PMID

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Article Title

Organization

Synopsis of some recent tactical application of bioisosteres in drug design.

Bristol-Myers Squibb Pharmaceutical Research And Development

Selective inhibition of the tumor marker aldo-keto reductase family member 1B10 by oleanolic acid.

Gifu Pharmaceutical University

Development of potent and selective inhibitors of aldo-keto reductase 1C3 (type 5 17ß-hydroxysteroid dehydrogenase) based on N-phenyl-aminobenzoates and their structure-activity relationships.

University Of Pennsylvania

Optimization of the Central Core of Indolinone-Acetic Acid-Based CRTH2 (DP2) Receptor Antagonists.

TBA

Synthesis, induced-fit docking investigations, and in vitro aldose reductase inhibitory activity of non-carboxylic acid containing 2,4-thiazolidinedione derivatives.

Universit£

Inhibition of 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) by aldose reductase inhibitors.

Monash University

Structural basis for the high all-trans-retinaldehyde reductase activity of the tumor marker AKR1B10.

Universitat Aut£Noma De Barcelona

Substituted pyrrol-1-ylacetic acids that combine aldose reductase enzyme inhibitory activity and ability to prevent the nonenzymatic irreversible modification of proteins from monosaccharides.

Aristotle University Of Thessaloniki

Molecular modeling of the aldose reductase-inhibitor complex based on the X-ray crystal structure and studies with single-site-directed mutants.

National Eye Institute

1-Benzopyran-4-one antioxidants as aldose reductase inhibitors.

Universit£

Novel spirosuccinimide aldose reductase inhibitors derived from isoquinoline-1,3-diones: 2-[(4-bromo-2-fluorophenyl)methyl]-6- fluorospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrone and congeners. 1.

Wyeth-Ayerst Research

Hydantoin bioisosteres. In vivo active spiro hydroxy acetic acid aldose reductase inhibitors.

Pfizer

A highly specific aldose reductase inhibitor, ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate, and its congeners.

Pfizer

Spiro hydantoin aldose reductase inhibitors derived from 8-aza-4-chromanones.

Pfizer

Spiro hydantoin aldose reductase inhibitors.

Pfizer

Design, synthesis, and biological evaluation of novel (1-thioxo-1,2,3,4-tetrahydro-ß-carbolin-9-yl)acetic acids as selective inhibitors for AKR1B1.

University Of Toyama

Construction of an Indonesian herbal constituents database and its use in Random Forest modelling in a search for inhibitors of aldose reductase.

King'S College London

Design, synthesis and evaluation of caffeic acid phenethyl ester-based inhibitors targeting a selectivity pocket in the active site of human aldo-keto reductase 1B10.

Gifu Pharmaceutical University

Structure-activity relationships of ganoderma acids from Ganoderma lucidum as aldose reductase inhibitors.

Sepuluh Nopember Institute Of Technology

(2-Benzyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-8-yl)-acetic acid: an aldose reductase inhibitor and antioxidant of zwitterionic nature.

Slovak Academy Of Sciences

Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists-discovery of AZD1981.

Astrazeneca R&D Charnwood

Discovery of potent, selective, and orally bioavailable alkynylphenoxyacetic acid CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases.

Merck Serono

Discovery of [3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl]acetic acids as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications.

The Institute For Diabetes Discovery

Furoxan nitric oxide donor coupled chrysin derivatives: synthesis and vasculoprotection.

Central South University

In vitro evaluation of 5-arylidene-2-thioxo-4-thiazolidinones active as aldose reductase inhibitors.

University Of Messina

6,7-Dihydroxy-4-phenylcoumarin as inhibitor of aldose reductase 2.

University Of Toyama

Chromene-3-carboxamide derivatives discovered from virtual screening as potent inhibitors of the tumour maker, AKR1B10.

Gifu Pharmaceutical University

Evaluation of aldose reductase inhibition and docking studies of 6'-nitro and 6',6''-dinitrorosmarinic acids.

National Hellenic Research Foundation

Design and synthesis of novel series of pyrrole based chemotypes and their evaluation as selective aldose reductase inhibitors. A case of bioisosterism between a carboxylic acid moiety and that of a tetrazole.

Aristotle University Of Thessaloniki

Inhibition of aldose reductase from cataracted eye lenses by finger millet (Eleusine coracana) polyphenols.

Central Food Technological Research Institute

Validation of an automated procedure for the prediction of relative free energies of binding on a set of aldose reductase inhibitors.

Università

Structure of aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity.

Monash University (Parkville Campus)

High-resolution structures of human aldose reductase holoenzyme in complex with stereoisomers of the potent inhibitor Fidarestat: stereospecific interaction between the enzyme and a cyclic imide type inhibitor.

Monash University (Parkville Campus)

Synthesis, activity, and molecular modeling studies of novel human aldose reductase inhibitors based on a marine natural product.

Instituto Biomar

A potent aldose reductase inhibitor, (2S,4S)-6-fluoro-2', 5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide (Fidarestat): its absolute configuration and interactions with the aldose reductase by X-ray crystallography.

Rational Drug Design Laboratories

Synthesis and aldose reductase inhibitory activity of 7-sulfamoylxanthone-2-carboxylic acids.

TBA

N-[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]- N-methylglycine (Tolrestat), a potent, orally active aldose reductase inhibitor.

TBA

Synthesis, absolute configuration, and conformation of the aldose reductase inhibitor sorbinil.

TBA

Aldose reductase inhibitors: a potential new class of agents for the pharmacological control of certain diabetic complications.

TBA

Antiinflammatory and aldose reductase inhibitory activity of some tricyclic arylacetic acids.

TBA

Rotationally restricted mimics of rigid molecules: nonspirocyclic hydantoin aldose reductase inhibitors.

Pfizer

Gossypol and derivatives: a new class of aldose reductase inhibitors.

University Of New Mexico School Of Medicine

Novel, potent aldose reductase inhibitors: 3,4-dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl] methyl]-1-phthalazineacetic acid (zopolrestat) and congeners.

Pfizer

Potent, orally active aldose reductase inhibitors related to zopolrestat: surrogates for benzothiazole side chain.

Pfizer

Orally active aldose reductase inhibitors: indazoleacetic, oxopyridazineacetic, and oxopyridopyridazineacetic acid derivatives.

Pfizer

Biological activities and quantitative structure-activity relationships of spiro[imidazolidine-4,4'(1'H)-quinazoline]-2,2',5(3'H)-triones as aldose reductase inhibitors.

Tanabe Seiyaku

New hybrid molecules combining benzothiophene or benzofuran with rhodanine as dual COX-1/2 and 5-LOX inhibitors: Synthesis, biological evaluation and docking study.

Alexandria University