PMID

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Article Title

Organization

New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III.

University Of Copenhagen

Synthesis and studies on the mGluR agonist activity of FAP4 stereoisomers.

Univ. Rouen

Tetrahydronaphthyridine and dihydronaphthyridinone ethers as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5).

Vanderbilt University Medical Center

Orally active metabotropic glutamate subtype 2 receptor positive allosteric modulators: structure-activity relationships and assessment in a rat model of nicotine dependence.

Sanford-Burnham Medical Research Institute

A virtual screening hit reveals new possibilities for developing group III metabotropic glutamate receptor agonists.

Universite Paris Descartes

(S)-homo-AMPA, a specific agonist at the mGlu6 subtype of metabotropic glutamic acid receptors.

Royal Danish School Of Pharmacy

Metabotropic glutamate receptors: novel targets for drug development.

Cns Research

Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu(4)) with oral efficacy in an antiparkin

Vanderbilt University Medical Center

Isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists.

Banyu Tsukuba Research Institute

L-(+)-2-Amino-4-thiophosphonobutyric acid (L-thioAP4), a new potent agonist of group III metabotropic glutamate receptors: increased distal acidity affords enhanced potency.

Université

Design and synthesis of APTCs (aminopyrrolidinetricarboxylic acids): identification of a new group III metabotropic glutamate receptor selective agonist.

Faust Pharmaceuticals

Development and profiling of mGlu

Vanderbilt University

Synthesis, in vitro pharmacology, structure-activity relationships, and pharmacokinetics of 3-alkoxy-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as potent and selective group II metabotropic glutamate receptor antagonists.

Taisho Pharmaceutical

(2S,1'S,2'R,3'R)-2-(2'-Carboxy-3'-hydroxymethylcyclopropyl) glycine is a highly potent group 2 and 3 metabotropic glutamate receptor agonist with oral activity.

Eli Lilly

Synthesis and SAR of a series of mGlu

Vanderbilt University

Discovery of VU6027459: A First-in-Class Selective and CNS Penetrant mGlu

Vanderbilt University

Discovery of an Orally Bioavailable and Central Nervous System (CNS) Penetrant mGlu

Vanderbilt University School Of Medicine

Surveying heterocycles as amide bioisosteres within a series of mGlu

Vanderbilt University

Discovery of Novel Central Nervous System Penetrant Metabotropic Glutamate Receptor Subtype 2 (mGlu

Vanderbilt University School Of Medicine

Discovery of VU6005649, a CNS Penetrant mGlu

Vanderbilt University

VU6010608, a Novel mGlu

Vanderbilt University