45 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Structure-based hybridization, synthesis and biological evaluation of novel tetracyclic heterocyclic azathioxanthone analogues as potential antitumor agents.
Taipei Medical University
Design, synthesis and evaluation of thiohydantoin derivatives as potent topoisomerase I (Top1) inhibitors with anticancer activity.
Shiv Nadar University
Stereoselective synthesis of 11-phenylundeca-5Z,9Z-dienoic acid and investigation of its human topoisomerase I and IIa inhibitory activity.
Russian Academy Of Science
Inhibitory activities against topoisomerase I and II by isoaurostatin derivatives and their structure-activity relationships.
Kumamoto University
Inhibition of human topoisomerases I and II by simocyclinone D8.
University Of Minnesota Medical School
Inverse virtual screening of antitumor targets: pilot study on a small database of natural bioactive compounds.
Universita Di Salerno
Synthesis and antiproliferative evaluation of certain indeno[1,2-c]quinoline derivatives. Part 2.
Kaohsiung Medical University
Cytotoxicity and inhibition of DNA topoisomerase I of polyhydroxylated triterpenoids and triterpenoid glycosides.
Stephen F. Austin State University
Indole alkaloids and other constituents of Rauwolfia serpentina.
Kobe Pharmaceutical University
Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex.
Decode Biostructures
Quantized surface complementarity diversity (QSCD): a model based on small molecule-target complementarity.
Neogenesis
Camptothecin and minor-groove binder hybrid molecules: synthesis, inhibition of topoisomerase I, and anticancer cytotoxicity in vitro.
University Of Alberta
Antiretroviral agents as inhibitors of both human immunodeficiency virus type 1 integrase and protease.
National Cancer Institute-Bethesda
Synthesis, topoisomerase I inhibitory activity, and in vivo evaluation of 11-azacamptothecin analogs.
Glaxo Inc. Research Institute
Plant antitumor agents. 30. Synthesis and structure activity of novel camptothecin analogs.
Research Triangle Institute
Catalytic inhibition of eukaryotic topoisomerases I and II by flavonol glycosides extracted from Vicia faba and Lotus edulis.
University Of Thessaly
Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases.
University Of Cagliari
A Strategy for Identifying Novel, Mechanistically Unique Inhibitors of Topoisomerase I
TBA
The synthesis and evaluation of flexible analogues of the topoisomerase I inhibitor, camptothecin
TBA
Synthesis and biological activities of topoisomerase I inhibitors, 6-arylmethylamino analogues of edotecarin.
Tsukuba Research Institute
Synthesis of new camptothecin analogs with improved antitumor activities.
Chugai Pharmaceutical
Total synthesis and biological evaluation of (5Z,9Z)-5,9-hexadecadienoic acid, an inhibitor of human topoisomerase I.
University Of Puerto Rico
Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonospora alba.
Kumamoto University
Synthesis, cytotoxicity, and DNA topoisomerase II inhibitory activity of benzofuroquinolinediones.
Ewha Womans University
Discovery of a fluoroindolo[2,3-a]carbazole clinical candidate with broad spectrum antitumor activity in preclinical tumor models superior to the marketed oncology drug, CPT-11.
The Bristol-Myers Squibb Pharmaceutical Research Institute
Camptothecin analogs with bulky, hydrophobic substituents at the 7-position via a Grignard reaction.
Research Triangle Institute
Inhibitory activities against topoisomerase I and II by polyhydroxybenzoyl amide derivatives and their structure-activity relationship.
Kumamoto University
Synthesis, topoisomerase I inhibition and structure-activity relationship study of 2,4,6-trisubstituted pyridine derivatives.
Liaoning Normal University
Synthesis and biological activities of NB-506 analogues modified at the glucose group.
Banyu Tsukuba Research Institute
Synthesis and biological activities of NB-506 analogues: Effects of the positions of two hydroxyl groups at the indole rings.
Banyu Tsukuba Research Institute In Collaboration With Merck Research Laboratories
Naphthazarin derivatives (II): formation of glutathione conjugate, inhibition of DNA topoisomerase-I and cytotoxicity.
Chungnam National University
Synthesis and biological activities of topoisomerase I inhibitors, 6-N-amino analogues of NB-506.
Banyu Tsukuba Research Institute
Indolocarbazole poisons of human topoisomerase I: regioisomeric analogues of ED-110.
Medichem Research
Water soluble inhibitors of topoisomerase I: quaternary salt derivatives of camptothecin.
Glaxo Wellcome Research Institute
Synthesis and antitumor activity of novel water soluble derivatives of camptothecin as specific inhibitors of topoisomerase I.
Glaxo Research Institute
Inhibition of herpes simplex virus type 1 helicase-primase by (dichloroanilino)purines and -pyrimidines.
Stanford University Medical School
Rigid analogs of camptothecin as DNA topoisomerase I inhibitors.
Glaxo Research Institute