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81 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
26898814 154 SAR exploration at the C-3 position of tetrahydro--carboline sstr3 antagonists.EBI Merck Research Laboratories
26005524 147 Discovery of MK-1421, a Potent, Selective sstr3 Antagonist, as a Development Candidate for Type 2 Diabetes.EBI Merck Research Laboratories
25699156 24 Treating pain with somatostatin receptor subtype 4 agonists.EBI Therachem Research Medilab (India) Pvt. Ltd.
25050159 71 Investigation of Cardiovascular Effects of Tetrahydro--carboline sstr3 antagonists.EBI Merck Research Laboratories
9934480 5 The solid phase synthesis of a series of tri-substituted hydantoin ligands for the somatostatin SST5 receptor.EBI Glaxo Wellcome Cambridge Chemistry Laboratory
18162395 89 Ergoline derivatives as highly potent and selective antagonists at the somatostatin sst 1 receptor.EBI Novartis Institutes for BioMedical Research
17507221 58 Identification and SAR of potent and selective non-peptide obeline somatostatin sst1 receptor antagonists.EBI Novartis Institutes for BioMedical Research
24900499 67 The Discovery of MK-4256, a Potent SSTR3 Antagonist as a Potential Treatment of Type 2 Diabetes.EBI TBA
24900466 55 Stimulation of Glucose-Dependent Insulin Secretion by a Potent, Selective sst3 Antagonist.EBI TBA
24900340 40 N-Methylated sst2 Selective Somatostatin Cyclic Peptide Analogue as a Potent Candidate for Treating Neurogenic Inflammation.EBI TBA
20666484 40 Novel octreotide dicarba-analogues with high affinity and different selectivity for somatostatin receptors.EBI University of Firenze
19351180 165 Novel, potent, and radio-iodinatable somatostatin receptor 1 (sst1) selective analogues.EBI The Clayton Foundation Laboratories for Peptide Biology
19067538 110 Highly potent 4-amino-indolo[2,3-c]azepin-3-one-containing somatostatin mimetics with a range of sst receptor selectivities.EBI Vrije Universiteit Brussel
18543899 171 Design and in vitro characterization of highly sst2-selective somatostatin antagonists suitable for radiotargeting.EBI University of Berne
18410084 115 Ring size of somatostatin analogues (ODT-8) modulates receptor selectivity and binding affinity.EBI Salk Institute
18410083 30 Ring size in octreotide amide modulates differently agonist versus antagonist binding affinity and selectivity.EBI Salk Institute
18210999 21 Novel sst5-selective somatostatin dicarba-analogues: synthesis and conformation-affinity relationships.EBI University of Firenze
16220980 43 Discovery of iodinated somatostatin analogues selective for hsst2 and hsst5 with excellent inhibition of growth hormone and prolactin release from rat pituitary cells.EBI University of California San Diego
15828816 100 N-terminal sugar conjugation and C-terminal Thr-for-Thr(ol) exchange in radioiodinated Tyr3-octreotide: effect on cellular ligand trafficking in vitro and tumor accumulation in vivo.EBI Technische Universit£t M£nchen
15658865 240 Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides.EBI Salk Institute
15982879 61 3-Thio-1,2,4-triazoles, novel somatostatin sst2/sst5 agonists.EBI Institut Henri Beaufour
14667213 90 Novel sst(4)-selective somatostatin (SRIF) agonists. 2. Analogues with beta-methyl-3-(2-naphthyl)alanine substitutions at position 8.EBI Salk Institute
14667212 110 Novel sst(4)-selective somatostatin (SRIF) agonists. 1. Lead identification using a betide scan.EBI Salk Institute
12477342 27 2002 Alfred Burger Award Address in Medicinal Chemistry. Natural products and design: interrelated approaches in drug discovery.EBI Merck Research Laboratories
11312929 90 Highly potent and subtype selective ligands derived by N-methyl scan of a somatostatin antagonist.EBI Tulane University Health Sciences Center
11520208 45 Identification of potent non-peptide somatostatin antagonists with sst(3) selectivity.EBI Institut Henri Beaufour
9544214 197 Potent antagonists of somatostatin: synthesis and biology.EBI Tulane University School of Medicine
9632348 37 Spiro[1H-indene-1,4'-piperidine] derivatives as potent and selective non-peptide human somatostatin receptor subtype 2 (sst2) agonists.EBI Merck Research Laboratories
9216843 32 Lanthionine-somatostatin analogs: synthesis, characterization, biological activity, and enzymatic stability studies.EBI University of California San Diego
11327607 67 Novel non-peptide ligands for the somatostatin sst3 receptor.EBI Institut Henri Beaufour
11266182 53 Synthesis of substituted imidazopyrazines as ligands for the human somatostatin receptor subtype 5.EBI Institut Henri Beaufour
21806016 78 N-imidazolebenzyl-histidine substitution in somatostatin and in its octapeptide analogue modulates receptor selectivity and function.EBI Salk Institute
21194941 2 Biological study of a somatostatin mimetic based on the 1-deoxynojrimycin scaffold.EBI Shandong University School of Medicine
20684600 53 Biological diversity from a structurally diverse library: systematically scanning conformational space using a pyranose scaffold.EBI Alchemia Ltd
20580234 43 Piperidinyl-nicotinamides as potent and selective somatostatin receptor subtype 5 antagonists.EBI F. Hoffmann-La Roche Inc
