PMID

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Article Title

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Design and synthesis of a new series of 3,5-disubstituted isoxazoles active against Trypanosoma cruzi and Leishmania amazonensis.

Federal University Of Santa Catarina

Inhibitory effect of phenothiazine- and phenoxazine-derived chloroacetamides on Leishmania major growth and Trypanosoma brucei trypanothione reductase.

University Of Wuerzburg

Applications of Fluorine in Medicinal Chemistry.

Bristol-Myers Squibb Research And Development

Dibenzosuberyl substituted polyamines and analogs of clomipramine as effective inhibitors of trypanothione reductase; molecular docking, and assessment of trypanocidal activities.

Canisius College

Synthesis and evaluation of the antiparasitic activity of bis-(arylmethylidene) cycloalkanones.

Universidade Federal De Minas Gerais

Identification of M. tuberculosis thioredoxin reductase inhibitors based on high-throughput docking using constraints.

Msd Animal Health Innovation

High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity.

Harvard Medical School

Inhibitors of Trypanosoma cruzi trypanothione reductase revealed by virtual screening and parallel synthesis.

Universit£T Heidelberg

Use of an additional hydrophobic binding site, the Z site, in the rational drug design of a new class of stronger trypanothione reductase inhibitor, quaternary alkylammonium phenothiazines.

University Of Manchester

Optimising inhibitors of trypanothione reductase using solid-phase chemistry.

University Of Southamton

Dihydroquinazolines as a novel class of Trypanosoma brucei trypanothione reductase inhibitors: discovery, synthesis, and characterization of their binding mode by protein crystallography.

University Of Dundee

A fast virtual screening approach to identify structurally diverse inhibitors of trypanothione reductase.

Universit£

Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity.

Monash University (Parkville Campus)

Assessing the trypanocidal potential of natural and semi-synthetic diketopiperazines from two deep water marine-derived fungi.

University Of California Santa Cruz

Discovery of novel and potent benzhydryl-tropane trypanocides highly selective for Trypanosoma cruzi.

Institute Of Medical Research

Neglected tropical diseases: multi-target-directed ligands in the search for novel lead candidates against Trypanosoma and Leishmania.

University Of Bologna

Interactions of methylene blue with human disulfide reductases and their orthologues from Plasmodium falciparum.

Biochemie-Zentrum Der Universit£T Heidelberg

Privileged structure-guided synthesis of quinazoline derivatives as inhibitors of trypanothione reductase.

Alma Mater Studiorum-Bologna University

 

Novel polyamine derivatives as potent competitive inhibitors of Trypanosoma cruzi trypanothione reductase

TBA

 

Synthesis of non reducible inhibitors for trypanothione reductase from Trypanosoma cruzi.

TBA

The use of natural product scaffolds as leads in the search for trypanothione reductase inhibitors.

Pontificia Universidad Catolica Del Peru

Novel alkylpolyaminoguanidines and alkylpolyaminobiguanides with potent antitrypanosomal activity.

Wayne State University

Antitrypanosomal, antileishmanial, and antimalarial activities of quaternary arylalkylammonium 2-amino-4-chlorophenyl phenyl sulfides, a new class of trypanothione reductase inhibitor, and of N-acyl derivatives of 2-amino-4-chlorophenyl phenyl sulfide.

University Of Manchester

Irreversible inactivation of trypanothione reductase by unsaturated Mannich bases: a divinyl ketone as key intermediate.

Biochemie-Zentrum Der UniversitäT Heidelberg

Beyond direct Nrf2 activation; reinvestigating 1,2,4-oxadiazole scaffold as a master key unlocking the antioxidant cellular machinery for cancer therapy.

Alexandria University

Efficient Dimerization Disruption of

Instituto De Qu£Mica M£Dica (Iqm-Csic)

Antitrypanosomal activities and cytotoxicity of 5-nitro-2-furancarbohydrazides.

Université

Piperlonguminine and Piperine Analogues as TrxR Inhibitors that Promote ROS and Autophagy and Regulate p38 and Akt/mTOR Signaling.

Nantong University

Antiprotozoal and cytotoxicity evaluation of sulfonamide and urea analogues of quinacrine.

University Of Cape Town

Polyamines with N-(3-phenylpropyl) substituents are effective competitive inhibitors of trypanothione reductase and trypanocidal agents.

Indiana State University

2- and 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: synthesis and correlation between redox cycling activities and in vitro cytotoxicity.

Umr 8525 Cnrs - Université

Parallel synthesis of a library of 1,4-naphthoquinones and automated screening of potential inhibitors of trypanothione reductase from Trypanosoma cruzi.

Université

Inhibition of Trypanosoma cruzi trypanothione reductase by acridines: kinetic studies and structure-activity relationships.

Heidelberg University

Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design.

Bristol-Myers Squibb

Novel electrophilic amides amenable by the Ugi reaction perturb thioredoxin system via thioredoxin reductase 1 (TrxR1) inhibition: Identification of DVD-445 as a new lead compound for anticancer therapy.

University Of Belgrade

Structure-activity relationships in 2-aminodiphenylsulfides against trypanothione reductase from Trypanosoma cruzi.

Ura Cnrs 1309

Phenothiazine inhibitors of trypanothione reductase as potential antitrypanosomal and antileishmanial drugs.

University Of Manchester

Conjugation of quinones with natural polyamines: toward an expanded antitrypanosomatid profile.

University Of Bologna

Novel curcumin analogue hybrids: Synthesis and anticancer activity.

Anhui Medical University

Synthesis and antikinetoplastid evaluation of bis(benzyl)spermidine derivatives.

Universit£

Synthesis and 2D-QSAR studies of neolignan-based diaryl-tetrahydrofuran and -furan analogues with remarkable activity against Trypanosoma cruzi and assessment of the trypanothione reductase activity.

University Of S£O Paulo

Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent.

Lanzhou University

Crassiflorone derivatives that inhibit Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase (TbGAPDH) and Trypanosoma cruzi trypanothione reductase (TcTR) and display trypanocidal activity.

University Of Bologna

Bistacrines as potential antitrypanosomal agents.

Julius-Maximilians-University Of W£Rzburg

Rational design of nitrofuran derivatives: Synthesis and valuation as inhibitors of Trypanosoma cruzi trypanothione reductase.

Universidad Nacional Del Litoral

Development of a novel virtual screening cascade protocol to identify potential trypanothione reductase inhibitors.

University Of Alberta