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415 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
26503905 51 Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity.EBI University Hospital Hradec Kralove
26363872 19 Synthesis and structure-activity relationship study of benzofuran-based chalconoids bearing benzylpyridinium moiety as potent acetylcholinesterase inhibitors.EBI Alzahra University
26159481 15 A computational view on the significance of E-ring in binding of (+)-arisugacin A to acetylcholinesterase.EBI Alchemical Research, LLC
26363866 39 New multifunctional melatonin-derived benzylpyridinium bromides with potent cholinergic, antioxidant, and neuroprotective properties as innovative drugs for Alzheimer's disease.EBI 1st Affiliated Hospital of Guangxi Medical University
26386602 97 Difluoromethyl ketones: Potent inhibitors of wild type and carbamate-insensitive G119S mutant Anopheles gambiae acetylcholinesterase.EBI Virginia Tech
26260334 28 Galantamine derivatives with indole moiety: Docking, design, synthesis and acetylcholinesterase inhibitory activity.EBI Medical University of Sofia
26242241 30 Synthesis, biological evaluation and molecular modeling of new tetrahydroacridine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.EBI Jagiellonian University Medical College
26222445 5 Carbamoyl Triazoles, Known Serine Protease Inhibitors, Are a Potent New Class of Antimalarials.EBI GlaxoSmithKline
26189031 52 Synthesis of novel triazoles and a tetrazole of escitalopram as cholinesterase inhibitors.EBI University of the Punjab
25678015 6 Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity.EBI Universitat de Barcelona
26105711 50 In vitro evaluation and in silico screening of synthetic acetylcholinesterase inhibitors bearing functionalized piperidine pharmacophores.EBI Visva-Bharati (a Central University)
26043948 44 Synthesis and in vitro kinetic evaluation of N-thiazolylacetamido monoquaternary pyridinium oximes as reactivators of sarin, O-ethylsarin and VX inhibited human acetylcholinesterase (hAChE).EBI Defence Research & Development Establishment (DRDE)
26003339 12 From AChE to BACE1 inhibitors: The role of the amine on the indanone scaffold.EBI University of Bologna
25678013 63 Design, synthesis and evaluation of chromone-2-carboxamido-alkylbenzylamines as multifunctional agents for the treatment of Alzheimer's disease.EBI Sichuan University
25082512 38 Design, synthesis and evaluation of rivastigmine and curcumin hybrids as site-activated multitarget-directed ligands for Alzheimer's disease therapy.EBI Zhejiang University
25282654 56 Design, synthesis and evaluation of novel tacrine-(▀-carboline) hybrids as multifunctional agents for the treatment of Alzheimer's disease.EBI China Pharmaceutical University
25260958 46 Design, synthesis and pharmacological evaluation of chalcone derivatives as acetylcholinesterase inhibitors.EBI Hu'nan University
26116179 5 Structure-based development of nitroxoline derivatives as potential multifunctional anti-Alzheimer agents.EBI University of Ljubljana
25921269 45 Discovery of potent carbonic anhydrase and acetylcholine esterase inhibitors: novel sulfamoylcarbamates and sulfamides derived from acetophenones.EBI AgriIbrahim£e£en University
26107513 172 Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases.EBI Universit£ degli Studi di Bari"Aldo Moro"
26003344 48 Isolation of cholinesterase and▀-secretase 1 inhibiting compounds from Lycopodiella cernua.EBI Catholic University of Daegu
25988399 126 Mitigation of Acetylcholine Esterase Activity in the 1,7-Diazacarbazole Series of Inhibitors of Checkpoint Kinase 1.EBI Argenta Discovery Ltd.
25871261 4 Polycyclic Polyprenylated Acylphloroglucinol Congeners Possessing Diverse Structures from Hypericum henryi.EBI Chinese Academy of Sciences
25778991 116 Design, synthesis and evaluation of scutellarein-O-alkylamines as multifunctional agents for the treatment of Alzheimer's disease.EBI Sichuan University
25812965 80 Multi-target tacrine-coumarin hybrids: cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease.EBI China Pharmaceutical University
25793650 47 Novel multitarget-directed ligands (MTDLs) with acetylcholinesterase (AChE) inhibitory and serotonergic subtype 4 receptor (5-HT4R) agonist activities as potential agents against Alzheimer's disease: the design of donecopride.EBI CERMN
25743215 1 Recent advances of chroman-4-one derivatives: synthetic approaches and bioactivities.EBI Mazandaran University of Medical Sciences
25621991 62 Development of multifunctional, heterodimeric isoindoline-1,3-dione derivatives as cholinesterase and▀-amyloid aggregation inhibitors with neuroprotective properties.EBI Jagiellonian University Medical College
25656088 32 Multifunctional tacrine-trolox hybrids for the treatment of Alzheimer's disease with cholinergic, antioxidant, neuroprotective and hepatoprotective properties.EBI China Pharmaceutical University
25418133 51 N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor.EBI Laboratorio de Qu�mica M�dica, (IQOG, CSIC)
25865131 40 Synthesis and biological evaluation of open-chain analogs of cyclic peptides as inhibitors of cellular Shp2 activity.EBI Hebei University of Science& Technology
25724825 27 Design, synthesis and evaluation of novel 5,6,7-trimethoxyflavone-6-chlorotacrine hybrids as potential multifunctional agents for the treatment of Alzheimer's disease.EBI Wenzhou Medical University
25707322 47 Isoindoline-1,3-dione derivatives targeting cholinesterases: design, synthesis and biological evaluation of potential anti-Alzheimer's agents.EBI Jagiellonian University Medical College
25684426 45 3-Oxoisoxazole-2(3H)-carboxamides and isoxazol-3-yl carbamates: Resistance-breaking acetylcholinesterase inhibitors targeting the malaria mosquito, Anopheles gambiae.EBI Virginia Tech
25614117 37 Multifunctional scutellarin-rivastigmine hybrids with cholinergic, antioxidant, biometal chelating and neuroprotective properties for the treatment of Alzheimer's disease.EBI Sichuan University
25597004 18 Iminosugars as a new class of cholinesterase inhibitors.EBI Universit£ de Strasbourg/CNRS (UMR 7509)
25089370 40 Synthesis and biological evaluation of novel tacrine derivatives and tacrine-coumarin hybrids as cholinesterase inhibitors.EBI P. J. Safarik University
25088549 47 Syntheses of coumarin-tacrine hybrids as dual-site acetylcholinesterase inhibitors and their activity against butylcholinesterase, A▀ aggregation, and▀-secretase.EBI Central China Normal University
25047936 183 Amine substitution of quinazolinones leads to selective nanomolar AChE inhibitors with 'inverted' binding mode.EBI Universit£t Regensburg
25019478 13 Flavones: an important scaffold for medicinal chemistry.EBI Punjabi University
25017625 45 Synthesis and cholinesterase inhibition of cativic acid derivatives.EBI Universidad Nacional del Sur
25016233 14 Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targeting▀-amyloid, tau, and cholinesterase pathologies.EBI Universitat de Barcelona
24934993 6 Coumarin hybrids as novel therapeutic agents.EBI Punjabi University
24909082 9 Synthesis and characterization of novel 1,2-oxazine-based small molecules that targets acetylcholinesterase.EBI N.D. Zelinsky Institute of Organic Chemistry
24811300 20 Biased and unbiased strategies to identify biologically active small molecules.EBI Institut de Chimie des Substances Naturelles
25537270 6 Sulfonamides as multifunctional agents for Alzheimer's disease.EBI University of Massachusetts Boston
25468034 33 Synthesis of aminoalkyl-substituted aurone derivatives as acetylcholinesterase inhibitors.EBI Kyung Hee University
25455147 4 Anithiactins A-C, modified 2-phenylthiazoles from a mudflat-derived Streptomyces sp.EBI Seoul National University
25454267 5 Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines.EBI TBA
25453793 1 Protective effects of aloe-emodin on scopolamine-induced memory impairment in mice and H2O2-induced cytotoxicity in PC12 cells.EBI TBA
25453812 21 New efficient imidazolium aldoxime reactivators for nerve agent-inhibited acetylcholinesterase.EBI Institute of Pharmacology and Toxicology
25259726 44 Multitarget drug design strategy: quinone-tacrine hybrids designed to block amyloid-▀ aggregation and to exert anticholinesterase and antioxidant effects.EBI Alma Mater Studiorum-University of Bologna
