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477 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
28253618 104 Discovery of Benzenesulfonamides with Potent Human Carbonic Anhydrase Inhibitory and Effective Anticonvulsant Action: Design, Synthesis, and Pharmacological Assessment.EBI University of Delhi
28256371 83 Synthesis of bulky-tailed sulfonamides incorporating pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-1(5H)-yl) moieties and evaluation of their carbonic anhydrases I, II, IV and IX inhibitory effects.EBI University of Wollongong
28161252 64 Synthesis and biological evaluation of cyclic imides incorporating benzenesulfonamide moieties as carbonic anhydrase I, II, IV and IX inhibitors.EBI King Saud University
28025002 80 Sulfonamide inhibition profile of the¿-carbonic anhydrase identified in the genome of the pathogenic bacterium Burkholderia pseudomallei the etiological agent responsible of melioidosis.EBI Istituto di Bioscienze e Biorisorse
25432060 92 Synthesis and carbonic anhydrase isoenzymes I, II, IX, and XII inhibitory effects of dimethoxybromophenol derivatives incorporating cyclopropane moieties.EBI Atat£rk University
28238511 36 Comparison of the anion inhibition profiles of theß- and¿-carbonic anhydrases from the pathogenic bacterium Burkholderia pseudomallei.EBI Istituto di Bioscienze e Biorisorse, CNR
28237553 76 Human carbonic anhydrase inhibitory profile of mono- and bis-sulfonamides synthesized via a direct sulfochlorination of 3- and 4-(hetero)arylisoxazol-5-amine scaffolds.EBI Saint Petersburg State University
28109946 84 Novel indolin-2-one-based sulfonamides as carbonic anhydrase inhibitors: Synthesis, in vitro biological evaluation against carbonic anhydrases isoforms I, II, IV and VII and molecular docking studies.EBI Kafrelsheikh University
28075587 102 Design and Synthesis of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs-CAIs) for the Treatment of Rheumatoid Arthritis.EBI University of Florence
27823879 88 New approach of delivering cytotoxic drugs towards CAIX expressing cells: A concept of dual-target drugs.EBI Maastricht University Medical Centre
1635066 17 Acetazolamide-like carbonic anhydrase inhibitors with topical ocular hypotensive activity.EBI Istituto Chimico Internazionale Dr. G. Rende
3735316 8 N-Substituted sulfonamide carbonic anhydrase inhibitors with topical effects on intraocular pressure.EBI TBA
12565948 120 Modelling of carbonic anhydrase inhibitory activity of sulfonamides using molecular negentropy.EBI A.P.S. University
28111158 100 Synthesis of isoxazole-containing sulfonamides with potent carbonic anhydrase II and VII inhibitory properties.EBI Abant Izzet Baysal University
28065499 84 Benzenesulfonamide bearing imidazothiadiazole and thiazolotriazole scaffolds as potent tumor associated human carbonic anhydrase IX and XII inhibitors.EBI Kurukshetra University
27919611 60 Discovery of 4-sulfamoyl-phenyl-ß-lactams as a new class of potent carbonic anhydrase isoforms I, II, IV and VII inhibitors: The first example of subnanomolar CA IV inhibitors.EBI National Institute of Pharmaceutical Education and Research (NIPER)
27914949 50 Anion inhibition profiles of the¿-carbonic anhydrase from the pathogenic bacterium Burkholderia pseudomallei responsible of melioidosis and highly drug resistant to common antibiotics.EBI Italy; Universit£ degliStudi di Firenze
28057408 44 Dithiocarbamates effectively inhibit theß-carbonic anhydrase from the dandruff-producing fungus Malassezia globosa.EBI Universit£ degli Studi di Firenze
28024887 52 5-Substituted-benzylsulfanyl-thiophene-2-sulfonamides with effective carbonic anhydrase inhibitory activity: Solution and crystallographic investigations.EBI Riga Technical University
27939347 52 Coumarins and other fused bicyclic heterocycles with selective tumor-associated carbonic anhydrase isoforms inhibitory activity.EBI Universit£ degli Studi di Firenze
27876475 68 Microwave assisted synthesis of novel tetrazole/sulfonamide derivatives based on octahydroacridine, xanthene and chromene skeletons as inhibitors of the carbonic anhydrases isoforms I, II, IV and VII.EBI Dumlupinar University
27884694 16 Synthesis and carbonic anhydrase inhibitory properties of novel chalcone substituted benzenesulfonamides.EBI Giresun University
