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21 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality.EBI
Johnson & Johnson Pharmaceutical Research & Development
4-Substituted trinems as broad spectrum beta-lactamase inhibitors: structure-based design, synthesis, and biological activity.EBI
Lek Pharmaceuticals
Structure-based design of beta-lactamase inhibitors. 2. Synthesis and evaluation of bridged sulfactams and oxamazins.EBI
F. Hoffmann-La Roche
Design, synthesis, and evaluation of 2 beta-alkenyl penam sulfone acids as inhibitors of beta-lactamases.EBI
F. Hoffmann-La Roche
The inhibition of metallo-beta-lactamase by thioxo-cephalosporin derivatives.EBI
University Of Huddersfield
The synthesis and SAR of rhodanines as novel class C beta-lactamase inhibitors.EBI
The R. W. Johnson Pharmaceutical Research Institute
 
The synthesis and lactamase inhibitory activity of 6-(carboxymethylene)penicillins and 7-(carboxymethylene)cephalosporinsEBI
TBA
Thiophenyl oxime-derived phosphonates as nano-molar class C beta-lactamase inhibitors reducing MIC of imipenem against Pseudomonas aeruginosa and Acinetobacter baumannii.EBI
Merck
Synthesis and SAR of novel benzoxaboroles as a new class of β-lactamase inhibitors.EBI
Anacor Pharmaceuticals
Mechanistic studies of the inactivation of TEM-1 and P99 by NXL104, a novel non-beta-lactam beta-lactamase inhibitor.EBI
Novexel
4,7-Dichloro benzothien-2-yl sulfonylaminomethyl boronic acid: first boronic acid-derived beta-lactamase inhibitor with class A, C, and D activity.EBI
Merck
 
Synthesis and biological activity of novel penem sulfoxides and sulfonesEBI
TBA
 
Mechanistic support for the stepwise process for inactivation of class A β-lactamases by clavulanateEBI
TBA
Structure-activity relationship of 6-methylidene penems bearing 6,5 bicyclic heterocycles as broad-spectrum beta-lactamase inhibitors: evidence for 1,4-thiazepine intermediates with C7 R stereochemistry by computational methods.EBI
Wyeth Research
Structure-activity relationship of 6-methylidene penems bearing tricyclic heterocycles as broad-spectrum beta-lactamase inhibitors: crystallographic structures show unexpected binding of 1,4-thiazepine intermediates.EBI
Wyeth Research
Spirocyclopropyl beta-lactams as mechanism-based inhibitors of serine beta-lactamases. Synthesis by rhodium-catalyzed cyclopropanation of 6-diazopenicillanate sulfone.EBI
Wyeth Research
Cephalosporin-derived inhibitors of beta-lactamase. Part 4: The C3 substituent.EBI
Southern Methodist University
Synthesis and biological activities of an alpha-methyl and a beta-methyl carbapenem and the corresponding unsubstituted compound.EBI
University Of Munich
Synthesis and biological activity of 7-alkylidenecephems.EBI
Southern Methodist University
Synthesis and beta-lactamase inhibitory properties of 2 beta-[(1,2,3-triazol-1-yl)methyl]-2 alpha-methylpenam-3 alpha-carboxylic acid 1,1-dioxide and related triazolyl derivatives.EBI
TBA