PMID

Data

Article Title

Organization

Optimization of N-benzoylindazole derivatives as inhibitors of human neutrophil elastase.

Universit£

Design and synthesis of selective keto-1,2,4-oxadiazole-based tryptase inhibitors.

Celera Genomics

Kinase inhibitors: not just for kinases anymore.

Northwestern University

Discovery of 1-(2-aminomethylphenyl)-3-trifluoromethyl-N- [3-fluoro-2'-(aminosulfonyl)[1,1'-biphenyl)]-4-yl]-1H-pyrazole-5-carboxyamide (DPC602), a potent, selective, and orally bioavailable factor Xa inhibitor(1).

Pharmaceutical Research Institute

Discovery of 1-[3-(aminomethyl)phenyl]-N-3-fluoro-2'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a highly potent, selective, and orally bioavailable inhibitor of blood coagulation factor Xa.

Dupont Pharmaceuticals

 

(3R, 4S)-3-Benzyl-4-bromomethyloxetan-2-one, a fast acting alternate substrate inhibitor of α-chymotrypsin

TBA

Isatin compounds as noncovalent SARS coronavirus 3C-like protease inhibitors.

Peking University

Novel, potent, selective, and orally bioavailable human betaII-tryptase inhibitors.

Celera Genomics

Ketene aminal-based lactam derivatives as a novel class of orally active FXa inhibitors.

Bristol-Myers Squibb Pharmaceutical Research Institute

P4 and P1' optimization of bicycloproline P2 bearing tetrapeptidyl alpha-ketoamides as HCV protease inhibitors.

Eli Lilly

N-[2,2-dimethyl-3-(N-(4-cyanobenzoyl)amino)nonanoyl]-L-phenylalanine ethyl ester as a stable ester-type inhibitor of chymotrypsin-like serine proteases: structural requirements for potent inhibition of alpha-chymotrypsin.

Nippon Steel