25226236 19 Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor.EBI University of Ljubljana
25222040 6 Biotransformation of huperzine A by a fungal endophyte of Huperzia serrata furnished sesquiterpenoid-alkaloid hybrids.EBI Zhejiang University
25205193 10 Synthesis and acetylcholinesterase inhibitory activity of Mannich base derivatives flavokawain B.EBI Hunan University
25190468 15 Assessment of antidotal efficacy of cholinesterase reactivators against paraoxon: In vitro reactivation kinetics and physicochemical properties.EBI Pt. Ravishankar Shukla University
25189690 94 Design, synthesis and biological evaluation of novel 6H-benzo[c]chromen-6-one, and 7,8,9,10-tetrahydro-benzo[c]chromen-6-one derivatives as potential cholinesterase inhibitors.EBI Eastern Mediterranean University
25156301 8 Shogaol-huprine hybrids: dual antioxidant and anticholinesterase agents with▀-amyloid and tau anti-aggregating properties.EBI Universitat de Barcelona
24980117 62 Synthesis ofa,▀-unsaturated carbonyl based compounds as acetylcholinesterase and butyrylcholinesterase inhibitors: characterization, molecular modeling, QSAR studies and effect against amyloid▀-induced cytotoxicity.EBI Universiti Kebangsaan Malaysia
24835788 28 Preparation, anticholinesterase activity and molecular docking of new lupane derivatives.EBI Universidad Nacional del Sur
24738476 15 New melatonin-N,N-dibenzyl(N-methyl)amine hybrids: potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease.EBI Instituto de Qu£mica M£dica
24731278 22 Synthesis and in vitro evaluation of anti-inflammatory activity of ester and amine derivatives of indoline in RAW 264.7 and peritoneal macrophages.EBI Bar Ilan University
24726809 72 Design, synthesis and biological evaluation of benzylisoquinoline derivatives as multifunctional agents against Alzheimer's disease.EBI China Pharmaceutical University
24721830 33 Synthesis and in vitro evaluation of bis-quaternary 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide derivatives as reactivators against sarin and VX inhibited human acetylcholinesterase (hAChE).EBI Defence Research & Development Establishment (DRDE)
24630558 31 Design, synthesis, and characterization of novel, nonquaternary reactivators of GF-inhibited human acetylcholinesterase.EBI Southwest Research Institute
24606395 8 Alkaloids from the roots of Stichoneuron caudatum and their acetylcholinesterase inhibitory activities.EBI University of Wollongong
24568372 40 Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents.EBI Universitat de Barcelona
24131448 7 Oxidative stress in Alzheimer's disease: are we connecting the dots?EBI University of Bologna
24704618 27 Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase.EBI Universit£ de Strasbourg
24704612 23 Design, synthesis, acetylcholinesterase inhibition and larvicidal activity of girgensohnine analogs on Aedes aegypti, vector of dengue fever.EBI Universidad Industrial de Santander
24681980 3 Fluorinated benzophenone derivatives: balanced multipotent agents for Alzheimer's disease.EBI University of Bologna
24657052 42 Quinolone-benzylpiperidine derivatives as novel acetylcholinesterase inhibitor and antioxidant hybrids for Alzheimer disease.EBI Universit£ de Franche Comt£
24220173 37 Preparation, in vitro evaluation and molecular modelling of pyridinium-quinolinium/isoquinolinium non-symmetrical bisquaternary cholinesterase inhibitors.EBI Charles University in Prague
24485122 9 Synthesis of aminoalkyl-substituted coumarin derivatives as acetylcholinesterase inhibitors.EBI Kyung Hee University
24220172 25 Novel tacrine-ebselen hybrids with improved cholinesterase inhibitory, hydrogen peroxide and peroxynitrite scavenging activity.EBI Sun Yat-sen University
24148993 4 Acetylcholinesterase inhibitors as Alzheimer therapy: from nerve toxins to neuroprotection.EBI Punjabi University
23984975 29 Divergent structure-activity relationships of structurally similar acetylcholinesterase inhibitors.EBI Ume£ University
23941108 1 Casuarinines A-J, lycodine-type alkaloids from Lycopodiastrum casuarinoides.EBI Fudan University
23454132 68 Synthesis and discovery of novel piperidone-grafted mono- and bis-spirooxindole-hexahydropyrrolizines as potent cholinesterase inhibitors.EBI Universiti Sains Malaysia
23422935 29 Synthesis of tacrine-lophine hybrids via one-pot four component reaction and biological evaluation as acetyl- and butyrylcholinesterase inhibitors.EBI Universidade Federal do Rio Grande do Sul
23395652 1 Structural analogs of huperzine A improve survival in guinea pigs exposed to soman.EBI University of Illinois at Chicago
23380475 7 Synthesis, biological evaluation and molecular modeling of aloe-emodin derivatives as new acetylcholinesterase inhibitors.EBI Hainan University
23286284 50 Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ("Danshen").EBI St. Jude Children's Research Hospital
23273608 20 Design, synthesis and evaluation of novel heterodimers of donepezil and huperzine fragments as acetylcholinesterase inhibitors.EBI The Hong Kong University of Science and Technology
23273219 17 Synthesis, molecular modeling and evaluation of novel N'-2-(4-benzylpiperidin-/piperazin-1-yl)acylhydrazone derivatives as dual inhibitors for cholinesterases and Aß aggregation.EBI Baskent University
23276831 11 Additional acetyl cholinesterase inhibitory property of diaryl pyrazoline derivatives.EBI Birla Institute of Technology
23199476 36 Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase.EBI Universit£ degli Studi di Bari Aldo Moro
17276075 4 Structure-activity relationships of methoctramine-related polyamines as muscarinic antagonist: effect of replacing the inner polymethylene chain with cyclic moieties.EBI Universit£ di Bologna
15317459 46 Modulation of binding strength in several classes of active site inhibitors of acetylcholinesterase studied by comparative binding energy analysis.EBI Universitat de Barcelona
12109912 9 Structure-activity relationships of methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists. 3. Effect of inserting the tetraamine backbone into a macrocyclic structure.EBI University of Bologna
11141093 20 Hexahydrochromeno[4,3-b]pyrrole derivatives as acetylcholinesterase inhibitors.EBI University of Bologna
14643329 30 3D-QSAR studies on natural acetylcholinesterase inhibitors of Sarcococca saligna by comparative molecular field analysis (CoMFA).EBI University of Innsbruck
21074294 60 Receptor-dependent (RD) 3D-QSAR approach of a series of benzylpiperidine inhibitors of human acetylcholinesterase (HuAChE).EBI Universidade Federal do Rio de Janeiro (UFRJ)
18976927 83 Synthesis and structure-activity relationships for biphenyl H3 receptor antagonists with moderate anti-cholinesterase activity.EBI Universit£ degli Studi di Parma
9435905 180 Three-dimensional quantitative structure-activity relationships from molecular similarity matrices and genetic neural networks. 2. Applications.EBI Harvard University
8558505 77 A comparative molecular field analysis study of N-benzylpiperidines as acetylcholinesterase inhibitors.EBI University of Missouri-St. Louis
3351860 56 Approaches to protection against nerve agent poisoning. (Naphthylvinyl)pyridine derivatives as potential antidotes.EBI Dynamac Corporation
3336013 52 Evaluation of the side arm of (naphthylvinyl)pyridinium inhibitors of choline acetyltransferase.EBI University of Pittsburgh
3965704 22 Synthesis of some quaternary ammonium alkylating agents and their effects on soman-inhibited acetylcholinesterase.EBI TBA
22795665 24 Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amines as potential drugs for the treatment of Alzheimer's disease.EBI Universit£ de Sfax
23151013 56 Carbamate derivatives of indolines as cholinesterase inhibitors and antioxidants for the treatment of Alzheimer's disease.EBI Bar Ilan University
23148598 8 Phenyltetrahydroisoquinoline-pyridinaldoxime conjugates as efficient uncharged reactivators for the dephosphylation of inhibited human acetylcholinesterase.EBI Universit£ de Rouen
23033965 37 Combining galantamine and memantine in multitargeted, new chemical entities potentially useful in Alzheimer's disease.EBI Istituto Italiano di Tecnologia
23062825 37 Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.EBI Abo Akademi University
22817559 4 Metaproterenol, isoproterenol, and their bisdimethylcarbamate derivatives as human cholinesterase inhibitors.EBI Institute for Medical Research and Occupational Health
