43 articles for thisTarget
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Fragment-Based Discovery of 2-Aminoquinazolin-4(3H)-ones As Novel Class Nonpeptidomimetic Inhibitors of the Plasmepsins I, II, and IV.
Latvian Institute Of Organic Synthesis
Chalcone scaffolds as anti-infective agents: structural and molecular target perspectives.
Guru Ghasidas Vishwavidyalaya (A Central University)
Plasmepsin inhibitory activity and structure-guided optimization of a potent hydroxyethylamine-based antimalarial hit.
Latvian Institute Of Organic Synthesis
Optimization of plasmepsin inhibitor by focusing on similar structural feature with chloroquine to avoid drug-resistant mechanism of Plasmodium falciparum.
Kyoto Pharmaceutical University
Evaluation of aminohydantoins as a novel class of antimalarial agents.
Saint Louis University
Discovery of non-peptide inhibitors of Plasmepsin II by structure-based virtual screening.
East China University Of Science And Technology
Identification of acridinyl hydrazides as potent aspartic protease inhibitors.
University Of Karachi
Incorporating molecular shape into the alignment-free Grid-Independent Descriptors.
Universitat Pompeu Fabra
Plasmepsin II inhibition and antiplasmodial activity of Primaquine-Statine 'double-drugs'.
University Of Milan
Identification of potent inhibitors of Plasmodium falciparum plasmepsin II from an encoded statine combinatorial library.
Pharmacopeia
New benzimidazole derivatives as antiplasmodial agents and plasmepsin inhibitors: synthesis and analysis of structure-activity relationships.
University Of Karachi
Identification of plasmepsin inhibitors as selective anti-malarial agents using ligand based drug design.
Trinity College
Quinolines and structurally related heterocycles as antimalarials.
National Institute Of Pharmaceutical Education And Research
Improvement of both plasmepsin inhibitory activity and antimalarial activity by 2-aminoethylamino substitution.
Kyoto Pharmaceutical University
Mechanism-based inhibitors of the aspartyl protease plasmepsin II as potential antimalarial agents.
Wayne State University
alpha-Substituted norstatines as the transition-state mimic in inhibitors of multiple digestive vacuole malaria aspartic proteases.
Uppsala University
Recent developments in the design and synthesis of hybrid molecules based on aminoquinoline ring and their antiplasmodial evaluation.
Universidad Industrial De Santander
Expedient solid-phase synthesis of both symmetric and asymmetric diol libraries targeting aspartic proteases.
National University Of Singapore
Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin.
Kyoto Pharmaceutical University
New antiinfective and human 5-HT2 receptor binding natural and semisynthetic compounds from the Jamaican sponge Smenospongia aurea.
The University Of Mississippi
Additional interaction of allophenylnorstatine-containing tripeptidomimetics with malarial aspartic protease plasmepsin II.
Kyoto Pharmaceutical University
High antiplasmodial activity of novel plasmepsins I and II inhibitors.
University Of Milan
Synthesis of malarial plasmepsin inhibitors and prediction of binding modes by molecular dynamics simulations.
Uppsala University
Design and synthesis of potent inhibitors of plasmepsin I and II: X-ray crystal structure of inhibitor in complex with plasmepsin II.
LinköPing University
Structural modification aimed for improving solubility of lead compounds in early phase drug discovery.
Indian Institute Of Technology (B.H.U.)
4-Aryl Pyrrolidines as a Novel Class of Orally Efficacious Antimalarial Agents. Part 1: Evaluation of 4-Aryl- N-benzylpyrrolidine-3-carboxamides.
Saint Louis University
Potent, low-molecular-weight non-peptide inhibitors of malarial aspartyl protease plasmepsin II.
University Of California
Evaluation of a structure-based statine cyclic diamino amide encoded combinatorial library against plasmepsin II and cathepsin D.
Pharmacopeia
Plasmepsin Inhibitors in Antimalarial Drug Discovery: Medicinal Chemistry and Target Validation (2000 to Present).
University Of Zambia
Exploiting Structural Dynamics To Design Open-Flap Inhibitors of Malarial Aspartic Proteases.
Latvian Institute Of Organic Synthesis
Peptidomimetic plasmepsin inhibitors with potent anti-malarial activity and selectivity against cathepsin D.
Latvian Institute Of Organic Synthesis
2-Aminoquinazolin-4(3H)-one based plasmepsin inhibitors with improved hydrophilicity and selectivity.
Latvian Institute Of Organic Synthesis
Antiplasmodial activity of hydroxyethylamine analogs: Synthesis, biological activity and structure activity relationship of plasmepsin inhibitors.
University Of Delhi
Characterisation of hydrazides and hydrazine derivatives as novel aspartic protease inhibitors.
University Of Karachi
Achiral oligoamines as versatile tool for the development of aspartic protease inhibitors.
Philipps University Marburg
High-speed optimization of inhibitors of the malarial proteases plasmepsin I and II.
Uppsala University
Design and synthesis of plasmepsin I and plasmepsin II inhibitors with activity in Plasmodium falciparum-infected cultured human erythrocytes.
Uppsala University
Potent inhibitors of the Plasmodium falciparum enzymes plasmepsin I and II devoid of cathepsin D inhibitory activity.
Uppsala University