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117 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
25922179 10 Design, synthesis and evaluation of novel 2-butyl-4-chloroimidazole derived peptidomimetics as Angiotensin Converting Enzyme (ACE) inhibitors.EBI CSIR-Indian Institute of Chemical Technology
25922884 5 Top-down Targeted Metabolomics Reveals a Sulfur-Containing Metabolite with Inhibitory Activity against Angiotensin-Converting Enzyme in Asparagus officinalis.EBI RIKEN Center for Sustainable Resource Science
25016232 109 CoMFA and CoMSIA analysis of ACE-inhibitory, antimicrobial and bitter-tasting peptides.EBI Tianjin University
24980116 3 Design and green synthesis of 2-(diarylalkyl)aminobenzothiazole derivatives and their dual activities as angiotensin converting enzyme inhibitors and calcium channel blockers.EBI CSIR-Indian Institute of Chemical Technology
24735644 19 Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid- hydrolysis.EBI INSERM
23777825 7 Design, synthesis and evaluation of novel 2-hydroxypyrrolobenzodiazepine-5,11-dione analogues as potent angiotensin converting enzyme (ACE) inhibitors.EBI CSIR-Indian Institute of Chemical Technology
23061607 10 Organosilicon molecules with medicinal applications.EBI University of California-Davis
18078750 76 Thiol-based angiotensin-converting enzyme 2 inhibitors: P1 modifications for the exploration of the S1 subsite.EBI GlaxoSmithKline
9379435 30 Validation of EGSITE2, a mixed integer program for deducing objective site models for experimental binding data.EBI University of Michigan
9171867 16 Dual metalloprotease inhibitors: mercaptoacetyl-based fused heterocyclic dipeptide mimetics as inhibitors of angiotensin-converting enzyme and neutral endopeptidase.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
7629809 140 Amino acid side chain descriptors for quantitative structure-activity relationship studies of peptide analogues.EBI University of Illinois at Chicago
8360884 134 Three-dimensional quantitative structure-activity relationship of angiotesin-converting enzyme and thermolysin inhibitors. II. A comparison of CoMFA models incorporating molecular orbital fields and desolvation free energies based on active-analog and complementary-receptor-field alignment rules.EBI Washington University
2329568 30 (Phosphinyloxy)acyl amino acid inhibitors of angiotensin converting enzyme. 2. Terminal amino acid analogues of (S)-1-[6-amino-2 [[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxohexyl]-L-proline.EBI Squibb Institute for Medical Research
3336020 34 (Phosphinyloxy)acyl amino acid inhibitors of angiotensin converting enzyme (ACE). 1. Discovery of (S)-1-[6-amino-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxohexyl]-L -proline a novel orally active inhibitor of ACE.EBI Squibb Institute for Medical Research
2991518 11 Synthesis and biological activity of carboxylic acid replacement analogues of the potent angiotensin converting enzyme inhibitor 5(S)-benzamido-4-oxo-6-phenylhexanoyl-L-proline.EBI TBA
2991517 4 Synthesis and biological activity of pentapeptide analogues of the potent angiotensin converting enzyme inhibitor 5(S)-benzamido-4-oxo-6-phenylhexanoyl-L-proline.EBI TBA
2984419 21 Angiotensin-converting enzyme inhibitors: synthesis and biological activity of acyl tripeptide analogues of enalapril.EBI TBA
6279843 27 Angiotensin-converting enzyme inhibitors: importance of the amide carbonyl of mercaptoacyl amino acids for hydrogen bonding to the enzyme.EBI TBA
6256550 8 Synthesis and biological activity of a ketomethylene analogue of a tripeptide inhibitor of angiotensin converting enzyme.EBI TBA
21413808 170 Synopsis of some recent tactical application of bioisosteres in drug design.EBI Bristol-Myers Squibb Pharmaceutical Research and Development
21381769 56 Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery.EBI Universite£ de Sherbrooke
22882079 26 Synthesis and evaluation of silanediols as highly selective uncompetitive inhibitors of human neutrophil elastase.EBI Aarhus University
21780776 40 Remarkable potential of thea-aminophosphonate/phosphinate structural motif in medicinal chemistry.EBI Wroclaw University of Technology
19715320 87 Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation.EBI University of Florida
19596577 26 Synthesis and enzymatic evaluation of novel partially fluorinated thiol dual ACE/NEP inhibitors.EBI Dipartimento di Chimica
18160283 26 Targeting ACE and ECE with dual acting inhibitors.EBI Universit£ de Montr£al
16220969 219 Designed multiple ligands. An emerging drug discovery paradigm.EBI Organon Laboratories
15658862 30 Endothelin-converting enzyme-1 inhibition and growth of human glioblastoma cells.EBI University Institute of Pathology
12477342 27 2002 Alfred Burger Award Address in Medicinal Chemistry. Natural products and design: interrelated approaches in drug discovery.EBI Merck Research Laboratories
10669559 180 Protease inhibitors: current status and future prospects.EBI University of Queensland
10882358 62 Hydroxamic acid derivatives as potent peptide deformylase inhibitors and antibacterial agents.EBI F. Hoffmann-La Roche Ltd.
