72 articles for thisTarget
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Synthesis and Enantiomeric Separation of a Novel Spiroketal Derivative: A Potent Human Telomerase Inhibitor with High in Vitro Anticancer Activity.
Istituto Di Farmacologia Traslazionale
Dihydropyrazole derivatives as telomerase inhibitors: Structure-based design, synthesis, SAR and anticancer evaluation in vitro and in vivo.
Anhui Medical University
Identification of human telomerase inhibitors having the core of N-acyl-4,5-dihydropyrazole with anticancer effects.
Hefei University Of Technology
Novel myricetin derivatives: Design, synthesis and anticancer activity.
Guizhou University
Design and synthesis of celastrol derivatives as anticancer agents.
Anhui Medical University
Novel pyrazole-5-carboxamide and pyrazole-pyrimidine derivatives: synthesis and anticancer activity.
Anhui Medical University
Novel multi-targeting anthra[2,3-b]thiophene-5,10-diones with guanidine-containing side chains: interaction with telomeric G-quadruplex, inhibition of telomerase and topoisomerase I and cytotoxic properties.
Russian Academy Of Sciences
Design and synthesis of new benzimidazole-carbazole conjugates for the stabilization of human telomeric DNA, telomerase inhibition, and their selective action on cancer cells.
Indian Institute Of Science
Novel coumarin-dihydropyrazole thio-ethanone derivatives: design, synthesis and anticancer activity.
Anhui Medical University
Telomere maintenance as a target for drug discovery.
University Of North Carolina At Chapel Hill
Toward the design of new DNA G-quadruplex ligands through rational analysis of polymorphism and binding data.
Universit£
New quinazoline derivatives for telomeric G-quadruplex DNA: effects of an added phenyl group on quadruplex binding ability.
Sun Yat-Sen University
Synthesis, biological evaluation, 3D-QSAR studies of novel aryl-2H-pyrazole derivatives as telomerase inhibitors.
Nanjing University
Structure-based design, synthesis and evaluation of novel anthra[1,2-d]imidazole-6,11-dione derivatives as telomerase inhibitors and potential for cancer polypharmacology.
National Defense Medical Center
Design and synthesis of novel 2-methyl-4,5-substitutedbenzo[f]-3,3a,4,5-tetrahydro-pyrazolo[1,5-d][1,4]oxazepin-8(7H)-one derivatives as telomerase inhibitors.
Guizhou University
Synthesis, molecular modeling and biological evaluation of 2-aminomethyl-5-(quinolin-2-yl)-1,3,4-oxadiazole-2(3H)-thione quinolone derivatives as novel anticancer agent.
Shandong University Of Technology
Disubstituted quinazoline derivatives as a new type of highly selective ligands for telomeric G-quadruplex DNA.
Sun Yat-Sen University
Stabilization and structural alteration of the G-quadruplex DNA made from the human telomeric repeat mediated by Tröger's base based novel benzimidazole derivatives.
India Institute Of Science
A new strategy for detection and development of tractable telomerase inhibitors.
University Of California
Improving the affinity of naphthalene diimide ligand to telomeric DNA by incorporating Zn²¿ ions into its dipicolylamine groups.
Research Center For Bio-Microsensing Technology
Design, synthesis and biological evaluation of heterocyclic azoles derivatives containing pyrazine moiety as potential telomerase inhibitors.
Nanjing University
ortho-Quinone tanshinones directly inhibit telomerase through an oxidative mechanism mediated by hydrogen peroxide.
University Of North Carolina
Design and synthesis of novel 5-phenyl-N-piperidine ethanone containing 4,5-dihydropyrazole derivatives as potential antitumor agents.
Anhui Medical University
Synthesis and molecular docking studies of novel 2-chloro-pyridine derivatives containing flavone moieties as potential antitumor agents.
Nanjing University
Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action.
Institut National De La Sant£
Structure-based design of benzylamino-acridine compounds as G-quadruplex DNA telomere targeting agents.
University Of London
Quadruplex-interactive agents as telomerase inhibitors: synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase.
University Of Texas At Austin
Molecular modeling studies on G-quadruplex complexes of telomerase inhibitors: structure-activity relationships.
The Institute Of Cancer Research
2,7-Disubstituted amidofluorenone derivatives as inhibitors of human telomerase.
The Institute Of Cancer Research
1,4- and 2,6-disubstituted amidoanthracene-9,10-dione derivatives as inhibitors of human telomerase.
The Institute Of Cancer Research
Shikonin derivatives: synthesis and inhibition of human telomerase.