27982595 1 When Does Chemical Elaboration Induce a Ligand To Change Its Binding Mode?EBI Fox Chase Cancer Center
27933963 60 Benzenesulfonamides Incorporating Flexible Triazole Moieties Are Highly Effective Carbonic Anhydrase Inhibitors: Synthesis and Kinetic, Crystallographic, Computational, and Intraocular Pressure Lowering Investigations.EBI Universit£ degli Studi di Firenze
27396930 48 Synthesis 4-[2-(2-mercapto-4-oxo-4H-quinazolin-3-yl)-ethyl]-benzenesulfonamides with subnanomolar carbonic anhydrase II and XII inhibitory properties.EBI Universit£ degli Studi di Firenze
27469982 6 Bortezomib inhibits bacterial and fungalß-carbonic anhydrases.EBI Universit£ degli Studi di Firenze
27144971 60 PEGylated Bis-Sulfonamide Carbonic Anhydrase Inhibitors Can Efficiently Control the Growth of Several Carbonic Anhydrase IX-Expressing Carcinomas.EBI Temple University School of Pharmacy
27290692 18 N-Nitrosulfonamides: A new chemotype for carbonic anhydrase inhibition.EBI Universit£ degli Studi di Firenze
27172398 20 An Unusual Natural Product Primary Sulfonamide: Synthesis, Carbonic Anhydrase Inhibition, and Protein X-ray Structures of Psammaplin C.EBI Griffith University
26700575 14 Kinetic and Structural Insights into the Mechanism of Binding of Sulfonamides to Human Carbonic Anhydrase by Computational and Experimental Studies.EBI Istituto Italiano di Tecnologia
27316543 24 Kinetic and X-ray crystallographic investigations of substituted 2-thio-6-oxo-1,6-dihydropyrimidine-benzenesulfonamides acting as carbonic anhydrase inhibitors.EBI Universit£ degli Studi di Firenze
27298005 92 Microwave assisted synthesis of novel acridine-acetazolamide conjugates and investigation of their inhibition effects on human carbonic anhydrase isoforms hCA I, II, IV and VII.EBI Dumlupinar University
27234893 36 Synthesis of 4-(thiazol-2-ylamino)-benzenesulfonamides with carbonic anhydrase I, II and IX inhibitory activity and cytotoxic effects against breast cancer cell lines.EBI Cairo University
27166574 52 Pyrazolylbenzo[d]imidazoles as new potent and selective inhibitors of carbonic anhydrase isoforms hCA IX and XII.EBI Kurukshetra University
27137360 100 Novel sulfonamide bearing coumarin scaffolds as selective inhibitors of tumor associated carbonic anhydrase isoforms IX and XII.EBI Kurukshetra University
26805033 426 Kinetically Selective Inhibitors of Human Carbonic Anhydrase Isozymes I, II, VII, IX, XII, and XIII.EBI Uppsala University
27068142 79 Acetylcholinesterase and carbonic anhydrase inhibitory properties of novel urea and sulfamide derivatives incorporating dopaminergic 2-aminotetralin scaffolds.EBI Erzurum Technical University
26972117 48 Comparison of the sulfonamide inhibition profiles of thea-,ß- and¿-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.EBI Universit£ degli Studi di Firenze
26951893 96 Isatin analogs as novel inhibitors of Candida spp.ß-carbonic anhydrase enzymes.EBI Bezmialem Vakif University
26920803 80 Sulfonamide inhibition studies of theß-carbonic anhydrase from the newly discovered bacterium Enterobacter sp. B13.EBI Recep Tayyip Erdogan University
26875933 72 Development of 3-(4-aminosulphonyl)-phenyl-2-mercapto-3H-quinazolin-4-ones as inhibitors of carbonic anhydrase isoforms involved in tumorigenesis and glaucoma.EBI DAIS
26853167 52 Anion inhibition studies of theß-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.EBI Universit£ degli Studi di Firenze
26840366 72 Amido/ureidosubstituted benzenesulfonamides-isatin conjugates as low nanomolar/subnanomolar inhibitors of the tumor-associated carbonic anhydrase isoform XII.EBI Egyptian Russian University
26832216 41 Sulfonamide inhibition studies of the¿-carbonic anhydrase from the Antarctic bacterium Colwellia psychrerythraea.EBI Universit£ degli Studi di Firenze
26741028 100 4-Arylbenzenesulfonamides as Human Carbonic Anhydrase Inhibitors (hCAIs): Synthesis by Pd Nanocatalyst-Mediated Suzuki-Miyaura Reaction, Enzyme Inhibition, and X-ray Crystallographic Studies.EBI Universit£ de Reims Champagne-Ardenne
26700752 46 Novel Small Molecule Inhibitors of Choline Kinase Identified by Fragment-Based Drug Discovery.EBI ARIAD Pharmaceuticals, Inc.
