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145 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
27161878 83 Exploring the 2- and 5-positions of the pyrazolo[4,3-d]pyrimidin-7-amino scaffold to target human A1 and A2A adenosine receptors.EBI Universit£ degli Studi di Firenze
26824742 43 Discovery of Potent and Highly Selective A2B Adenosine Receptor Antagonist Chemotypes.EBI Uppsala University
26756468 44 Discovery of Novel Adenosine Receptor Agonists That Exhibit Subtype Selectivity.EBI University of Warwick
26356532 39 Discovery of Molecular Therapeutics for Glaucoma: Challenges, Successes, and Promising Directions.EBI Georgia Institute of Technology
26781932 109 Discovery of aminoquinazoline derivatives as human A(2A) adenosine receptor antagonists.EBI Merck Research Laboratories
26638043 66 Structural refinement of pyrazolo[4,3-d]pyrimidine derivatives to obtain highly potent and selective antagonists for the human A3 adenosine receptor.EBI Universit£ degli Studi di Firenze
26717203 129 5,7-Disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazines as pharmacological tools to explore the antagonist selectivity profiles toward adenosine receptors.EBI Universit£ di Trieste
26046697 46 One-pot reaction to obtain N,N'-disubstituted guanidines of pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine scaffold as human A3 adenosine receptor antagonists.EBI Universit£ degli Studi di Ferrara
25780876 205 Design, synthesis, and biological evaluation of novel 2-((2-(4-(substituted)phenylpiperazin-1-yl)ethyl)amino)-5'-N-ethylcarboxamidoadenosines as potent and selective agonists of the A2A adenosine receptor.EBI Universit£ degli Studi di Ferrara
25699637 91 5'-C-Ethyl-tetrazolyl-N(6)-substituted adenosine and 2-chloro-adenosine derivatives as highly potent dual acting A1 adenosine receptor agonists and A3 adenosine receptor antagonists.EBI University of Camerino
25633494 128 A facile and novel synthesis of N(2)-, C(6)-substituted pyrazolo[3,4-d]pyrimidine-4 carboxylate derivatives as adenosine receptor antagonists.EBI National University of Singapore
25063944 56 7-Amino-2-phenylpyrazolo[4,3-d]pyrimidine derivatives: structural investigations at the 5-position to target human A1 and A(2A) adenosine receptors. Molecular modeling and pharmacological studies.EBI Universit£ di Firenze
24972108 256 Scaffold decoration at positions 5 and 8 of 1,2,4-triazolo[1,5-c]pyrimidines to explore the antagonist profiling on adenosine receptors: a preliminary structure-activity relationship study.EBI Universit£ di Trieste
24164628 186 Adenosine A2A receptor as a drug discovery target.EBI Merck Research Laboratories
24669958 39 Agonists for the adenosine A1 receptor with tunable residence time. A Case for nonribose 4-amino-6-aryl-5-cyano-2-thiopyrimidines.EBI Leiden University
23427825 45 2-Arylpyrazolo[4,3-d]pyrimidin-7-amino derivatives as new potent and selective human A3 adenosine receptor antagonists. Molecular modeling studies and pharmacological evaluation.EBI Universit£ di Firenze
23245803 87 Synthesis and structure-activity relationships of 2-hydrazinyladenosine derivatives as A(2A) adenosine receptor ligands.EBI University of Bonn
23231967 23 Selective and potent adenosine A3 receptor antagonists by methoxyaryl substitution on the N-(2,6-diarylpyrimidin-4-yl)acetamide scaffold.EBI University of Santiago de Compostela
23171656 23 Pyrazolo[1,5-c]quinazoline derivatives and their simplified analogues as adenosine receptor antagonists: synthesis, structure-affinity relationships and molecular modeling studies.EBI Universita' di Firenze
20371139 16 Synthesis and pharmacological evaluation of novel substituted 9-deazaxanthines as A2B receptor antagonists.EBI Universidade de A Coru£a