Chinese Academy Of Science
JFCR39, a panel of 39 human cancer cell lines, and its application in the discovery and development of anticancer drugs.
Tianjin Key Laboratory On Technologies Enabling Development Of Clinical Therapeutics And Diagnostics
Synthesis, biological evaluation, and molecular docking studies of 1,3,4-oxadiazole derivatives possessing 1,4-benzodioxan moiety as potential anticancer agents.
Nanjing University
Design and synthesis of N-phenylacetyl (sulfonyl) 4,5-dihydropyrazole derivatives as potential antitumor agents.
Nanjing University
N-cyclic bay-substituted perylene G-quadruplex ligands have selective antiproliferative effects on cancer cells and induce telomere damage.
Sapienza University Of Rome
Synthesis, biological evaluation, and molecular docking studies of 2-chloropyridine derivatives possessing 1,3,4-oxadiazole moiety as potential antitumor agents.
Nanjing University
Synthesis and molecular docking study of novel coumarin derivatives containing 4,5-dihydropyrazole moiety as potential antitumor agents.
Anhui University Of Technology
Prediction of telomerase inhibitory activity for acridinic derivatives based on chemical structure.
Central University Of Las Villas
Synthesis and biological evaluation of novel 4,5-bis(dialkylaminoalkyl)-substituted acridines as potent telomeric G-quadruplex ligands.
Universit£
BRACO19 analog dimers with improved inhibition of telomerase and hPot 1.
University Of North Carolina At Chapel Hill
Rational design of substituted diarylureas: a scaffold for binding to G-quadruplex motifs.
University Of London
5-N-methylated quindoline derivatives as telomeric g-quadruplex stabilizing ligands: effects of 5-N positive charge on quadruplex binding affinity and cell proliferation.
Sun Yat-Sen University
Aminoacyl-anthraquinone conjugates as telomerase inhibitors: synthesis, biophysical and biological evaluation.
University Of Padova
Synthesis, human telomerase inhibition and anti-proliferative studies of a series of 2,7-bis-substituted amido-anthraquinone derivatives.
National Defense Medical Center
Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonospora alba.
Kumamoto University
Tri-, tetra- and heptacyclic perylene analogues as new potential antineoplastic agents based on DNA telomerase inhibition.
University Of Padova
Trisubstituted acridines as G-quadruplex telomere targeting agents. Effects of extensions of the 3,6- and 9-side chains on quadruplex binding, telomerase activity, and cell proliferation.
University Of London
Evaluation of by disubstituted acridone derivatives as telomerase inhibitors: the importance of G-quadruplex binding.
University Of London
Synthesis, biophysical and biological evaluation of 3,6-bis-amidoacridines with extended 9-anilino substituents as potent G-quadruplex-binding telomerase inhibitors.
University Of London School Of Pharmacy
Trisubstituted acridine derivatives as potent and selective telomerase inhibitors.
University Of London
Inhibition of telomerase by BIBR 1532 and related analogues.
University Of Texas At Dallas
Synthesis of 6-formyl-pyridine-2-carboxylate derivatives and their telomerase inhibitory activities.
Seoul National University
Benzoindoloquinolines interact with DNA tetraplexes and inhibit telomerase.
National Museum Of Natural History
Antitumor polycyclic acridines. 8.(1) Synthesis and telomerase-inhibitory activity of methylated pentacyclic acridinium salts.
University Of Nottingham
Small molecule/nucleic acid affinity chromatography: application for the identification of telomerase inhibitors which target its key RNA/DNA heteroduplex.
University Of Missouri
Solid-Phase synthesis of a library constructed of aromatic phosphate, long alkyl chains and tryptophane components, and identification of potent dipeptide telomerase inhibitors.
Kyushu University
Azidothymidine "Clicked" into 1,2,3-Triazoles: First Report on Carbonic Anhydrase-Telomerase Dual-Hybrid Inhibitors.
Universit£
A novel inhibitor of human telomerase derived from 10H-indolo[3,2-b]quinoline.
Reading University
Human telomerase inhibition by substituted acridine derivatives.
The Institute Of Cancer Research
Inhibition of human telomerase by PNA-cationic peptide conjugates.
University Of Cambridge
Cinnamamide: An insight into the pharmacological advances and structure-activity relationships.
National Institute Of Pharmaceutical Education And Research (Niper)
Human telomerase inhibition by regioisomeric disubstituted amidoanthracene-9,10-diones.
The Institute Of Cancer Research
Inhibition of human telomerase by a G-quadruplex-interactive compound.
Institute For Drug Development