26850377 80 Sulfonamide inhibition studies of theß-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.EBI Universit£ degli Studi di Firenze
26810836 28 Kinetic and X-ray crystallographic investigations on carbonic anhydrase isoforms I, II, IX and XII of a thioureido analog of SLC-0111.EBI University of Florida College of Medicine
26810710 116 A novel library of saccharin and acesulfame derivatives as potent and selective inhibitors of carbonic anhydrase IX and XII isoforms.EBI 'G. D'Annunzio' University of Chieti-Pescara
26804228 28 Pyridazinone substituted benzenesulfonamides as potent carbonic anhydrase inhibitors.EBI Jamia Hamdard (Hamdard University)
26688270 104 Thioxocoumarins Show an Alternative Carbonic Anhydrase Inhibition Mechanism Compared to Coumarins.EBI Universit£ degli Studi di Firenze
26803577 92 Synthesis of 4-sulfamoylphenyl-benzylamine derivatives with inhibitory activity against human carbonic anhydrase isoforms I, II, IX and XII.EBI Harran University
26611920 50 Optimization of allosteric MEK inhibitors. Part 2: Taming the sulfamide group balances compound distribution properties.EBI Bayer HealthCare AG
26691758 160 Sulfonamide inhibition studies of thea-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA.EBI Universit£ degli Studi di Firenze
26520662 45 Interaction of carbonic anhydrase isozymes I, II, and IX with some pyridine and phenol hydrazinecarbothioamide derivatives.EBI Balikesir University
26497049 110 Discovery of 1,1'-Biphenyl-4-sulfonamides as a New Class of Potent and Selective Carbonic Anhydrase XIV Inhibitors.EBI Sapienza Universit£ di Roma
26498394 105 Inhibition of mammalian carbonic anhydrase isoforms I-XIV with a series of phenolic acid esters.EBI Universit£ degli Studi di Firenze
26408817 69 Isatin-pyrazole benzenesulfonamide hybrids potently inhibit tumor-associated carbonic anhydrase isoforms IX and XII.EBI Egyptian Russian University
26534780 22 Carbonic anhydrase inhibitors: Design, synthesis, kinetic, docking and molecular dynamics analysis of novel glycine and phenylalanine sulfonamide derivatives.EBI Gebze Technical University
26498393 116 New natural product carbonic anhydrase inhibitors incorporating phenol moieties.EBI Aristotle University of Thessaloniki
26432607 60 Click-tailed coumarins with potent and selective inhibitory action against the tumor-associated carbonic anhydrases IX and XII.EBI Universit£ degli Studi di Firenze
26422787 68 Synthesis of novel acridine bis-sulfonamides with effective inhibitory activity against the carbonic anhydrase isoforms I, II, IX and XII.EBI Dumlupinar University
25998503 12 Activity and anion inhibition studies of thea-carbonic anhydrase from Thiomicrospira crunogena XCL-2 Gammaproteobacterium.EBI University of Florida
25992880 90 Discovery and Development of the Aryl O-Sulfamate Pharmacophore for Oncology and Women's Health.EBI University of Bath
26347950 32 Phosphate Chemical Probes Designed for Location Specific Inhibition of Intracellular Carbonic Anhydrases.EBI Griffith University
26319622 12 Cyclodextrin complexation highly enhances efficacy of arylsulfonylureido benzenesulfonamide carbonic anhydrase inhibitors as a topical antiglaucoma agents.EBI Universit£ degli Studi di Firenze
26276436 45 Carbonic anhydrase inhibitors: Design, synthesis and structural characterization of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms.EBI Universit£ degli Studi di Messina
26233435 76 Synthesis of sulfonamides incorporating piperazinyl-ureido moieties and their carbonic anhydrase I, II, IX and XII inhibitory activity.EBI University of Cagliari
26264840 104 Exploring new Probenecid-based carbonic anhydrase inhibitors: Synthesis, biological evaluation and docking studies.EBI 'G. D'Annunzio' University of Chieti-Pescara
