27 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Article Title
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Development of Potent and Selective Antagonists for the UTP-Activated P2Y
University Of Bonn
Synthesis and structure-activity relationship of uracil nucleotide derivatives towards the identification of human P2Y6 receptor antagonists.
Bar-Ilan University
4-Alkyloxyimino derivatives of uridine-5'-triphosphate: distal modification of potent agonists as a strategy for molecular probes of P2Y2, P2Y4, and P2Y6 receptors.
National Institute Of Diabetes And Digestive And Kidney Diseases
Discovery of 2-(phenoxypyridine)-3-phenylureas as small molecule P2Y1 antagonists.
Bristol-Myers Squibb Research And Development
UDP made a highly promising stable, potent, and selective P2Y6-receptor agonist upon introduction of a boranophosphate moiety.
Bar-Ilan University
Discovery of potent competitive antagonists and positive modulators of the P2X2 receptor.
University Of Bonn
Human P2Y(14) receptor agonists: truncation of the hexose moiety of uridine-5'-diphosphoglucose and its replacement with alkyl and aryl groups.
National Institute Of Diabetes And Digestive And Kidney Diseases
Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: nucleotide mimetics derived from uridine-5'-carboxamide.
University Of Bonn
Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists.
Niddk
Lipophilic modifications to dinucleoside polyphosphates and nucleotides that confer antagonist properties at the platelet P2Y12 receptor.
Inspire Pharmaceuticals
Molecular modeling of the human P2Y2 receptor and design of a selective agonist, 2'-amino-2'-deoxy-2-thiouridine 5'-triphosphate.
National Institute Of Diabetes And Digestive And Kidney Diseases
Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4, and P2Y6 receptors.
University Of Bonn
Structure-activity relationships of uridine 5'-diphosphate analogues at the human P2Y6 receptor.
National Institute Of Diabetes And Digestive And Kidney Diseases
Methanocarba modification of uracil and adenine nucleotides: high potency of Northern ring conformation at P2Y1, P2Y2, P2Y4, and P2Y11 but not P2Y6 receptors.
National Institute Of Diabetes
Synthesis and P2Y receptor activity of a series of uridine dinucleoside 5'-polyphosphates.
Inspire Pharmaceuticals
Pyrimidine nucleotides with 4-alkyloxyimino and terminal tetraphosphated-ester modifications as selective agonists of the P2Y(4) receptor.
Niddk
Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors.
University Of Bonn
Pyrimidine ribonucleotides with enhanced selectivity as P2Y(6) receptor agonists: novel 4-alkyloxyimino, (S)-methanocarba, and 5'-triphosphate gamma-ester modifications.
National Institute Of Diabetes And Digestive And Kidney Diseases
Synthesis and P2Y receptor activity of nucleoside 5'-phosphonate derivatives.
Ghent University
Human P2Y(6) receptor: molecular modeling leads to the rational design of a novel agonist based on a unique conformational preference.
Niddk
Structure-Based Design of 3-(4-Aryl-1H-1,2,3-triazol-1-yl)-Biphenyl Derivatives as P2Y14 Receptor Antagonists.
National Institute Of Diabetes And Digestive And Kidney Diseases
Structure-Activity Relationship of Purine and Pyrimidine Nucleotides as Ecto-5'-Nucleotidase (CD73) Inhibitors.
National Institute Of Diabetes And Digestive And Kidney Diseases
4-Alkyloxyimino-cytosine nucleotides: tethering approaches to molecular probes for the P2Y
National Institute Of Diabetes And Digestive And Kidney Diseases