10508425 68 Mixture-based synthetic combinatorial libraries.EBI Torrey Pines Institute for Molecular Studies
8544178 46 New alpha-thiol dipeptide dual inhibitors of angiotensin-I converting enzyme and neutral endopeptidase EC CIBA-GEIGY Corporation
8021926 41 New thiol inhibitors of neutral endopeptidase EC synthesis and enzyme active-site recognition.EBI INSERM
8021921 28 Dual angiotensin converting enzyme/thromboxane synthase inhibitors.EBI CIBA-GEIGY Corporation
8340909 14 Excursions in drug discovery.EBI Merck Research Laboratories
1995891 9 Configuration and preferential solid-state conformations of perindoprilat (S-9780). Comparison with the crystal structures of other ACE inhibitors and conclusions related to structure-activity relationships.EBI Institut de Chimie des Substances Naturelles
1995872 5 Molecular and crystal structures of MDL27,467A hydrochloride and quinapril hydrochloride, two ester derivatives of potent angiotensin converting enzyme inhibitors.EBI University of Calgary
2160536 13 Angiotensin converting enzyme inhibitors. 10. Aryl sulfonamide substituted N-[1-carboxy-3-phenylpropyl]-L-alanyl-L-proline derivatives as novel antihypertensives.EBI Rorer Central Research
2120440 22 Orally potent human renin inhibitors derived from angiotensinogen transition state: design, synthesis, and mode of interaction.EBI Kissei Pharmaceutical Company, Ltd.
2153207 31 Phosphoramidate peptide inhibitors of human skin fibroblast collagenase.EBI University of Kentucky
2544729 8 Angiotensin converting enzyme inhibitors: spirapril and related compounds.EBI Schering-Plough Corporation
2566685 44 Inhibition of aminopeptidases by peptides containing ketomethylene and hydroxyethylene amide bond replacements.EBI University of Wisconsin-Madison
2913292 23 Studies on angiotensin converting enzyme inhibitors. 4. Synthesis and angiotensin converting enzyme inhibitory activities of 3-acyl-1-alkyl-2-oxoimidazolidine-4-carboxylic acid derivatives.EBI Tanabe Seiyaku Co., Ltd.
2836590 34 Angiotensin-converting enzyme inhibitors. Mercaptan, carboxyalkyl dipeptide, and phosphinic acid inhibitors incorporating 4-substituted prolines.EBI Princ
2832605 2 Synthesis and pharmacological activity of angiotensin converting enzyme inhibitors: N-(mercaptoacyl)-4-substituted-(S)-prolines.EBI Schering-Plough Corporation
3339612 9 Angiotensin-converting enzyme inhibitors. 2. Perhydroazepin-2-one derivatives.EBI Sankyo Co., Ltd.
