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207 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
26546218 13 Structure-activity-relationship of amide and sulfonamide analogs of omarigliptin.EBI Merck Research Laboratories
26200936 39 Applications of Fluorine in Medicinal Chemistry.EBI Bristol-Myers Squibb Research and Development
26372650 9 Design, synthesis and biological evaluation of novel pyrazolo-pyrimidinones as DPP-IV inhibitors in diabetes.EBI National Institute of Pharmaceutical Education and Research-Ahmedabad
26222445 5 Carbamoyl Triazoles, Known Serine Protease Inhibitors, Are a Potent New Class of Antimalarials.EBI GlaxoSmithKline
25147615 108 Discovery of Imigliptin, a Novel Selective DPP-4 Inhibitor for the Treatment of Type 2 Diabetes.EBI XuanZhu Pharma
25164763 95 Design, synthesis and biological evaluation of 4-fluoropyrrolidine-2-carbonitrile and octahydrocyclopenta[b]pyrrole-2-carbonitrile derivatives as dipeptidyl peptidase IV inhibitors.EBI Shanghai Institute of Materia Medica
26005541 33 Design, Synthesis, and Pharmacological Evaluation of Fused▀-Homophenylalanine Derivatives as Potent DPP-4 Inhibitors.EBI Chinese Academy of Sciences
25815154 13 Synthesis of New DPP-4 Inhibitors Based on a Novel Tricyclic Scaffold.EBI University Park Nottingham
25838146 5 Synthesis and potent inhibitory activities of carboxybenzyl-substituted 8-(3-(R)-aminopiperidin-1-yl)-7-(2-chloro/cyanobenzyl)-3-methyl-3,7-dihydro-purine-2,6-diones as dipeptidyl peptidase IV (DPP-IV) inhibitors.EBI Southern Medical University
25596166 4 Discovery of 3H-imidazo[4,5-c]quinolin-4(5H)-ones as potent and selective dipeptidyl peptidase IV (DPP-4) inhibitors: use of a carboxylate prodrug to improve bioavailability.EBI Sumitomo Dainippon Pharma Co., Ltd
24948564 5 Structure based virtual screening of MDPI database: discovery of structurally diverse and novel DPP-IV inhibitors.EBI Jamia Hamdard
25457126 55 (R)-3-amino-1-((3aS,7aS)-octahydro-1H-indol-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one derivatives as potent inhibitors of dipeptidyl peptidase-4: design, synthesis, biological evaluation, and molecular modeling.EBI Chinese Academy of Sciences
25443644 10 Thiophenes, polyacetylenes and terpenes from the aerial parts of Eclipata prostrate.EBI TBA
24617858 239 Extended structure-activity relationship and pharmacokinetic investigation of (4-quinolinoyl)glycyl-2-cyanopyrrolidine inhibitors of fibroblast activation protein (FAP).EBI University of Antwerp
24099035 5 Dipeptidyl peptidase IV and its inhibitors: therapeutics for type 2 diabetes and what else?EBI CHUV-UNIL
24675378 33 Design, synthesis and biological evaluation of novel aminomethyl-piperidones based DPP-IV inhibitors.EBI M.S. University of Baroda
24660890 12 Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes.EBI Merck & Co., Inc.
24044354 11 A general method for making peptide therapeutics resistant to serine protease degradation: application to dipeptidyl peptidase IV substrates.EBI Tufts University
23434133 18 Discovery of potent dipeptidyl peptidase IV inhibitors through pharmacophore hybridization and hit-to-lead optimization.EBI Chinese Academy of Science
23594271 68 Identification of selective and potent inhibitors of fibroblast activation protein and prolyl oligopeptidase.EBI Tufts University Sackler School of Biomedical Sciences
23416006 28 Substituted piperidinyl glycinyl 2-cyano-4,5-methano pyrrolidines as potent and stable dipeptidyl peptidase IV inhibitors.EBI Bristol-Myers Squibb Research and Development
22503246 32 Long-acting peptidomimetics based DPP-IV inhibitors.EBI Zydus Research Centre
23072865 59 Novel series of 3-amino-N-(4-aryl-1,1-dioxothian-4-yl)butanamides as potent and selective dipeptidyl peptidase IV inhibitors.EBI Toray Industries, Inc.