23164658 78 2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents.EBI University of Bologna
23041347 33 Design, synthesis, and bioevaluation of benzamides: novel acetylcholinesterase inhibitors with multi-functions on butylcholinesterase, Aß aggregation, andß-secretase.EBI Central China Normal University
23026084 17 Lead optimization studies towards the discovery of novel carbamates as potent AChE inhibitors for the potential treatment of Alzheimer's disease.EBI CSIR Central Drug Research Institute
22944335 43 O-Hydroxyl- or o-amino benzylamine-tacrine hybrids: multifunctional biometals chelators, antioxidants, and inhibitors of cholinesterase activity and amyloid-ß aggregation.EBI Sun Yat-sen University
23078965 19 Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: synthesis, biological assessment, and molecular modeling.EBI Instituto de Qu£mica Org£nica General (CSIC)
22775474 9 Geranylphenazinediol, an acetylcholinesterase inhibitor produced by a Streptomyces species.EBI Kieler Wirkstoff-Zentrum (KiWiZ) at the Helmholtz-Zenrum f�r Ozeanforschung GEOMAR
22172310 47 Synthesis and evaluation of novel 4-[(3H,3aH,6aH)-3-phenyl)-4,6-dioxo-2-phenyldihydro-2H-pyrrolo[3,4-d]isoxazol-5(3H,6H,6aH)-yl]benzoic acid derivatives as potent acetylcholinesterase inhibitors and anti-amnestic agents.EBI Punjabi University
22818849 36 Synthesis, design and biological evaluation of novel highly potent tacrine congeners for the treatment of Alzheimer's disease.EBI P. J. Safarik University
22831800 32 Synthesis of phenserine analogues and evaluation of their cholinesterase inhibitory activities.EBI Meiji Pharmaceutical University
22704921 34 Development and evaluation of multifunctional agents for potential treatment of Alzheimer's disease: application to a pyrimidine-2,4-diamine template.EBI University of Waterloo
22503231 66 Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine.EBI Laboratorio de Radicales Libres y Qu�mica Computacional (IQOG, CSIC)
22425563 16 Prospective acetylcholinesterase inhibitory activity of indole and its analogs.EBI Naresuan University
22243648 112 New tacrine-4-oxo-4H-chromene hybrids as multifunctional agents for the treatment of Alzheimer's disease, with cholinergic, antioxidant, andß-amyloid-reducing properties.EBI Instituto de Qu£mica M£dica
22445674 43 Cholinestrase inhibitory effects of geranylated flavonoids from Paulownia tomentosa fruits.EBI Graduate School of Gyeongsang National University
22185619 50 Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases.EBI Universitat de Barcelona
21189039 3 Biotransformation of turmerones by Aspergillus niger.EBI Kinki University
20875743 90 Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity relaEBI Pfizer Inc.
21144749 55 Preparation, in vitro screening and molecular modelling of symmetrical 4-tert-butylpyridinium cholinesterase inhibitors--analogues of SAD-128.EBI University of Defence
21215642 10 Mono-oxime bisquaternary acetylcholinesterase reactivators with prop-1,3-diyl linkage-Preparation, in vitro screening and molecular docking.EBI University of Defence
20951037 25 Substituted spiro [2.3'] oxindolespiro [3.2¿]-5,6-dimethoxy-indane-1¿-one-pyrrolidine analogue as inhibitors of acetylcholinesterase.EBI Universiti Sains Malaysia
20684563 176 Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential.EBI H. Lundbeck A/S
20627738 32 Long-acting anticholinesterases for myasthenia gravis: synthesis and activities of quaternary phenylcarbamates of neostigmine, pyridostigmine and physostigmine.EBI National Institute on Aging
20575555 45 Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives.EBI Universidad Autonoma de Madrid
20176490 8 Acetylcholinesterase inhibitors from the toadstool Cortinarius infractus.EBI Institute of Plant Biochemistry
20025280 3 Probing Torpedo californica acetylcholinesterase catalytic gorge with two novel bis-functional galanthamine derivatives.EBI Istituto di Cristallografia
19879672 16 Structural aspects of flavonoids as inhibitors of human butyrylcholinesterase.EBI Institute for Medical Research and Occupational Health
19473849 33 Synthesis and structure-activity relationship of Huprine derivatives as human acetylcholinesterase inhibitors.EBI COBRA-CNRS UMR 6014& FR 3038
18954037 40 Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 4. Further investigation on the inner spacer.EBI University of Bologna
18538575 3 Petrosamine, a potent anticholinesterase pyridoacridine alkaloid from a Thai marine sponge Petrosia n. sp.EBI Mahidol University
18640842 45 New tacrine-dihydropyridine hybrids that inhibit acetylcholinesterase, calcium entry, and exhibit neuroprotection properties.EBI CSIC)
16989531 10 Taspine: bioactivity-guided isolation and molecular ligand-target insight of a potent acetylcholinesterase inhibitor from Magnolia x soulangiana.EBI Leopold Franzens-Universit£t
11374978 12 Coumarins isolated from Angelica gigas inhibit acetylcholinesterase: structure-activity relationships.EBI Seoul National University
18517184 47 Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.EBI Laboratori de Qu�mica Farmac�utica (Unitat Associada al CSIC)
18479118 113 Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.EBI Universit£ di Siena
15568781 2 Indole glucoalkaloids from Chimarrhis turbinata and their evaluation as antioxidant agents and acetylcholinesterase inhibitors.EBI Instituto de Qu£mica da Universidade Estadual Paulista
18249544 12 Lead identification of acetylcholinesterase inhibitors-histamine H3 receptor antagonists from molecular modeling.EBI Johnson& Johnson Pharmaceutical Research and Development
18333606 29 Bis-(-)-nor-meptazinols as novel nanomolar cholinesterase inhibitors with high inhibitory potency on amyloid-beta aggregation.EBI Fudan University
18232655 32 Synthesis and biological evaluation of NO-donor-tacrine hybrids as hepatoprotective anti-Alzheimer drug candidates.EBI TBA
17998161 19 Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds.EBI University of Bologna
18181565 71 Multi-target-directed ligands to combat neurodegenerative diseases.EBI University of Bologna
18023348 16 4-Aminopyridine derivatives with anticholinesterase and antiamnesic activity.EBI Sapienza Universit£ di Roma
17854153 2 Brunneins A-C, beta-carboline alkaloids from Cortinarius brunneus.EBI Institute of Plant Biochemistry
17822295 13 Benzylphenethylamine alkaloids from Hosta plantaginea with inhibitory activity against tobacco mosaic virus and acetylcholinesterase.EBI Chinese Academy of Sciences
17904850 3 Cryptadines A and B, novel C27N3-type pentacyclic alkaloids from Lycopodium cryptomerinum.EBI Hoshi University
17944454 34 First gallamine-tacrine hybrid: design and characterization at cholinesterases and the M2 muscarinic receptor.EBI University of Bonn
17888667 33 Synthesis and screening for acetylcholinesterase inhibitor activity of some novel 2-butyl-1,3-diaza-spiro[4,4]non-1-en-4-ones: derivatives of irbesartan key intermediate.EBI University of Mysore
17850125 66 Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer's disease.EBI University of Bologna
17154513 56 Binding of 13-amidohuprines to acetylcholinesterase: exploring the ligand-induced conformational change of the gly117-gly118 peptide bond in the oxyanion hole.EBI Universitat de Barcelona
16483771 5 Isoquinoline derivatives as potential acetylcholinesterase inhibitors.EBI Naresuan University
16220969 219 Designed multiple ligands. An emerging drug discovery paradigm.EBI Organon Laboratories
15715468 44 Novel anticholinesterases based on the molecular skeletons of furobenzofuran and methanobenzodioxepine.EBI National Institute on Aging
15887964 47 Further studies on the interaction of the 5-hydroxytryptamine3 (5-HT3) receptor with arylpiperazine ligands. development of a new 5-HT3 receptor ligand showing potent acetylcholinesterase inhibitory properties.EBI Universit£ di Siena
15633997 18 Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid-beta aggregation.EBI University of Bologna
15481986 69 A docking score function for estimating ligand-protein interactions: application to acetylcholinesterase inhibition.EBI University of Kansas
15993600 54 Design, synthesis, and evaluation of 2-phenoxy-indan-1-one derivatives as acetylcholinesterase inhibitors.EBI Zhejiang University
15214773 76 Fragment-based drug discovery.EBI Sunesis Pharmaceuticals Inc.
