BindingDB logo
myBDB logout

529 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
27227326 156 Discovery of 7-(Prolinol-N-yl)-2-phenylamino-thiazolo[5,4-d]pyrimidines as Novel Non-Nucleoside Partial Agonists for the A2A Adenosine Receptor: Prediction from Molecular Modeling.EBI Julius-Maximilians-Universit£t W£rzburg
27485602 183 Similarities and differences in affinity and binding modes of tricyclic pyrimido- and pyrazinoxanthines at human and rat adenosine receptors.EBI Jagiellonian University Medical College
27161878 83 Exploring the 2- and 5-positions of the pyrazolo[4,3-d]pyrimidin-7-amino scaffold to target human A1 and A2A adenosine receptors.EBI Universit£ degli Studi di Firenze
26890707 27 Purine (N)-Methanocarba Nucleoside Derivatives Lacking an Exocyclic Amine as Selective A3 Adenosine Receptor Agonists.EBI National Institute of Diabetes and Digestive and Kidney Diseases
26824742 43 Discovery of Potent and Highly Selective A2B Adenosine Receptor Antagonist Chemotypes.EBI Uppsala University
26988801 55 Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.EBI Jagiellonian University Medical College
26819673 55 Tetrahydroisoquinoline Phenols: Selective Estrogen Receptor Downregulator Antagonists with Oral Bioavailability in Rat.EBI AstraZeneca
26756468 44 Discovery of Novel Adenosine Receptor Agonists That Exhibit Subtype Selectivity.EBI University of Warwick
26356532 39 Discovery of Molecular Therapeutics for Glaucoma: Challenges, Successes, and Promising Directions.EBI Georgia Institute of Technology
26776359 21 Carbamate substituted 2-amino-4,6-diphenylpyrimidines as adenosine receptor antagonists.EBI North-West University
26781932 109 Discovery of aminoquinazoline derivatives as human A(2A) adenosine receptor antagonists.EBI Merck Research Laboratories
26638043 66 Structural refinement of pyrazolo[4,3-d]pyrimidine derivatives to obtain highly potent and selective antagonists for the human A3 adenosine receptor.EBI Universit£ degli Studi di Firenze
26717203 129 5,7-Disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazines as pharmacological tools to explore the antagonist selectivity profiles toward adenosine receptors.EBI Universit£ di Trieste
26392370 66 1,3,7-Triethyl-substituted xanthines--possess nanomolar affinity for the adenosine A1 receptor.EBI North-West University
26210506 26 Structure-kinetics relationships of Capadenoson derivatives as adenosine A1 receptor agonists.EBI Leiden University
26191370 34 Rigidified A3 Adenosine Receptor Agonists: 1-Deazaadenine Modification Maintains High in Vivo Efficacy.EBI National Institute of Diabetes and Digestive and Kidney Diseases
26141910 1 Synthesis and biological evaluation of a new series of 2-amino-3-aroyl thiophene derivatives as agonist allosteric modulators of the A1 adenosine receptor. A position-dependent effect study.EBI Universit£ di Ferrara
26048804 57 Use of molecular modeling aided design to dial out hERG liability in adenosine A(2A) receptor antagonists.EBI Merck Research Laboratories
26046697 46 One-pot reaction to obtain N,N'-disubstituted guanidines of pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine scaffold as human A3 adenosine receptor antagonists.EBI Universit£ degli Studi di Ferrara
25969169 54 A solid-phase combinatorial approach for indoloquinolizidine-peptides with high affinity at D(1) and D(2) dopamine receptors.EBI University of Barcelona
25780876 205 Design, synthesis, and biological evaluation of novel 2-((2-(4-(substituted)phenylpiperazin-1-yl)ethyl)amino)-5'-N-ethylcarboxamidoadenosines as potent and selective agonists of the A2A adenosine receptor.EBI Universit£ degli Studi di Ferrara
25699637 91 5'-C-Ethyl-tetrazolyl-N(6)-substituted adenosine and 2-chloro-adenosine derivatives as highly potent dual acting A1 adenosine receptor agonists and A3 adenosine receptor antagonists.EBI University of Camerino
25633494 128 A facile and novel synthesis of N(2)-, C(6)-substituted pyrazolo[3,4-d]pyrimidine-4 carboxylate derivatives as adenosine receptor antagonists.EBI National University of Singapore
25701253 23 Synthesis and SAR studies of analogues of 4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-N-thiazol-2-yl-benzamide (Lu AA41063) as adenosine A2A receptor ligands with improved aqueous solubility.EBI H. Lundbeck A/S
25686851 54 Novel thiazole-thiophene conjugates as adenosine receptor antagonists: synthesis, biological evaluation and docking studies.EBI B. V. Patel Pharmaceutical Education and Research Development (PERD) Centre
25063944 56 7-Amino-2-phenylpyrazolo[4,3-d]pyrimidine derivatives: structural investigations at the 5-position to target human A1 and A(2A) adenosine receptors. Molecular modeling and pharmacological studies.EBI Universit£ di Firenze
24972108 256 Scaffold decoration at positions 5 and 8 of 1,2,4-triazolo[1,5-c]pyrimidines to explore the antagonist profiling on adenosine receptors: a preliminary structure-activity relationship study.EBI Universit£ di Trieste
24969016 16 Extended N(6) substitution of rigid C2-arylethynyl nucleosides for exploring the role of extracellular loops in ligand recognition at the A3 adenosine receptor.EBI National Institute of Diabetes and Digestive and Kidney Diseases
24863744 15 DDD-028: a potent potential non-opioid, non-cannabinoid analgesic for neuropathic and inflammatory pain.EBI University of Missouri
25497490 30 1,2,4-triazolo[1,5-a]quinoxaline derivatives and their simplified analogues as adenosine A3 receptor antagonists. Synthesis, structure-affinity relationships and molecular modeling studies.EBI Universit£ di Firenze
25462223 27 Further studies on pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as potent and selective human A1 adenosine receptor antagonists.EBI Universit£ degli Studi di Firenze
25221664 21 Structure-Based Design of Reactive Nucleosides for Site-Specific Modification of the A2A Adenosine Receptor.EBI National Institute of Diabetes and Digestive and Kidney Diseases
25181013 4 Synthesis and biological evaluation of novel allosteric enhancers of the A1 adenosine receptor based on 2-amino-3-(4'-chlorobenzoyl)-4-substituted-5-arylethynyl thiophene.EBI Universit£ di Ferrara
24871036 13 4-aminoquinolone piperidine amides: noncovalent inhibitors of DprE1 with long residence time and potent antimycobacterial activity.EBI AstraZeneca
24164628 186 Adenosine A2A receptor as a drug discovery target.EBI Merck Research Laboratories
24669958 39 Agonists for the adenosine A1 receptor with tunable residence time. A Case for nonribose 4-amino-6-aryl-5-cyano-2-thiopyrimidines.EBI Leiden University
9438021 97 Flavonoid derivatives as adenosine receptor antagonists: a comparison of the hypothetical receptor binding site based on a comparative molecular field analysis model.EBI National Institute of Diabetes
23200243 5 Fluorescent ligands for adenosine receptors.EBI National Institute of Diabetes and Digestive and Kidney Diseases
23597047 5 Structure-based approaches to ligands for G-protein-coupled adenosine and P2Y receptors, from small molecules to nanoconjugates.EBI National Institute of Diabetes and Digestive and Kidney Diseases
23516963 99 Substituted 7-amino-5-thio-thiazolo[4,5-d]pyrimidines as potent and selective antagonists of the fractalkine receptor (CX3CR1).EBI AstraZeneca
23427825 45 2-Arylpyrazolo[4,3-d]pyrimidin-7-amino derivatives as new potent and selective human A3 adenosine receptor antagonists. Molecular modeling studies and pharmacological evaluation.EBI Universit£ di Firenze
23245803 87 Synthesis and structure-activity relationships of 2-hydrazinyladenosine derivatives as A(2A) adenosine receptor ligands.EBI University of Bonn
23231967 23 Selective and potent adenosine A3 receptor antagonists by methoxyaryl substitution on the N-(2,6-diarylpyrimidin-4-yl)acetamide scaffold.EBI University of Santiago de Compostela
23171656 23 Pyrazolo[1,5-c]quinazoline derivatives and their simplified analogues as adenosine receptor antagonists: synthesis, structure-affinity relationships and molecular modeling studies.EBI Universita' di Firenze
22277057 11 Highly potent and selective fluorescent antagonists of the human adenosine A3 receptor based on the 1,2,4-triazolo[4,3-a]quinoxalin-1-one scaffold.EBI University of Nottingham
17249651 4 New fluorescent adenosine A1-receptor agonists that allow quantification of ligand-receptor interactions in microdomains of single living cells.EBI University of Nottingham
1542091 38 A steric and electrostatic comparison of three models for the agonist/antagonist binding site on the adenosine A1 receptor.EBI Center for Bio-Pharmaceutical Sciences
20806896 3 Effects of conformational restriction of 2-amino-3-benzoylthiophenes on A(1) adenosine receptor modulation.EBI Monash University (Parkville Campus)
20371139 16 Synthesis and pharmacological evaluation of novel substituted 9-deazaxanthines as A2B receptor antagonists.EBI Universidade de A Coru£a
20382540 9 In silico directed chemical probing of the adenosine receptor family.EBI Universidade do Minho
20137957 35 Synthesis and pharmacological evaluation of novel 1,3,8- and 1,3,7,8-substituted xanthines as adenosine receptor antagonists.EBI Universidade de Porto
19682912 80 Synthesis and pharmacological evaluation of novel 1- and 8-substituted-3-furfuryl xanthines as adenosine receptor antagonists.EBI Universidade de Santiago de Compostela
19346133 58 Synthesis of novel 1-alkyl-8-substituted-3-(3-methoxypropyl) xanthines as putative A(2B) receptor antagonists.EBI Universidade de A Coru£a
17418915 48 QSAR study on a novel series of 8-azaadenine analogues proposed as A1 adenosine receptor antagonists.EBI University of Pisa
16392813 329 Design, synthesis, and structure-activity relationships of 1-,3-,8-, and 9-substituted-9-deazaxanthines at the human A2B adenosine receptor.EBI Universit£ di Bari
2016708 26 2-aralkoxyadenosines: potent and selective agonists at the coronary artery A2 adenosine receptor.EBI University of South Florida
23098605 248 Exploring the directionality of 5-substitutions in a new series of 5-alkylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine as a strategy to design novel human a(3) adenosine receptor antagonists.EBI Universit£ di Trieste
22468757 171 Medicinal chemistry of A3 adenosine receptor modulators: pharmacological activities and therapeutic implications.EBI Universit£ di Ferrara
22921089 62 Structural sweet spot for A1 adenosine receptor activation by truncated (N)-methanocarba nucleosides: receptor docking and potent anticonvulsant activity.EBI National Institute of Diabetes and Digestive and Kidney Diseases
22889387 2 Synthesis and biological evaluation of 2-amino-3-(4-chlorobenzoyl)-4-[(4-arylpiperazin-1-yl)methyl]-5-substituted-thiophenes. effect of the 5-modification on allosteric enhancer activity at the A1 adenosine receptor.EBI Universit£ di Ferrara
22827545 11 Identifying novel adenosine receptor ligands by simultaneous proteochemometric modeling of rat and human bioactivity data.EBI Leiden/Amsterdam Center for Drug Research
22738238 29 Orally active adenosine A(1) receptor agonists with antinociceptive effects in mice.EBI University of North Carolina at Chapel Hill
22239465 26 Design and characterization of optimized adenosine A2A/A1 receptor antagonists for the treatment of Parkinson's disease.EBI Janssen Research and Development, L.L.C.
