107 articles for thisTarget
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Synthesis and bioevaluation of novel benzodipyranone derivatives as P-glycoprotein inhibitors for multidrug resistance reversal agents.
China Medical University
Structure-activity relationships of dibenzoylhydrazines for the inhibition of P-glycoprotein-mediated quinidine transport.
Kyoto University
The combination of quinazoline and chalcone moieties leads to novel potent heterodimeric modulators of breast cancer resistance protein (BCRP/ABCG2).
University Of Bonn
Optimization by Molecular Fine Tuning of Dihydro-ß-agarofuran Sesquiterpenoids as Reversers of P-Glycoprotein-Mediated Multidrug Resistance.
Instituto Universitario De Bio-Org£Nica&Quot;Antonio Gonz£Lez&Quot
Flavonoid derivatives as selective ABCC1 modulators: Synthesis and functional characterization.
University Of Regensburg
The interaction of 4-thiazolidinone derivatives containing indolin-2-one moiety with P-glycoprotein studied using K562 cell lines.
The First Affiliated Hospital Of Dalian Medical University
Optimization of permethyl ningalin B analogs as P-glycoprotein inhibitors.
Ocean University Of China
Discovery of substituted 1,4-dihydroquinolines as novel promising class of P-glycoprotein inhibitors: First structure-activity relationships and bioanalytical studies.
Martin-Luther-University Halle-Wittenberg
Potent and Nontoxic Chemosensitizer of P-Glycoprotein-Mediated Multidrug Resistance in Cancer: Synthesis and Evaluation of Methylated Epigallocatechin, Gallocatechin, and Dihydromyricetin Derivatives.
The Hong Kong Polytechnic University
Restoration of Chemosensitivity in P-Glycoprotein-Dependent Multidrug-Resistant Cells by Dihydro-ß-agarofuran Sesquiterpenes from Celastrus vulcanicola.
Instituto Universitario De Bio-Org£Nica Antonio Gonz£Lez (Iubo-Ag)
In vitro investigations into the roles of drug transporters and metabolizing enzymes in the disposition and drug interactions of dolutegravir, a HIV integrase inhibitor.
Glaxosmithkline
HM30181 Derivatives as Novel Potent and Selective Inhibitors of the Breast Cancer Resistance Protein (BCRP/ABCG2).
University Of Bonn
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding.
Universit£
Investigating the binding interactions of the anti-Alzheimer's drug donepezil with CYP3A4 and P-glycoprotein.
University Of Waterloo
Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate P-glycoprotein (P-gp) activity froms2 receptor affinity in mixed P-gp/s2 receptor agents.
Universit£
SAR studies on tetrahydroisoquinoline derivatives: the role of flexibility and bioisosterism to raise potency and selectivity toward P-glycoprotein.
Universit£
Potent nonimmunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition.
Novartis Institutes For Biomedical Research
4,5-Di-substituted benzyl-imidazol-2-substituted amines as the structure template for the design and synthesis of reversal agents against P-gp-mediated multidrug resistance breast cancer cells.
Ocean University Of China
Design and synthesis of human ABCB1 (P-glycoprotein) inhibitors by peptide coupling of diverse chemical scaffolds on carboxyl and amino termini of (S)-valine-derived thiazole amino acid.
St. John'S University
Synthesis, biological evaluation and 3D-QSAR studies of new chalcone derivatives as inhibitors of human P-glycoprotein.
Medical University Vienna
SAR study on arylmethyloxyphenyl scaffold: looking for a P-gp nanomolar affinity.
Universit£
Investigation of quinazolines as inhibitors of breast cancer resistance protein (ABCG2).
University Of Bonn
Development of 3,4-dihydroisoquinolin-1(2H)-one derivatives for the Positron Emission Tomography (PET) imaging ofs2 receptors.
Universit£
Synthesis of N(4)-(substituted phenyl)-N(4)-alkyl/desalkyl-9H-pyrimido[4,5-b]indole-2,4-diamines and identification of new microtubule disrupting compounds that are effective against multidrug resistant cells.
Duquesne University
Potent and selective tariquidar bioisosters as potential PET radiotracers for imaging P-gp.
Universit£
Benzanilide-Biphenyl Replacement: A Bioisosteric Approach to Quinoline Carboxamide-Type ABCG2 Modulators.
University Of Regensburg
Docking and 3D-QSAR (quantitative structure activity relationship) studies of flavones, the potent inhibitors of p-glycoprotein targeting the nucleotide binding domain.
Chosun University
Intrinsic and acquired forms of resistance against the anticancer ruthenium compound KP1019 [indazolium trans-[tetrachlorobis(1H-indazole)ruthenate (III)] (FFC14A).