3005569 16 Conformationally restricted inhibitors of angiotensin converting enzyme: synthesis and computations.EBI TBA
3531517 17 Design and synthesis of potent and specific renin inhibitors containing difluorostatine, difluorostatone, and related analogues.EBI TBA
3020249 28 Synthesis of novel angiotensin converting enzyme inhibitor quinapril and related compounds. A divergence of structure-activity relationships for non-sulfhydryl and sulfhydryl types.EBI TBA
2993618 19 Synthesis and biological activity of modified peptide inhibitors of angiotensin-converting enzyme.EBI TBA
2983076 13 Conformational analysis and active site modelling of angiotensin-converting enzyme inhibitors.EBI TBA
2983075 24 Angiotensin converting enzyme inhibitors. (Mercaptoaroyl)amino acids.EBI TBA
2999395 30 Angiotensin converting enzyme inhibitors: N-substituted D-glutamic acid gamma dipeptides.EBI TBA
2999394 21 Angiotensin converting enzyme inhibitors: structure-activity profile of 1-benzazepin-2-one derivatives.EBI TBA
3906126 10 Difluorostatine- and difluorostatone-containing peptides as potent and specific renin inhibitors.EBI TBA
2995669 8 Synthesis and biological properties of (carboxyalkyl)amino-substituted bicyclic lactam inhibitors of angiotensin converting enzyme.EBI TBA
2981324 69 Angiotensin-converting enzyme inhibitors. New orally active antihypertensive (mercaptoalkanoyl)- and [(acylthio)alkanoyl]glycine derivatives.EBI TBA
6330355 7 Bicyclic lactam inhibitors of angiotensin converting enzyme.EBI TBA
6310113 28 Angiotensin converting enzyme inhibitors: 1-glutarylindoline-2-carboxylic acids derivatives.EBI TBA
6310112 63 Angiotensin converting enzyme inhibitors: N-substituted monocyclic and bicyclic amino acid derivatives.EBI TBA
9873498 4 Probing the importance of spacial and conformational domains in captopril analogs for angiotensin converting enzyme activity.EBI Universit£ de Montr£al
21782455 16 Synthesis and evaluation of novel 2-butyl-4-chloro-1-methylimidazole embedded chalcones and pyrazoles as angiotensin converting enzyme (ACE) inhibitors.EBI India Institute of Chemical Technology
21621881 30 Angiotensin-I-converting enzyme inhibitory peptides: Chemical feature based pharmacophore generation.EBI Zhejiang University
19949058 15 Blockade of X4-tropic HIV-1 cellular entry by GSK812397, a potent noncompetitive CXCR4 receptor antagonist.EBI GlaxoSmithKline Research and Development
20167484 24 The synthesis and angiotensin converting enzyme (ACE) inhibitory activity of chalcones and their pyrazole derivatives.EBI University of Calabria
19899765 69 Phosphinic tripeptides as dual angiotensin-converting enzyme C-domain and endothelin-converting enzyme-1 inhibitors.EBI CEA, DSV, Service d'Ingenierie Moleculaire des Proteines (SIMOPRO)
19703773 63 The identification of beta-hydroxy carboxylic acids as selective MMP-12 inhibitors.EBI GSK Medicines Research Centre
8904845 3 Isolation and structure of leukotriene-A4 hydrolase inhibitor: 8(S)-amino-2(R)-methyl-7-oxononanoic acid produced by Streptomyces diastaticus.EBI Searle Research and Development
19042128 76 Synthesis and biological evaluation of N-mercaptoacylcysteine derivatives as leukotriene A4 hydrolase inhibitors.EBI Santen Pharmaceutical Co., Ltd
18790648 317 Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.EBI University of Athens
18701300 55 Synthesis and elastase-inhibiting activity of 2-pyridinyl-isothiazol-3(2H)-one 1,1-dioxides.EBI University of Leipzig
18674901 32 Synthesis and biological evaluation of N-mercaptoacylproline and N-mercaptoacylthiazolidine-4-carboxylic acid derivatives as leukotriene A4 hydrolase inhibitors.EBI Santen Pharmaceutical Co., Ltd
16784850 14 Synthesis of novel keto-ACE analogues as domain-selective angiotensin I-converting enzyme inhibitors.EBI University of Cape Town
16784843 4 Synthesis and molecular modeling of a lisinopril-tryptophan analogue inhibitor of angiotensin I-converting enzyme.EBI University of Cape Town
16464585 4 Structure-activity relationship study between Ornithyl-Proline and Lysyl-Proline based tripeptidomimics as angiotensin-converting enzyme inhibitors.EBI Institute of Genomics and Integrative Biology
15125946 9 Silanediol peptidomimetics. Evaluation of four diastereomeric ACE inhibitors.EBI State University of New York
11551755 18 Asymmetric synthesis of BB-3497--a potent peptide deformylase inhibitor.EBI British Biotech Pharmaceuticals Limited
11384231 26 2-(2-Oxo-1,4-dihydro-2H-quinazolin-3-yl)- and 2-(2,2-dioxo-1,4-dihydro-2H-2lambda6-benzo[1,2,6]thiadiazin-3-yl)-N-hydroxy-acetamides as potent and selective peptide deformylase inhibitors.EBI F. Hoffmann-La Roche Ltd.