20382540 9 In silico directed chemical probing of the adenosine receptor family.EBI Universidade do Minho
20137957 35 Synthesis and pharmacological evaluation of novel 1,3,8- and 1,3,7,8-substituted xanthines as adenosine receptor antagonists.EBI Universidade de Porto
19682912 80 Synthesis and pharmacological evaluation of novel 1- and 8-substituted-3-furfuryl xanthines as adenosine receptor antagonists.EBI Universidade de Santiago de Compostela
19346133 58 Synthesis of novel 1-alkyl-8-substituted-3-(3-methoxypropyl) xanthines as putative A(2B) receptor antagonists.EBI Universidade de A Coru£a
16392813 329 Design, synthesis, and structure-activity relationships of 1-,3-,8-, and 9-substituted-9-deazaxanthines at the human A2B adenosine receptor.EBI Universit£ di Bari
23098605 248 Exploring the directionality of 5-substitutions in a new series of 5-alkylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine as a strategy to design novel human a(3) adenosine receptor antagonists.EBI Universit£ di Trieste
22827545 11 Identifying novel adenosine receptor ligands by simultaneous proteochemometric modeling of rat and human bioactivity data.EBI Leiden/Amsterdam Center for Drug Research
21664729 142 Synthesis and biological activity of tricyclic cycloalkylimidazo-, pyrimido- and diazepinopurinediones.EBI Jagiellonian University Medical College
22568637 158 Water-soluble pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines as human A3 adenosine receptor antagonists.EBI Universit£ di Ferrara
22703703 6 In search for new chemical entities as adenosine receptor ligands: development of agents based on benzo-¿-pyrone skeleton.EBI Universidade do Porto
22677030 29 New chromene scaffolds for adenosine A(2A) receptors: synthesis, pharmacology and structure-activity relationships.EBI Universidade do Minho
22432713 64 Synthesis and pharmacological evaluation of dual acting antioxidant A(2A) adenosine receptor agonists.EBI Monash University
22257095 65 3-aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: a novel template for the design of highly selective A2B adenosine receptor antagonists.EBI Universit£ di Pisa
22220592 27 Discovery of 1,2,4-triazine derivatives as adenosine A(2A) antagonists using structure based drug design.EBI Heptares Therapeutics Limited
21286238 9 Discovery of New Human A(2A) Adenosine Receptor Agonists: Design, Synthesis, and Binding Mode of Truncated 2-Hexynyl-4'-thioadenosine.EBI Ewha Womans University
21210664 74 Discovery of phosphoric acid mono-{2-[(E/Z)-4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-benzoylimino]-thiazol-3-ylmethyl} ester (Lu AA47070): a phosphonooxymethylene prodrug of a potent and selective hA(2A) receptor antagonist.EBI H. Lundbeck A/S
20541935 131 4-Substituted-7-N-alkyl-N-acetyl 2-aminobenzothiazole amides: drug-like and non-xanthine based A2B adenosine receptor antagonists.EBI Roche Research Center
20408530 98 Novel N2-substituted pyrazolo[3,4-d]pyrimidine adenosine A3 receptor antagonists: inhibition of A3-mediated human glioblastoma cell proliferation.EBI Universit£ di Pisa
20188574 141 2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists.EBI University of Bonn
19569717 251 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity.EBI Institute
19282184 195 8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands.EBI University of Camerino
18637670 80 2-Amino-6-furan-2-yl-4-substituted nicotinonitriles as A2A adenosine receptor antagonists.EBI Leiden/Amsterdam Center for Drug Research
18407496 127 Antagonists of the human adenosine A2A receptor. Part 2: Design and synthesis of 4-arylthieno[3,2-d]pyrimidine derivatives.EBI Vernalis (R&D) Ltd
18321039 144 Discovery of a novel A2B adenosine receptor antagonist as a clinical candidate for chronic inflammatory airway diseases.EBI CV Therapeutics Inc.