Institute Of Cancer Research
Inhibitory effects of a cyclosporin derivative, SDZ PSC 833, on transport of doxorubicin and vinblastine via human P-glycoprotein.
Kobe University
Inhibitory potencies of 1,4-dihydropyridine calcium antagonists to P-glycoprotein-mediated transport: comparison with the effects on CYP3A4.
Kanazawa University
Inhibitory effects of CYP3A4 substrates and their metabolites on P-glycoprotein-mediated transport.
Kanazawa University
Cepharanthin, a multidrug resistant modifier, is a substrate for P-glycoprotein.
Kyoto University Hospital
Ranking of P-glycoprotein substrates and inhibitors by a calcein-AM fluorometry screening assay.
Strasbourg 1 University
Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa?
The University Of Kansas
HMG-CoA reductase inhibitors (statins) characterized as direct inhibitors of P-glycoprotein.
Schering-Plough Research Institute
Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4.
Schering-Plough Research Institute
The farnesyl protein transferase inhibitor SCH66336 is a potent inhibitor of MDR1 product P-glycoprotein.
Schering-Plough Research Institute
Cholesterol interaction with the daunorubicin binding site of P-glycoprotein.
Schering-Plough Research Institute
P-glycoprotein interactions of nefazodone and trazodone in cell culture.
Tufts University School Of Medicine
Methadone inhibits rhodamine123 transport in Caco-2 cells.
Tufts University School Of Medicine
Evaluation of the interaction of loratadine and desloratadine with P-glycoprotein.
Schering-Plough Research Institute
Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors.
Schering-Plough Research Institute
Interaction of common azole antifungals with P glycoprotein.
Schering-Plough Research Institute
Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes.
Vanderbilt University School Of Medicine
Lopinavir: acute exposure inhibits P-glycoprotein; extended exposure induces P-glycoprotein.
Tufts University School Of Medicine
Mibefradil is a P-glycoprotein substrate and a potent inhibitor of both P-glycoprotein and CYP3A in vitro.
Vanderbilt University School Of Medicine
Interaction of morphine, fentanyl, sufentanil, alfentanil, and loperamide with the efflux drug transporter P-glycoprotein.
Vanderbilt University
Interaction of omeprazole, lansoprazole and pantoprazole with P-glycoprotein.
Institute Of Clinical Pharmacology
Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein.
Dr. Margarete Fischer-Bosch-Institute Of Clinical Pharmacology
Inhibition of the P-glycoprotein- and multidrug resistance protein-mediated efflux of anthracyclines and calceinacetoxymethyl ester by PAK-104P.
Universit£
Reversal of P-glycoprotein-mediated MDR by 5,7,3',4',5'-pentamethoxyflavone and SAR.
Chosun University
Differential interaction of 3-hydroxy-3-methylglutaryl-coa reductase inhibitors with ABCB1, ABCC2, and OATP1B1.
Pfizer
Differential effects of the optical isomers of KR30031 on cardiotoxicity and on multidrug resistance reversal activity.
Korea Research Institute Of Chemical Technology
Imaging reversal of multidrug resistance in living mice with bioluminescence: MDR1 P-glycoprotein transports coelenterazine.
Washington University
Selectivity of the multidrug resistance modulator, LY335979, for P-glycoprotein and effect on cytochrome P-450 activities.
Eli Lilly
New potent P-glycoprotein inhibitors carrying a polycyclic scaffold.
University Of Bologna
Increased anti-P-glycoprotein activity of baicalein by alkylation on the A ring.
Yale University
C-7 analogues of progesterone as potent inhibitors of the P-glycoprotein efflux pump.
Georgetown University School Of Medicine
Synthesis and evaluation of hapalosin and analogs as MDR-reversing agents.
Eisai Research Institute
Thiorhodamines containing amide and thioamide functionality as inhibitors of the ATP-binding cassette drug transporter P-glycoprotein (ABCB1).
The State University Of New York
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Uppsala University
Pharmacokinetics and interactions of a novel antagonist of chemokine receptor 5 (CCR5) with ritonavir in rats and monkeys: role of CYP3A and P-glycoprotein.
Merck Research Laboratories
Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein.
Eli Lilly
Effect of modulators on the ATPase activity and vanadate nucleotide trapping of human P-glycoprotein.
Eli Lilly
Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4.
Dr. Margarete Fischer-Bosch-Institute Of Clinical Pharmacology
PSC833, cyclosporin A, and dexniguldipine effects on cellular calcein retention and inhibition of the multidrug resistance pump in human leukemic lymphoblasts.
University Of Tennessee Medical Center
Nonclinical pharmacokinetics of oseltamivir and oseltamivir carboxylate in the central nervous system.