19786348 261 Benzoxazole piperidines as selective and potent somatostatin receptor subtype 5 antagonists.EBI F. Hoffmann-La Roche Inc
18020391 12 From astemizole to a novel hit series of small-molecule somatostatin 5 receptor antagonists via GPCR affinity profiling.EBI F. Hoffmann-La Roche Inc
18020390 37 Discovery of the first nonpeptidic, small-molecule, highly selective somatostatin receptor subtype 5 antagonists: a chemogenomics approach.EBI F. Hoffmann-La Roche Inc
17559206 22 New sst4/5-selective somatostatin peptidomimetics based on a constrained tryptophan scaffold.EBI Vrije Universiteit Brussel
16854054 30 Novel sst2-selective somatostatin agonists. Three-dimensional consensus structure by NMR.EBI Salk Institute
15658864 225 Somatostatin receptor 1 selective analogues: 2. N(alpha)-Methylated scan.EBI Salk Institute
14667215 64 Novel sst(4)-selective somatostatin (SRIF) agonists. 4. Three-dimensional consensus structure by NMR.EBI Salk Institute
14667214 185 Novel sst(4)-selective somatostatin (SRIF) agonists. 3. Analogues amenable to radiolabeling.EBI Salk Institute
11931620 40 Human somatostatin receptor specificity of backbone-cyclic analogues containing novel sulfur building units.EBI Hebrew University
11405660 155 Potent somatostatin undecapeptide agonists selective for somatostatin receptor 1 (sst1).EBI Salk Institute
11311064 84 N-Methyl scan of somatostatin octapeptide agonists produces interesting effects on receptor subtype specificity.EBI Tulane University Health Sciences Center
11212124 41 Nipecotic and iso-nipecotic amides as potent and selective somatostatin subtype-2 receptor agonists.EBI Merck Research Laboratories
11133079 10 Optimization of a somatostatin mimetic via constrained amino acid and backbone incorporation.EBI University of California
10354394 216 Highly potent cyclic disulfide antagonists of somatostatin.EBI Tulane University School of Medicine
10091708 32 Potent, orally bioavailable somatostatin agonists: good absorption achieved by urea backbone cyclization.EBI Merck Research Laboratories
9667958 40 Design, synthesis, and biological activities of potent and selective somatostatin analogues incorporating novel peptoid residues.EBI University of California San Diego
9554871 43 Modulation of receptor and receptor subtype affinities using diastereomeric and enantiomeric monosaccharide scaffolds as a means to structural and biological diversity. A new route to ether synthesis.EBI University of Pennsylvania
9216844 14 A refined model for the somatostatin pharmacophore: conformational analysis of lanthionine-sandostatin analogs.EBI University of California San Diego
24378707 45 [DOTA]Somatostatin-14 analogs and their (111)In-radioligands: effects of decreasing ring-size on sst1-5 profile, stability and tumor targeting.EBI INRASTES
24342240 20 A tetradecapeptide somatostatin dicarba-analog: Synthesis, structural impact and biological activity.EBI Institute for Research in Biomedicine (IRB Barcelona)
12773038 130 A novel somatostatin mimic with broad somatotropin release inhibitory factor receptor binding and superior therapeutic potential.EBI Novartis Pharma
11448228 25 Peptide folding induces high and selective affinity of a linear and small beta-peptide to the human somatostatin receptor 4.EBI ETH Zurich
30429950 98 Optimization of Preclinical Metabolism for Somatostatin Receptor Subtype 5-Selective Antagonists.EBI Merck & Co.
30429949 59 Discovery and Pharmacology of a Novel Somatostatin Subtype 5 (SSTR5) Antagonist: Synergy with DPP-4 Inhibition.EBI Merck & Co.
28988629 28 Design and synthesis of a novel series of orally active, selective somatostatin receptor 2 agonists for the treatment of type 2 diabetes.EBI Takeda Pharmaceutical Company Limited
28642028 36 Discovery of novel 5-oxa-2,6-diazaspiro[3.4]oct-6-ene derivatives as potent, selective, and orally available somatostatin receptor subtype 5 (SSTR5) antagonists for treatment of type 2 diabetes mellitus.EBI SCOHIA PHARMA, Inc.
28622905 32 Discovery of novel somatostatin receptor subtype 5 (SSTR5) antagonists: Pharmacological studies and design to improve pharmacokinetic profiles and human Ether-a-go-go-related gene (hERG) inhibition.EBI Takeda Pharmaceutical Co., Ltd
26595185 30 Novel biphenyl bis-sulfonamides as acetyl and butyrylcholinesterase inhibitors: Synthesis, biological evaluation and molecular modeling studies.BDB Government College University
25787859 13 Design, Synthesis and Biological Evaluation of Imidazo[1,2-a]pyridine Derivatives as Novel DPP-4 Inhibitors.BDB China Pharmaceutical University
25283372 27 Repurposing human PDE4 inhibitors for neglected tropical diseases. Evaluation of analogs of the human PDE4 inhibitor GSK-256066 as inhibitors of PDEB1 of Trypanosoma brucei.BDB Northeastern University
19351113 30 Discovery of 2-(2-chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one (PF-514273), a novel, bicyclic lactam-based cannabinoid-1 receptor antagonist for the treatment of obesity.BDB Pfizer Inc
16275085 29 Synthesis and biological evaluation of biphenylsulfonamide carboxylate aggrecanase-1 inhibitors.BDB Wyeth Research
16759091 28 Discovery of a novel family of SARS-CoV protease inhibitors by virtual screening and 3D-QSAR studies.BDB National Tsing Hua University