18321038 85 Probing distal regions of the A2B adenosine receptor by quantitative structure-activity relationship modeling of known and novel agonists.EBI National Institute of Diabetes and Digestive and Kidney Diseases
18077171 108 1,3-Dipropyl-8-(1-phenylacetamide-1H-pyrazol-3-yl)-xanthine derivatives as highly potent and selective human A(2B) adenosine receptor antagonists.EBI Universit£ di Ferrara
18226909 162 1-, 3- and 8-substituted-9-deazaxanthines as potent and selective antagonists at the human A2B adenosine receptor.EBI Universit£ di Bari
17933541 145 5'-Carbamoyl derivatives of 2'-C-methyl-purine nucleosides as selective A1 adenosine receptor agonists: affinity, efficacy, and selectivity for A1 receptor from different species.EBI Universit£ di Camerino
17927167 107 5-amino-2-phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazin-1-one: a versatile scaffold to obtain potent and selective A3 adenosine receptor antagonists.EBI Universit£ di Pisa
17306548 84 N(6)-[(hetero)aryl/(cyclo)alkyl-carbamoyl-methoxy-phenyl]-(2-chloro)-5'-N-ethylcarboxamido-adenosines: the first example of adenosine-related structures with potent agonist activity at the human A(2B) adenosine receptor.EBI Universit£ di Ferrara
17378544 121 Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor.EBI National Institute of Diabetes and Digestive and Kidney Diseases
17228880 76 Synthesis and biological evaluation of novel 1-deoxy-1-[6-[((hetero)arylcarbonyl)hydrazino]- 9H-purin-9-yl]-N-ethyl-beta-D-ribofuranuronamide derivatives as useful templates for the development of A2B adenosine receptor agonists.EBI Universit£ di Ferrara
16487705 107 N6-ethyl-2-alkynyl NECAs, selective human A3 adenosine receptor agonists.EBI University of Virginia
16509587 72 Synthesis and biological studies of a new series of 5-heteroarylcarbamoylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidines as human A3 adenosine receptor antagonists. Influence of the heteroaryl substituent on binding affinity and molecular modeling investigations.EBI Universit£ degli Studi di Trieste
16250647 71 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.EBI Universit£ degli Studi di Urbino Carlo Bo
15771453 22 Development of spin-labeled probes for adenosine receptors.EBI University of Bonn
15743197 37 Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists.EBI Universit£ di Camerino
15267242 54 Synthesis and biological activity of new potential agonists for the human adenosine A2A receptor.EBI IIQAB (CSIC)
15876531 28 A new orally bioavailable dual adenosine A2B/A3 receptor antagonist with therapeutic potential.EBI Novartis Institutes for Biomedical Research
15084123 24 Novel amino acid derived natural products from the ascidian Atriolum robustum: identification and pharmacological characterization of a unique adenosine derivative.EBI University of Bonn
14998332 328 Design, synthesis, and biological evaluation of new 8-heterocyclic xanthine derivatives as highly potent and selective human A2B adenosine receptor antagonists.EBI Universit£ di Ferrara
15239649 24 New, non-adenosine, high-potency agonists for the human adenosine A2B receptor with an improved selectivity profile compared to the reference agonist N-ethylcarboxamidoadenosine.EBI University of Leiden
12646033 124 Design, synthesis, and biological evaluation of C9- and C2-substituted pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as new A2A and A3 adenosine receptors antagonists.EBI Universit£ di Ferrara
12109910 8 N(6)-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting point for searching A(2B) ligands.EBI Universit£ di Camerino
11262085 92 Thiazole and thiadiazole analogues as a novel class of adenosine receptor antagonists.EBI Vrije Universiteit
10841798 64 Methanocarba analogues of purine nucleosides as potent and selective adenosine receptor agonists.EBI National Institute of Diabetes
10212124 26 5'-N-substituted carboxamidoadenosines as agonists for adenosine receptors.EBI Leiden University
11459663 19 Introduction of alkynyl chains on C-8 of adenosine led to very selective antagonists of the A(3) adenosine receptor.EBI Universit£ di Camerino
22148859 190 Novel 1,3-dipropyl-8-(3-benzimidazol-2-yl-methoxy-1-methylpyrazol-5-yl)xanthines as potent and selective A2B adenosine receptor antagonists.EBI University of Ferrara
22204739 136 Pyrrolo- and pyrazolo-[3,4-e][1,2,4]triazolo[1,5-c]pyrimidines as adenosine receptor antagonists.EBI Universit£ di Ferrara
21214204 100 Synthesis and Biological Evaluation of a New Series of 1,2,4-Triazolo[1,5-a]-1,3,5-triazines as Human A(2A) Adenosine Receptor Antagonists with Improved Water Solubility.EBI Universita di Trieste
