PMID

Data

Article Title

Organization

Acyclic tethers mimicking subunits of polysaccharide ligands: selectin antagonists.

Institut De Recherches Cliniques De Montr£Al (Ircm)

Optimization of highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase.

Pfizer

A new approach to explore the binding space of polysaccharide-based ligands: selectin antagonists.

TBA

Rational design of novel, potent small molecule pan-selectin antagonists.

Revotar Biopharmaceuticals

Development of potent non-carbohydrate imidazole-based small molecule selectin inhibitors with antiinflammatory activity.

Ontogen

Novel synthetic inhibitors of selectin-mediated cell adhesion: synthesis of 1,6-bis[3-(3-carboxymethylphenyl)-4-(2-alpha-D- mannopyranosyloxy)phenyl]hexane (TBC1269).

Texas Biotechnology

Studies on selectin blockers. 7. Structure-activity relationships of sialyl Lewis X mimetics based on modified Ser-Glu dipeptides.

Kanebo

Studies on selection blockers. 5. Design, synthesis, and biological profile of sialyl Lewis x mimetics based on modified serine-glutamic acid dipeptides.

Kanebo

Sulfated galactocerebrosides as potential antiinflammatory agents.

Bristol-Myers Squibb Pharmaceutical Research Institute

Studies on selectin blocker. 1. Structure-activity relationships of sialyl Lewis X analogs.

Institute Of Cancer Research

Studies on selectin blocker. 3. Investigation of the carbohydrate ligand sialyl Lewis X recognition site of P-selectin.

Kanebo

Studies on selectin blockers. 2. Novel selectin blocker as potential therapeutics for inflammatory disorders.

New Drug Research Laboratory

Rational design and synthesis of small molecule, non-oligosaccharide selectin inhibitors: (alpha-D-mannopyranosyloxy)biphenyl-substituted carboxylic acids.

Texas Biotechnology

Design and synthesis of a new sialyl Lewis X mimetic: how selective are the selectin receptors?

Universit£

A solid-phase synthesis for beta-turn mimetics of sialyl Lewis X.

Nippon Organon K.K.

Synthesis of sialyl Lewis X mimetics using the Ugi four-component reaction.

Scripps Research Institute

Discovery of 2-[1-(4-chlorophenyl)cyclopropyl]-3-hydroxy-8-(trifluoromethyl)quinoline-4-carboxylic acid (PSI-421), a P-selectin inhibitor with improved pharmacokinetic properties and oral efficacy in models of vascular injury.

Pfizer

Synthesis of fluorinated C-mannopeptides as sialyl Lewisx mimics for E- and P-selectin inhibition.

Universit£

Isolation and structure determination of sulfonoquinovosyl dipalmitoyl glyceride, a P-selectin receptor inhibitor from the alga Dictyochloris fragrans.

Bristol-Myers Squibb Pharmaceutical Research Institute

 

Chemical and enzymatic synthesis of high-affinity selectin ligands

TBA

 

Design and synthesis of an α-mannosyl terpenoid as selective inhibitor of P-selectin

TBA

 

Synthesis and biological activity of novel sialyl-lewis^X conjugates

TBA

2-(4-Chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[H]quinoline-4-carboxylic acid (PSI-697): identification of a clinical candidate from the quinoline salicylic acid series of P-selectin antagonists.

Wyeth Research

Quinic acid derivatives as sialyl Lewis(x)-mimicking selectin inhibitors: design, synthesis, and crystal structure in complex with E-selectin.

Wyeth

Sialyl Lewis(x) analogs based on a quinic acid scaffold as the fucose mimic.

National Chemical Engineering Institute In Paris

Structural modification aimed for improving solubility of lead compounds in early phase drug discovery.

Indian Institute Of Technology (B.H.U.)

Drug design, synthesis, and evaluation of a non-sugar-based selectin antagonist.

Organon K.K.

Aryl C-glycosides: physiologically stable glycomimetics of sialyl Lewis X.

Sankyo

Cinnamamide: An insight into the pharmacological advances and structure-activity relationships.

National Institute Of Pharmaceutical Education And Research (Niper)

Selectin-ligand interactions revealed by molecular dynamics simulation in solution.

Kanebo

Carbohydrates in an acidic multivalent assembly: nanomolar P-selectin inhibitors.

Lawrence Berkeley National Laboratories