21664729 142 Synthesis and biological activity of tricyclic cycloalkylimidazo-, pyrimido- and diazepinopurinediones.EBI Jagiellonian University Medical College
22568637 158 Water-soluble pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines as human A3 adenosine receptor antagonists.EBI Universit£ di Ferrara
22486652 44 Optimization of adenosine 5'-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening.EBI National Institute of Diabetes and Digestive and Kidney Diseases
22559880 52 Structure-guided design of A(3) adenosine receptor-selective nucleosides: combination of 2-arylethynyl and bicyclo[3.1.0]hexane substitutions.EBI National Institute of Diabetes and Digestive and Kidney Diseases
22677030 29 New chromene scaffolds for adenosine A(2A) receptors: synthesis, pharmacology and structure-activity relationships.EBI Universidade do Minho
22432713 64 Synthesis and pharmacological evaluation of dual acting antioxidant A(2A) adenosine receptor agonists.EBI Monash University
22236250 16 Exploring activity cliffs in medicinal chemistry.EBI Rheinische Friedrich-Wilhelms-Universit£t
22257095 65 3-aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: a novel template for the design of highly selective A2B adenosine receptor antagonists.EBI Universit£ di Pisa
22220592 27 Discovery of 1,2,4-triazine derivatives as adenosine A(2A) antagonists using structure based drug design.EBI Heptares Therapeutics Limited
21210664 74 Discovery of phosphoric acid mono-{2-[(E/Z)-4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-benzoylimino]-thiazol-3-ylmethyl} ester (Lu AA47070): a phosphonooxymethylene prodrug of a potent and selective hA(2A) receptor antagonist.EBI H. Lundbeck A/S
20875743 90 Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity relaEBI Pfizer Inc.
20931963 112 Discovery of a novel 5-HT(3) antagonist/5-HT(1A) agonist 3-amino-5,6,7,8-tetrahydro-2-{4-[4-(quinolin-2-yl)piperazin-1-yl]butyl}quinazolin-4(3H)-one (TZB-30878) as an orally bioavailable agent for irritable bowel syndrome.EBI ASKA Pharmaceutical Co, Ltd
20598555 3 2-phenyl-1-[4-(2-piperidine-1-yl-ethoxy)benzyl]-1H-benzimidazoles as ligands for the estrogen receptor: synthesis and pharmacological evaluation.EBI Freie Universit£t Berlin
20684563 176 Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential.EBI H. Lundbeck A/S
20541935 131 4-Substituted-7-N-alkyl-N-acetyl 2-aminobenzothiazole amides: drug-like and non-xanthine based A2B adenosine receptor antagonists.EBI Roche Research Center
20408530 98 Novel N2-substituted pyrazolo[3,4-d]pyrimidine adenosine A3 receptor antagonists: inhibition of A3-mediated human glioblastoma cell proliferation.EBI Universit£ di Pisa
20303771 24 Novel 8-(furan-2-yl)-3-substituted thiazolo [5,4-e][1,2,4] triazolo[1,5-c] pyrimidine-2(3H)-thione derivatives as potential adenosine A(2A) receptor antagonists.EBI University of Delhi
20188574 141 2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists.EBI University of Bonn
19569717 251 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity.EBI Institute
19463000 50 High-affinity, non-nucleotide-derived competitive antagonists of platelet P2Y12 receptors.EBI University of Bonn
19282184 195 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands.EBI University of Camerino
18637670 80 2-Amino-6-furan-2-yl-4-substituted nicotinonitriles as A2A adenosine receptor antagonists.EBI Leiden/Amsterdam Center for Drug Research
10757709 8 Luteolin, a compound with adenosine A(1) receptor-binding activity, and chromone and dihydronaphthalenone constituents from Senna siamea.EBI Leiden University
16562853 22 Alkaloids from Eschscholzia californica and their capacity to inhibit binding of [3H]8-Hydroxy-2-(di-N-propylamino)tetralin to 5-HT1A receptors in Vitro.EBI Tom's of Maine
18262425 27 Synthesis of eudistomin D analogues and its effects on adenosine receptors.EBI Hokkaido University
18424135 131 Design of (N)-methanocarba adenosine 5'-uronamides as species-independent A3 receptor-selective agonists.EBI National Institute of Diabetes and Digestive and Kidney Diseases
18411049 134 Antagonists of the human adenosine A2A receptor. Part 3: Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpurines.EBI Vernalis (R&D) Ltd
18407496 127 Antagonists of the human adenosine A2A receptor. Part 2: Design and synthesis of 4-arylthieno[3,2-d]pyrimidine derivatives.EBI Vernalis (R&D) Ltd
18406614 56 Antagonists of the human adenosine A2A receptor. Part 1: Discovery and synthesis of thieno[3,2-d]pyrimidine-4-methanone derivatives.EBI Vernalis (R&D) Ltd
18321039 144 Discovery of a novel A2B adenosine receptor antagonist as a clinical candidate for chronic inflammatory airway diseases.EBI CV Therapeutics Inc.
18321038 85 Probing distal regions of the A2B adenosine receptor by quantitative structure-activity relationship modeling of known and novel agonists.EBI National Institute of Diabetes and Digestive and Kidney Diseases
18077171 108 1,3-Dipropyl-8-(1-phenylacetamide-1H-pyrazol-3-yl)-xanthine derivatives as highly potent and selective human A(2B) adenosine receptor antagonists.EBI Universit£ di Ferrara
18042389 42 N6-substituted C5'-modified adenosines as A1 adenosine receptor agonists.EBI Monash University (Parkville Campus)
18258439 69 A new generation of adenosine receptor antagonists: from di- to trisubstituted aminopyrimidines.EBI Leiden/Amsterdam Center for Drug Research
18226909 162 1-, 3- and 8-substituted-9-deazaxanthines as potent and selective antagonists at the human A2B adenosine receptor.EBI Universit£ di Bari
17483457 58 A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.EBI Abbott Laboratories
18255292 35 Structure-activity relationships of 2-chloro-N6-substituted-4'-thioadenosine-5'-N,N-dialkyluronamides as human A3 adenosine receptor antagonists.EBI Ewha Womans University
18068994 4 New QSAR combined strategy for the design of A1 adenosine receptor agonists.EBI Central University of Las Villas
17933541 145 5'-Carbamoyl derivatives of 2'-C-methyl-purine nucleosides as selective A1 adenosine receptor agonists: affinity, efficacy, and selectivity for A1 receptor from different species.EBI Universit£ di Camerino
17337182 23 Potent and selective xanthine-based inhibitors of phosphodiesterase 5.EBI Novartis Institutes of Biomedical Research
17967536 34 Structure-activity relationships of adenosines with heterocyclic N6-substituents.EBI Monash University (Parkville Campus)
17927167 107 5-amino-2-phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazin-1-one: a versatile scaffold to obtain potent and selective A3 adenosine receptor antagonists.EBI Universit£ di Pisa
17306548 84 N(6)-[(hetero)aryl/(cyclo)alkyl-carbamoyl-methoxy-phenyl]-(2-chloro)-5'-N-ethylcarboxamido-adenosines: the first example of adenosine-related structures with potent agonist activity at the human A(2B) adenosine receptor.EBI Universit£ di Ferrara
15566292 153 Novel bicyclic piperazine derivatives of triazolotriazine and triazolopyrimidines as highly potent and selective adenosine A2A receptor antagonists.EBI Biogen Idec Inc.
17378544 121 Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor.EBI National Institute of Diabetes and Digestive and Kidney Diseases
17309246 108 N6-methoxy-2-alkynyladenosine derivatives as highly potent and selective ligands at the human A3 adenosine receptor.EBI Universit£ di Camerino
17228880 76 Synthesis and biological evaluation of novel 1-deoxy-1-[6-[((hetero)arylcarbonyl)hydrazino]- 9H-purin-9-yl]-N-ethyl-beta-D-ribofuranuronamide derivatives as useful templates for the development of A2B adenosine receptor agonists.EBI Universit£ di Ferrara
17228876 36 SAR of a series of 5,6-dihydro-(9H)-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-alpha]pyridines as potent inhibitors of human eosinophil phosphodiesterase.EBI Pfizer Global Research and Development
17201410 4 Structure-activity relationship study of prion inhibition by 2-aminopyridine-3,5-dicarbonitrile-based compounds: parallel synthesis, bioactivity, and in vitro pharmacokinetics.EBI University of California-San Francisco
16487705 107 N6-ethyl-2-alkynyl NECAs, selective human A3 adenosine receptor agonists.EBI University of Virginia
16509587 72 Synthesis and biological studies of a new series of 5-heteroarylcarbamoylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidines as human A3 adenosine receptor antagonists. Influence of the heteroaryl substituent on binding affinity and molecular modeling investigations.EBI Universit£ degli Studi di Trieste
16366607 81 2-(Benzimidazol-2-yl)quinoxalines: a novel class of selective antagonists at human A(1) and A(3) adenosine receptors designed by 3D database searching.EBI Universit£ di Napoli"Federico II"
16250647 71 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.EBI Universit£ degli Studi di Urbino Carlo Bo
15771453 22 Development of spin-labeled probes for adenosine receptors.EBI University of Bonn
15771447 24 A series of ligands displaying a remarkable agonistic-antagonistic profile at the adenosine A1 receptor.EBI Leiden/Amsterdam Center for Drug Research
15771445 22 Binding thermodynamics as a tool to investigate the mechanisms of drug-receptor interactions: thermodynamics of cytoplasmic steroid/nuclear receptors in comparison with membrane receptors.EBI University of Ferrara
15771443 94 Novel diamino derivatives of [1,2,4]triazolo[1,5-a][1,3,5]triazine as potent and selective adenosine A2a receptor antagonists.EBI Biogen Idec, Inc.
