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Recent discovery of non-nucleobase thymidine phosphorylase inhibitors targeting cancer.

Aimst University

Discovery of mixed type thymidine phosphorylase inhibitors endowed with antiangiogenic properties: synthesis, pharmacological evaluation and molecular docking study of 2-thioxo-pyrazolo[1,5-a][1,3,5]triazin-4-ones. Part II.

National University Of Singapore

Fragment-based approach to the design of 5-chlorouracil-linked-pyrazolo[1,5-a][1,3,5]triazines as thymidine phosphorylase inhibitors.

National University Of Singapore

Design of novel potent inhibitors of human uridine phosphorylase-1: synthesis, inhibition studies, thermodynamics, and in vitro influence on 5-fluorouracil cytotoxicity.

Pontifical Catholic University Of Rio Grande Do Sul

A structure-activity relationship study of 1,2,4-triazolo[1,5-a][1,3,5]triazin-5,7-dione and its 5-thioxo analogues on anti-thymidine phosphorylase and associated anti-angiogenic activities.

National University Of Singapore

Synthesis of pyrazolo[1,5-a][1,3,5]triazine derivatives as inhibitors of thymidine phosphorylase.

National University Of Singapore

Structural diversity of nucleoside phosphonic acids as a key factor in the discovery of potent inhibitors of rat T-cell lymphoma thymidine phosphorylase.

Academy Of Sciences Of The Czech Republic

Aminoimidazolylmethyluracil analogues as potent inhibitors of thymidine phosphorylase and their bioreductive nitroimidazolyl prodrugs.

University Of Manchester

Identification of a novel class of inhibitor of human and Escherichia coli thymidine phosphorylase by in silico screening.

University Of Manchester

Design of novel N-(2,4-dioxo-1,2,3,4-tetrahydro-thieno[3,2-d]pyrimidin-7-yl)-guanidines as thymidine phosphorylase inhibitors, and flexible docking to a homology model.

Attenuon

8-Aza-7,9-dideazaxanthine acyclic nucleoside phosphonate inhibitors of thymidine phosphorylase.

Academy Of Sciences Of The Czech Republic

The role of phosphate in the action of thymidine phosphorylase inhibitors: Implications for the catalytic mechanism.

University At Buffalo

Xanthine oxidase-activated prodrugs of thymidine phosphorylase inhibitors.

The University Of Manchester

Synthesis and evaluation of multisubstrate bicyclic pyrimidine nucleoside inhibitors of human thymidine phosphorylase.

Attenuon

5'-O-tritylinosine and analogues as allosteric inhibitors of human thymidine phosphorylase.

Instituto De QuíMica MéDica (Csic)

Potential tumor-selective nitroimidazolylmethyluracil prodrug derivatives: inhibitors of the angiogenic enzyme thymidine phosphorylase.

University Of Manchester

Structure-activity relationship of biaryl acylsulfonamide analogues on the human EP(3) prostanoid receptor.

Merck Frosst Centre For Therapeutic Research

Novel nonsubstrate inhibitors of human thymidine phosphorylase, a potential target for tumor-dependent angiogenesis.

Istituto Di Genetica Biochimica Ed Evoluzionistica

Design of Novel Inhibitors of Human Thymidine Phosphorylase: Synthesis, Enzyme Inhibition, in Vitro Toxicity, and Impact on Human Glioblastoma Cancer.

Universidade Federal Do Pampa

1,3,5-Triazines: A promising scaffold for anticancer drugs development.

Universit£

Synthesis and biological evaluation of novel 1-(aryl-aldehyde-oxime)uracil derivatives as a new class of thymidine phosphorylase inhibitors.

Yunnan University

Rational design of bis-indolylmethane-oxadiazole hybrids as inhibitors of thymidine phosphorylase.

Imam Abdulrahman Bin Faisal University

Discovery of 5-Substituted-6-chlorouracils as Efficient Inhibitors of Human Thymidine Phosphorylase.

Gilead Sciences

Design and synthesis of novel 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase.

Academy Of Sciences Of The Czech Republic