15139762 133 Interaction of cycloSal-pronucleotides with cholinesterases from different origins. A structure-activity relationship.EBI University of Hamburg
12502352 28 Specific targeting of acetylcholinesterase and butyrylcholinesterase recognition sites. Rational design of novel, selective, and highly potent cholinesterase inhibitors.EBI Universit£ di Siena
11831902 12 Pyridophens: binary pyridostigmine-aprophen prodrugs with differential inhibition of acetylcholinesterase, butyrylcholinesterase, and muscarinic receptors.EBI Institute of Research
11741490 18 Synthesis, in vitro pharmacology, and molecular modeling of syn-huprines as acetylcholinesterase inhibitors.EBI Universitat de Barcelona
11495583 62 Design, synthesis, and structure-activity relationships of a series of 3-[2-(1-benzylpiperidin-4-yl)ethylamino]pyridazine derivatives as acetylcholinesterase inhibitors.EBI Universit£ Louis Pasteur
11101357 84 New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease.EBI Universitat de Barcelona
10052979 45 Aminopyridazines as acetylcholinesterase inhibitors.EBI Universit£ Louis Pasteur
10508425 68 Mixture-based synthetic combinatorial libraries.EBI Torrey Pines Institute for Molecular Studies
10464010 40 Synthesis, in vitro pharmacology, and molecular modeling of very potent tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease.EBI Universitat de Barcelona
9784091 25 Acetylcholinesterase noncovalent inhibitors based on a polyamine backbone for potential use against Alzheimer's disease.EBI University of Bologna
8978837 60 Structure-based alignment and comparative molecular field analysis of acetylcholinesterase inhibitors.EBI University of North Carolina
8893840 12 The simulated binding of (+/-)-2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]meth yl] -1H-inden-1-one hydrochloride (E2020) and related inhibitors to free and acylated acetylcholinesterases and corresponding structure-activity analyses.EBI Eisai Co., Ltd.
7707311 18 Design and synthesis of 1-heteroaryl-3-(1-benzyl-4-piperidinyl)propan-1-one derivatives as potent, selective acetylcholinesterase inhibitors.EBI Pfizer Inc.
7490731 45 Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride and related compounds.EBI Eisai Company, Ltd.
7658452 52 Synthesis and evaluation of 5-amino-5,6,7,8-tetrahydroquinolinones as potential agents for the treatment of Alzheimer's disease.EBI Hoechst-Roussel Pharmaceuticals, Inc
8496937 30 Synthesis of 2-imidazolidinylidenepropanedinitrile derivatives as stimulators of gastrointestinal motility.EBI Kyowa Hakko Kogyo Co., Ltd.
1573636 26 Syntheses, resolution, and structure-activity relationships of potent acetylcholinesterase inhibitors: 8-carbaphysostigmine analogues.EBI Pfizer Inc.
1552502 74 Synthesis and cholinergic properties of bis[[(dimethylamino)methyl]furanyl] analogues of ranitidine.EBI University of South Carolina
2033583 10 Structure-activity studies on a potent antagonist to organophosphate-induced toxicity.EBI University of Iowa
2016711 5 Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 4. Effect of various side-chain substituents on therapeutic activity against anticholinesterase intoxication.EBI SRI International
1766006 7 Delineating the pharmacophoric elements of huperzine A: importance of the unsaturated three-carbon bridge to its AChE inhibitory activity.EBI Mayo Clinic Jacksonville
2913310 68 Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 2. Preparation and in vitro and in vivo evaluation of 1-(alkoxymethyl)-2-[(hydroxyimino)methyl]-3-methylimida zolium halides for reactivation of organophosphorus-inhibited acetylcholinesterases.EBI SRI International
3746817 21 Nonquaternary cholinesterase reactivators. 4. Dialkylaminoalkyl thioesters of alpha-keto thiohydroximic acids as reactivators of ethyl methylphosphonyl- and 1,2,2-trimethylpropyl methylphosphonyl-acetylcholinesterase in vitro.EBI TBA
11858995 1 Anionic cyclophanes as potential reversal agents of muscle relaxants by chemical chelation.EBI Organon Laboratories Ltd.
12182862 54 Novel piperidinium and pyridinium agents as water-soluble acetylcholinesterase inhibitors for the reversal of neuromuscular blockade.EBI Organon Laboratories Ltd.
12182861 35 Quaternary salts of E2020 analogues as acetylcholinesterase inhibitors for the reversal of neuromuscular block.EBI Organon Laboratories Ltd.
12031333 5 Synthesis of more potent analogues of the acetylcholinesterase inhibitor, huperzine B.EBI Georgetown University Medical Center
11551765 7 Synthesis and acetylcholinesterase inhibition of 5-desamino huperzine A derivatives.EBI Universit£t Wien
11078202 3 Synthesis, chiral chromatographic separation, and biological activities of the enantiomers of 10,10-dimethylhuperzine A.EBI Georgetown University Medical Center
10476864 22 Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors.EBI Hong Kong University of Science and Technology
9873409 2 Synthesis and acetylcholinesterase inhibitory activity of (+/-)-14-fluorohuperzine A.EBI Chinese Academy of Sciences
21438612 4 Amidine-oximes: reactivators for organophosphate exposure.EBI Human BioMolecular Research Institute
22206546 42 Nonquaternary reactivators for organophosphate-inhibited cholinesterases.EBI Human BioMolecular Research Institute
22257528 5 A review on coumarins as acetylcholinesterase inhibitors for Alzheimer's disease.EBI Punjabi University
22054058 22 Synthesis of monomeric derivatives to probe memoquin's bivalent interactions.EBI University of Bologna
21420206 38 N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease.EBI Instituto de Qu£mica M£dica
22023459 42 Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.EBI Universitat Aut£noma de Barcelona
22019465 28 Searching for the Multi-Target-Directed Ligands against Alzheimer's disease: discovery of quinoxaline-based hybrid compounds with AChE, H3R and BACE 1 inhibitory activities.EBI Zhejiang University
22001085 22 Synthesis and testing of trifluoromethyl-containing phosphonate-peptide conjugates as inhibitors of serine hydrolases.EBI Moscow State University
22000936 33 Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues.EBI University of Lisbon
21955943 47 Investigation of the pyrazinones as PDE5 inhibitors: evaluation of regioisomeric projections into the solvent region.EBI Pfizer Inc.