21908194 88 Does the combination of optimal substitutions at the C²-, N¿?¿- and N¿?¿-positions of the pyrazolo-triazolo-pyrimidine scaffold guarantee selective modulation of the human A3 adenosine receptors?EBI National University of Singapore
21675777 139 New 2-heterocyclyl-imidazo[2,1-i]purin-5-one derivatives as potent and selective human A3 adenosine receptor antagonists.EBI Universit£ di Ferrara
21388809 76 Discovery of benzothiazole-based adenosine A2B receptor antagonists with improved A2A selectivity.EBI Roche Research Center
21186795 142 Pyrimidine derivatives as potent and selective A3 adenosine receptor antagonists.EBI University of Santiago de Compostela
21055932 137 Discovery of novel quinolinone adenosine A2B antagonists.EBI Ligand Pharmaceuticals
20937560 54 Pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as selective human A(1) adenosine receptor ligands.EBI Dipartimento di Scienze Farmaceutiche
20728355 47 Identification and optimization of substituted 5-aminopyrazoles as potent and selective adenosine A1 receptor antagonists.EBI Bayer Schering Pharma AG
20537438 101 Insights into binding modes of adenosine A(2B) antagonists with ligand-based and receptor-based methods.EBI East China University of Science and Technology
20307065 122 The significance of 2-furyl ring substitution with a 2-(para-substituted) aryl group in a new series of pyrazolo-triazolo-pyrimidines as potent and highly selective hA(3) adenosine receptors antagonists: new insights into structure-affinity relationship and receptor-antagonist recognition.EBI National University of Singapore
20304654 79 Synthesis and pharmacological characterization of a new series of 5,7-disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazine derivatives as adenosine receptor antagonists: A preliminary inspection of ligand-receptor recognition process.EBI National University of Singapore
20138516 29 Discovery of potent and selective bicyclic A(2B) adenosine receptor antagonists via bioisosteric amide replacement.EBI Rhône-Poulenc Rorer
20137946 81 Discovery of N-(5,6-diarylpyridin-2-yl)amide derivatives as potent and selective A(2B) adenosine receptor antagonists.EBI Rhône-Poulenc Rorer
19733067 84 Discovery and optimization of potent and selective functional antagonists of the human adenosine A2B receptor.EBI Vernalis (R&D) Ltd
20031406 85 Synthesis and evaluation of two series of 4'-aza-carbocyclic nucleosides as adenosine A2A receptor agonists.EBI Novartis Institutes for BioMedical Research
20202853 12 Synthesis of theophylline derivatives and study of their activity as antagonists at adenosine receptors.EBI Universidad de M£laga
19743865 22 2-Phenylpyrazolo[4,3-d]pyrimidin-7-one as a new scaffold to obtain potent and selective human A3 adenosine receptor antagonists: new insights into the receptor-antagonist recognition.EBI Universit£ di Firenze
19501513 474 Combining selectivity and affinity predictions using an integrated Support Vector Machine (SVM) approach: An alternative tool to discriminate between the human adenosine A(2A) and A(3) receptor pyrazolo-triazolo-pyrimidine antagonists binding sites.EBI Universit£ di Padova
19362836 83 Antagonists of the human A(2A) receptor. Part 5: Highly bio-available pyrimidine-4-carboxamides.EBI Vernalis (R+D) Ltd.
19398343 48 1,3-dialkyl-8-N-substituted benzyloxycarbonylamino-9-deazaxanthines as potent adenosine receptor ligands: Design, synthesis, structure-affinity and structure-selectivity relationships.EBI Universidade de Santiago de Compostela
19317449 76 N6-Cycloalkyl- and N6-bicycloalkyl-C5'(C2')-modified adenosine derivatives as high-affinity and selective agonists at the human A1 adenosine receptor with antinociceptive effects in mice.EBI University of Camerino
19140664 82 N-[6-amino-2-(heteroaryl)pyrimidin-4-yl]acetamides as A2A receptor antagonists with improved drug like properties and in vivo efficacy.EBI Neurocrine Biosciences
19072055 224 Antagonists of the human A(2A) adenosine receptor. 4. Design, synthesis, and preclinical evaluation of 7-aryltriazolo[4,5-d]pyrimidines.EBI Vernalis R&D Ltd
19006671 136 Structure-activity relationship studies of a new series of imidazo[2,1-f]purinones as potent and selective A(3) adenosine receptor antagonists.EBI Università di Ferrara
18938084 78 1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A2B adenosine receptor antagonists: design, synthesis, structure-affinity and structure-selectivity relationships.EBI Università degli Studi di Bari
18226896 129 Selective, high affinity A(2B) adenosine receptor antagonists: N-1 monosubstituted 8-(pyrazol-4-yl)xanthines.EBI CV Therapeutics Inc.