15743197 37 Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists.EBI Universit£ di Camerino
16078833 37 6-aryl-8H-indeno[1,2-d]thiazol-2-ylamines: A1 adenosine receptor agonist allosteric enhancers having improved potency.EBI University of Virginia
15481989 70 Synthesis and biological evaluation of novel N6-[4-(substituted)sulfonamidophenylcarbamoyl]adenosine-5'-uronamides as A3 adenosine receptor agonists.EBI Universit£ di Ferrara
15341491 62 2-Pyrazolyl-N(6)-substituted adenosine derivatives as high affinity and selective adenosine A(3) receptor agonists.EBI CV Therapeutics Inc.
15267242 54 Synthesis and biological activity of new potential agonists for the human adenosine A2A receptor.EBI IIQAB (CSIC)
15876531 28 A new orally bioavailable dual adenosine A2B/A3 receptor antagonist with therapeutic potential.EBI Novartis Institutes for Biomedical Research
15863334 6 Geometry, topology, and atom-weights assembly descriptors to predicting A1 adenosine receptors agonists.EBI Experimental Sugar Cane Station
15341938 6 Design and synthesis of 3'-ureidoadenosine-5'-uronamides: effects of the 3'-ureido group on binding to the A3 adenosine receptor.EBI Ewha Womans University
15084123 24 Novel amino acid derived natural products from the ascidian Atriolum robustum: identification and pharmacological characterization of a unique adenosine derivative.EBI University of Bonn
14998332 328 Design, synthesis, and biological evaluation of new 8-heterocyclic xanthine derivatives as highly potent and selective human A2B adenosine receptor antagonists.EBI Universit£ di Ferrara
15239649 24 New, non-adenosine, high-potency agonists for the human adenosine A2B receptor with an improved selectivity profile compared to the reference agonist N-ethylcarboxamidoadenosine.EBI University of Leiden
15214785 58 1,2,4-triazolo[4,3-a]quinoxalin-1-one moiety as an attractive scaffold to develop new potent and selective human A3 adenosine receptor antagonists: synthesis, pharmacological, and ligand-receptor modeling studies.EBI Universit£ degli Studi di Firenze
15139758 50 Incorporating molecular shape into the alignment-free Grid-Independent Descriptors.EBI Universitat Pompeu Fabra
12672250 10 N6-cyclopentyl-2-(3-phenylaminocarbonyltriazene-1-yl)adenosine (TCPA), a very selective agonist with high affinity for the human adenosine A1 receptor.EBI Leiden University
12646033 124 Design, synthesis, and biological evaluation of C9- and C2-substituted pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as new A2A and A3 adenosine receptors antagonists.EBI Universit£ di Ferrara
11881988 16 Ribose-modified nucleosides as ligands for adenosine receptors: synthesis, conformational analysis, and biological evaluation of 1'-C-methyl adenosine analogues.EBI Universit£ di Camerino
12383013 44 Synthesis, molecular modeling studies, and pharmacological activity of selective A(1) receptor antagonists.EBI Universit£ degli Studi di Genova
11784146 9 2,5'-Disubstituted adenosine derivatives: evaluation of selectivity and efficacy for the adenosine A(1), A(2A), and A(3) receptor.EBI Leiden/Amsterdam Center for Drug Research
12139454 56 Imidazo[2,1-i]purin-5-ones and related tricyclic water-soluble purine derivatives: potent A(2A)- and A(3)-adenosine receptor antagonists.EBI University of Bonn
12109910 8 N(6)-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting point for searching A(2B) ligands.EBI Universit£ di Camerino
11262085 92 Thiazole and thiadiazole analogues as a novel class of adenosine receptor antagonists.EBI Vrije Universiteit
11170643 171 Design, synthesis, and evaluation of novel A2A adenosine receptor agonists.EBI University of Virginia
11462973 47 3-Aryl[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-ones: a new class of selective A1 adenosine receptor antagonists.EBI Universit£ di Pisa
11708915 52 Neoceptor concept based on molecular complementarity in GPCRs: a mutant adenosine A(3) receptor with selectively enhanced affinity for amine-modified nucleosides.EBI National Institute of Diabetes and Digestive and Kidney Diseases
11585444 295 From hit to lead. Analyzing structure-profile relationships.EBI F-59000 Lille
11170630 46 Nucleosides and nucleotides. 200. Reinvestigation of 5'-N-ethylcarboxamidoadenosine derivatives: structure-activity relationships for P(3) purinoceptor-like proteins.EBI Hokkaido University
11520205 4 5'-O-alkyl ethers of N,2-substituted adenosine derivatives: partial agonists for the adenosine A1 and A3 receptors.EBI Leiden/Amsterdam Center for Drug Research
10649980 52 N-cycloalkyl derivatives of adenosine and 1-deazaadenosine as agonists and partial agonists of the A(1) adenosine receptor.EBI Universit£ di Camerino
10956189 98 A novel class of highly potent and selective A1 adenosine antagonists: structure-affinity profile of a series of 1,8-naphthyridine derivatives.EBI Universit£ di Pisa
10841798 64 Methanocarba analogues of purine nucleosides as potent and selective adenosine receptor agonists.EBI National Institute of Diabetes
10212125 14 N6,5'-Disubstituted adenosine derivatives as partial agonists for the human adenosine A3 receptor.EBI Leiden/Amsterdam Center for Drug Research
10212124 26 5'-N-substituted carboxamidoadenosines as agonists for adenosine receptors.EBI Leiden University
9703464 40 Structure-activity relationships and molecular modeling of 3, 5-diacyl-2,4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists.EBI National Institute of Diabetes
9703463 102 Synthesis and biological activity of a new series of N6-arylcarbamoyl, 2-(Ar)alkynyl-N6-arylcarbamoyl, and N6-carboxamido derivatives of adenosine-5'-N-ethyluronamide as A1 and A3 adenosine receptor agonists.EBI Universit£ di Ferrara
9667957 5 Nucleosides and nucleotides. 177. 9-(6,7-dideoxy-beta-D-allo-hept-5- ynofuranosyl)adenine: a selective and potent ligand for P3 purinoceptor-like protein.EBI Hokkaido University
9572897 49 2'-C-Methyl analogues of selective adenosine receptor agonists: synthesis and binding studies.EBI Universit£ di Camerino
9438026 41 5'-substituted adenosine analogs as new high-affinity partial agonists for the adenosine A1 receptor.EBI Leiden/Amsterdam Center for Drug Research
9371242 54 N6-cyclopentyl-3'-substituted-xylofuranosyladenosines: a new class of non-xanthine adenosine A1 receptor antagonists.EBI University of Ghent
9191951 8 9-Benzyladenines: potent and selective cAMP phosphodiesterase inhibitors.EBI UPR 421 du CNRS
8691477 28 N6,C8-distributed adenosine derivatives as partial agonists for adenosine A1 receptors.EBI Leiden/Amsterdam Center for Drug Research
8576924 69 Novel N6-(substituted-phenylcarbamoyl)adenosine-5'-uronamides as potent agonists for A3 adenosine receptors.EBI Universit£ di Ferrara
8917655 72 6-phenyl-1,4-dihydropyridine derivatives as potent and selective A3 adenosine receptor antagonists.EBI National Institute of Diabetes
8863798 52 2-alkenyl and 2-alkyl derivatives of adenosine and adenosine-5'-N-ethyluronamide: different affinity and selectivity of E- and Z-diastereomers at A2A adenosine receptors.EBI Universit£ di Camerino
8709132 92 Interaction of 1,4-dihydropyridine and pyridine derivatives with adenosine receptors: selectivity for A3 receptors.EBI National Institute of Diabetes
7739005 143 2-Aralkynyl and 2-heteroalkynyl derivatives of adenosine-5'-N-ethyluronamide as selective A2a adenosine receptor agonists.EBI Universit£ di Camerino
7707320 99 Search for new purine- and ribose-modified adenosine analogues as selective agonists and antagonists at adenosine receptors.EBI National Institute of Diabetes
7562934 38 Ribose-modified adenosine analogues as potential partial agonists for the adenosine receptor.EBI Leiden University
7658444 56 2-[N'-(3-arylallylidene)hydrazino]adenosines showing A2a adenosine agonist properties and vasodilation activity.EBI Universit£ di Milano
7752196 103 Structure-activity relationships of 9-alkyladenine and ribose-modified adenosine derivatives at rat A3 adenosine receptors.EBI National Institute of Diabetes
8126704 79 Structure-activity relationships of N6-benzyladenosine-5'-uronamides as A3-selective adenosine agonists.EBI National Institute of Diabetes
7996542 32 N6-substituted adenosine receptor agonists. Synthesis and pharmacological activity as potent antinociceptive agents.EBI Carpibem
7966162 39 Selective ligands for rat A3 adenosine receptors: structure-activity relationships of 1,3-dialkylxanthine 7-riboside derivatives.EBI National Institute of Diabetes
7932588 48 2-Substitution of N6-benzyladenosine-5'-uronamides enhances selectivity for A3 adenosine receptors.EBI National Institute of Diabetes
8201607 50 2-Alkynyl derivatives of adenosine-5'-N-ethyluronamide: selective A2 adenosine receptor agonists with potent inhibitory activity on platelet aggregation.EBI Universit£ di Camerino
8246243 5 Photoisomerization of a potent and selective adenosine A2 antagonist, (E)-1,3-Dipropyl-8-(3,4-dimethoxystyryl)-7-methylxanthine.EBI Kyowa Hakko Kogyo Co., Ltd.
8355252 31 Adenosine A1 antagonists. 3. Structure-activity relationships on amelioration against scopolamine- or N6-((R)-phenylisopropyl)adenosine-induced cognitive disturbance.EBI Kyowa Hakko Kogyo Co., Ltd.
1548682 74 8-Polycycloalkyl-1,3-dipropylxanthines as potent and selective antagonists for A1-adenosine receptors.EBI Kyowa Hakko Kogyo Co., Ltd.
1738138 58 Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential.EBI NIDDK
1469688 31 2-(N'-aralkylidenehydrazino)adenosines: potent and selective coronary vasodilators.EBI University of South Florida
1433217 21 Synthesis and biological activity of N6-(p-sulfophenyl)alkyl and N6-sulfoalkyl derivatives of adenosine: water-soluble and peripherally selective adenosine agonists.EBI National Institute of Diabetes
1732541 30 Nucleosides and nucleotides. 103. 2-Alkynyladenosines: a novel class of selective adenosine A2 receptor agonists with potent antihypertensive effects.EBI Hokkaido University
1501234 55 Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure.EBI Kyowa Hakko Kogyo Co., Ltd.