10698448 23 N-formyl hydroxylamine containing dipeptides: generation of a new class of vasopeptidase inhibitors.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
9925736 16 Vasopeptidase inhibitors: incorporation of geminal and spirocyclic substituted azepinones in mercaptoacyl dipeptides.EBI The Bristol-Myers Squibb Pharmaceutical Research Institute
9484512 130 Highly selective and orally active inhibitors of type IV collagenase (MMP-9 and MMP-2): N-sulfonylamino acid derivatives.EBI Shionogi & Co., Ltd.
9046341 44 Meta-substituted benzofused macrocyclic lactams as zinc metalloprotease inhibitors.EBI CIBA-GEIGY Corporation
8558518 38 Dual metalloprotease inhibitors. 6. Incorporation of bicyclic and substituted monocyclic azepinones as dipeptide surrogates in angiotensin-converting enzyme/neutral endopeptidase inhibitors.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
8496905 6 Synthesis and analgesic effects of N-[3-[(hydroxyamino) carbonyl]-1-oxo-2(R)-benzylpropyl]-L-isoleucyl-L-leucine, a new potent inhibitor of multiple neurotensin/neuromedin N degrading enzymes.EBI CCIPE-Faculté de Pharmacie
8421293 32 Exploration of neutral endopeptidase active site by a series of new thiol-containing inhibitors.EBI INSERM
8360888 12 Application of a conformationally restricted Phe-Leu dipeptide mimetic to the design of a combined inhibitor of angiotensin I-converting enzyme and neutral endopeptidase 24.11.EBI Marion Merrell Dow Research Institute
8254612 8 Heterocyclic lactam derivatives as dual angiotensin converting enzyme and neutral endopeptidase 24.11 inhibitors.EBI CIBA-GEIGY Corporation
8057292 83 Mercaptoacyl amino acid inhibitors of atriopeptidase. 1. Structure-activity relationship studies of methionine and S-alkylcysteine derivatives.EBI Schering-Plough Research Institute
7966160 7 PRO_LIGAND: an approach to de novo molecular design. 2. Design of novel molecules from molecular field analysis (MFA) models and pharmacophores.EBI Proteus Molecular Design Ltd.
7837244 33 Non-peptidic inhibitors of human leukocyte elastase. 4. Design, synthesis, and in vitro and in vivo activity of a series of beta-carbolinone-containing trifluoromethyl ketones.EBI ZENECA Pharmaceuticals
3669006 10 Angiotensin-converting enzyme inhibitors: perhydro-1,4-thiazepin-5-one derivatives.EBI Sankyo Co., Ltd.
3009814 56 Angiotensin-converting enzyme inhibitors: new orally active 1,4-thiazepine-2,5-diones, 1,4-thiazine-2,5-diones, and 1,4-benzothiazepine-2,5-diones possessing antihypertensive activity.EBI TBA
2995664 19 N alpha-(diphenoxyphosphoryl)-L-alanyl-L-proline, N alpha-[bis (4-nitrophenoxy)phosphoryl]-L-alanyl-L-proline, and N alpha-[ (2-phenylethyl)phenoxyphosphoryl]-L-alanyl-L-proline: releasers of potent inhibitors of angiotensin converting enzyme at physiological pH and temperature.EBI TBA
1738153 45 A novel class of enkephalinase inhibitors containing a C-terminal sulfo group.EBI Dainippon Pharmaceutical Co., Ltd.
12358520 27 Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitors.BDB Millennium Pharmaceuticals
18324760 34 Development of Potent and Selective Phosphinic Peptide Inhibitors of Angiotensin-Converting Enzyme 2.BDB University of Athens