23121075 119 P2-substituted N-acylprolylpyrrolidine inhibitors of prolyl oligopeptidase: biochemical evaluation, binding mode determination, and assessment in a cellular model of synucleinopathy.EBI University of Antwerp
23025999 33 Structure-based design of pyridopyrimidinediones as dipeptidyl peptidase IV inhibitors.EBI Takeda California
21780776 40 Remarkable potential of thea-aminophosphonate/phosphinate structural motif in medicinal chemistry.EBI Wroclaw University of Technology
22959556 57 Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl]thiazolidine): a highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.EBI Mitsubishi Tanabe Pharma Corporation
22938786 86 Discovery of 3H-imidazo[4,5-c]quinolin-4(5H)-ones as potent and selective dipeptidyl peptidase IV (DPP-4) inhibitors.EBI Dainippon Sumitomo Pharma Co., Ltd
22850208 60 Dipeptidyl peptidase-4 inhibitor withß-amino amide scaffold: synthesis, SAR and biological evaluation.EBI Dong-A Pharm. Co., Ltd
22853995 57 4-Substituted boro-proline dipeptides: synthesis, characterization, and dipeptidyl peptidase IV, 8, and 9 activities.EBI Tufts University School of Medicine
22824762 39 Fused bicyclic heteroarylpiperazine-substituted L-prolylthiazolidines as highly potent DPP-4 inhibitors lacking the electrophilic nitrile group.EBI Mitsubishi Tanabe Pharma Corporation
22525314 159 Acylated Gly-(2-cyano)pyrrolidines as inhibitors of fibroblast activation protein (FAP) and the issue of FAP/prolyl oligopeptidase (PREP)-selectivity.EBI University of Antwerp (UA)
22475866 19 Novel pyrrolopyrimidine analogues as potent dipeptidyl peptidase IV inhibitors based on pharmacokinetic property-driven optimization.EBI Chinese Academy of Sciences
22377519 23 An example of designed multiple ligands spanning protein classes: dual MCH-1R antagonists/DPPIV inhibitors.EBI Prosidion Ltd
21764322 33 Identification of 3-aminomethyl-1,2-dihydro-4-phenyl-1-isoquinolones: a new class of potent, selective, and orally active non-peptide dipeptidyl peptidase IV inhibitors that form a unique interaction with Lys554.EBI Takeda Pharmaceutical Company Limited
21218817 52 Discovery of a 3-pyridylacetic acid derivative (TAK-100) as a potent, selective and orally active dipeptidyl peptidase IV (DPP-4) inhibitor.EBI Takeda Pharmaceutical Company Limited
21106276 18 The highly potent and selective dipeptidyl peptidase IV inhibitors bearing a thienopyrimidine scaffold effectively treat type 2 diabetes.EBI Chinese Academy of Sciences
20718420 167 Substituted 4-carboxymethylpyroglutamic acid diamides as potent and selective inhibitors of fibroblast activation protein.EBI National Health Research Institutes
20058865 59 Inhibitors of prolyl oligopeptidases for the therapy of human diseases: defining diseases and inhibitors.EBI McGill University
19715320 87 Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation.EBI University of Florida
19375196 22 Synthesis and evaluation of structurally constrained imidazolidin derivatives as potent dipeptidyl peptidase IV inhibitors.EBI Sichuan University
19217790 68 Medicinal chemistry approaches to the inhibition of dipeptidyl peptidase-4 for the treatment of type 2 diabetes.EBI Matrix Laboratories Limited
18243000 43 Synthesis and structure-activity relationships of potent 4-fluoro-2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors.EBI Taisho Pharmaceutical Co., Ltd
18485703 37 3,5-Dihydro-imidazo[4,5-d]pyridazin-4-ones: a class of potent DPP-4 inhibitors.EBI Boehringer Ingelheim Pharma GmbH& Co. KG
18346892 42 Structure-based design and synthesis of benzimidazole derivatives as dipeptidyl peptidase IV inhibitors.EBI Takeda San Diego
17962025 24 Discovery of long-acting N-(cyanomethyl)-N-alkyl-L-prolinamide inhibitors of dipeptidyl peptidase IV.EBI Minase Research Institute
18331795 44 Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors.EBI Merck& Co. Inc.