1495019 19 Nucleosides and nucleotides. 112. 2-(1-Hexyn-1-yl)adenosine-5'-uronamides: a new entry of selective A2 adenosine receptor agonists with potent antihypertensive activity.EBI Hokkaido University
1619615 40 2-Alkynyl derivatives of adenosine and adenosine-5'-N-ethyluronamide as selective agonists at A2 adenosine receptors.EBI Universit£ di Camerino
1613750 23 Nucleosides and nucleotides. 107. 2-(cycloalkylalkynyl)adenosines: adenosine A2 receptor agonists with potent antihypertensive effects.EBI Yamasa Shoyu Co., Ltd
1895305 25 N6,9-disubstituted adenines: potent, selective antagonists at the A1 adenosine receptor.EBI University of South Florida
1875349 47 Highly selective adenosine A2 receptor agonists in a series of N-alkylated 2-aminoadenosines.EBI CIBA-GEIGY Corporation
2016707 34 2-Alkoxyadenosines: potent and selective agonists at the coronary artery A2 adenosine receptor.EBI University of South Florida
2002461 26 1H-imidazo[4,5-c]quinolin-4-amines: novel non-xanthine adenosine antagonists.EBI Center for Bio-Pharmaceutical Sciences
2002448 50 N6-substituted adenosine receptor agonists: potential antihypertensive agents.EBI Warner-Lambert Company
1766003 11 Activity of N6-substituted 2-chloroadenosines at A1 and A2 adenosine receptors.EBI University of South Florida
2374150 109 4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants.EBI Pfizer Central Research
2362269 15 2-(Arylalkylamino)adenosin-5'-uronamides: a new class of highly selective adenosine A2 receptor ligands.EBI CIBA-GEIGY Corporation
2258897 12 A novel synthesis of xanthines: support for a new binding mode for xanthines with respect to adenosine at adenosine receptors.EBI Merrell Dow Research Institute
2754711 52 Sulfur-containing 1,3-dialkylxanthine derivatives as selective antagonists at A1-adenosine receptors.EBI NIDDK
2754691 43 C2,N6-disubstituted adenosines: synthesis and structure-activity relationships.EBI Warner-Lambert Company
2709373 51 Electrophilic derivatives of purines as irreversible inhibitors of A1 adenosine receptors.EBI NIDDK
2909748 9 N6-bicycloalkyladenosines with unusually high potency and selectivity for the adenosine A1 receptor.EBI Warner-Lambert Company
3385722 19 N6-[2-(3,5-dimethoxyphenyl)-2-(2-methylphenyl)ethyl]adenosine and its uronamide derivatives. Novel adenosine agonists with both high affinity and high selectivity for the adenosine A2 receptor.EBI Warner-Lambert Company
3373486 22 Adenosine receptor agonists: synthesis and biological evaluation of 1-deaza analogues of adenosine derivatives.EBI Universit£ di Camerino
3351851 9 Photoaffinity labeling adenosine A1 receptors with an antagonist 125I-labeled aryl azide derivative of 8-phenylxanthine.EBI University of Virginia School of Medicine
3351850 32 125I-labeled 8-phenylxanthine derivatives: antagonist radioligands for adenosine A1 receptors.EBI University of Virginia School of Medicine
3336027 16 N6-(arylalkyl)adenosines. Identification of N6-(9-fluorenylmethyl)adenosine as a highly potent agonist for the adenosine A2 receptor.EBI Warner-Lambert Company
3572985 14 N6-phenyladenosines: pronounced effect of phenyl substituents on affinity for A2 adenosine receptors.EBI TBA
2888894 16 N6-(2,2-diphenylethyl)adenosine, a novel adenosine receptor agonist with antipsychotic-like activity.EBI Parke-Davis Pharmaceutical Research Division
3018244 33 N6-substituted N-alkyladenosine-5'-uronamides: bifunctional ligands having recognition groups for A1 and A2 adenosine receptors.EBI TBA
3005574 18 Ribose-modified adenosine analogues as adenosine receptor agonists.EBI TBA
2993623 19 Functionalized congeners of adenosine: preparation of analogues with high affinity for A1-adenosine receptors.EBI TBA
2991519 98 Synthesis of xanthines as adenosine antagonists, a practical quantitative structure-activity relationship application.EBI TBA
2984420 49 1,3-Dialkyl-8-(p-sulfophenyl)xanthines: potent water-soluble antagonists for A1- and A2-adenosine receptors.EBI TBA
2995663 13 N6-cycloalkyladenosines. Potent, A1-selective adenosine agonists.EBI TBA
6279840 17 Adenosine receptors: targets for future drugs.EBI TBA
15203164 38 Structure-affinity relationships of 5'-aromatic ethers and 5'-aromatic sulfides as partial A1 adenosine agonists, potential supraventricular anti-arrhythmic agents.EBI CV Therapeutics, Inc.
15203136 37 (+/-)8-Amino-5,6,7,8-tetrahydroisoquinolines as novel antinociceptive agents.EBI Virginia Commonwealth University
12617898 13 Design, synthesis and binding affinity of 3'-fluoro analogues of Cl-IB-MECA as adenosine A3 receptor ligands.EBI Seoul National University
11277527 2 Synthesis and use of FSCPX, an irreversible adenosine A1 antagonist, as a 'receptor knock-down' tool.EBI Vrije Universiteit
11714602 18 7-Nitrobenzofurazan (NBD) derivatives of 5'-N-ethylcarboxamidoadenosine (NECA) as new fluorescent probes for human A(3) adenosine receptors.EBI Universit£ di Pisa
11459663 19 Introduction of alkynyl chains on C-8 of adenosine led to very selective antagonists of the A(3) adenosine receptor.EBI Universit£ di Camerino
11392549 45 Ring-Constrained (N)-methanocarba nucleosides as adenosine receptor agonists: independent 5'-uronamide and 2'-deoxy modifications.EBI NIDDK
10714510 36 The discovery and synthesis of highly potent, A2a receptor agonists.EBI Glaxo Wellcome Medicines Research Centre
10999489 29 2-Nitro analogues of adenosine and 1-deazaadenosine: synthesis and binding studies at the adenosine A1, A2A and A3 receptor subtypes.EBI University of Amsterdam
10230614 7 Adenosine receptor ligands with oxygenated N6-substituents.EBI Deakin University
9871585 23 Diimidazo[1,2-c:4',5'-e]pyrimidines: N6-N1 conformationally restricted adenosines.EBI Griffith University
9871584 15 Diimidazo[1,2-c:4',5'-e]pyrimidines: adenosine agonist activity demonstrated by microphysiometry.EBI Griffith University
9873707 12 Fluorescent probes for adenosine receptors: synthesis and biology of N6-dansylaminoalkyl-substituted NECA derivatives.EBI GlaxoWellcome Medicines Research Center
22148859 190 Novel 1,3-dipropyl-8-(3-benzimidazol-2-yl-methoxy-1-methylpyrazol-5-yl)xanthines as potent and selective A2B adenosine receptor antagonists.EBI University of Ferrara
22104008 64 Evaluation of molecular modeling of agonist binding in light of the crystallographic structure of an agonist-bound A2A adenosine receptor.EBI National Institute of Diabetes and Digestive and Kidney Diseases
22142423 27 Structure-activity relationships of truncated C2- or C8-substituted adenosine derivatives as dual acting A2A and A3 adenosine receptor ligands.EBI Ewha Womans University
22204739 136 Pyrrolo- and pyrazolo-[3,4-e][1,2,4]triazolo[1,5-c]pyrimidines as adenosine receptor antagonists.EBI Universit£ di Ferrara
22182575 1 Structure-activity relationships of 2-amino-3-aroyl-4-[(4-arylpiperazin-1-yl)methyl]thiophenes. Part 2: Probing the influence of diverse substituents at the phenyl of the arylpiperazine moiety on allosteric enhancer activity at the A¿? adenosine receptor.EBI Universit£ di Ferrara
21214204 100 Synthesis and Biological Evaluation of a New Series of 1,2,4-Triazolo[1,5-a]-1,3,5-triazines as Human A(2A) Adenosine Receptor Antagonists with Improved Water Solubility.EBI Universita di Trieste
21988093 316 Highly potent, selective, and orally active phosphodiesterase 10A inhibitors.EBI Pfizer Inc.
21955943 47 Investigation of the pyrazinones as PDE5 inhibitors: evaluation of regioisomeric projections into the solvent region.EBI Pfizer Inc.
21908194 88 Does the combination of optimal substitutions at the C²-, N¿?¿- and N¿?¿-positions of the pyrazolo-triazolo-pyrimidine scaffold guarantee selective modulation of the human A3 adenosine receptors?EBI National University of Singapore
21675777 139 New 2-heterocyclyl-imidazo[2,1-i]purin-5-one derivatives as potent and selective human A3 adenosine receptor antagonists.EBI Universit£ di Ferrara
21616671 13 Synthesis, structure-affinity relationships, and molecular modeling studies of novel pyrazolo[3,4-c]quinoline derivatives as adenosine receptor antagonists.EBI Universita' di Firenze
21185184 27 Molecular probes for the A2A adenosine receptor based on a pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine scaffold.EBI National Institute of Diabetes and Digestive and Kidney Diseases
21401121 16 The identification of the 2-phenylphthalazin-1(2H)-one scaffold as a new decorable core skeleton for the design of potent and selective human A3 adenosine receptor antagonists.EBI Universita` degli Studi di Firenze
21388809 76 Discovery of benzothiazole-based adenosine A2B receptor antagonists with improved A2A selectivity.EBI Roche Research Center
21419626 24 Design and optimisation of orally active TLR7 agonists for the treatment of hepatitis C virus infection.EBI Pfizer Inc.