26160114 101 Probing the 'bipolar' nature of the carbonic anhydrase active site: aromatic sulfonamides containing 1,3-oxazol-5-yl moiety as picomolar inhibitors of cytosolic CA I and CA II isoforms.EBI Saint Petersburg State University
26191373 52 Carbonic Anhydrase Glycoinhibitors belonging to the Aminoxysulfonamide Series.EBI Institut des Biomol£cules Max Mousseron (IBMM) UMR 5247 CNRS-ENSCM-Universit£ de Montpellier
26174556 41 Sulfonamide inhibition studies of the¿-carbonic anhydrase from the Antarctic bacterium Pseudoalteromonas haloplanktis.EBI Universit£ degli Studi di Firenze
26115571 38 Cyclin dependent kinase (CDK) inhibitors as anticancer drugs.EBI Eli Lilly and Company
26233796 68 Synthesis and carbonic anhydrase I, II, IX and XII inhibitory activity of sulfamates incorporating piperazinyl-ureido moieties.EBI University of Cagliari
26203869 18 Mapping Selective Inhibition of the Cancer-Related Carbonic Anhydrase IX Using Structure-Activity Relationships of Glucosyl-Based Sulfamates.EBI University of Florida
26105196 52 Sulfonamide bearing pyrazolylpyrazolines as potent inhibitors of carbonic anhydrase isoforms I, II, IX and XII.EBI Kurukshetra University
26073006 56 New 4-[(3-cyclohexyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzene-1-sulfonamides, synthesis and inhibitory activity toward carbonic anhydrase I, II, IX, XII.EBI University of Cagliari
26073005 18 Synthesis and carbonic anhydrase inhibitory properties of novel uracil derivatives.EBI AgriIbrahim£e£en University
26068018 76 Structure and inhibition studies of a type II beta-carbonic anhydrase psCA3 from Pseudomonas aeruginosa.EBI University of Florida
25168748 37 Anion inhibition study of theß-class carbonic anhydrase (PgiCAb) from the oral pathogen Porphyromonas gingivalis.EBI Universit£ degli Studi di Firenze
25168745 64 Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum--the¿-carbonic anhydrases.EBI Istituto di Bioscienze e Biorisorse (IBBR)-CNR
26145820 47 Cloning, characterization and anion inhibition studies of a new¿-carbonic anhydrase from the Antarctic bacterium Pseudoalteromonas haloplanktis.EBI Istituto di Bioscienze e Biorisorse
26048024 84 Design and synthesis of benzothiazole-6-sulfonamides acting as highly potent inhibitors of carbonic anhydrase isoforms I, II, IX and XII.EBI Jazan University
26088336 96 5-Aryl-1H-pyrazole-3-carboxylic acids as selective inhibitors of human carbonic anhydrases IX and XII.EBI University of Belgrade
25921269 45 Discovery of potent carbonic anhydrase and acetylcholine esterase inhibitors: novel sulfamoylcarbamates and sulfamides derived from acetophenones.EBI AgriIbrahim£e£en University
25921266 48 New pyrazolo[4,3-e][1,2,4]triazine sulfonamides as carbonic anhydrase inhibitors.EBI Siedlce University of Natural Sciences and Humanities
26007302 56 New amide derivatives of Probenecid as selective inhibitors of carbonic anhydrase IX and XII: biological evaluation and molecular modelling studies.EBI University of Chieti-Pescara
26005525 5 Design and Validation of FRESH, a Drug Discovery Paradigm Resting on Robust Chemical Synthesis.EBI Emory University
25875209 60 6-Substituted sulfocoumarins are selective carbonic anhdydrase IX and XII inhibitors with significant cytotoxicity against colorectal cancer cells.EBI Latvian Institute of Organic Synthesis
25815148 10 a-Carbonic Anhydrases Possess Thioesterase Activity.EBI Universit£ degli Studi di Firenze
25913118 95 Synthesis of Schiff base derivatives of 4-(2-aminoethyl)-benzenesulfonamide with inhibitory activity against carbonic anhydrase isoforms I, II, IX and XII.EBI Harran University
25912674 52 Synthesis, carbonic anhydrase inhibition and cytotoxic activity of novel chromone-based sulfonamide derivatives.EBI Cairo University
25728019 16 Design, synthesis, and evaluation of NO-donor containing carbonic anhydrase inhibitors to lower intraocular pressure.EBI Pfizer Inc.