18053726 364 Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality.EBI Johnson& Johnson Pharmaceutical Research& Development
18039579 59 Design and synthesis of DPP-IV inhibitors lacking the electrophilic nitrile group.EBI Ono Pharmaceutical Co., Ltd
18201067 276 Discovery of potent and selective dipeptidyl peptidase IV inhibitors derived from beta-aminoamides bearing subsituted triazolopiperazines.EBI Merck Research Laboratories
17869513 112 Imidazopiperidine amides as dipeptidyl peptidase IV inhibitors for the treatment of diabetes.EBI Merck Research Laboratories
17331715 19 Synthesis, biological evaluation and structural determination of beta-aminoacyl-containing cyclic hydrazine derivatives as dipeptidyl peptidase IV (DPP-IV) inhibitors.EBI Korea Research Institute of Chemical Technology
17822893 61 (3R,4S)-4-(2,4,5-Trifluorophenyl)-pyrrolidin-3-ylamine inhibitors of dipeptidyl peptidase IV: synthesis, in vitro, in vivo, and X-ray crystallographic characterization.EBI Pfizer Global Research and Development
17113301 83 Lead optimization of [(S)-gamma-(arylamino)prolyl]thiazolidine focused on gamma-substituent: Indoline compounds as potent DPP-IV inhibitors.EBI Mitsubishi Pharma Corporation
15357972 30 Synthesis and DP-IV inhibition of cyano-pyrazoline derivatives as potent anti-diabetic agents.EBI Korea Research Institute of Chemical Technology
14584950 132 Design, synthesis, and SAR of potent and selective dipeptide-derived inhibitors for dipeptidyl peptidases.EBI University of Antwerp (UIA)
9622551 14 Specific and irreversible cyclopeptide inhibitors of dipeptidyl peptidase IV activity of the T-cell activation antigen CD26.EBI Universit£ de Versailles
8642568 28 Structure-activity relationships of boronic acid inhibitors of dipeptidyl peptidase IV. 1. Variation of the P2 position of Xaa-boroPro dipeptides.EBI Boehringer Ingelheim Pharmaceuticals Inc.
12270155 56 Development of potent and selective dipeptidyl peptidase II inhibitors.EBI University of Antwerp (UIA)
10915049 22 1-Aminomethylisoquinoline-4-carboxylates as novel dipeptidylpeptidase IV inhibitors.EBI Novartis Institute for Biomedical Research
10098663 37 Nonpeptide small-molecular inhibitors of dipeptidyl peptidase IV: N-phenylphthalimide analogs.EBI University of Tokyo
22177783 122 Novel heterocyclic DPP-4 inhibitors for the treatment of type 2 diabetes.EBI Argenta Discovery Ltd.
