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In vitro and in silico PTP-1B inhibition and in vivo antidiabetic activity of semisynthetic moronic acid derivatives.

Universidad Aut£Noma Del Estado De Morelos

Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors.

Indiana University School Of Medicine

Synthesis of oleanolic acid derivatives: In vitro, in vivo and in silico studies for PTP-1B inhibition.

Universidad Aut£Noma Del Estado De Morelos

Crystal structures of the apo form and a complex of human LMW-PTP with a phosphonic acid provide new evidence of a secondary site potentially related to the anchorage of natural substrates.

University Of Campinas

Is RK-682 a promiscuous enzyme inhibitor? Synthesis and in vitro evaluation of protein tyrosine phosphatase inhibition of racemic RK-682 and analogues.

University Of Campinas

A potent and selective inhibitor for the UBLCP1 proteasome phosphatase.

Indiana University

Therapeutic potential of targeting the oncogenic SHP2 phosphatase.

Indiana University School Of Medicine

Synthesis, biological activity and structure-activity relationships of new benzoic acid-based protein tyrosine phosphatase inhibitors endowed with insulinomimetic effects in mouse C2C12 skeletal muscle cells.

University Of Messina

A potent and selective small-molecule inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases.

Indiana University School Of Medicine

Discovery and evaluation of novel inhibitors of mycobacterium protein tyrosine phosphatase B from the 6-Hydroxy-benzofuran-5-carboxylic acid scaffold.

Indiana University School Of Medicine

Low molecular weight phosphotyrosine protein phosphatases as emerging targets for the design of novel therapeutic agents.

University Of Messina

Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells.

University Of Southern California

Antidiabetic activity of some pentacyclic acid triterpenoids, role of PTP-1B: in vitro, in silico, and in vivo approaches.

Universidad Aut£Noma Del Estado De Morelos

New 4-[(5-arylidene-2-arylimino-4-oxo-3-thiazolidinyl)methyl]benzoic acids active as protein tyrosine phosphatase inhibitors endowed with insulinomimetic effect on mouse C2C12 skeletal muscle cells.

University Of Messina

5-Arylidene-2,4-thiazolidinediones as inhibitors of protein tyrosine phosphatases.

Universit£

Small molecule inhibitors of SHP2 tyrosine phosphatase discovered by virtual screening.

Indiana University

Fragment-based discovery of selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA.

University Of California

Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2).

Indiana University School Of Medicine

Synthesis, activity and molecular modeling of a new series of chromones as low molecular weight protein tyrosine phosphatase inhibitors.

University Of Modena And R.E.

5-Arylidene-2-phenylimino-4-thiazolidinones as PTP1B and LMW-PTP inhibitors.

University Of Messina

Structure-Based Design of Active-Site-Directed, Highly Potent, Selective, and Orally Bioavailable Low-Molecular-Weight Protein Tyrosine Phosphatase Inhibitors.

Eli Lilly

Design and synthesis of potent, non-peptidic inhibitors of HPTPbeta.

Procter & Gamble Pharmaceuticals

Discovery of Orally Bioavailable Purine-Based Inhibitors of the Low-Molecular-Weight Protein Tyrosine Phosphatase.

University Of California

Inhibition of Low Molecular Weight Protein Tyrosine Phosphatase by an Induced-Fit Mechanism.

Purdue University

SAR of non-hydrolysable analogs of pyridoxal 5'-phosphate against low molecular weight protein tyrosine phosphatase isoforms.

Saint John'S University

Allosteric Inhibitors of SHP2 with Therapeutic Potential for Cancer Treatment.

Chinese Academy Of Sciences

X-ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors.

Yale University