25581127 14 Carbonic anhydrase inhibitors with dual-tail moieties to match the hydrophobic and hydrophilic halves of the carbonic anhydrase active site.EBI Griffith University
25553540 6 1,3,4-Thiadiazoles: a potent multi targeted pharmacological scaffold.EBI University of Mississippi
25882523 120 Theß-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides.EBI University of Tampere and Tampere University Hospital
25863492 44 N-Acylsulfonamides strongly inhibit human carbonic anhydrase isoenzymes I and II.EBI Atat£rk University
25846066 88 Synthesis of a new series of dithiocarbamates with effective human carbonic anhydrase inhibitory activity and antiglaucoma action.EBI Universit£ degli Studi di Firenze
25773015 80 Sulfonamide inhibition studies of the¿-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune.EBI Universit£ degliStudi di Firenze
25766630 100 A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects.EBI Universit£ degli Studi di Firenze
25757603 79 New approaches to the synthesis of sildenafil analogues and their enzyme inhibitory activity.EBI Siedlce University of Natural Sciences and Humanities
25753329 56 Synthesis of 6-aryl-substituted sulfocoumarins and investigation of their carbonic anhydrase inhibitory action.EBI Latvian Institute of Organic Synthesis
25533402 76 Sulfonamide inhibition studies of the¿-class carbonic anhydrase from the malaria pathogen Plasmodium falciparum.EBI Universit£ degli Studi di Firenze
25147616 92 Carbonic Anhydrase Inhibition with Benzenesulfonamides and Tetrafluorobenzenesulfonamides Obtained via Click Chemistry.EBI Universit£ di Sassari
25129169 80 Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: theß-class (PgiCAb) versus the¿-class (PgiCA) enzymes.EBI Istituto di Biochimica delle Proteine - CNR
25116076 14 Exploring the influence of the protein environment on metal-binding pharmacophores.EBI University of California
25050173 42 Sulfonamides with Potent Inhibitory Action and Selectivity against thea-Carbonic Anhydrase from Vibrio cholerae.EBI Universit£ degli Studi di Firenze
25050167 40 Carbonic anhydrase inhibitors: design, synthesis, and biological evaluation of novel sulfonyl semicarbazide derivatives.EBI Bharati Vidyapeeth's College of Pharmacy
25027802 56 Selective inhibition of human carbonic anhydrases by novel amide derivatives of probenecid: synthesis, biological evaluation and molecular modelling studies.EBI Sapienza University of Rome
25022971 124 Furazan and furoxan sulfonamides are stronga-carbonic anhydrase inhibitors and potential antiglaucoma agents.EBI Universit£ degli Studi di Torino
25019479 96 Cyclic tertiary sulfamates: selective inhibition of the tumor-associated carbonic anhydrases IX and XII by N- and O-substituted acesulfame derivatives.EBI Sapienza University of Rome
25011913 42 Synthesis of sulfonamides with effective inhibitory action against Porphyromonas gingivalis¿-carbonic anhydrase.EBI Universit£ degli Studi di Firenze
24948563 44 Flow synthesis and biological activity of aryl sulfonamides as selective carbonic anhydrase IX and XII inhibitors.EBI University of Perugia
25468040 77 Inhibition studies of new ureido-substituted sulfonamides incorporating a GABA moiety against human carbonic anhydrase isoforms I-XIV.EBI TBA
25456084 100 4-Functionalized 1,3-diarylpyrazoles bearing 6-aminosulfonylbenzothiazole moiety as potent inhibitors of carbonic anhydrase isoforms hCA I, II, IX and XII.EBI Kurukshetra University
25442309 120 Carbonic anhydrase inhibitory activity of sulfonamides and carboxylic acids incorporating cyclic imide scaffolds.EBI King Saud University