22019046 35 Discovery and pharmacological characterization of N-[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide hydrochloride (anagliptin hydrochloride salt) as a potent and selective DPP-IV inhibitor.EBI Sanwa Kagaku Kenkyusho Co. Ltd
21996520 149 7-Oxopyrrolopyridine-derived DPP4 inhibitors-mitigation of CYP and hERG liabilities via introduction of polar functionalities in the active site.EBI Bristol-Myers Squibb Research and Development
21996517 5 Molecular dynamics simulations and MM/GBSA methods to investigate binding mechanisms of aminomethylpyrimidine inhibitors with DPP-IV.EBI Graduate University of the Chinese Academy of Sciences
21865048 29 2-({6-[(3R)-3-amino-3-methylpiperidine-1-yl]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-5H-pyrrolo[3,2-d]pyrimidine-5-yl}methyl)-4-fluorobenzonitrile (DSR-12727): a potent, orally active dipeptidyl peptidase IV inhibitor without mechanism-based inactivation of CYP3A.EBI Dainippon Sumitomo Pharma Co. Ltd
21711053 106 Structure-activity relationship studies on isoindoline inhibitors of dipeptidyl peptidases 8 and 9 (DPP8, DPP9): is DPP8-selectivity an attainable goal?EBI University of Antwerp (UA)
21741847 20 Discovery of potent, selective, and orally bioavailable quinoline-based dipeptidyl peptidase IV inhibitors targeting Lys554.EBI Takeda Pharmaceutical Company Limited
21570283 29 Discovery of DA-1229: a potent, long acting dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes.EBI Dong-A Pharm. Co., Ltd
21478015 6 Non-competitive and selective dipeptidyl peptidase IV inhibitors with phenethylphenylphthalimide skeleton derived from thalidomide-relateda-glucosidase inhibitors and liver X receptor antagonists.EBI The University of Tokyo
21388136 9 Pro-soft Val-boroPro: a strategy for enhancing in vivo performance of boronic acid inhibitors of serine proteases.EBI Tufts University Sackler School of Graduate Biomedical Sciences
21435872 5 Aza-annulation on the 16-dehydropregnenolone, via tandem intermolecular aldol process and intramolecular Michael addition.EBI Central Drug Research Institute
21334204 26 Discovery of potent dipeptidyl peptidase IV inhibitors derived fromß-aminoamides bearing substituted [1,2,3]-triazolopiperidines for the treatment of type 2 diabetes.EBI Shandong University of Traditional Chinese Medicine
21324688 36 1-((3S,4S)-4-amino-1-(4-substituted-1,3,5-triazin-2-yl) pyrrolidin-3-yl)-5,5-difluoropiperidin-2-one inhibitors of DPP-4 for the treatment of type 2 diabetes.EBI Pfizer Inc.
21320777 375 Synthesis and evaluation of [(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]cyclohexanes and 4-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]piperidines as DPP-4 inhibitors.EBI Merck Research Laboratories
21306895 46 Discovery ofß-aminoacyl containing thiazolidine derivatives as potent and selective dipeptidyl peptidase IV inhibitors.EBI Korea Research Institute of Chemical Technology
21186796 83 Design and synthesis of pyrimidinone and pyrimidinedione inhibitors of dipeptidyl peptidase IV.EBI Takeda San Diego, Inc.
21163664 24 Design and synthesis of 3-pyridylacetamide derivatives as dipeptidyl peptidase IV (DPP-4) inhibitors targeting a bidentate interaction with Arg125.EBI Takeda Pharmaceutical Company Limited
21074430 53 Discovery of new chemotype dipeptidyl peptidase IV inhibitors having (R)-3-amino-3-methyl piperidine as a pharmacophore.EBI Dainippon Sumitomo Pharma Co., Ltd
20800322 10 Synthesis, biological assay in vitro and molecular docking studies of new imidazopyrazinone derivatives as potential dipeptidyl peptidase IV inhibitors.EBI East China University of Science and Technology
20833042 51 Synthesis, SAR, and atropisomerism of imidazolopyrimidine DPP4 inhibitors.EBI Bristol-Myers Squibb Research and Development
20684603 101 Discovery of 6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamides as potent, selective dipeptidyl peptidase-4 (DPP4) inhibitors.EBI Bristol-Myers Squibb
20598534 105 Synthesis and SAR of azolopyrimidines as potent and selective dipeptidyl peptidase-4 (DPP4) inhibitors for type 2 diabetes.EBI Bristol-Myers Squibb
20488704 28 Synthesis and biological evaluation of bicyclo[3.3.0] octane derivatives as dipeptidyl peptidase 4 inhibitors for the treatment of type 2 diabetes.EBI Shanghai Hengrui Pharmaceuticals Co., Ltd
20488702 21 Synthesis and biological evaluation of azobicyclo[3.3.0] octane derivatives as dipeptidyl peptidase 4 inhibitors for the treatment of type 2 diabetes.EBI Shanghai Hengrui Pharmaceuticals Co., Ltd
20483603 106 (2S,4S)-1-[2-(1,1-dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV.EBI National Health Research Institutes
20031408 9 Aryl- and heteroaryl-substituted aminobenzo[a]quinolizines as dipeptidyl peptidase IV inhibitors.EBI F Hoffmann-La Roche Ltd
20031405 19 Discovery of carmegliptin: a potent and long-acting dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.EBI F Hoffmann-La Roche Ltd
20000418 1 Application of the dipeptidyl peptidase IV (DPPIV/CD26) based prodrug approach to different amine-containing drugs.EBI Instituto de Qu£mica M£dica (C.S.I.C.)