18189346 21 Identification of novel, water-soluble, 2-amino-N-pyrimidin-4-yl acetamides as A2A receptor antagonists with in vivo efficacy.EBI Neurocrine Biosciences
17827019 86 Phenylethyl-substituted pyrimido[2,1-f]purinediones and related compounds: structure-activity relationships as adenosine A(1) and A(2A) receptor ligands.EBI Jagiellonian University Medical College
17689079 36 Dual acting antioxidant A1 adenosine receptor agonists.EBI Monash University (Parkville Campus)
17469811 45 Discovery and characterization of 4'-(2-furyl)-N-pyridin-3-yl-4,5'-bipyrimidin-2'-amine (LAS38096), a potent, selective, and efficacious A2B adenosine receptor antagonist.EBI Almirall
17300165 39 2,6,8-trisubstituted 1-deazapurines as adenosine receptor antagonists.EBI Leiden/Amsterdam Center for Drug Research
17236762 23 Potent, selective, and orally active adenosine A2A receptor antagonists: arylpiperazine derivatives of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines.EBI Schering-Plough Research Institute
17125265 49 Tricyclic imidazoline derivatives as potent and selective adenosine A1 receptor antagonists.EBI Biogen Idec, Inc.
17125264 60 Potent and orally bioavailable 8-bicyclo[2.2.2]octylxanthines as adenosine A1 receptor antagonists.EBI Biogen Idec, Inc.
17045477 136 N6-Cycloalkyl-2-substituted adenosine derivatives as selective, high affinity adenosine A1 receptor agonists.EBI CV Therapeutics Inc.
16821798 62 A new synthesis of sulfonamides by aminolysis of p-nitrophenylsulfonates yielding potent and selective adenosine A2B receptor antagonists.EBI University of Bonn
16821770 78 Pharmacophore based receptor modeling: the case of adenosine A3 receptor antagonists. An approach to the optimization of protein models.EBI Università degli Studi di Siena
16789747 71 4-amido-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-ones as new potent and selective human A3 adenosine receptor antagonists. synthesis, pharmacological evaluation, and ligand-receptor modeling studies.EBI Università di Firenze
16759111 149 Novel 1,3-disubstituted 8-(1-benzyl-1H-pyrazol-4-yl) xanthines: high affinity and selective A2B adenosine receptor antagonists.EBI CV Therapeutics Inc.
16697192 59 New pyrrolopyrimidin-6-yl benzenesulfonamides: potent A2B adenosine receptor antagonists.EBI Rhône-Poulenc Rorer
16289820 14 Conversion of A3 adenosine receptor agonists into selective antagonists by modification of the 5'-ribofuran-uronamide moiety.EBI National Institute of Diabetes and Digestive and Kidney Diseases
16275090 136 Novel 1,3-dipropyl-8-(1-heteroarylmethyl-1H-pyrazol-4-yl)-xanthine derivatives as high affinity and selective A2B adenosine receptor antagonists.EBI CV Therapeutics Inc.
16250640 7 Molecular modeling and molecular dynamics simulation of the human A2B adenosine receptor. The study of the possible binding modes of the A2B receptor antagonists.EBI M. V. Lomonosov Moscow State University
16033279 47 New 2-arylpyrazolo[4,3-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists.EBI Università di Ferrara
16000006 59 New pyrrolo[2,1-f]purine-2,4-dione and imidazo[2,1-f]purine-2,4-dione derivatives as potent and selective human A3 adenosine receptor antagonists.EBI Università di Ferrara
15664822 101 The discovery of a selective, high affinity A(2B) adenosine receptor antagonist for the potential treatment of asthma.EBI CV Therapeutics, Inc.
