The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 2.8M data for 1.2M Compounds and 9.2K Targets. Of those, 1,346K data for 622K Compounds and 4.5K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

If BindingDB was of value to your research, please take a moment to donate to this nonprofit project. Your donation will let us provide you with more data and improved service.

Advanced Search

54 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Rapid, Structure-Based Exploration of Pipecolic Acid Amides as Novel Selective Antagonists of the FK506-Binding Protein 51.EBI
Max Planck Institute Of Psychiatry
Applications of Fluorine in Medicinal Chemistry.EBI
Bristol-Myers Squibb Research And Development
Structure-Affinity Relationship Analysis of Selective FKBP51 Ligands.EBI
Max Planck Institute Of Psychiatry
Increasing the efficiency of ligands for FK506-binding protein 51 by conformational control.EBI
Max Institute Of Psychiatry
Structure-based design of novel, urea-containing FKBP12 inhibitors.EBI
Agouron Pharmaceuticals
 
High-affinity FKBP-12 ligands derived from (R)-()-carvone. Synthesis and evaluation of FK506 pyranose ring replacementsEBI
TBA
 
Design, synthesis and evaluation of dual domain FKBP ligandsEBI
TBA
Synopsis of some recent tactical application of bioisosteres in drug design.EBI
Bristol-Myers Squibb Pharmaceutical Research And Development
Evaluation of synthetic FK506 analogues as ligands for the FK506-binding proteins 51 and 52.EBI
Max Planck Institute Of Psychiatry
Exploration of pipecolate sulfonamides as binders of the FK506-binding proteins 51 and 52.EBI
Max Planck Institute Of Psychiatry
Pipecolic acid derivatives as small-molecule inhibitors of the Legionella MIP protein.EBI
University Of Wu£Rzburg
Joys of molecules. 2. Endeavors in chemical biology and medicinal chemistry.EBI
The Scripps Research Institute
New analgesic drugs derived from phencyclidine.EBI
TBA
Immunophilins: beyond immunosuppression.EBI
Guilford Pharmaceuticals
Cleavage of the cyclohexyl-subunit of rapamycin results in loss of immunosuppressive activity.EBI
Novartis Pharma
 
Synthesis of FK506-Cyclosporin hybrid macrocyclesEBI
TBA
 
Design, synthesis and X-ray crystallographic studies of [7.3.1] and [8.3.1] macrocyclic FKBP-12 ligandsEBI
TBA
 
Preparation and in vitro activities of naphthyl and indolyl ether derivatives of the FK-506 related immunosuppressive macrolide ascomycinEBI
TBA
 
Synthesis and FKBP binding of small molecule mimics of the tricarbonyl region of FK506EBI
TBA
 
Alkyl ether derivatives of the FK-506 related, immunosuppressive macrolide L-683,742 (C31-O-desmethyl ascomycin)EBI
TBA
 
Alkyl ether analogs of the FK-506 related, immunosuppressive macrolide L-683,590 (ascomycin)EBI
TBA
 
Synthesis and evaluation of dual domain macrocyclic FKBP12 ligands.EBI
TBA
 
Synthesis and study of a non macrocyclic FK506 derivative.EBI
TBA
 
The contribution to binding of the pyranoside substituents in the excised binding domain of FK-506EBI
TBA
 
The affinity of the excised binding domain of FK-506 for the immunophilin FKBP12.EBI
TBA
Nuclear magnetic resonance fragment-based identification of novel FKBP12 inhibitors.EBI
University Of California San Diego
Contemporary mTOR inhibitor scaffolds to diseases breakdown: A patent review (2015-2021).EBI
University Of Hradec Kralove
Structure-Based Design of High-Affinity Macrocyclic FKBP51 Inhibitors.EBI
Technical University Darmstadt
Regulation of gene expression by synthetic dimerizers with novel specificity.EBI
Ariad Gene Therapeutics
Targeting Protein Folding: A Novel Approach for the Treatment of Pathogenic Bacteria.EBI
University Of W£Rzburg
Discovery of a novel family of FKBP12 "reshapers" and their use as calcium modulators in skeletal muscle under nitro-oxidative stress.EBI
Universidad Del Pa£S Vasco Upv/Ehu
Targeted Covalent Inhibition of EBI
Broad Institute Of Mit And Harvard
Synthesis of N-glyoxyl prolyl and pipecolyl amides and thioesters and evaluation of their in vitro and in vivo nerve regenerative effects.EBI
Guilford Pharmaceuticals
Solid-phase synthesis of FKBP12 inhibitors: N-sulfonyl and N-carbamoylprolyl/pipecolyl amides.EBI
Guilford Pharmaceuticals
Use of parallel-synthesis combinatorial libraries for rapid identification of potent FKBP12 inhibitors.EBI
Guilford Pharmaceuticals
Antifungal rapamycin analogues with reduced immunosuppressive activity.EBI
Abbott Laboratories
Fluoresceinated FKBP12 ligands for a high-throughput fluorescence polarization assay.EBI
Bristol-Myers Squibb Pharmaceutical Research Institute
Investigating protein-ligand interactions with a mutant FKBP possessing a designed specificity pocket.EBI
Ariad Gene Therapeutics
Retention of immunosuppressant activity in an ascomycin analogue lacking a hydrogen-bonding interaction with FKBP12.EBI
Abbott Laboratories
Synthesis and cytotoxic evaluation of cycloheximide derivatives as potential inhibitors of FKBP12 with neuroregenerative properties.EBI
Max-Planck Research Unit
Potent immunosuppressive C32-O-arylethyl ether derivatives of ascomycin with reduced toxicity.EBI
Merck Research Laboratories
C32-O-phenalkyl ether derivatives of the immunosuppressant ascomycin: a tether length study.EBI
Merck Research Laboratories
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design.EBI
Bristol-Myers Squibb
C32-O-imidazol-2-yl-methyl ether derivatives of the immunosuppressant ascomycin with improved therapeutic potential.EBI
Merck Research Laboratories
Emerging and Re-Emerging Warheads for Targeted Covalent Inhibitors: Applications in Medicinal Chemistry and Chemical Biology.EBI
Eberhard Karls University T£Bingen
Investigations of neurotrophic inhibitors of FK506 binding protein via Monte Carlo simulations.EBI
Yale University
32-Ascomycinyloxyacetic acid derived immunosuppressants. Independence of immunophilin binding and immunosuppressive potency.EBI
Abbott Laboratories
Chemogenomic Profiling of Human and Microbial FK506-Binding Proteins.EBI
Max Planck Institute Of Psychiatry
A calcineurin antifungal strategy with analogs of FK506.EBI
Amplyx Pharmaceuticals
Structure-activity studies of rapamycin analogs: evidence that the C-7 methoxy group is part of the effector domain and positioned at the FKBP12-FRAP interface.BDB
Smithkline Beecham Pharmaceuticals
Design, synthesis, and biological activity of novel polycyclic aza-amide FKBP12 ligands.BDB
Pfizer