19833514 104 The design of potent and selective inhibitors of DPP-4: optimization of ADME properties by amide replacements.EBI Santhera Pharmaceuticals (Switzerland) Ltd
19576767 142 From lead to preclinical candidate: optimization of beta-homophenylalanine based inhibitors of dipeptidyl peptidase IV.EBI Santhera Pharmaceuticals (Switzerland) Ltd
19539471 130 Aminopiperidine-fused imidazoles as dipeptidyl peptidase-IV inhibitors.EBI Merck& Co. Inc.
19515557 47 Discovery of beta-homophenylalanine based pyrrolidin-2-ylmethyl amides and sulfonamides as highly potent and selective inhibitors of dipeptidyl peptidase IV.EBI Santhera Pharmaceuticals (Switzerland) Ltd
19482472 30 Bicyclic cyanothiazolidines as novel dipeptidyl peptidase 4 inhibitors.EBI Phenomix Corporation
19285862 30 Piperidinyl-2-phenethylamino inhibitors of DPP-IV for the treatment of type 2 diabetes.EBI Pfizer Global Research and Development
19275964 64 (3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: a potent, selective, orally active dipeptidyl peptidase IV inhibitor.EBI Pfizer Global Research & Development
19269819 102 Rational design and synthesis of potent and long-lasting glutamic acid-based dipeptidyl peptidase IV inhibitors.EBI National Health Research Institutes
19261480 113 Novel trans-2-aryl-cyclopropylamine analogues as potent and selective dipeptidyl peptidase IV inhibitors.EBI National Health Research Institutes
18996694 30 Synthesis and biological evaluation of homopiperazine derivatives with beta-aminoacyl group as dipeptidyl peptidase IV inhibitors.EBI Korea Research Institute of Chemical Technology
18819797 24 (3R)-3-amino-4-(2,4,5-trifluorophenyl)-N-{4-[6-(2-methoxyethoxy)benzothiazol-2-yl]tetrahydropyran-4-yl}butanamide as a potent dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.EBI Toray Industries Inc.
18783201 27 Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: determinants of potency and in vivo efficacy and safety.EBI Tufts University
18650094 12 Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor.EBI Institut de Recerca Biomèdica de Barcelona
18602260 177 Discovery of conformationally rigid 3-azabicyclo[3.1.0]hexane-derived dipeptidyl peptidase-IV inhibitors.EBI Ranbaxy Research Laboratories
18570365 29 The many roles for fluorine in medicinal chemistry.EBI Merck Research Laboratories
18556199 234 Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 1: identification of dipeptide derived leads.EBI University of Antwerp
18556198 125 Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 2: isoindoline containing inhibitors.EBI University of Antwerp
18524582 52 Discovery of new binding elements in DPP-4 inhibition and their applications in novel DPP-4 inhibitor design.EBI Merck Research Laboratories
18457385 41 Recent developments in fragment-based drug discovery.EBI Astex Therapeutics Ltd.