15294001 88 Piperazine derivatives of [1,2,4]triazolo[1,5-a][1,3,5]triazine as potent and selective adenosine A2a receptor antagonists.EBI Biogen Idec, Inc.
15203160 119 Structure-activity relationships of adenosine A3 receptor ligands: new potential therapy for the treatment of glaucoma.EBI Otsuka Pharmaceutical Factory, Inc.
15177485 2 A mild, efficient and alpha-selective glycosidation by using potassium dodecatungstocobaltate trihydrate as catalyst.EBI University of Isfahan
14761205 56 Preparation, properties, reactions, and adenosine receptor affinities of sulfophenylxanthine nitrophenyl esters: toward the development of sulfonic acid prodrugs with peroral bioavailability.EBI University of Bonn
13678407 57 Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as adenosine receptor antagonists. Influence of the N5 substituent on the affinity at the human A 3 and A 2B adenosine receptor subtypes: a molecular modeling investigation.EBI Università degli Studi di Trieste
12166943 81 1,2,4-Triazolo[5,1-i]purine derivatives as highly potent and selective human adenosine A(3) receptor ligands.EBI Nutrition Research Institute
12166930 21 Synthesis, biological properties, and molecular modeling investigation of the first potent, selective, and water-soluble human A(3) adenosine receptor antagonist.EBI TBA
12014951 139 Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions.EBI National Institute of Diabetes & Digestive & Kidney Diseases
11906291 129 1,8-disubstituted xanthine derivatives: synthesis of potent A2B-selective adenosine receptor antagonists.EBI University of Bonn
11831890 278 Synthesis, biological activity, and molecular modeling investigation of new pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as human A(3) adenosine receptor antagonists.EBI Università degli Studi di Ferrara
11754583 112 7-Substituted 5-amino-2-(2-furyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as A2A adenosine receptor antagonists: a study on the importance of modifications at the side chain on the activity and solubility.EBI Università degli Studi di Ferrara
11495585 16 Fluorosulfonyl- and bis-(beta-chloroethyl)amino-phenylamino functionalized pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives: irreversible antagonists at the human A3 adenosine receptor and molecular modeling studies.EBI Università degli Studi di Ferrara
11170626 55 2-Alkynyl-8-aryl-9-methyladenines as novel adenosine receptor antagonists: their synthesis and structure-activity relationships toward hepatic glucose production induced via agonism of the A(2B) receptor.EBI Eisai Company, Ltd.
11123985 176 Pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists: influence of the chain at the N(8) pyrazole nitrogen.EBI Università degli Studi di Ferrara
11087559 7 Design, radiosynthesis, and biodistribution of a new potent and selective ligand for in vivo imaging of the adenosine A(2A) receptor system using positron emission tomography.EBI University of Milano-Bicocca
10737749 182 Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A(2B) adenosine receptors.EBI National Institute of Diabetes
10669571 24 Water-soluble phosphate prodrugs of 1-propargyl-8-styrylxanthine derivatives, A(2A)-selective adenosine receptor antagonists.EBI University of Würzburg
9667972 119 Derivatives of the triazoloquinazoline adenosine antagonist (CGS 15943) having high potency at the human A2B and A3 receptor subtypes.EBI National Institute of Diabetes
26851736 160 Synthesis and pharmacological characterization of novel xanthine carboxylate amides as A2A adenosine receptor ligands exhibiting bronchospasmolytic activity.BDB Panjab University
11809867 38 A(3) adenosine receptors in human neutrophils and promyelocytic HL60 cells: a pharmacological and biochemical study.BDB University of Ferrara
10779381 34 [(3)H]MRE 3008F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A(3) adenosine receptors.BDB University of Ferrara
10496952 37 Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells.BDB University of Virginia
9933143 11 Comparison of CGS 15943, ZM 241385 and SCH 58261 as antagonists at human adenosine receptors.BDB Schering-Plough Research Institute
15734651 135 A neoceptor approach to unraveling microscopic interactions between the human A2A adenosine receptor and its agonists.BDB National Institutes of Health
19695884 156 Antagonists of the human A(2A) receptor. Part 6: Further optimization of pyrimidine-4-carboxamides.BDB Vernalis (R&D) Ltd