21924611 38 Selective cholinesterase inhibition by lanostane triterpenes from fruiting bodies of Ganoderma lucidum.EBI Chungnam National University
21920739 14 Synthesis and in vitro evaluation of 7-methoxy-N-(pent-4-enyl)-1,2,3,4-tetrahydroacridin-9-amine-new tacrine derivate with cholinergic properties.EBI Charles University in Prague
21924801 20 Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease.EBI University of Bologna
21939219 16 Benzofurans from Styrax agrestis as acetylcholinesterase inhibitors: structure-activity relationships and molecular modeling studies.EBI Guangzhou University of Chinese Medicine
21873056 50 Development of 2-substituted-N-(naphth-1-ylmethyl) and N-benzhydrylpyrimidin-4-amines as dual cholinesterase and Aß-aggregation inhibitors: Synthesis and biological evaluation.EBI University of Waterloo
21798635 32 Multi-target strategy to address Alzheimer's disease: design, synthesis and biological evaluation of new tacrine-based dimers.EBI Institut f£r Molekulare Physiologie
21733699 121 Requirements for mammalian carboxylesterase inhibition by substituted ethane-1,2-diones.EBI St. Jude Children's Research Hospital
21570751 8 Synthesis, biological activity and HPLC validation of 1,2,3,4-tetrahydroacridine derivatives as acetylcholinesterase inhibitors.EBI Medical University
21459491 96 Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease.EBI Universit£ degli Studi di Genova
21435752 76 New potent human acetylcholinesterase inhibitors in the tetracyclic triterpene series with inhibitory potency on amyloid β aggregation.EBI CNRS
19443217 60 Synthesis and biological evaluation of novel gamma-carboline analogues of Dimebon as potent 5-HT6 receptor antagonists.EBI Chemical Diversity Research Institute
19423342 10 Novel carbamate cholinesterase inhibitors that release biologically active amines following enzyme inhibition.EBI Sention Inc.
21397996 36 Benzophenone-based derivatives: a novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.EBI University of Bologna
21417225 116 Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: a systematic investigation of the influence of linker and cationic heads over affinity and selectivity.EBI Universidad de Granada
21236667 16 Multitargeted drugs discovery: balancing anti-amyloid and anticholinesterase capacity in a single chemical entity.EBI Department of Pharmaceutical Sciences-Alma Mater Studiorum-Bologna University
21216144 13 (+)-Arisugacin A--computational evidence of a dual binding site covalent inhibitor of acetylcholinesterase.EBI Alchemical Research, LLC
21429752 72 Design, synthesis and structure-activity relationship (SAR) studies of 2,4-disubstituted pyrimidine derivatives: dual activity as cholinesterase and A β-aggregation inhibitors.EBI University of Waterloo
21397501 54 Preparation, in vitro screening and molecular modelling of symmetrical bis-quinolinium cholinesterase inhibitors--implications for early myasthenia gravis treatment.EBI Charles University
21236521 58 Preparation and in vitro screening of symmetrical bis-isoquinolinium cholinesterase inhibitors bearing various connecting linkage--implications for early Myasthenia gravis treatment.EBI University of Defence
20954721 12 Triterpenoidal alkaloids from Buxus natalensis and their acetylcholinesterase inhibitory activity.EBI The University of Winnipeg
21163662 39 Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3-carbonitriles.EBI Laboratorio de Radicales Libres y Qu�mica Computacional (IQOG, CSIC)
20926162 14 Old phenothiazine and dibenzothiadiazepine derivatives for tomorrow's neuroprotective therapies against neurodegenerative diseases.EBI Instituto de Qu£mica M£dica
21105730 30 Structure-activity relationships of substituted 1-pyridyl-2-phenyl-1,2-ethanediones: potent, selective carboxylesterase inhibitors.EBI St. Jude Children's Research Hospital
20801550 9 Synthesis, characterization, oxidative degradation, antibacterial activity and acetylcholinesterase/butyrylcholinesterase inhibitory effects of some new phosphorus(V) hydrazides.EBI Tarbiat Modares University
20817518 23 Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease.EBI Charles University
20684567 38 Novel carbamates as orally active acetylcholinesterase inhibitors found to improve scopolamine-induced cognition impairment: pharmacophore-based virtual screening, synthesis, and pharmacology.EBI Central Drug Research Institute
20655219 7 Structure-activity studies on acetylcholinesterase inhibition in the lycorine series of Amaryllidaceae alkaloids.EBI McMaster University
18438404 13 Activation of the endocannabinoid system by organophosphorus nerve agents.EBI University of California
20420456 6 Polyamines in drug discovery: from the universal template approach to the multitarget-directed ligand design strategy.EBI University of Bologna
20545360 38 Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties.EBI Instituto de Quimica Medica
20053484 417 Prediction of acetylcholinesterase inhibitors and characterization of correlative molecular descriptors by machine learning methods.EBI Sichuan University
20350807 7 Molecular modelling, synthesis and acetylcholinesterase inhibition of ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate.EBI Laboratorio de Radicales Libres y Química Computacional (IQOG, CSIC)
20144867 32 Synthesis of physostigmine analogues and evaluation of their anticholinesterase activities.EBI Zhejiang University
20138518 40 Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage-initial study for Myasthenia gravis implications.EBI Military Health Sciences
20137941 44 Design, synthesis and evaluation of carbamate-modified (-)-N(1)-phenethylnorphysostigmine derivatives as selective butyrylcholinesterase inhibitors.EBI Kyoto University
20137934 38 Design, synthesis, evaluation and QSAR analysis of N(1)-substituted norcymserine derivatives as selective butyrylcholinesterase inhibitors.EBI Kyoto University
19856923 40 Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease.EBI Instituto de Quimica Medica (CSIC)
20189400 16 Synthesis and kinetic analysis of some phosphonate analogs of cyclophostin as inhibitors of human acetylcholinesterase.EBI University of Missouri St. Louis
20181484 46 Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants.EBI Dalhousie University
20171894 49 Targeting Alzheimer's disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238.EBI University of Bologna
19726199 30 Rational design and synthesis of highly potent anti-acetylcholinesterase activity huperzine A derivatives.EBI The Chinese Academy of Sciences
19692250 52 Design, synthesis and evaluation of flavonoid derivatives as potent AChE inhibitors.EBI Zhejiang University
19954865 10 Synthesis and AChE inhibitory activity of new chiral tetrahydroacridine analogues from terpenic cyclanones.EBI Universidade Federal do Rio Grande do Sul
19813747 12 Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks.EBI University of Bologna
19493592 30 Active site directed docking studies: synthesis and pharmacological evaluation of cis-2,6-dimethyl piperidine sulfonamides as inhibitors of acetylcholinesterase.EBI University of Mysore
19422203 1 Pyrrolidinoindoline alkaloids from Selaginella moellendorfii.EBI Chinese Academy of Sciences
19505825 12 Structure-activity relationships of memoquin: Influence of the chain chirality in the multi-target mechanism of action.EBI Alma Mater Studiorum-Bologna University