21186795 142 Pyrimidine derivatives as potent and selective A3 adenosine receptor antagonists.EBI University of Santiago de Compostela
21055932 137 Discovery of novel quinolinone adenosine A2B antagonists.EBI Ligand Pharmaceuticals
20973483 2 In vivo characterization of a dual adenosine A2A/A1 receptor antagonist in animal models of Parkinson's disease.EBI Johnson& Johnson Pharmaceutical Research and Development
20943397 18 Molecular modeling study on potent and selective adenosine A(3) receptor agonists.EBI University of Camerino
20937560 54 Pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as selective human A(1) adenosine receptor ligands.EBI Dipartimento di Scienze Farmaceutiche
20728355 47 Identification and optimization of substituted 5-aminopyrazoles as potent and selective adenosine A1 receptor antagonists.EBI Bayer Schering Pharma AG
20826090 4 Design, synthesis, and binding of homologated truncated 4'-thioadenosine derivatives at the human A3 adenosine receptors.EBI Ewha Womans University
20659802 52 Hit-to-lead optimization of a series of carboxamides of ethyl 2-amino-4-phenylthiazole-5-carboxylates as novel adenosine A2A receptor antagonists.EBI H. Lundbeck A/S
20591666 66 A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase.EBI Università degli Studi di Milano
20537438 101 Insights into binding modes of adenosine A(2B) antagonists with ligand-based and receptor-based methods.EBI East China University of Science and Technology
20385496 66 Synthesis and evaluation of new N6-substituted adenosine-5'-N-methylcarboxamides as A3 adenosine receptor agonists.EBI Monash University
20347304 68 Methylene amine substituted arylindenopyrimidines as potent adenosine A(2A)/A(1) antagonists.EBI Johnson& Johnson Pharmaceutical Research and Development
20338760 72 Optimization of arylindenopyrimidines as potent adenosine A(2A)/A(1) antagonists.EBI Johnson& Johnson Pharmaceutical Research and Development
20116907 15 Synthesis and theoretical studies on energetics of novel N- and O- perfluoroalkyl triazole tagged thienopyrimidines--their potential as adenosine receptor ligands.EBI Institute of Chemical Technology
20345101 38 Hybrid ortho/allosteric ligands for the adenosine A(1) receptor.EBI Leiden University
20307065 122 The significance of 2-furyl ring substitution with a 2-(para-substituted) aryl group in a new series of pyrazolo-triazolo-pyrimidines as potent and highly selective hA(3) adenosine receptors antagonists: new insights into structure-affinity relationship and receptor-antagonist recognition.EBI National University of Singapore
20304654 79 Synthesis and pharmacological characterization of a new series of 5,7-disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazine derivatives as adenosine receptor antagonists: A preliminary inspection of ligand-receptor recognition process.EBI National University of Singapore
20138516 29 Discovery of potent and selective bicyclic A(2B) adenosine receptor antagonists via bioisosteric amide replacement.EBI Rhône-Poulenc Rorer
20137946 81 Discovery of N-(5,6-diarylpyridin-2-yl)amide derivatives as potent and selective A(2B) adenosine receptor antagonists.EBI Rhône-Poulenc Rorer
20031406 85 Synthesis and evaluation of two series of 4'-aza-carbocyclic nucleosides as adenosine A2A receptor agonists.EBI Novartis Institutes for BioMedical Research
20202853 12 Synthesis of theophylline derivatives and study of their activity as antagonists at adenosine receptors.EBI Universidad de M£laga
19879151 58 Design and synthesis of N(6)-substituted-4'-thioadenosine-5'-uronamides as potent and selective human A(3) adenosine receptor agonists.EBI Ewha Womans University
19751980 26 3- and 6-Substituted 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridines as A1 adenosine receptor allosteric modulators and antagonists.EBI Monash University (Parkville Campus)
19580286 44 Nucleoside-5'-monophosphates as prodrugs of adenosine A2A receptor agonists activated by ecto-5'-nucleotidase.EBI University of Bonn
19743865 22 2-Phenylpyrazolo[4,3-d]pyrimidin-7-one as a new scaffold to obtain potent and selective human A3 adenosine receptor antagonists: new insights into the receptor-antagonist recognition.EBI Universit£ di Firenze
19499950 64 Functionalized congeners of A3 adenosine receptor-selective nucleosides containing a bicyclo[3.1.0]hexane ring system.EBI National Institute of Diabetes and Digestive and Kidney Diseases
19839592 37 Synthesis and biological evaluation of 2-alkynyl-N6-methyl-5'-N-methylcarboxamidoadenosine derivatives as potent and highly selective agonists for the human adenosine A3 receptor.EBI University of Camerino
19836950 9 Design, synthesis and biological evaluation of a bivalent micro opiate and adenosine A1 receptor antagonist.EBI Aix-Marseille Universit£
19501513 474 Combining selectivity and affinity predictions using an integrated Support Vector Machine (SVM) approach: An alternative tool to discriminate between the human adenosine A(2A) and A(3) receptor pyrazolo-triazolo-pyrimidine antagonists binding sites.EBI Universit£ di Padova
19481943 23 Synthesis of hybrid analogues of caffeine and eudistomin D and its affinity for adenosine receptors.EBI Hokkaido University
19375920 30 Structure-activity relationships of truncated adenosine derivatives as highly potent and selective human A3 adenosine receptor antagonists.EBI Ewha Womans University
19362836 83 Antagonists of the human A(2A) receptor. Part 5: Highly bio-available pyrimidine-4-carboxamides.EBI Vernalis (R+D) Ltd.
9214739 1 Adenosine-1 active ligands: cirsimarin, a flavone glycoside from Microtea debilis.EBI University of Antwerp
19398343 48 1,3-dialkyl-8-N-substituted benzyloxycarbonylamino-9-deazaxanthines as potent adenosine receptor ligands: Design, synthesis, structure-affinity and structure-selectivity relationships.EBI Universidade de Santiago de Compostela
19317449 76 N6-Cycloalkyl- and N6-bicycloalkyl-C5'(C2')-modified adenosine derivatives as high-affinity and selective agonists at the human A1 adenosine receptor with antinociceptive effects in mice.EBI University of Camerino
19301821 55 Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a new scaffold to develop potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies.EBI Universita di Firenze
19230680 58 Synthesis, biological assays and QSAR studies of N-(9-benzyl-2-phenyl-8-azapurin-6-yl)-amides as ligands for A1 adenosine receptors.EBI Università di Pisa
19181527 61 Synthesis and SAR studies of trisubstituted purinones as potent and selective adenosine A2A receptor antagonists.EBI Pharmacopeia, Inc.
19140664 82 N-[6-amino-2-(heteroaryl)pyrimidin-4-yl]acetamides as A2A receptor antagonists with improved drug like properties and in vivo efficacy.EBI Neurocrine Biosciences
19072055 224 Antagonists of the human A(2A) adenosine receptor. 4. Design, synthesis, and preclinical evaluation of 7-aryltriazolo[4,5-d]pyrimidines.EBI Vernalis R&D Ltd
19059776 38 Synthesis of 2-amino-5-benzoyl-4-(2-furyl)thiazoles as adenosine A(2A) receptor antagonists.EBI Pharmacopeia, Inc.
19036477 32 Synthesis of a series of 8-(substituted-phenyl)xanthines and a study on the effects of substitution pattern of phenyl substituents on affinity for adenosine A(1) and A(2A) receptors.EBI University Institute of Pharmaceutical Sciences
19006671 136 Structure-activity relationship studies of a new series of imidazo[2,1-f]purinones as potent and selective A(3) adenosine receptor antagonists.EBI Università di Ferrara
18996701 38 Novel potent and highly selective human A(3) adenosine receptor antagonists belonging to the 4-amido-2-arylpyrazolo[3,4-c]quinoline series: molecular docking analysis and pharmacological studies.EBI Università di Firenze
18938084 78 1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A2B adenosine receptor antagonists: design, synthesis, structure-affinity and structure-selectivity relationships.EBI Università degli Studi di Bari
18835161 37 2,6-Diaryl-4-acylaminopyrimidines as potent and selective adenosine A(2A) antagonists with improved solubility and metabolic stability.EBI Neurocrine Biosciences
18811138 41 Structure-activity relationships of truncated D- and l-4'-thioadenosine derivatives as species-independent A3 adenosine receptor antagonists.EBI Ewha Womans University
18771255 16 2-aminothienopyridazines as novel adenosine A1 receptor allosteric modulators and antagonists.EBI Monash University
18752961 51 Selective A(3) adenosine receptor antagonists derived from nucleosides containing a bicyclo[3.1.0]hexane ring system.EBI National Institute of Diabetes and Digestive and Kidney Diseases
18729349 28 Synthesis and biological evaluation of 2-amino-3-(4-chlorobenzoyl)-4-[N-(substituted) piperazin-1-yl]thiophenes as potent allosteric enhancers of the A1 adenosine receptor.EBI Dipartimento di Scienze Farmaceutiche
18468446 55 Synthesis, ligand-receptor modeling studies and pharmacological evaluation of novel 4-modified-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as potent and selective human A3 adenosine receptor antagonists.EBI Universita' di Firenze
18045744 16 N6-1,3-diphenylurea derivatives of 2-phenyl-9-benzyladenines and 8-azaadenines: synthesis and biological evaluation as allosteric modulators of A2A adenosine receptors.EBI Università di Pisa
17602796 5 Synthesis and adenosine receptor binding studies of some novel triazolothienopyrimidines.EBI University College of Pharmaceutical Sciences
12398547 9 Lignans isolated from valerian: identification and characterization of a new olivil derivative with partial agonistic activity at A(1) adenosine receptors.EBI University of Bonn
12193019 2 Naturally occurring cembranes from an Australian sarcophyton species.EBI AstraZeneca R&D Griffith University
10757728 2 Isolation of psammaplin A 11'-sulfate and bisaprasin 11'-sulfate from the marine sponge Aplysinella rhax.EBI Griffith University
10757710 5 Anthoptilides A-E, new Briarane diterpenes from the Australian sea pen Anthoptilum cf. kukenthali.EBI Griffith University
10543913 1 Isolation of xestosterol esters of brominated acetylenic fatty acids from the marine sponge xestospongia testudinariaEBI Griffith University
10395519 1 Interference of linoleic acid fraction in some receptor binding assays.EBI Leiden University
9514015 6 Bioactive pyridoacridine alkaloids from the micronesian sponge Oceanapia sp.EBI Institut für Biowissenschaften
18329269 77 Synthesis of N-pyrimidinyl-2-phenoxyacetamides as adenosine A2A receptor antagonists.EBI Neurocrine Biosciences
18226896 129 Selective, high affinity A(2B) adenosine receptor antagonists: N-1 monosubstituted 8-(pyrazol-4-yl)xanthines.EBI CV Therapeutics Inc.
18189346 21 Identification of novel, water-soluble, 2-amino-N-pyrimidin-4-yl acetamides as A2A receptor antagonists with in vivo efficacy.EBI Neurocrine Biosciences
17827019 86 Phenylethyl-substituted pyrimido[2,1-f]purinediones and related compounds: structure-activity relationships as adenosine A(1) and A(2A) receptor ligands.EBI Jagiellonian University Medical College
17689079 36 Dual acting antioxidant A1 adenosine receptor agonists.EBI Monash University (Parkville Campus)
17665891 60 New 2-arylpyrazolo[3,4-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies.EBI Università di Firenze
17560111 32 Design, synthesis, and biological evaluation of LNA nucleosides as adenosine A3 receptor ligands.EBI Santaris Pharma A/S
17555308 30 Discovery of a new nucleoside template for human A3 adenosine receptor ligands: D-4'-thioadenosine derivatives without 4'-hydroxymethyl group as highly potent and selective antagonists.EBI Ewha Womans University
17539620 13 Novel ergopeptides as dual ligands for adenosine and dopamine receptors.EBI Institut d'Investigacions Biomèdiques August Pi i
17499511 46 N9-benzyl-substituted 1,3-dimethyl- and 1,3-dipropyl-pyrimido[2,1-f]purinediones: synthesis and structure-activity relationships at adenosine A1 and A2A receptors.EBI Jagiellonian University
17469811 45 Discovery and characterization of 4'-(2-furyl)-N-pyridin-3-yl-4,5'-bipyrimidin-2'-amine (LAS38096), a potent, selective, and efficacious A2B adenosine receptor antagonist.EBI Almirall
17300165 39 2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists.EBI Leiden/Amsterdam Center for Drug Research
17236762 23 Potent, selective, and orally active adenosine A2A receptor antagonists: arylpiperazine derivatives of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines.EBI Schering-Plough Research Institute
17149867 51 2-triazole-substituted adenosines: a new class of selective A3 adenosine receptor agonists, partial agonists, and antagonists.EBI Ghent University
17125265 49 Tricyclic imidazoline derivatives as potent and selective adenosine A1 receptor antagonists.EBI Biogen Idec, Inc.
