28 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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A matrix-focused structure-activity and binding site flexibility study of quinolinol inhibitors of botulinum neurotoxin serotype A.
U.S. Army Medical Research Institute Of Infectious Diseases
Interactions of a potent cyclic peptide inhibitor with the light chain of botulinum neurotoxin A: Insights from X-ray crystallography.
Brookhaven National Laboratory
Computer-aided identification, synthesis, and biological evaluation of novel inhibitors for botulinum neurotoxin serotype A.
Stony Brook University
Benzoquinones as inhibitors of botulinum neurotoxin serotype A.
The Scripps Research Institute
Second generation steroidal 4-aminoquinolines are potent, dual-target inhibitors of the botulinum neurotoxin serotype A metalloprotease and P. falciparum malaria.
University Of Belgrade
Identification of clinically viable quinolinol inhibitors of botulinum neurotoxin A light chain.
The Scripps Research Institute
Synthesis/biological evaluation of hydroxamic acids and their prodrugs as inhibitors for Botulinum neurotoxin A light chain.
The Scripps Research Institute
Investigating the selectivity of metalloenzyme inhibitors.
University Of California San Diego
4-Amino-7-chloroquinolines: probing ligand efficiency provides botulinum neurotoxin serotype A light chain inhibitors with significant antiprotozoal activity.
University Of Belgrade
Virtual medicinal chemistry: in silico pre-docking functional group transformation for discovery of novel inhibitors of botulinum toxin serotype A light chain.
Panthera Biopharma
Evaluation of adamantane hydroxamates as botulinum neurotoxin inhibitors: synthesis, crystallography, modeling, kinetic and cellular based studies.
The Scripps Research Institute
Paclitaxel is an inhibitor and its boron dipyrromethene derivative is a fluorescent recognition agent for botulinum neurotoxin subtype A.
Lakehead University And Thunder Bay Regional Research Institute
The C-terminus of Botulinum A Protease Has Profound and Unanticipated Kinetic Consequences Upon the Catalytic Cleft.
The Scripps Research Institute
Identification of a Natural Product Antagonist against the Botulinum Neurotoxin Light Chain Protease.
TBA
The synthesis of 2,5-bis(4-amidinophenyl)thiophene derivatives providing submicromolar-range inhibition of the botulinum neurotoxin serotype A metalloprotease.
University Of Belgrade
Pharmacophore Refinement Guides the Rational Design of Nanomolar-Range Inhibitors of the Botulinum Neurotoxin Serotype A Metalloprotease.
TBA
Reexamining hydroxamate inhibitors of botulinum neurotoxin serotype A: extending towards theß-exosite.
Fox Chase Chemical Diversity Center
Synthesis and biological evaluation of botulinum neurotoxin a protease inhibitors.
Microbiotix
A chemotype that inhibits three unrelated pathogenic targets: the botulinum neurotoxin serotype A light chain, P. falciparum malaria, and the Ebola filovirus.
University Of Belgrade
Synthesis and evaluation of library of betulin derivatives against the botulinum neurotoxin A protease.
The Scripps Research Institute
Identification and biochemical characterization of small-molecule inhibitors of Clostridium botulinum neurotoxin serotype A.
U.S. Army Medical Research Institute Of Infectious Diseases
Benzylidene cyclopentenediones: First irreversible inhibitors against botulinum neurotoxin A's zinc endopeptidase.
The Scripps Research Institute
Pharmacophore-guided lead optimization: the rational design of a non-zinc coordinating, sub-micromolar inhibitor of the botulinum neurotoxin serotype a metalloprotease.
National Cancer Institute At Frederick
Identification of small molecule inhibitors of botulinum neurotoxin serotype E via footprint similarity.
Stony Brook University
Newly Designed Quinolinol Inhibitors Mitigate the Effects of Botulinum Neurotoxin A in Enzymatic, Cell-Based, and ex Vivo Assays.
The Scripps Research Institute