19215141 8 Antioxidant and anticholinesterase activity evaluation of ent-kaurane diterpenoids from Sideritis arguta.EBI Istanbul University
19485411 2 Site-activated multifunctional chelator with acetylcholinesterase and neuroprotective-neurorestorative moieties for Alzheimer's therapy.EBI Institute of Science
19162488 57 Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and beta-secretase.EBI Chinese Academy of Sciences
18817366 43 Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors.EBI Trinity College
18786825 30 Tacrine based human cholinesterase inhibitors: synthesis of peptidic-tethered derivatives and their effect on potency and selectivity.EBI European Research Centre for Drug Discovery and Development (NatSynDrugs)
18701300 55 Synthesis and elastase-inhibiting activity of 2-pyridinyl-isothiazol-3(2H)-one 1,1-dioxides.EBI University of Leipzig
18681480 14 Bioactive 5alpha-pregnane-type steroidal alkaloids from Sarcococca hookeriana.EBI Bielefeld University
18662884 56 2-Phenoxy-indan-1-one derivatives as acetylcholinesterase inhibitors: a study on the importance of modifications at the side chain on the activity.EBI Zhejiang University
18650096 17 Solid-phase synthesis and biological evaluation of a parallel library of 2,3-dihydro-1,5-benzothiazepines.EBI Quaid-i-Azam University
18605718 17 Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush.EBI UniVersity of Bologna
18585045 22 Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors.EBI Università di Bari
18550228 40 Design, synthesis and evaluation of galanthamine derivatives as acetylcholinesterase inhibitors.EBI Zhejiang University
18524585 20 Design, synthesis and evaluation of isaindigotone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors.EBI Sun Yat-sen University
18485717 3 Lycoparins A-C, new alkaloids from Lycopodium casuarinoides inhibiting acetylcholinesterase.EBI Hoshi University
18436348 68 Design, synthesis and AChE inhibitory activity of indanone and aurone derivatives.EBI Zhejiang University
18419109 18 Benzofuran-based hybrid compounds for the inhibition of cholinesterase activity, beta amyloid aggregation, and abeta neurotoxicity.EBI University of Bologna
18396354 29 Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors.EBI University of Bologna
17624631 9 Chemiluminescent high-throughput microassay applied to imidazo[2,1-b]thiazole derivatives as potential acetylcholinesterase and butyrylcholinesterase inhibitors.EBI Università di Bologna
10869205 2 The application of HPLC with on-line coupled UV/MS-biochemical detection for isolation of an acetylcholinesterase inhibitor from narcissus 'Sir Winston Churchill'.EBI Leiden University
18047264 10 Multi-target-directed drug design strategy: from a dual binding site acetylcholinesterase inhibitor to a trifunctional compound against Alzheimer's disease.EBI Bologna University
17918819 114 Synthesis and structure-activity relationship for a novel class of potent and selective carbamate-based inhibitors of hormone selective lipase with acute in vivo antilipolytic effects.EBI Novo Nordisk A/S
17655212 56 Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives.EBI University of Bologna
17503851 2 Fawcettimine-related alkaloids from Lycopodium serratum.EBI Chiba University
17399985 136 Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.EBI St. Jude Children's Research Hospital
17317172 9 Methyl 2-(2-(4-formylphenoxy)acetamido)-2-substituted acetate derivatives: a new class of acetylcholinesterase inhibitors.EBI Sun Yat-sen University
17188496 3 Carinatumins A-C, new alkaloids from Lycopodium carinatum inhibiting acetylcholinesterase.EBI Hoshi University
17181144 30 Novel multipotent tacrine-dihydropyridine hybrids with improved acetylcholinesterase inhibitory and neuroprotective activities as potential drugs for the treatment of Alzheimer's disease.EBI CSIC)
17126020 58 Study on dual-site inhibitors of acetylcholinesterase: Highly potent derivatives of bis- and bifunctional huperzine B.EBI Chinese Academy of Sciences
17008100 54 Cholinesterase inhibitors: SAR and enzyme inhibitory activity of 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones.EBI University of Bologna
16945529 42 6-Hydroxy- and 6-methoxy-beta-carbolines as acetyl- and butyrylcholinesterase inhibitors.EBI Friedrich-Schiller-Universität Jena
16942022 20 Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge.EBI Institute of Science
16821800 96 Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder. Synthesis and activity of functionalized glutaramides.EBI Pfizer Global Research and Development
16735118 23 Synthesis and efficacy of 1-[bis(4-fluorophenyl)-methyl]piperazine derivatives for acetylcholinesterase inhibition, as a stimulant of central cholinergic neurotransmission in Alzheimer's disease.EBI University of Mysore
16107154 41 Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety.EBI St. Jude Children's Research Hospital
15878275 11 Synthesis of tricyclic analogs of stephaoxocanidine and their evaluation as acetylcholinesterase inhibitors.EBI Universidad Nacional de Rosario
15801859 40 Anchor-GRIND: filling the gap between standard 3D QSAR and the GRid-INdependent descriptors.EBI IMIM/Universitat Pompeu Fabra
15686892 14 A rate determining step change in the pre-steady state of acetylcholinesterase inhibitions by 1,n-alkane-di-N-butylcarbamates.EBI National Chung-Hsing University
15664805 15 Synthesis and acetylcholinesterase inhibition of derivatives of huperzine B.EBI Chinese Academy of Sciences
15603953 13 Isoterreulactone A, a novel meroterpenoid with anti-acetylcholinesterase activity produced by Aspergillus terreus.EBI Korea Research Institute of Bioscience and Biotechnology
15588084 4 Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 3. Effect of replacing the inner polymethylene chain with cyclic moieties.EBI University of Bologna
15566295 2 Acetylcholinesterase inhibitory activity of scopolin and scopoletin discovered by virtual screening of natural products.EBI Leopold-Franzens University of Innsbruck
14711311 104 Synthesis and structure-activity relationship for a novel class of potent and selective carbamoyl-triazole based inhibitors of hormone sensitive lipase.EBI Novo Nordisk A/S
14584959 55 Molecular docking studies of natural cholinesterase-inhibiting steroidal alkaloids from Sarcococca saligna.EBI University of Innsbruck
14521407 87 Design and synthesis of pyrrolidine-5,5'-trans-lactams (5-oxo-hexahydropyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 4. Antiviral activity and plasma stability.EBI GlaxoSmithKline Research and Development
12729674 6 Synthesis, anticholinesterase activity and structure-activity relationships of m-Aminobenzoic acid derivatives.EBI Instituto Politécnico Nacional
12646025 12 Design, synthesis, and pharmacological profile of novel fused pyrazolo[4,3-d]pyridine and pyrazolo[3,4-b][1,8]naphthyridine isosteres: a new class of potent and selective acetylcholinesterase inhibitors.EBI Universidade Federal do Rio de Janeiro
12620072 3 Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 2. Role of the substituents on the phenyl ring and nitrogen atoms of caproctamine.EBI University of Bologna
11755352 40 Oxyaniliniums as acetylcholinesterase inhibitors for the reversal of neuromuscular block.EBI Organon Laboratories Ltd.
