The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 2.8M data for 1.2M Compounds and 9.2K Targets. Of those, 1,346K data for 622K Compounds and 4.5K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

If BindingDB was of value to your research, please take a moment to donate to this nonprofit project. Your donation will let us provide you with more data and improved service.

Advanced Search

21 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Arylpiperidines as a new class of oxidosqualene cyclase inhibitors.EBI
Ludwig-Maximilians University
Aminopropylindenes derived from Grundmann's ketone as a novel chemotype of oxidosqualene cyclase inhibitors.EBI
Ludwig-Maximilians-Universit£T M£Nchen
Influence of conformation on GRIND-based three-dimensional quantitative structure-activity relationship (3D-QSAR).EBI
Universit£
GRIND-based 3D-QSAR to predict inhibitory activity for similar enzymes, OSC and SHC.EBI
Casmedchem Laboratory
Cytotoxic effects of combination of oxidosqualene cyclase inhibitors with atorvastatin in human cancer cells.EBI
Centre Hospitalier Universitaire Vaudois (Chuv) And University Of Lausanne (Unil
Design, synthesis, and biological evaluation of new (2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-ol ethers as inhibitors of human and Trypanosoma cruzi oxidosqualene cyclase.EBI
Universit£
Synthesis and structure-activity studies of novel orally active non-terpenoic 2,3-oxidosqualene cyclase inhibitors.EBI
F. Hoffmann-La Roche
Inhibitors of human 2,3-oxidosqualene cyclase (OSC) discovered by virtual screening.EBI
Institute Of Microbial Chemistry
Novel pyrrole- and 1,2,3-triazole-based 2,3-oxidosqualene cyclase inhibitors.EBI
Institute Of Microbial Chemistry
 
Inhibition of oxidosqualene cyclase by substituted quinolizidinesEBI
TBA
Oxidosqualene cyclase from Saccharomyces cerevisiae, Trypanosoma cruzi, Pneumocystis carinii and Arabidopsis thaliana expressed in yeast: a model for the development of novel antiparasitic agents.EBI
Università
Design and evaluation of a novel series of 2,3-oxidosqualene cyclase inhibitors with low systemic exposure, relationship between pharmacokinetic properties and ocular toxicity.EBI
Laboratoire Glaxosmithkline
Oxidosqualene cyclase inhibitors as antimicrobial agents.EBI
University Of Utah
Binding structures and potencies of oxidosqualene cyclase inhibitors with the homologous squalene-hopene cyclase.EBI
Albert-Ludwigs-University Of Freiburg
A novel series of 4-piperidinopyridine and 4-piperidinopyrimidine inhibitors of 2,3-oxidosqualene cyclase-lanosterol synthase.EBI
Astrazeneca
29-Methylidene-2,3-oxidosqualene derivatives as stereospecific mechanism-based inhibitors of liver and yeast oxidosqualene cyclase.EBI
Università
Synthesis and inhibition studies of sulfur-substituted squalene oxide analogues as mechanism-based inhibitors of 2,3-oxidosqualene-lanosterol cyclase.EBI
Simon Fraser University
NAD-based inhibitors with anticancer potential.EBI
University Of Minnesota
Discovery of N-(2,3,5-triazoyl)mycophenolic amide and mycophenolic epoxyketone as novel inhibitors of human IMPDH.EBI
Hokkaido University
Antifungal benzo[b]thiophene 1,1-dioxide IMPDH inhibitors exhibit pan-assay interference (PAINS) profiles.EBI
The University Of Queensland
NMR Biochemical Assay for Oxidosqualene Cyclase: Evaluation of Inhibitor Activities on Trypanosoma cruzi and Human Enzymes.EBI
National Institute Of Advanced Industrial Science And Technology (Aist)