17125264 60 Potent and orally bioavailable 8-bicyclo[2.2.2]octylxanthines as adenosine A1 receptor antagonists.EBI Biogen Idec, Inc.
17045477 136 N6-Cycloalkyl-2-substituted adenosine derivatives as selective, high affinity adenosine A1 receptor agonists.EBI CV Therapeutics Inc.
17028066 41 Synthesis, biological activity and molecular modelling of new trisubstituted 8-azaadenines with high affinity for A1 adenosine receptors.EBI Università di Pisa
16971117 33 Identification of non-furan containing A2A antagonists using database mining and molecular similarity approaches.EBI Vernalis (R&D) Ltd
16821798 62 A new synthesis of sulfonamides by aminolysis of p-nitrophenylsulfonates yielding potent and selective adenosine A2B receptor antagonists.EBI University of Bonn
16821770 78 Pharmacophore based receptor modeling: the case of adenosine A3 receptor antagonists. An approach to the optimization of protein models.EBI Università degli Studi di Siena
16789747 71 4-amido-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-ones as new potent and selective human A3 adenosine receptor antagonists. synthesis, pharmacological evaluation, and ligand-receptor modeling studies.EBI Università di Firenze
16759111 149 Novel 1,3-disubstituted 8-(1-benzyl-1H-pyrazol-4-yl) xanthines: high affinity and selective A2B adenosine receptor antagonists.EBI CV Therapeutics Inc.
16722654 15 Structure-activity relationships of new 1H-imidazo[4,5-c]quinolin-4-amine derivatives as allosteric enhancers of the A3 adenosine receptor.EBI Leiden University
16697192 59 New pyrrolopyrimidin-6-yl benzenesulfonamides: potent A2B adenosine receptor antagonists.EBI Rhône-Poulenc Rorer
16686529 37 2,6-disubstituted and 2,6,8-trisubstituted purines as adenosine receptor antagonists.EBI Leiden/Amsterdam Center for Drug Research
16458504 37 Synthesis, in vitro and in vivo evaluation of [O-methyl-11C] 2-{4-[4-(3-methoxyphenyl)piperazin-1-yl]-butyl}-4-methyl-2H-[1,2,4]-triazine-3,5-dione: a novel agonist 5-HT1A receptor PET ligand.EBI Columbia University College of Physicians and Surgeons
16392812 75 Structure-activity relationships of 2-chloro-N6-substituted-4'-thioadenosine-5'-uronamides as highly potent and selective agonists at the human A3 adenosine receptor.EBI Ewha Womans University
16366590 12 Semi-rational design of (north)-methanocarba nucleosides as dual acting A(1) and A(3) adenosine receptor agonists: novel prototypes for cardioprotection.EBI National Institute of Diabetes and Digestive and Kidney Diseases
16335918 68 1,2,4-Triazolo[1,5-a]quinoxaline as a versatile tool for the design of selective human A3 adenosine receptor antagonists: synthesis, biological evaluation, and molecular modeling studies of 2-(hetero)aryl- and 2-carboxy-substituted derivatives.EBI Università degli Studi di Firenze
16321527 1 Synthesis and biological characterization of [3H] (2-amino-4,5,6,7-tetrahydrobenzo[b]thiophen-3-yl)-(4-chlorophenyl)-methanone, the first radiolabelled adenosine A1 allosteric enhancer.EBI Università di Ferrara
16289820 14 Conversion of A3 adenosine receptor agonists into selective antagonists by modification of the 5'-ribofuran-uronamide moiety.EBI National Institute of Diabetes and Digestive and Kidney Diseases
16279775 61 Synthesis and 3D QSAR of new pyrazolo[3,4-b]pyridines: potent and selective inhibitors of A1 adenosine receptors.EBI Università degli Studi di Siena
16275090 136 Novel 1,3-dipropyl-8-(1-heteroarylmethyl-1H-pyrazol-4-yl)-xanthine derivatives as high affinity and selective A2B adenosine receptor antagonists.EBI CV Therapeutics Inc.
16153830 64 Synthesis of [1,2,4]triazolo[1,5-a]pyrazines as adenosine A2A receptor antagonists.EBI Biogen Idec, Inc.
16099648 128 1,8-Naphthyridin-4-one derivatives as new ligands of A2A adenosine receptors.EBI Dipartimento di Scienze Farmaceutiche
16033279 47 New 2-arylpyrazolo[4,3-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists.EBI Università di Ferrara
16033270 44 "Reversine" and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists.EBI National Institute of Diabetes and Digestive and Kidney Diseases
16000006 59 New pyrrolo[2,1-f]purine-2,4-dione and imidazo[2,1-f]purine-2,4-dione derivatives as potent and selective human A3 adenosine receptor antagonists.EBI Università di Ferrara
15771421 96 (N)-methanocarba 2,N6-disubstituted adenine nucleosides as highly potent and selective A3 adenosine receptor agonists.EBI National Institute of Diabetes and Digestive and Kidney Diseases
15664822 101 The discovery of a selective, high affinity A(2B) adenosine receptor antagonist for the potential treatment of asthma.EBI CV Therapeutics, Inc.
15664803 46 Synthesis of alkyne derivatives of a novel triazolopyrazine as A(2A) adenosine receptor antagonists.EBI Biogen Idec Inc.
15588088 58 2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists.EBI Leiden/Amsterdam Center for Drug Research
15341934 28 Triamino derivatives of triazolotriazine and triazolopyrimidine as adenosine A2a receptor antagonists.EBI Biogen Idec, Inc.
15341933 40 Studies on adenosine A2a receptor antagonists: comparison of three core heterocycles.EBI Biogen Idec, Inc.
15294001 88 Piperazine derivatives of [1,2,4]triazolo[1,5-a][1,3,5]triazine as potent and selective adenosine A2a receptor antagonists.EBI Biogen Idec, Inc.
15203160 119 Structure-activity relationships of adenosine A3 receptor ligands: new potential therapy for the treatment of glaucoma.EBI Otsuka Pharmaceutical Factory, Inc.
15177485 2 A mild, efficient and alpha-selective glycosidation by using potassium dodecatungstocobaltate trihydrate as catalyst.EBI University of Isfahan
15163184 227 Study on affinity profile toward native human and bovine adenosine receptors of a series of 1,8-naphthyridine derivatives.EBI Università di Pisa
15149696 44 Comparison of inhibitory activity of isomeric triazolopyridine derivatives towards adenosine receptor subtypes or do similar structures reveal similar bioactivities?EBI F. Hoffmann-LaRoche Ltd
15006389 33 2-(N-acyl) and 2-N-acyl-N(6)-substituted analogues of adenosine and their affinity at the human adenosine receptors.EBI Inotek Pharmaceuticals Corporation
14761205 56 Preparation, properties, reactions, and adenosine receptor affinities of sulfophenylxanthine nitrophenyl esters: toward the development of sulfonic acid prodrugs with peroral bioavailability.EBI University of Bonn
14741297 46 Synthesis and SAR evaluation of 1,2,4-triazoles as A(2A) receptor antagonists.EBI F Hoffmann-La Roche AG
14736246 5 Synthesis and biological evaluation of 2,3,5-substituted [1,2,4]thiadiazoles as allosteric modulators of adenosine receptors.EBI Leiden University
14698198 31 Affinity and intrinsic efficacy (IE) of 5'-carbamoyl adenosine analogues for the A1 adenosine receptor--efforts towards the discovery of a chronic ventricular rate control agent for the treatment of atrial fibrillation (AF).EBI CV Therapeutics
13678407 57 Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as adenosine receptor antagonists. Influence of the N5 substituent on the affinity at the human A 3 and A 2B adenosine receptor subtypes: a molecular modeling investigation.EBI Università degli Studi di Trieste
12723950 2 2-Amino-3-benzoylthiophene allosteric enhancers of A1 adenosine agonist binding: new 3, 4-, and 5-modifications.EBI Deakin University
12540233 16 3'-Aminoadenosine-5'-uronamides: discovery of the first highly selective agonist at the human adenosine A3 receptor.EBI Pfizer Inc.
12408725 1 Synthesis and evaluation of no-carrier-added 8-cyclopentyl-3-(3-[(18)F]fluoropropyl)-1-propylxanthine ([(18)F]CPFPX): a potent and selective A(1)-adenosine receptor antagonist for in vivo imaging.EBI Forschungszentrum Jülich GmbH
12408713 54 Design, synthesis and biological evaluation of novel N-alkyl- and N-acyl-(7-substituted-2-phenylimidazo[1,2-a][1,3,5]triazin-4-yl)amines (ITAs) as novel A(1) adenosine receptor antagonists.EBI Università di Pisa
12372528 12 New irreversible adenosine A(1) antagonists based on FSCPX.EBI Monash University (Parkville Campus)
12270178 74 Structure-affinity relationships of the affinity of 2-pyrazolyl adenosine analogues for the adenosine A2A receptor.EBI CV Therapeutics
12166943 81 1,2,4-Triazolo[5,1-i]purine derivatives as highly potent and selective human adenosine A(3) receptor ligands.EBI Nutrition Research Institute
12166930 21 Synthesis, biological properties, and molecular modeling investigation of the first potent, selective, and water-soluble human A(3) adenosine receptor antagonist.EBI TBA
12139445 36 Pyrido[2,1-f]purine-2,4-dione derivatives as a novel class of highly potent human A(3) adenosine receptor antagonists.EBI Instituto de Química Médica (CSIC)
12039562 15 2-Aminothiazoles: a new class of agonist allosteric enhancers of A(1) adenosine receptors.EBI University of Virginia
12014951 139 Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions.EBI National Institute of Diabetes & Digestive & Kidney Diseases
11960496 50 5'-Deoxy congeners of 9-(3-amido-3-deoxy-beta-D-xylofuranosyl)-N(6)-cyclopentyladenine: new adenosine A(1) receptor antagonists and inverse agonists.EBI Ghent University
11906291 129 1,8-disubstituted xanthine derivatives: synthesis of potent A2B-selective adenosine receptor antagonists.EBI University of Bonn
11831890 278 Synthesis, biological activity, and molecular modeling investigation of new pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as human A(3) adenosine receptor antagonists.EBI Università degli Studi di Ferrara
11754583 112 7-Substituted 5-amino-2-(2-furyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as A2A adenosine receptor antagonists: a study on the importance of modifications at the side chain on the activity and solubility.EBI Università degli Studi di Ferrara
11549462 11 Synthesis and biological data of 4-amino-1-(2-chloro-2-phenylethyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl esters, a new series of A1-adenosine receptor (A1AR) ligands.EBI Facoltà di Farmacia dell'Università degli Studi di Genova
11495585 16 Fluorosulfonyl- and bis-(beta-chloroethyl)amino-phenylamino functionalized pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives: irreversible antagonists at the human A3 adenosine receptor and molecular modeling studies.EBI Università degli Studi di Ferrara
11454470 17 Substituted 4-phenyl-2-(phenylcarboxamido)-1,3-thiazole derivatives as antagonists for the adenosine A(1) receptor.EBI Leiden/Amsterdam Center for Drug Research
11206456 7 High-pressure synthesis of enantiomerically pure C-6 substituted pyrazol.EBI AstraZeneca R&D Griffith University
11170626 55 2-Alkynyl-8-aryl-9-methyladenines as novel adenosine receptor antagonists: their synthesis and structure-activity relationships toward hepatic glucose production induced via agonism of the A(2B) receptor.EBI Eisai Company, Ltd.