11754575 51 Design and synthesis of pyrrolidine-5,5-trans-lactams (5-oxohexahydropyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 2. Potency and chirality.EBI GlaxoSmithKline Research and Development
11689088 22 Synthesis and screening for antiacetylcholinesterase activity of (1-benzyl-4-oxopiperidin-3-ylidene)methylindoles and -pyrroles related to donepezil.EBI Università di Bologna
10890154 14 Synthetic conversion of ACAT inhibitor to acetylcholinesterase inhibitor.EBI Kitasato University
10612585 4 Synthesis and acetylcholinesterase inhibitory activity of huperzine A-E2020 combined compound.EBI Institute of Materia Medica
10346939 30 Synthesis of novel phenserine-based-selective inhibitors of butyrylcholinesterase for Alzheimer's disease.EBI National Institute on Aging Intramural Research Program
9871686 23 Design and synthesis of monocyclic beta-lactams as mechanism-based inhibitors of human cytomegalovirus protease.EBI Glaxo Wellcome Research and Development
9871563 31 Synthesis and activity studies of N-[omega-N'-(adamant-1'-yl)aminoalkyl]- 2-(4'-dimethylaminophenyl)acetamides: in the search of selective inhibitors for the different molecular forms of acetylcholinesterase.EBI Istituto di Strutturistica Chimica G. Giacomello
9357518 74 Novel tacrine analogues for potential use against Alzheimer's disease: potent and selective acetylcholinesterase inhibitors and 5-HT uptake inhibitors.EBI University of Strathclyde
9301662 50 Synthesis and study of thiocarbonate derivatives of choline as potential inhibitors of acetylcholinesterase.EBI University of North Texas
9288171 28 Total syntheses and anticholinesterase activities of (3aS)-N(8)-norphysostigmine, (3aS)-N(8)-norphenserine, their antipodal isomers, and other N(8)-substituted analogues.EBI National Institute on Aging
8709135 20 Identification of a 3-hydroxylated tacrine metabolite in rat and man: metabolic profiling implications and pharmacology.EBI Warner-Lambert Company
8558530 4 Substituted (pyrroloamino)pyridines: potential agents for the treatment of Alzheimer's disease.EBI Hoechst-Roussel Pharmaceuticals Inc.
8558529 195 Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeutic agents for Alzheimer's disease.EBI Hoechst-Roussel Pharmaceuticals Inc.
8126709 49 Novel [2-(4-piperidinyl)ethyl](thio)ureas: synthesis and antiacetylcholinesterase activity.EBI Centre de Recherche Pierre Fabre Médicament
8064800 32 Novel benzisoxazole derivatives as potent and selective inhibitors of acetylcholinesterase.EBI Pfizer Inc.
8057278 43 Central cholinergic agents. 6. Synthesis and evaluation of 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1H-1-benzazepi n-8-yl)-1-propanones and their analogs as central selective acetylcholinesterase inhibitors.EBI Takeda Chemical Industries, Ltd.
8027982 19 Syntheses and anticholinesterase activity of tetrahydrobenzazepine carbamates.EBI Pfizer Inc.
7932538 54 Docking analysis of a series of benzylamino acetylcholinesterase inhibitors with a phthalimide, benzoyl, or indanone moiety.EBI Takeda Chemical Industries, Ltd.
7636858 25 Flexible 1-[(2-aminoethoxy)alkyl]-3-ar(o)yl(thio)ureas as novel acetylcholinesterase inhibitors. Synthesis and biochemical evaluation.EBI Centre de Recherche Pierre Fabre
7636841 16 5,7-dihydro-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-6H- pyrrolo[3,2-f]-1,2-benzisoxazol-6-one: a potent and centrally-selective inhibitor of acetylcholinesterase with an improved margin of safety.EBI Pfizer Inc
6827532 2 In vitro and in vivo protection of acetylcholinesterase against organophosphate poisoning by pretreatment with a novel derivative of 1,3,2-dioxaphosphorinane 2-oxide.EBI TBA
6492073 1 Structure-activity relationships for reactivators of organophosphorus-inhibited acetylcholinesterase: quaternary salts of 2-[(hydroxyimino)methyl]imidazole.EBI TBA
3783578 36 Nonquaternary cholinesterase reactivators. 3. 3(5)-Substituted 1,2,4-oxadiazol-5(3)-aldoximes and 1,2,4-oxadiazole-5(3)-thiocarbohydroximates as reactivators of organophosphonate-inhibited eel and human acetylcholinesterase in vitro.EBI TBA
3669008 1 Carbamate ester derivatives as potential prodrugs of the presynaptic dopamine autoreceptor agonist (-)-3-(3-hydroxyphenyl)-N-propylpiperidine.EBI Astra Alab AB
3385720 2 (+/-)-9-Amino-1,2,3,4-tetrahydroacridin-1-ol. A potential Alzheimer's disease therapeutic of low toxicity.EBI Hoechst-Roussel Pharmaceuticals, Inc.
2913311 25 Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 3. Synthesis and evaluation of (alkenyloxy)-, (alkynyloxy)-, and (aralkyloxy)methyl quaternarized 2-[(hydroxyimino)methyl]-1-alkylimidazolium halides as reactivators and therapy for soman intoxication.EBI SRI International
2202827 53 Alfred Burger award address. Bioactive alkaloids. 4. Results of recent investigations with colchicine and physostigmine.EBI NIDDK
1738152 21 Conformational analyses and molecular-shape comparisons of a series of indanone-benzylpiperidine inhibitors of acetylcholinesterase.EBI University of Illinois
1738151 69 QSAR analyses of the substituted indanone and benzylpiperidine rings of a series of indanone-benzylpiperidine inhibitors of acetylcholinesterase.EBI University of Illinois
1507203 96 Synthesis and cholinergic properties of N-aryl-2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethylamino analogs of ranitidine.EBI University of South Carolina
1469686 53 Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-(2-phthalimidoethyl)piperidine and related derivatives.EBI Eisai Co., Ltd.