F. Hoffmann-La Roche
From taxuspine x to structurally simplified taxanes with remarkable p-glycoprotein inhibitory activity.
TBA
Effects of human immunodeficiency virus protease inhibitors on the intestinal absorption of tenofovir disoproxil fumarate in vitro.
Gilead Sciences
Potent and selective inhibitors of breast cancer resistance protein (ABCG2) derived from the p-glycoprotein (ABCB1) modulator tariquidar.
University Of Regensburg
Functional assay and structure-activity relationships of new third-generation P-glycoprotein inhibitors.
University Of Bonn
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives.
Universit£
Synthesis and biological evaluation of (hetero)arylmethyloxy- and arylmethylamine-phenyl derivatives as potent P-glycoprotein modulating agents.
Universita Degli Studi Di Bari
Self-organizing maps for identification of new inhibitors of P-glycoprotein.
University Of Vienna
Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells.
Universit£
Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery.
F. Hoffmann-La Roche
Pharmacophore model of drugs involved in P-glycoprotein multidrug resistance: explanation of structural variety (hypothesis).
Bulgarian Academy Of Sciences
Cyclosporins: structure-activity relationships for the inhibition of the human MDR1 P-glycoprotein ABC transporter.
Strasbourg 1 University
Aureobasidins: structure-activity relationships for the inhibition of the human MDR1 P-glycoprotein ABC-transporter.
Strasbourg 1 University
Substituted 4-acylpyrazoles and 4-acylpyrazolones: synthesis and multidrug resistance-modulating activity.
University Of Vienna
Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein.
Universit£
Overcoming human P-glycoprotein-dependent multidrug resistance with novel dihydro-ß-agarofuran sesquiterpenes.
Instituto Universitario De Bio-Org£Nica Antonio Gonz£Lez (Iubo-Ag)
Solid phase synthesis of tariquidar-related modulators of ABC transporters preferring breast cancer resistance protein (ABCG2).
Universidad Nacional De Colombia
A novel approach for predicting P-glycoprotein (ABCB1) inhibition using molecular interaction fields.
University Of Perugia
Interaction potential of etravirine with drug transporters assessed in vitro.
University Hospital Heidelberg
Structure-activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP).
University Of Bonn
Potent and fully noncompetitive peptidomimetic inhibitor of multidrug resistance P-glycoprotein.
Umr 5086 Cnrs
Phenylsulfonylfuroxans as modulators of multidrug-resistance-associated protein-1 and P-glycoprotein.
Universita Degli Studi Di Torino
Antimalarial and antitrypanosomal activity of a series of amide and sulfonamide derivatives of a 2,5-diaminobenzophenone.
Philipps-Universit£T Marburg
Rhodamine inhibitors of P-glycoprotein: an amide/thioamide"switch" for ATPase activity.
The State University Of New York
2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties.
Universita Degli Studi Di Bari
Bis-pyranobenzoquinones as a new family of reversal agents of the multidrug resistance phenotype mediated by P-glycoprotein in mammalian cells and the protozoan parasite Leishmania.
Instituto Universitario De Bio-OrgáNica Antonio GonzáLez
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum.
Università
Biological evaluation, structure-activity relationships, and three-dimensional quantitative structure-activity relationship studies of dihydro-beta-agarofuran sesquiterpenes as modulators of P-glycoprotein-dependent multidrug resistance.
Instituto Universitario De Bio-Organica Antonio Gonzalez
In vitro activity of novel dual action MDR anthranilamide modulators with inhibitory activity on CYP-450 (Part 2).
Université
Arylmethyloxyphenyl derivatives: small molecules displaying P-glycoprotein inhibition.
Università
Biological evaluation of bishydroxymethyl-substituted cage dimeric 1,4-dihydropyridines as a novel class of p-glycoprotein modulating agents in cancer cells.
Martin-Luther-University Halle-Wittenberg
Synthesis, in vitro and in vivo evaluation of [O-methyl-11C] 2-{4-[4-(3-methoxyphenyl)piperazin-1-yl]-butyl}-4-methyl-2H-[1,2,4]-triazine-3,5-dione: a novel agonist 5-HT1A receptor PET ligand.
Columbia University College Of Physicians And Surgeons
Synthesis and in vivo validation of [O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)piperazin- 1-yl]butyl}-4-methyl-2H-[1,2,4]triazine-3,5-dione: a novel 5-HT1A receptor agonist positron emission tomography ligand.
Columbia University College Of Physicians And Surgeons
Tricyclic isoxazoles are novel inhibitors of the multidrug resistance protein (MRP1).
Eli Lilly
Cycloalkylpiperazines as HIV-1 Protease Inhibitors: Enhanced Oral Absorption
Merck Research Laboratories