11150167 28 Fluorosulfonyl-substituted xanthines as selective irreversible antagonists for the A(1)-adenosine receptor.EBI Deakin University
11123985 176 Pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists: influence of the chain at the N(8) pyrazole nitrogen.EBI Università degli Studi di Ferrara
11101355 26 7-Deazaadenines bearing polar substituents: structure-activity relationships of new A(1) and A(3) adenosine receptor antagonists.EBI University of Leipzig
11087559 7 Design, radiosynthesis, and biodistribution of a new potent and selective ligand for in vivo imaging of the adenosine A(2A) receptor system using positron emission tomography.EBI University of Milano-Bicocca
10956220 93 Synthesis and structure-activity relationships of a new set of 2-arylpyrazolo[3,4-c]quinoline derivatives as adenosine receptor antagonists.EBI Universita' di Firenze
10841801 33 Isoquinoline and quinazoline urea analogues as antagonists for the human adenosine A(3) receptor.EBI Vrije Universiteit
10737749 182 Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A(2B) adenosine receptors.EBI National Institute of Diabetes
10737748 81 1,2,4-Triazolo[4,3-a]quinoxalin-1-one: a versatile tool for the synthesis of potent and selective adenosine receptor antagonists.EBI Universita' di Firenze
10698437 7 Synthesis and preliminary biological evaluation of [3H]-MRE 3008-F20: the first high affinity radioligand antagonist for the human A3 adenosine receptors.EBI Università di Ferrara
10669571 24 Water-soluble phosphate prodrugs of 1-propargyl-8-styrylxanthine derivatives, A(2A)-selective adenosine receptor antagonists.EBI University of Würzburg
10579811 70 Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists.EBI Università degli Studi di Ferrara
10514293 31 Selective A(3) adenosine receptor antagonists: water-soluble 3, 5-diacyl-1,2,4-trialkylpyridinium salts and their oxidative generation from dihydropyridine precursors.EBI National Institute of Diabetes
10479294 13 Allosteric modulation of the adenosine A(1) receptor. Synthesis and biological evaluation of novel 2-amino-3-benzoylthiophenes as allosteric enhancers of agonist binding.EBI Leiden/Amsterdam Center for Drug Research
10479279 20 N-substituted adenosines as novel neuroprotective A(1) agonists with diminished hypotensive effects.EBI Novo Nordisk A/S
10476879 52 Selective A1-adenosine receptor antagonists identified using yeast Saccharomyces cerevisiae functional assays.EBI Cadus Pharmaceutical Corporation
10450966 16 Discovery of FR166124, a novel water-soluble pyrazolo-[1,5-a]pyridine adenosine A1 receptor antagonist.EBI Fujisawa Pharmaceutical Co., Ltd.
10447949 27 Chiral resolution and stereospecificity of 6-phenyl-4-phenylethynyl- 1,4-dihydropyridines as selective A(3) adenosine receptor antagonists.EBI National Institute of Diabetes
10052977 82 Synthesis, CoMFA analysis, and receptor docking of 3,5-diacyl-2, 4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists.EBI National Institute of Diabetes
9873431 18 The synthesis of new adenosine A3 selective ligands containing bioisosteric isoxazoles.EBI Novo Nordisk A/S
9767637 31 A novel class of adenosine A3 receptor ligands. 2. Structure affinity profile of a series of isoquinoline and quinazoline compounds.EBI Vrije Universiteit
9767636 38 A novel class of adenosine A3 receptor ligands. 1. 3-(2-Pyridinyl)isoquinoline derivatives.EBI Vrije Universiteit
9667972 119 Derivatives of the triazoloquinazoline adenosine antagonist (CGS 15943) having high potency at the human A2B and A3 receptor subtypes.EBI National Institute of Diabetes
9622554 59 Design, synthesis, and biological evaluation of a second generation of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as potent and selective A2A adenosine receptor antagonists.EBI Università di Ferrara
9513594 41 Novel 3-aralkyl-7-(amino-substituted)-1,2,3-triazolo[4,5-d]pyrimidines with high affinity toward A1 adenosine receptors.EBI Università di Pisa
9484505 12 A1 adenosine receptor antagonists as ligands for positron emission tomography (PET) and single-photon emission tomography (SPET).EBI Forschungszentrum Jülich GmbH
9435909 90 Synthesis and structure-activity relationships of 3,7-dimethyl-1-propargylxanthine derivatives, A2A-selective adenosine receptor antagonists.EBI Julius-Maximilians-Universität Würzburg
9258367 99 Structure-activity relationships of 4-(phenylethynyl)-6-phenyl-1,4-dihydropyridines as highly selective A3 adenosine receptor antagonists.EBI National Institute of Diabetes
9191953 11 Synthesis and biological evaluation of the enantiomers of the potent and selective A1-adenosine antagonist 1,3-dipropyl-8-[2-(5,6-epoxynorbonyl)]-xanthine.EBI CV Therapeutics
8863792 22 Synthesis and structure-activity relationship of pyrazolo[3,4-d]pyrimidines: potent and selective adenosine A1 receptor antagonists.EBI Griffith University
8863790 55 Derivatives of the triazoloquinazoline adenosine antagonist (CGS15943) are selective for the human A3 receptor subtype.EBI National Institute of Diabetes
8809156 2 Synthesis and cardiotonic activity of novel pyrimidine derivatives: crystallographic and quantum chemical studies.EBI Università di Padova
8691445 70 Chiral pyrrolo[2,3-d]pyrimidine and pyrimido[4,5-b]indole derivatives: structure-activity relationships of potent, highly stereoselective A1-adenosine receptor antagonists.EBI Julius-Maximilians-Universität Würzburg
8691424 61 Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists.EBI National Institute of Diabetes
8676354 42 Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives: potent and selective A(2A) adenosine antagonists.EBI Università degli Studi di Ferrara
8576921 63 Interactions of flavonoids and other phytochemicals with adenosine receptors.EBI National Institute of Diabetes
8558508 55 Tetrahydrobenzothiophenone derivatives as a novel class of adenosine receptor antagonists.EBI National Institute of Diabetes
8496906 43 Bronchodilator activity of xanthine derivatives substituted with functional groups at the 1- or 7-position.EBI Hokuriku University
8496902 66 Structure-activity relationships of 8-styrylxanthines as A2-selective adenosine antagonists.EBI National Institute of Diabetes
8410976 60 Effect of trifluoromethyl and other substituents on activity of xanthines at adenosine receptors.EBI National Institutes of Health
8258823 16 Xanthines with C8 chiral substituents as potent and selective adenosine A1 antagonists.EBI Marion Merrell Dow Research Institute
8230124 48 Synthesis of paraxanthine analogs (1,7-disubstituted xanthines) and other xanthines unsubstituted at the 3-position: structure-activity relationships at adenosine receptors.EBI Pharmazeutische Chemie
8182711 39 Synthesis and structure-activity relationships of deazaxanthines: analogs of potent A1- and A2-adenosine receptor antagonists.EBI Eberhard-Karls-Universität Tübingen
8120866 54 Inhibition of cyclic nucleotide phosphodiesterase by derivatives of 1,3-bis(cyclopropylmethyl)xanthine.EBI SmithKline Beecham Pharmaceuticals
8071944 37 8-Azaxanthine derivatives as antagonists of adenosine receptors.EBI Università di Camerino
8064798 44 Substituted 1,3-dipropylxanthines as irreversible antagonists of A1 adenosine receptors.EBI University of South Florida
7932565 92 Structure-activity relationships of 1,3-dialkylxanthine derivatives at rat A3 adenosine receptors.EBI National Institute of Diabetes
7731018 64 Tricyclic heteroaromatic systems. Synthesis and A1 and A2a adenosine binding activities of some 1-aryl-1,4-dihydro-3-methyl[1]benzopyrano[2,3-c] pyrazol-4-ones, 1-aryl-4,9-dihydro-3-methyl-1H-pyrazolo[3,4-b]quinolin-4- ones, and 1-aryl-1H-imidazo[4,5-b]quinoxalines.EBI Università di Firenze
6315938 1 Neurotransmitter receptor binding and drug discovery.EBI TBA
6090665 28 Mesoionic xanthine analogues: antagonists of adenosine receptors.EBI TBA
3806606 48 Synthesis and structure-activity relationships of pyrazolo[4,3-d]pyrimidin-7-ones as adenosine receptor antagonists.EBI TBA
3806597 19 Xanthine functionalized congeners as potent ligands at A2-adenosine receptors.EBI TBA
3806581 68 Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors.EBI TBA
3361572 19 Structure-activity profile of a series of novel triazoloquinazoline adenosine antagonists.EBI CIBA-GEIGY Corporation
3361571 15 [1,2,4]Triazolo[4,3-a]quinoxalin-4-amines: a new class of A1 receptor selective adenosine antagonists.EBI Warner-Lambert Company
3172141 15 Benzo[1,2-c:5,4-c']dipyrazoles: non-xanthine adenosine antagonists.EBI Merrell Dow Research Institute
3016270 20 Analogues of 1,3-dipropyl-8-phenylxanthine: enhancement of selectivity at A1-adenosine receptors by aryl substituents.EBI TBA
2993622 18 Functionalized congeners of 1,3-dialkylxanthines: preparation of analogues with high affinity for adenosine receptors.EBI TBA
2892936 10 Synthesis and potential antipsychotic activity of 1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidines.EBI Warner-Lambert Company
2875184 11 (5-Amino-1,3-dimethyl-1H-pyrazol-4-yl)(2-fluorophenyl)methanones . A series of novel potential antipsychotic agents.EBI TBA
2795597 22 Linear and proximal benzo-separated alkylated xanthines as adenosine-receptor antagonists.EBI University of South Florida
2724296 56 Effects of 8-phenyl and 8-cycloalkyl substituents on the activity of mono-, di-, and trisubstituted alkylxanthines with substitution at the 1-, 3-, and 7-positions.EBI National Institutes of Health
2342066 5 A model for the antagonist binding site on the adenosine A1 receptor, based on steric, electrostatic, and hydrophobic properties.EBI Center for Bio-Pharmaceutical Sciences
2213835 33 7-Deaza-2-phenyladenines: structure-activity relationships of potent A1 selective adenosine receptor antagonists.EBI National Institute of Diabetes
2213834 19 Imidazodiazepinediones: a new class of adenosine receptor antagonists.EBI National Institute of Diabetes
2016719 34 1,3,8-trisubstituted xanthines. Effects of substitution pattern upon adenosine receptor A1/A2 affinity.EBI Nova Pharmaceutical Corporation
1992150 30 8-(Dicyclopropylmethyl)-1,3-dipropylxanthine: a potent and selective adenosine A1 antagonist with renal protective and diuretic activities.EBI Kyowa Hakko Kogyo Co., Ltd.
