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29 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
28105280 39 GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an ImprovedEBI Genentech, Inc.
26919761 107 Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design.EBI Pharmaron-Beijing Co. Ltd.
26653877 47 Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors.EBI University of Copenhagen
25375781 4 Positive allosteric modulators of 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors belonging to 4-cyclopropyl-3,4-dihydro-2h-1,2,4-pyridothiadiazine dioxides and diversely chloro-substituted 4-cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides.EBI University of Liege
23432124 2 Studies on an (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) receptor antagonist IKM-159: asymmetric synthesis, neuroactivity, and structural characterization.EBI Yokohama City University
21190850 25 Structure based evolution of a novel series of positive modulators of the AMPA receptor.EBI Merck Research Laboratories
20408529 32 4-hydroxy-1,2,5-oxadiazol-3-yl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and molecular pharmacological characterization at ionotropic glutamate receptors of compounds related to glutamate and its homologues.EBI Universit£ degli Studi di Torino
18269227 14 Structures of the ligand-binding core of iGluR2 in complex with the agonists (R)- and (S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic acid explain their unusual equipotency.EBI University of Copenhagen
17672447 25 Functional characterization of Tet-AMPA [tetrazolyl-2-amino-3-(3-hydroxy-5-methyl- 4-isoxazolyl)propionic acid] analogues at ionotropic glutamate receptors GluR1-GluR4. The molecular basis for the functional selectivity profile of 2-Bn-Tet-AMPA.EBI University of Copenhagen
17348638 25 Synthesis and pharmacological characterization of N3-substituted willardiine derivatives: role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLUK5 kainate receptor antagonists.EBI University Walk
12238915 18 Ethyl (3S,4aR,6S,8aR)-6-(4-ethoxycar- bonylimidazol-1-ylmethyl)decahydroiso-quinoline-3-carboxylic ester: a prodrug of a GluR5 kainate receptor antagonist active in two animal models of acute migraine.EBI Lilly Research Laboratories
9357531 58 Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes.EBI University of Bristol
10969973 103 4-Alkylidenyl glutamic acids, potent and selective GluR5 agonists.EBI Eli Lilly and Company Ltd
21923187 5 A new phenylalanine derivative acts as an antagonist at the AMPA receptor GluA2 and introduces partial domain closure: synthesis, resolution, pharmacology, and crystal structure.EBI University of Copenhagen
21067182 37 Biostructural and Pharmacological Studies of Bicyclic Analogues of the 3-Isoxazolol Glutamate Receptor Agonist Ibotenic AcidEBI TBA
20971003 50 N-substituted pyrrolidines and tetrahydrofurans as novel AMPAR positive modulators.EBI GlaxoSmithKline
20839777 25 Positive allosteric modulators of thea-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor.EBI Merck Research Laboratories
20356304 9 alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) antagonists: from bench to bedside.EBI Novartis Pharma AG
20096591 84 Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands.EBI University of California
18754610 2 6-Azido-7-nitro-1,4-dihydroquinoxaline-2,3-dione (ANQX) forms an irreversible bond to the active site of the GluR2 AMPA receptor.EBI University of California San Francisco
16879964 60 A novel class of AMPA receptor allosteric modulators. Part 1: design, synthesis, and SAR of 3-aryl-4-cyano-5-substituted-heteroaryl-2-carboxylic acid derivatives.EBI Lilly S.A.
16872827 97 A novel class of positive allosteric modulators of AMPA receptors: design, synthesis, and structure-activity relationships of 3-biphenyl-4-yl-4-cyano-5-ethyl-1-methyl-1H-pyrrole-2-carboxylic acid, LY2059346.EBI Eli Lilly and Co
16610801 34 Structure-activity relationship studies on N3-substituted willardiine derivatives acting as AMPA or kainate receptor antagonists.EBI University Walk
15974569 21 Two prodrugs of potent and selective GluR5 kainate receptor antagonists actives in three animal models of pain.EBI Centro de Investigación Lilly
15857151 37 Convergent synthesis and pharmacology of substituted tetrazolyl-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid analogues.EBI The Danish University of Pharmaceutical Sciences
14667236 61 2-arylureidobenzoic acids: selective noncompetitive antagonists for the homomeric kainate receptor subtype GluR5.EBI The Danish University of Pharmaceutical Sciences
12747796 39 Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO).EBI The Danish University of Pharmaceutical Sciences
10821708 138 4-Alkyl- and 4-cinnamylglutamic acid analogues are potent GluR5 kainate receptor agonists.EBI Lilly, S.A.
16690725 29 Pharmacological characterization of the competitive GLUK5 receptor antagonist decahydroisoquinoline LY466195 in vitro and in vivo.BDB Eli Lilly and Company