PMID

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Article Title

Organization

Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein-Protein Interaction.

Janssen Research and Development

Discovery of highly potent TNFa inhibitors using virtual screen.

Peking University

Prediction of anti-tumor chemical probes of a traditional Chinese medicine formula by HPLC fingerprinting combined with molecular docking.

The Second People'S Hospital of Fujian Provinc

Solvent Selection for Insoluble Ligands, a Challenge for Biological Assay Development: A TNF-?/SPD304 Study.

The Centre For Research and Technology of Thessaly (Ce.Re.Te.Th.)

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces.

University of California San Francisco

Substituted isoquinolines and quinazolines as potential antiinflammatory agents. Synthesis and biological evaluation of inhibitors of tumor necrosis factor alpha.

University of California

Discovery of 3-OH-3-methylpipecolic hydroxamates: potent orally active inhibitors of aggrecanase and MMP-13.

Pfizer

Discovery of a Novel Potent and Selective Calcium Release-Activated Calcium Channel Inhibitor: 2,6-Difluoro-

Lupin

Identification and Validation of New Interleukin-2 Ligands Using DNA-Encoded Libraries.

Philochem

Structure based design and synthesis of novel Toll-like Receptor 2 (TLR 2) lipid antagonists.

Neuropore Therapies

Rationally designed TNF-? inhibitors: Identification of promising cytotoxic agents.

Guru Nanak Dev University

Development of Orally Efficacious Allosteric Inhibitors of TNF? via Fragment-Based Drug Design.

Abbvie

Fragment-to-Lead Medicinal Chemistry Publications in 2019.

Novartis Institutes For Biomedical Research

Biologic-like In Vivo Efficacy with Small Molecule Inhibitors of TNF? Identified Using Scaffold Hopping and Structure-Based Drug Design Approaches.

Bristol Myers Squibb

Discovery of an Orally Active Small-Molecule Tumor Necrosis Factor-? Inhibitor.

Huazhong University of Science and Technology

Development of Small-Molecules Targeting Receptor Activator of Nuclear Factor-?B Ligand (RANKL)-Receptor Activator of Nuclear Factor-?B (RANK) Protein-Protein Interaction by Structure-Based Virtual Screening and Hit Optimization.

Shanghai Jiaotong University School of Medicine

Structural modifications of thalidomide produce analogs with enhanced tumor necrosis factor inhibitory activity.

Celgene

Potent inhibition of tumor necrosis factor-alpha production by tetrafluorothalidomide and tetrafluorophthalimides.

Institute of Technology

Substituted xanthines, pteridinediones, and related compounds as potential antiinflammatory agents. Synthesis and biological evaluation of inhibitors of tumor necrosis factor alpha.

University of California

Beta-aryl-succinic acid hydroxamates as dual inhibitors of matrix metalloproteinases and tumor necrosis factor alpha converting enzyme.

Preclinical Research Novartis Pharma

Synthesis and in vitro evaluations of 6-(hetero)-aryl-imidazo[1,2-b]pyridazine-3-sulfonamide's as an inhibitor of TNF-? production.

Padmashri Vikhe Patil College of Arts

Synthesis and biological evaluation of pyridine-linked indanone derivatives: Potential agents for inflammatory bowel disease.

Yeungnam University

Synthesis, pH dependent, plasma and enzymatic stability of bergenin prodrugs for potential use against rheumatoid arthritis.

Csir-Indian Institute of Integrative Medicine

A novel small-molecule tumor necrosis factor a inhibitor attenuates inflammation in a hepatitis mouse model.

Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College