18243422 35 Synthesis and biological evaluation of pyrazoline analogues with beta-amino acyl group as dipeptidyl peptidase IV inhibitors.EBI Korea Research Institute of Chemical Technology
18207285 26 A three-dimensional pharmacophore model for dipeptidyl peptidase IV inhibitors.EBI National Health Research Institutes
18068977 3 Inhibition of dipeptidyl peptidase-IV (DPP-IV) by atorvastatin.EBI St. John's University
18052023 30 8-(3-(R)-aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a highly potent, selective, long-acting, and orally bioavailable DPP-4 inhibitor for the treatment of type 2 diabetes.EBI Boehringer Ingelheim Pharma GmbH & Co. KG
17977724 83 Design and synthesis of potent amido- and benzyl-substituted cis-3-amino-4-(2-cyanopyrrolidide)pyrrolidinyl DPP-IV inhibitors.EBI Pfizer Global Research and Development
17958345 75 Irreversible inhibition of dipeptidyl peptidase 8 by dipeptide-derived diaryl phosphonates.EBI University of Antwerp
17937986 39 Potent non-nitrile dipeptidic dipeptidyl peptidase IV inhibitors.EBI Bristol-Myers Squibb Research and Development
17883259 17 Anti-Helicobacter pylori and thrombin inhibitory components from Chinese dragon's blood, Dracaena cochinchinensis.EBI Chinese Academy of Sciences
17851076 77 4-arylcyclohexylalanine analogs as potent, selective, and orally active inhibitors of dipeptidyl peptidase IV.EBI Merck Research Laboratories
17827003 68 Design, synthesis, and biological evaluation of triazolopiperazine-based beta-amino amides as potent, orally active dipeptidyl peptidase IV (DPP-4) inhibitors.EBI Merck Research Laboratories
17562364 150 Discovery of 3-aminopiperidines as potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitors.EBI Merck Research Laboratories
17544668 55 Synthesis, SAR, and X-ray structure of novel potent DPPIV inhibitors: oxadiazolyl ketones.EBI LG Life Sciences, Ltd
17502141 25 Modeling assisted rational design of novel, potent, and selective pyrrolopyrimidine DPP-4 inhibitors.EBI Merck Research Laboratories
17434732 99 Triazolopiperazine-amides as dipeptidyl peptidase IV inhibitors: close analogs of JANUVIA (sitagliptin phosphate).EBI Merck Research Laboratories
17433672 16 Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin.EBI Merck Research Laboratories
17418568 50 1,3-disubstituted 4-aminopiperidines as useful tools in the optimization of the 2-aminobenzo[a]quinolizine dipeptidyl peptidase IV inhibitors.EBI F. Hoffmann-La Roche Ltd
17317162 60 [(S)-gamma-(4-Aryl-1-piperazinyl)-l-prolyl]thiazolidines as a novel series of highly potent and long-lasting DPP-IV inhibitors.EBI Mitsubishi Pharma Corporation
17293118 30 Design and synthesis of new potent dipeptidyl peptidase IV inhibitors with enhanced ex vivo duration.EBI Minase Research Institute
17292611 21 Design and synthesis of long-acting inhibitors of dipeptidyl peptidase IV.EBI Minase Research Institute
17194587 106 3-[2-((2S)-2-cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-butyramide analogues as selective DPP-IV inhibitors for the treatment of type-II diabetes.EBI National Health Research Institutes
17174090 50 Synthesis and structure-activity relationship of N-acyl-Gly-, N-acyl-Sar- and N-blocked-boroPro inhibitors of FAP, DPP4, and POP.EBI Genentech
17055271 18 Synthesis and activity of a potent, specific azabicyclo[3.3.0]-octane-based DPP II inhibitor.EBI Tufts University School of Medicine
16844373 25 Synthesis and dipeptidyl peptidase inhibition of N-(4-substituted-2,4-diaminobutanoyl)piperidines.EBI Laboratory of Medicinal Chemistry University of Antwerp
16722626 94 cis-2,5-dicyanopyrrolidine inhibitors of dipeptidyl peptidase IV: synthesis and in vitro, in vivo, and X-ray crystallographic characterization.EBI Pfizer Global Research and Development
16321524 8 In silico fragment-based discovery of DPP-IV S1 pocket binders.EBI Santhera Pharmaceuticals
16168640 82 2-Cyano-4-fluoro-1-thiovalylpyrrolidine analogues as potent inhibitors of DPP-IV.EBI GlaxoSmithKline Research and Development
16115768 11 New fluorinated pyrrolidine and azetidine amides as dipeptidyl peptidase IV inhibitors.EBI Pfizer Global Research and Development
16085416 45 Synthesis and structure-activity relationship of N-alkyl Gly-boro-Pro inhibitors of DPP4, FAP, and DPP7.EBI ActivX Biosciences, Inc.