1895306 7 Synthesis and adenosine receptor affinity of a series of pyrazolo[3,4-d]pyrimidine analogues of 1-methylisoguanosine.EBI Griffith University
1694546 33 Structure-activity relationships of 8-cycloalkyl-1,3-dipropylxanthines as antagonists of adenosine receptors.EBI Vanderbilt University
1613758 52 (E)-1,3-dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists.EBI Kyowa Hakko Kogyo Co., Ltd
1507211 15 Conformationally restrained, chiral (phenylisopropyl)amino-substituted pyrazolo[3,4-d]pyrimidines and purines with selectivity for adenosine A1 and A2 receptors.EBI Marion Merrell Dow Research Institute
1469687 21 2-(N'-alkylidenehydrazino)adenosines: potent and selective coronary vasodilators.EBI University of South Florida
1404238 7 7,8-Dihydro-8-ethyl-2-(3-noradamantyl)-4-propyl-1H-imidazo[2,1-i]purin-5(4H)-one: a potent and water-soluble adenosine A1 antagonist.EBI Kyowa Hakko Kogyo Co., Ltd.
1331453 75 Effects of alkyl substitutions of xanthine skeleton on bronchodilation.EBI Hokuriku University
28135235 71 An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED.BDB Novartis Institutes for BioMedical Research
27439119 16 Structure-Based Screening of Uncharted Chemical Space for Atypical Adenosine Receptor AgonistsBDB Uppsala University
27282729 22 4-amino-6-alkyloxy-2-alkylthiopyrimidine derivatives as novel non-nucleoside agonists for the adenosine A1 receptor.BDB Università di Napoli Federico II
26851736 160 Synthesis and pharmacological characterization of novel xanthine carboxylate amides as A2A adenosine receptor ligands exhibiting bronchospasmolytic activity.BDB Panjab University
26042529 21 Development of novel adenosine receptor ligands based on the 3-amidocoumarin scaffold.BDB Universidade do Porto
25746740 23 The adenosine receptor affinities and monoamine oxidase B inhibitory properties of sulfanylphthalimide analogues.BDB North-West University
23480235 20 N-[9-(ortho-fluorobenzyl)-2-phenyl-8-azapurin-6-yl]-amides as potent and selective ligands for A1 adenosine receptors.BDB Universit£ di Pisa
17350268 18 Synthesis of hybrid molecules of caffeine and eudistomin D and its effects on adenosine receptors.BDB Hokkaido University
17221184 55 Synthesis and in vivo evaluation of a novel 5-HT1A receptor agonist radioligand [O-methyl- 11C]2-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)dione in nonhuman primates.BDB Columbia University
16675639 28 Desvenlafaxine succinate: A new serotonin and norepinephrine reuptake inhibitor.BDB Wyeth Research
15831442 46 Beneficial effects of a new 20-hydroxyeicosatetraenoic acid synthesis inhibitor, TS-011 [N-(3-chloro-4-morpholin-4-yl) phenyl-N'-hydroxyimido formamide], on hemorrhagic and ischemic stroke.BDB Taisho Pharmaceutical Co., Ltd
15131245 86 SR147778 [5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethyl-N-(1-piperidinyl)-1H-pyrazole-3-carboxamide], a new potent and selective antagonist of the CB1 cannabinoid receptor: biochemical and pharmacological characterization.BDB Sanofi-Synthelabo Recherche
12431845 84 Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder.BDB Lilly Research Laboratories
11809867 38 A(3) adenosine receptors in human neutrophils and promyelocytic HL60 cells: a pharmacological and biochemical study.BDB University of Ferrara
11750183 29 Extended radioligand binding profile of iloperidone: a broad spectrum dopamine/serotonin/norepinephrine receptor antagonist for the management of psychotic disorders.BDB Novartis Pharma
11750180 139 Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors.BDB Lilly Research Laboratories
11191840 25 Cloning of a chick A3 adenosine receptor: characterization of ligand binding and receptor-effector coupling of chick A1 and A3 adenosine receptors.BDB University of Illinois at Chicago
10779381 34 [(3)H]MRE 3008F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A(3) adenosine receptors.BDB University of Ferrara
10496952 37 Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells.BDB University of Virginia
10494877 50 2-Substituted N-ethylcarboxamidoadenosine derivatives as high-affinity agonists at human A3 adenosine receptors.BDB Universität Würzburg
9933143 11 Comparison of CGS 15943, ZM 241385 and SCH 58261 as antagonists at human adenosine receptors.BDB Schering-Plough Research Institute
9459024 9 Adenosine receptor agonists: synthesis and biological evaluation of the diastereoisomers of 2-(3-hydroxy-3-phenyl-1-propyn-1-yl)NECA.BDB Università di Camerino
9454810 72 SR 144528, the first potent and selective antagonist of the CB2 cannabinoid receptor.BDB Sanofi Recherche
8996189 24 Cloning, expression and pharmacological characterization of rabbit adenosine A1 and A3 receptors.BDB Pfizer Inc.
8996185 121 Neurochemical characteristics of amisulpride, an atypical dopamine D2/D3 receptor antagonist with both presynaptic and limbic selectivity.BDB Synthélabo Recherche
8887981 72 A-85380 [3-(2(S)-azetidinylmethoxy) pyridine]: in vitro pharmacological properties of a novel, high affinity alpha 4 beta 2 nicotinic acetylcholine receptor ligand.BDB Abbott Laboratories
8821530 16 In vitro and in vivo profile of SB 206553, a potent 5-HT2C/5-HT2B receptor antagonist with anxiolytic-like properties.BDB SmithKline Beecham Pharmaceuticals
8386236 11 In vitro and in vivo pharmacological characterization of N6-cyclopentyl-9-methyladenine (N-0840): a selective, orally active A1 adenosine receptor antagonist.BDB Whitby Research, Inc.
8022403 113 A binding site model and structure-activity relationships for the rat A3 adenosine receptor.BDB National Institute of Diabetes, Digestive and Kidney Diseases
8012715 38 GR113808: a novel, selective antagonist with high affinity at the 5-HT4 receptor.BDB Glaxo Group Research Ltd.
7921604 16 The effects of SB 204070, a highly potent and selective 5-HT4 receptor antagonist, on guinea-pig distal colon.BDB SmithKline Beecham Pharmaceuticals
7582508 13 The in vitro pharmacology of ZM 241385, a potent, non-xanthine A2a selective adenosine receptor antagonist.BDB ZENECA Pharmaceuticals
7518514 46 (S)-3-methyl-5-(1-methyl-2-pyrrolidinyl) isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: I. In vitro characterization.BDB Abbott Laboratories
3252029 9 Characterization of cardiac A1 adenosine receptors by ligand binding and photoaffinity labeling.BDB University of Illinois at Chicago
3216901 5 2-Chloro-N6-cyclopentyladenosine: a highly selective agonist at A1 adenosine receptors.BDB Pharmakologisches Institut, Heidelberg
3208837 3 2',3'-Dideoxy-N6-cyclohexyladenosine: an adenosine derivative with antagonist properties at adenosine receptors.BDB Pharmakologisches Institut
3010074 129 Characterization of the A2 adenosine receptor labeled by [3H]NECA in rat striatal membranes.BDB Warner-Lambert/Parke-Davis Pharmaceutical Research
2997628 56 Xanthine derivatives as antagonists at A1 and A2 adenosine receptors.BDB TBA
2825043 23 8-Cyclopentyl-1,3-dipropylxanthine (DPCPX)--a selective high affinity antagonist radioligand for A1 adenosine receptors.BDB Universität Heidelberg
2795469 9 CGS 21680C, an A2 selective adenosine receptor agonist with preferential hypotensive activity.BDB CIBA-Geigy Corporation
2067592 83 Comparison of A1 adenosine receptors in brain from different species by radioligand binding and photoaffinity labelling.BDB Universität Heidelberg
1857334 1 Cloning and expression of an A1 adenosine receptor from rat brain.BDB National Institute of Mental Health
1661335 95 Receptor binding profiles of amiloride analogues provide no evidence for a link between receptors and the Na+/H+ exchanger, but indicate a common structure on receptor proteins.BDB Center for Bio-Pharmaceutical Sciences
1554381 19 Agonist activity of 2- and 5'-substituted adenosine analogs and their N6-cycloalkyl derivatives at A1- and A2-adenosine receptors coupled to adenylate cyclase.BDB National Institutes of Diabetes and Digestive and Kidney Diseases
15734651 135 A neoceptor approach to unraveling microscopic interactions between the human A2A adenosine receptor and its agonists.BDB National Institutes of Health
19695884 156 Antagonists of the human A(2A) receptor. Part 6: Further optimization of pyrimidine-4-carboxamides.BDB Vernalis (R&D) Ltd
18947224 54 Lead Optimization of 4-Acetylamino-2-(3,5-dimethylpyrazol-1-yl)-6-pyridylpyrimidines as A2A Adenosine Receptor Antagonists for the Treatment of Parkinson's Disease.BDB Neurocrine Bioscience
18783211 14 Synthesis of bivalent beta2-adrenergic and adenosine A1 receptor ligands.BDB Monash University
18269230 87 Derivatives of 4-Amino-6-hydroxy-2-mercaptopyrimidine as Novel, Potent, and Selective A3 Adenosine Receptor Antagonists.BDB Universita di Napoli
18307293 75 2-Amino-N-pyrimidin-4-ylacetamides as A2A Receptor Antagonists: 2. Reduction of hERG Activity, Observed Species Selectivity, and Structure-Activity Relationships.BDB Neuroscience
18307292 34 2-Amino-N-pyrimidin-4-ylacetamides as A2A Receptor Antagonists: 1. Structure-Activity Relationships and Optimization of Heterocyclic Substituents.BDB Neuroscience