25438758 44 Ferrier sulfamidoglycosylation of glycals catalyzed by nitrosonium tetrafluoroborate: towards new carbonic anhydrase glycoinhibitors.EBI Ecole Nationale Sup£rieure de Chimie de Montpellier
25358084 143 Discovery and characterization of novel selective inhibitors of carbonic anhydrase IX.EBI Vilnius University
25358036 64 A class of 4-sulfamoylphenyl-¿-aminoalkyl ethers with effective carbonic anhydrase inhibitory action and antiglaucoma effects.EBI Universit£ degli Studi di Firenze
25310626 80 Structural insights on carbonic anhydrase inhibitory action, isoform selectivity, and potency of sulfonamides and coumarins incorporating arylsulfonylureido groups.EBI Universit£ degli Studi di Firenze
25267005 70 Inhibition of carbonic anhydrase isoforms I, II, IX and XII with novel Schiff bases: identification of selective inhibitors for the tumor-associated isoforms over the cytosolic ones.EBI Universit£ degli Studi di Firenze
25255434 84 Novel sulfonamides bearing pyrrole and pyrrolopyrimidine moieties as carbonic anhydrase inhibitors: Synthesis, cytotoxic activity and molecular modeling.EBI King Saud University
25254302 44 Structural insights into carbonic anhydrase IX isoform specificity of carbohydrate-based sulfamates.EBI Griffith University
25245672 5 Substituted thieno[2,3-b]thiophenes and related congeners: Synthesis,ß-glucuronidase inhibition activity, crystal structure, and POM analyses.EBI King Saud University
25194929 28 Quinazoline-sulfonamides with potent inhibitory activity against thea-carbonic anhydrase from Vibrio cholerae.EBI Salman Bin Abdulaziz University
25156300 48 Attachment of carbohydrates to methoxyaryl moieties leads to highly selective inhibitors of the cancer associated carbonic anhydrase isoforms IX and XII.EBI Universidad Nacional de La Plata
24878360 76 Carbonic anhydrase inhibitors: Synthesis, molecular docking, cytotoxic and inhibition of the human carbonic anhydrase isoforms I, II, IX, XII with novel benzenesulfonamides incorporating pyrrole, pyrrolopyrimidine and fused pyrrolopyrimidine moieties.EBI King Saud University
24871996 124 Carbonic anhydrase inhibitors. Synthesis of a novel series of 5-substituted 2,4-dichlorobenzenesulfonamides and their inhibition of human cytosolic isozymes I and II and the transmembrane tumor-associated isozymes IX and XII.EBI Medical University of Gdansk
24856184 24 Oxidation of cyanobenzocycloheptatrienes: Synthesis, photooxygenation reaction and carbonic anhydrase isoenzymes inhibition properties of some new benzotropone derivatives.EBI AgriIbrahim£e£en University
24813742 98 Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors.EBI Universit£ degli Studi
24792813 80 Sulfonamide inhibition studies of twoß-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.EBI Kochi Medical School
24746465 90 Carbonic anhydrase inhibitors. Inhibition of human cytosolic isoforms I and II with (reduced) Schiff's bases incorporating sulfonamide, carboxylate and carboxymethyl moieties.EBI ENSCM/UMII/UMR-CNRS 5635
24713308 48 Pyrazolo[4,3-e][1,2,4]triazine sulfonamides as carbonic anhydrase inhibitors with antitumor activity.EBI Siedlce University of Natural Sciences and Humanities
24589511 60 Synthesis and carbonic anhydrase I, II, IX and XII inhibition studies of 4-N,N-disubstituted sulfanilamides incorporating 4,4,4-trifluoro-3-oxo-but-1-enyl, phenacylthiourea and imidazol-2(3H)-one/thione moieties.EBI University of Cagliari
24689792 54 Cyclic secondary sulfonamides: unusually good inhibitors of cancer-related carbonic anhydrase enzymes.EBI Griffith University
24650641 110 Arylamino bisphosphonates: potent and selective inhibitors of the tumor-associated carbonic anhydrase XII.EBI Universit£ degli Studi 'Aldo Moro' di Bari