16084722 55 Boro-norleucine as a P1 residue for the design of selective and potent DPP7 inhibitors.EBI ActivX Biosciences
15927466 52 Glutamic acid analogues as potent dipeptidyl peptidase IV and 8 inhibitors.EBI National Health Research Institutes
15863294 36 1-((S)-gamma-substituted prolyl)-(S)-2-cyanopyrrolidine as a novel series of highly potent DPP-IV inhibitors.EBI Mitsubishi Pharma Corporation
15380217 87 Potent and selective proline derived dipeptidyl peptidase IV inhibitors.EBI Merck & Co. Inc.
15324904 52 Substituted piperazines as novel dipeptidyl peptidase IV inhibitors.EBI Merck & Co. Inc.
15324903 49 Discovery of potent and selective beta-homophenylalanine based dipeptidyl peptidase IV inhibitors.EBI Merck & Co.
15293982 12 Dipeptidyl peptidase IV inhibitors for the treatment of diabetes.EBI Merck Research Laboratories
15139769 87 Gamma-amino-substituted analogues of 1-[(S)-2,4-diaminobutanoyl]piperidine as highly potent and selective dipeptidyl peptidase II inhibitors.EBI University of Antwerp
15012982 129 Diastereoselective synthesis and configuration-dependent activity of (3-substituted-cycloalkyl)glycine pyrrolidides and thiazolidides as dipeptidyl peptidase IV inhibitors.EBI Merck Research Laboratories
14980678 88 Fluoropyrrolidine amides as dipeptidyl peptidase IV inhibitors.EBI Merck Research Laboratories
14684294 79 4-Amino cyclohexylglycine analogues as potent dipeptidyl peptidase IV inhibitors.EBI Merck & Co. Inc.
12801240 105 1-[[(3-hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties.EBI Novartis Institute for Biomedical Research
12036346 12 1-[2-[(5-Cyanopyridin-2-yl)amino]ethylamino]acetyl-2-(S)-pyrrolidinecarbonitrile: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties.EBI TBA
10090787 25 Structure-activity relationship of diaryl phosphonate esters as potent irreversible dipeptidyl peptidase IV inhibitors.EBI University of Antwerp (UIA)
9873385 3 A potent dipeptide inhibitor of dipeptidyl peptidase IV.EBI Tanabe Seiyaku Co., Ltd.
28215601 21 Design and synthesis of quinazoline-3,4-(4H)-diamine endowed with thiazoline moiety as new class for DPP-4 and DPPH inhibitor.BDB Jamia Hamdard (Hamdard University)
25216392 5 Design, synthesis, biological screening, and molecular docking studies of piperazine-derived constrained inhibitors of DPP-IV for the treatment of type 2 diabetes.BDB CSIR-Central Drug Research Institute
24674599 35 Identification of dipeptidyl peptidase IV inhibitors: virtual screening, synthesis and biological evaluation.BDB China Pharmaceutical University
23581745 10 Synthesis, evaluation and molecular docking of prolyl-fluoropyrrolidine derivatives as dipeptidyl peptidase IV inhibitors.BDB Delhi Institute of Pharmaceutical Sciences and Research
12739951 91 Rapid parallel synthesis of dipeptide diphenyl phosphonate esters as inhibitors of dipeptidyl peptidases.BDB University of Anterwerp
17350841 92 4-aminophenylalanine and 4-aminocyclohexylalanine derivatives as potent, selective, and orally bioavailable inhibitors of dipeptidyl peptidase IV.BDB Merck Research Laboratories
17441705 28 Discovery of alogliptin: a potent, selective, bioavailable, and efficacious inhibitor of dipeptidyl peptidase IV.BDB Takeda Pharmaceutical Company Ltd.
