roche Palo Alto

A quantitative analysis of kinase inhibitor selectivity.

Ambit Biosciences

Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors.

University Of California

Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor.

Pfizer

TrkA kinase inhibitors from a library of modified and isosteric Staurosporine aglycone.

Cephalon

Structure-based design of novel 2-amino-6-phenyl-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-ones as potent and orally active inhibitors of lymphocyte specific kinase (Lck): synthesis, SAR, and in vivo anti-inflammatory activity.

Amgen

Macrocyclic ureas as potent and selective Chk1 inhibitors: an improved synthesis, kinome profiling, structure-activity relationships, and preliminary pharmacokinetics.

Abbott Laboratories

3D-QSAR CoMFA on cyclin-dependent kinase inhibitors.

Institut Curie

Comprehensive analysis of kinase inhibitor selectivity.

Ambit Biosciences

CNS and antimalarial activity of synthetic meridianin and psammopemmin analogs.

University Of South Florida

Design, synthesis, and testing of an 6-O-linked series of benzimidazole based inhibitors of CDK5/p25.

Duquesne University

Discovery of a potent, selective, and orally bioavailable pyridinyl-pyrimidine phthalazine aurora kinase inhibitor.

Amgen

AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML).

Ambit Biosciences

Imidazo[2,1-b]thiazoles: multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases.

Abbott Laboratories

Selectively nonselective kinase inhibition: striking the right balance.

Schering-Plough

Synthesis and antiproliferative activity of 7-azaindirubin-3'-oxime, a 7-aza isostere of the natural indirubin pharmacophore.

University Of Athens

Imidazo[1,2-a]pyrazine diaryl ureas: inhibitors of the receptor tyrosine kinase EphB4.

Cgi Pharmaceuticals

Design and synthesis of 6-oxo-1,6-dihydropyridines as CDK5 inhibitors.

Amgen

2-{3-[4-(Alkylsulfinyl)phenyl]-1-benzofuran-5-yl}-5-methyl-1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3beta with good brain permeability.

Takeda Pharmaceutical

Synthesis and biological evaluation of 3,6-diamino-1H-pyrazolo[3,4-b]pyridine derivatives as protein kinase inhibitors.

Laboratorio De Radicales Libres Y QuÍMica Computacional (Iqog, Csic)

Synthesis and biological activities of aminopyrimidyl-indoles structurally related to meridianins.

Clermont Universit£

Identification of potential cellular targets of aloisine A by affinity chromatography.

Cnrs Usr-3151

From a natural product lead to the identification of potent and selective benzofuran-3-yl-(indol-3-yl)maleimides as glycogen synthase kinase 3beta inhibitors that suppress proliferation and survival of pancreatic cancer cells.

University Of Illinois At Chicago

Synthesis and cytotoxic activity of new azepino[3',4':4,5]pyrrolo[2,1-a]isoquinolin-12-ones.

Universidad Nacional AutóNoma De MéXico

Synthesis of new dipyrrolo- and furopyrrolopyrazinones related to tripentones and their biological evaluation as potential kinases (CDKs1-5, GSK-3) inhibitors.

Université

Novel 9-oxo-thiazolo[5,4-f]quinazoline-2-carbonitrile derivatives as dual cyclin-dependent kinase 1 (CDK1)/glycogen synthase kinase-3 (GSK-3) inhibitors: synthesis, biological evaluation and molecular modeling studies.

Université

Discovery of aminoquinazolines as potent, orally bioavailable inhibitors of Lck: synthesis, SAR, and in vivo anti-inflammatory activity.

Amgen

Identification of potent 5-pyrimidinyl-2-aminothiazole CDK4, 6 inhibitors with significant selectivity over CDK1, 2, 5, 7, and 9.

Banyu Tsukuba Research Institute

A small molecule-kinase interaction map for clinical kinase inhibitors.

Ambit Biosciences

Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer's disease.

Pfizer

Chromone containing sulfonamides as potent carbonic anhydrase inhibitors.

Ondokuz Mayis University

Identification of Novel Selective Lysine-Specific Demethylase 1 (LSD1) Inhibitors Using a Pharmacophore-Based Virtual Screening Combined with Docking.

China Pharmaceutical University

7-Azaindole derivatives as potential partial nicotinic agonists.

Solvay Pharmaceuticals