23664215 45 Discovery of new potent inhibitors for carbonic anhydrase IX by structure-based virtual screening.EBI East China University of Science and Technology
23647428 84 Xanthates and trithiocarbonates strongly inhibit carbonic anhydrases and show antiglaucoma effects in vivo.EBI Universit£ degli Studi di Firenze
22883029 80 The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides.EBI Universit£ degli Studi di Firenze
23490152 15 Structural effect of phenyl ring compared to thiadiazole based adamantyl-sulfonamides on carbonic anhydrase inhibition.EBI University of Florida
23429054 48 Optimization of heterocyclic substituted benzenesulfonamides as novel carbonic anhydrase IX inhibitors and their structure activity relationship.EBI East China University of Science and Technology
23414807 70 Anion inhibition studies of thea-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.EBI Universit£ degli Studi di Firenze
23414801 38 Kinetic and anion inhibition studies of aß-carbonic anhydrase (FbiCA 1) from the C4 plant Flaveria bidentis.EBI Istituto di Biostrutture e Bioimmagini
23394864 16 Novel sulfamides as potential carbonic anhydrase isoenzymes inhibitors.EBI Atat£rk University
23394791 177 4-Substituted-2,3,5,6-tetrafluorobenzenesulfonamides as inhibitors of carbonic anhydrases I, II, VII, XII, and XIII.EBI Vilnius University Institute of Biotechnology
23352754 28 o-Benzenedisulfonimido-sulfonamides are potent inhibitors of the tumor-associated carbonic anhydrase isoforms CA IX and CA XII.EBI Istanbul University
23290254 92 Carbonic anhydrase inhibitors: benzenesulfonamides incorporating cyanoacrylamide moieties are low nanomolar/subnanomolar inhibitors of the tumor-associated isoforms IX and XII.EBI Salman Bin Abdulaziz University
23266178 115 Inhibition pattern of sulfamide-related compounds in binding to carbonic anhydrase isoforms I, II, VII, XII and XIV.EBI National University of La Plata
23206986 259 QSAR studies of sulfamate and sulfamide inhibitors targeting human carbonic anhydrase isozymes I, II, IX and XII.EBI Romanian Academy
23199483 25 Glycosidic carbonic anhydrase IX inhibitors: a sweet approach against cancer.EBI Ecole Nationale Sup£rieure de Chimie de Montpellier
23168081 72 New selective carbonic anhydrase IX inhibitors: synthesis and pharmacological evaluation of diarylpyrazole-benzenesulfonamides.EBI Univ. Lille Nord de France
23121721 6 Synthesis of 1,4-bis(indolin-1-ylmethyl)benzene derivatives and their structure-activity relationships for the interaction of human carbonic anhydrase isoforms I and II.EBI Karamanoglu Mehmetbey University
23078755 14 Ana-carbonic anhydrase from the thermophilic bacterium Sulphurihydrogenibium azorense is the fastest enzyme known for the CO2 hydration reaction.EBI Istituto di Biochimica delle Proteine (IBP)
23018095 36 Salicylaldoxime derivatives as new leads for the development of carbonic anhydrase inhibitors.EBI Universit£ degli Studi di Pisa
23010455 108 Synthesis of C-cinnamoyl glycosides and their inhibitory activity against mammalian carbonic anhydrases.EBI Universidad Nacional de La Plata
22974493 13 Purification and characterization of carbonic anhydrase from sheep kidney and effects of sulfonamides on enzyme activity.EBI Agri Ibrahim Cecen University
22892213 168 Natural product coumarins that inhibit human carbonic anhydrases.EBI Griffith University
22705188 73 Superacid synthesis of halogen containing N-substituted-4-aminobenzene sulfonamides: new selective tumor-associated carbonic anhydrase inhibitors.EBI Superacide et Chimie des syst£mes£ team-Universit£ de Poitiers
22668600 200 Mono-/dihydroxybenzoic acid esters and phenol pyridinium derivatives as inhibitors of the mammalian carbonic anhydrase isoforms I, II, VII, IX, XII and XIV.EBI Universit£ degli Studi di Firenze