27282589 54 Structure-activity relationship studies of benzyl-, phenethyl-, and pyridyl-substituted tetrahydroacridin-9-amines as multitargeting agents to treat Alzheimer's disease.BDB University of Waterloo
27479541 24 Design, synthesis and biological evaluation of coumarin derivatives as novel acetylcholinesterase inhibitors that attenuate H2O2-induced apoptosis in SH-SY5Y cells.BDB Shenyang Pharmaceutical University
27441832 43 Synthesis and in vitro acetylcholinesterase and butyrylcholinesterase inhibitory potential of hydrazide based Schiff bases.BDB Hazara University
27231830 27 Identification of novel acetylcholinesterase inhibitors: Indolopyrazoline derivatives and molecular docking studies.BDB AIMST University
26595185 30 Novel biphenyl bis-sulfonamides as acetyl and butyrylcholinesterase inhibitors: Synthesis, biological evaluation and molecular modeling studies.BDB Government College University
25941042 28 Design, synthesis, and biological evaluation of scutellarein carbamate derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.BDB Sichuan University
26042530 40 Discovery of isoalloxazine derivatives as a new class of potential anti-Alzheimer agents and their synthesis.BDB The M. S. University of Baroda
25965977 15 Design and synthesis of newer potential 4-(N-acetylamino)phenol derived piperazine derivatives as potential cognition enhancers.BDB Panjab University
25956827 13 Antioxidant and acetylcholinesterase inhibition properties of novel bromophenol derivatives.BDB Ataturk University
24040835 14 The natural product dihydrotanshinone I provides a prototype for uncharged inhibitors that bind specifically to the acetylcholinesterase peripheral site with nanomolar affinity.BDB Mayo Clinic College of Medicine
22901043 9 Probing the peripheral site of human butyrylcholinesterase.BDB Dalhousie University
22726458 28 Synthesis and Biological Evaluation of 3-thiazolocoumarinyl Schiff-base Derivatives as Cholinesterase Inhibitors.BDB COMSATS Institute of Information Technology
18825527 22 Acetylcholinesterase/butyrylcholinesterase inhibition activity of some new carbacylamidophosphate derivatives.BDB Tarbiat Modares University
18821258 11 Synthesis and biological evaluation of new donepezil-like Thiaindanones as AChE inhibitors.BDB Centre d'Etudes et de Recherche sur le Médicament de Normandie
18666002 6 Structure-activity study of phosphoramido acid esters as acetylcholinesterase inhibitors.BDB Imam Hossein University
17252943 10 New natural cholinesterase inhibiting and calcium channel blocking quinoline alkaloids.BDB University of Karachi
15895683 14 Synthesis and inhibitory potential towards acetylcholinesterase, butyrylcholinesterase and lipoxygenase of some variably substituted chalcones.BDB Quaid-i-Azam University
20455574 9 Site-activated chelators targeting acetylcholinesterase and monoamine oxidase for Alzheimer's therapy.BDB The Weizmann Institute of Science
20081854 6 Rapid behavior-based identification of neuroactive small molecules in the zebrafish.BDB Harvard Medical School
19663388 40 Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds.BDB Universitat de Barcelona
19374444 45 Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease.BDB CSIC
12725862 9 Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition.BDB University of North Carolina at Chapel Hill
17941623 72 Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1.BDB St. Jude Research Hospital
17378546 325 Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.BDB St. Jude Research Hospital
15828829 300 Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.BDB University of Mississippi
17902635 86 New potent acetylcholinesterase inhibitors in the tetracyclic triterpene series.BDB CNRS
17149883 62 Novel heterobivalent tacrine derivatives as cholinesterase inhibitors with notable selectivity toward butyrylcholinesterase.BDB Rheinische Friedrich-Wilhelms-Universitat Bonn
16913695 12 Structural determinants of Torpedo californica acetylcholinesterase inhibition by the novel and orally active carbamate based anti-alzheimer drug ganstigmine (CHF-2819).BDB Istituto di Cristallografia
11708910 42 Methyl analogues of the experimental Alzheimer drug phenserine: synthesis and structure/activity relationships for acetyl- and butyrylcholinesterase inhibitory action.BDB National Institutes of Health
12166941 42 Anticholinesterase activity of compounds related to geneserine tautomers. N-Oxides and 1,2-oxazines.BDB National Institutes of Health
15537349 18 Design, synthesis, and biological evaluation of conformationally restricted rivastigmine analogues.BDB University of Bologna
12773032 4 3-(4-[[Benzyl(methyl)amino]methyl]phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation: a dual function lead for Alzheimer's disease therapy.BDB University of Bologna
15689148 19 Bis-huperzine B: highly potent and selective acetylcholinesterase inhibitors.BDB Shanghai Institute of Materia Medica
9767635 42 Acetylcholinesterase inhibitors: synthesis and structure-activity relationships of omega-[N-methyl-N-(3-alkylcarbamoyloxyphenyl)- methyl]aminoalkoxyheteroaryl derivatives.BDB University of Bologna
12431053 293 Novel dual inhibitors of AChE and MAO derived from hydroxy aminoindan and phenethylamine as potential treatment for Alzheimer's disease.BDB Teva Pharmaceutical Industries
11689067 34 Acetylcholinesterase inhibitors: SAR and kinetic studies on omega-[N-methyl-N-(3-alkylcarbamoyloxyphenyl)methyl]aminoalkoxyaryl derivatives.BDB University of Bologna
15974596 36 Cholinesterase inhibitors: xanthostigmine derivatives blocking the acetylcholinesterase-induced beta-amyloid aggregation.BDB University of Bologna
9632370 34 Syntheses and anticholinesterase activities of (3aS)-N1, N8-bisnorphenserine, (3aS)-N1,N8-bisnorphysostigmine, their antipodal isomers, and other potential metabolites of phenserine.BDB University of North Carolina at Chapel Hill
12196020 3 X-ray structures of Torpedo californica acetylcholinesterase complexed with (+)-huperzine A and (-)-huperzine B: structural evidence for an active site rearrangement.BDB Weizmann Institute of Science
11888271 2 Kinetic and structural studies on the interaction of cholinesterases with the anti-Alzheimer drug rivastigmine.BDB Weizmann Institute of Science
16570913 65 Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine.BDB National Institutes of Health
16722663 12 Discovery of huperzine A-tacrine hybrids as potent inhibitors of human cholinesterases targeting their midgorge recognition sites.BDB Universita di Siena
15771413 24 Synthesis and pharmacological evaluation of huprine-tacrine heterodimers: subnanomolar dual binding site acetylcholinesterase inhibitors.BDB Universitat de Barcelona
11425559 24 Novel and potent tacrine-related hetero- and homobivalent ligands for acetylcholinesterase and butyrylcholinesterase.BDB Universita degli Studi di Siena
15658850 22 Rational approach to discover multipotent anti-Alzheimer drugs.BDB University of Bologna
11563919 20 A structure-based design approach to the development of novel, reversible AChE inhibitors.BDB Syngenta
10218828 16 Evaluation of short-tether bis-THA AChE inhibitors. A further test of the dual binding site hypothesis.BDB Hong Kong University of Science and Technology
8798583 19 Highly potent, selective, and low cost bis-tetrahydroaminacrine inhibitors of acetylcholinesterase. Steps toward novel drugs for treating Alzheimer's disease.BDB Mayo Foundation for Medical Education and Research
10632067 50 Dual-site binding of bivalent 4-aminopyridine- and 4-aminoquinoline-based AChE inhibitors: contribution of the hydrophobic alkylene tether to monomer and dimer affinities.BDB Hong Kong University of Science and Technology
12517147 6 Acetylcholinesterase complexed with bivalent ligands related to huperzine a: experimental evidence for species-dependent protein-ligand complementarity.BDB Weizmann Institute of Science
9839013 32 Potent acetylcholinesterase inhibitors: design, synthesis, and structure-activity relationships of bis-interacting ligands in the galanthamine series.BDB CNRS
15563167 10 The complex of a bivalent derivative of galanthamine with torpedo acetylcholinesterase displays drastic deformation of the active-site gorge: implications for structure-based drug design.BDB Weizmann Institute of Science
10514292 42 Heterodimeric tacrine-based acetylcholinesterase inhibitors: investigating ligand-peripheral site interactions.BDB Hong Kong University of Science and Technology
2362265 40 Novel piperidine derivatives. Synthesis and anti-acetylcholinesterase activity of 1-benzyl-4-[2-(N-benzoylamino)ethyl]piperidine derivatives.BDB Tsukuba Research Laboratories
2754707 39 9-Amino-1,2,3,4-tetrahydroacridin-1-ols: synthesis and evaluation as potential Alzheimer's disease therapeutics.BDB Hoechst-Roussel Pharmaceuticals, Inc.
10732965 25 Acetylcholinesterase inhibitors for potential use in Alzheimer's disease: molecular modeling, synthesis and kinetic evaluation of 11H-indeno-[1,2-b]-quinolin-10-ylamine derivatives.BDB University of Bologna
16230018 28 Donepezil-tacrine hybrid related derivatives as new dual binding site inhibitors of AChE.BDB Neuropharma
12014965 38 Homodimeric tacrine congeners as acetylcholinesterase inhibitors.BDB National Defense Medical Center
16279781 50 Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease.BDB Neuropharma
16420031 46 Novel tacrine-melatonin hybrids as dual-acting drugs for Alzheimer disease, with improved acetylcholinesterase inhibitory and antioxidant properties.BDB Instituto de Quimica Medica (CSIC)
10821713 23 SAR of 9-amino-1,2,3,4-tetrahydroacridine-based acetylcholinesterase inhibitors: synthesis, enzyme inhibitory activity, QSAR, and structure-based CoMFA of tacrine analogues.BDB University of Bologna
15324879 12 Synthesis and evaluation of tacrine-E2020 hybrids as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.BDB Shanghai Institute of Materia Medica
15771436 38 Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors.BDB Universita di Siena