17337342 20 Affinity-based ranking of ligands for DPP-4 from mixtures.BDB Merck Research Laboratories
17291750 93 Optimization of 1,4-diazepan-2-one containing dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes.BDB Merck Research Laboratories
17367123 37 Discovery and structure-activity relationships of piperidinone- and piperidine-constrained phenethylamines as novel, potent, and selective dipeptidyl peptidase IV inhibitors.BDB Abbott Laboratories
17276063 38 Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit.BDB Abbott Laboratories
17239592 9 Discovery of non-covalent dipeptidyl peptidase IV inhibitors which induce a conformational change in the active site.BDB Lilly Research Laboratories
17010607 26 Xanthine mimetics as potent dipeptidyl peptidase IV inhibitors.BDB Abbott Laboratories
17055272 30 (3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one, a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.BDB Merck Research Laboratories
17064063 18 Discovery of ((4R,5S)-5-amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a highly potent, selective, orally efficacious, and safe dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.BDB Abbott Laboratories
17034148 51 Discovery of 2-[4-{{2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic acid (ABT-279): a very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes.BDB Abbott Laboratories
15771423 98 Fluoro-olefins as peptidomimetic inhibitors of dipeptidyl peptidases.BDB University of Antwerp
15664838 54 Novel isoindoline compounds for potent and selective inhibition of prolyl dipeptidase DPP8.BDB National Health Research Institutes
16581245 72 Substituted pyrrolidine-2,4-dicarboxylic acid amides as potent dipeptidyl peptidase IV inhibitors.BDB National Health Research Institutes
15837304 132 Dipeptidyl peptidase IV inhibitors derived from beta-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole.BDB Merck Research Laboratories
16376077 23 Seco-prolinenitrile inhibitors of dipeptidyl peptidase IV define minimal pharmacophore requirements at P1.BDB Bristol-Myers Squibb Pharmaceutical Research Institute
16392822 87 2-[3-[2-[(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]- 1,2,3,4-tetrahydroisoquinoline: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV.BDB National Health Research Institutes
16919457 144 Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitors.BDB Merck Research Laboratories
16768443 12 Crystal structures of DPP-IV (CD26) from rat kidney exhibit flexible accommodation of peptidase-selective inhibitors.BDB Abbott Laboratories
15006388 34 Aminomethylpyrimidines as novel DPP-IV inhibitors: a 10(5)-fold activity increase by optimization of aromatic substituents.BDB Hoffmann-La Roche Inc.
16376544 10 The reversed binding of beta-phenethylamine inhibitors of DPP-IV: X-ray structures and properties of novel fragment and elaborated inhibitors.BDB Santhera Pharmaceuticals
16033281 19 Discovery and preclinical profile of Saxagliptin (BMS-477118): a highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.BDB Bristol-Myers Squibb Pharmaceutical Research Institute
15863311 244 Discovery of potent and selective phenylalanine based dipeptidyl peptidase IV inhibitors.BDB Merck Research Laboratories
15908206 164 Discovery of potent and selective orally bioavailable beta-substituted phenylalanine derived dipeptidyl peptidase IV inhibitors.BDB Merck Research Laboratories
16332437 92 Discovery of potent, selective, and orally bioavailable pyridone-based dipeptidyl peptidase-4 inhibitors.BDB Merck Research Laboratories
15634008 32 (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.BDB Merck Research Laboratories
16759103 64 (2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]-pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.BDB Merck Research Laboratories
16236500 26 Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors.BDB Johnson & Johnson Pharmaceutical
16759095 56 Discovery, structure-activity relationship, and pharmacological evaluation of (5-substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as potent dipeptidyl peptidase IV inhibitors.BDB Abbott Laboratories