23391336 80 Cloning, characterization, and sulfonamide and thiol inhibition studies of ana-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease.EBI University of Tampere and Tampere University Hospital
23265903 9 Inhibition of theß-carbonic anhydrases from Mycobacterium tuberculosis with C-cinnamoyl glycosides: identification of the first inhibitor with anti-mycobacterial activity.EBI Universidad Nacional de Rosario
23265898 20 Novel small molecule protein arginine deiminase 4 (PAD4) inhibitors.EBI Universit£ degli Studi di Firenze
23241068 84 Sulfocoumarins (1,2-benzoxathiine-2,2-dioxides): a class of potent and isoform-selective inhibitors of tumor-associated carbonic anhydrases.EBI Latvian Association of Human Genetics
23218470 24 Facile synthesis and characterization of novel pyrazole-sulfonamides and their inhibition effects on human carbonic anhydrase isoenzymes.EBI Dumlupinar University
23200251 44 Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition.EBI Kochi Medical School
21130650 42 Correlation analyses on binding affinity of substituted benzenesulfonamides with carbonic anhydrase using ab initio MO calculations on their complex structures (II).EBI The University of Tokushima Graduate School
20443227 37 3D-QSAR study of benzene sulfonamide analogs as carbonic anhydrase II inhibitors.EBI GITAM University
1920359 40 Topically active carbonic anhydrase inhibitors. 4. [(Hydroxyalkyl)sulfonyl]benzene and [(hydroxyalkyl)sulfonyl]thiophenesulfonamides.EBI Merck Sharp& Dohme Research Laboratories
2299640 23 Topically active carbonic anhydrase inhibitors. 3. Benzofuran- and indole-2-sulfonamides.EBI Merck Sharp and Dohme Research Laboratories
2585443 32 Topically active carbonic anhydrase inhibitors. 2. Benzo[b]thiophenesulfonamide derivatives with ocular hypotensive activity.EBI Merck Sharp& Dohme Research Laboratories
2810337 41 Topically active carbonic anhydrase inhibitors. 1. O-acyl derivatives of 6-hydroxybenzothiazole-2-sulfonamide.EBI Merck Sharp& Dohme Research Laboratory
23072866 72 Anion inhibition studies of the fastest carbonic anhydrase (CA) known, the extremo-CA from the bacterium Sulfurihydrogenibium azorense.EBI Universit£ degli Studi di Firenze
21413808 170 Synopsis of some recent tactical application of bioisosteres in drug design.EBI Bristol-Myers Squibb Pharmaceutical Research and Development
22910138 96 Carbonic anhydrase inhibitors. Regioselective synthesis of novel series 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XII.EBI TBA
23181552 10 DNA cloning, characterization, and inhibition studies of ana-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.EBI Istituto di Biochimica delle Proteine-CNR
23176597 14 Structure-activity relationships and blood distribution of antiplasmodial aminopeptidase-1 inhibitors.EBI INSERM
23067387 105 Tricyclic sulfonamides incorporating benzothiopyrano[4,3-c]pyrazole and pyridothiopyrano[4,3-c]pyrazole effectively inhibita- andß-carbonic anhydrase: X-ray crystallography and solution investigations on 15 isoforms.EBI Universit£ di Pisa
22894736 99 Carbamoylphosphonates control tumor cell proliferation and dissemination by simultaneously inhibiting carbonic anhydrase IX and matrix metalloproteinase-2. Toward nontoxic chemotherapy targeting tumor microenvironment.EBI The Hebrew University of Jerusalem
21354674 14 The many faces of the adamantyl group in drug design.EBI University of Sydney
22775345 74 Development of potent carbonic anhydrase inhibitors incorporating both sulfonamide and sulfamide groups.EBI Istituto di Biostrutture e Bioimmagini-CNR
22621623 44 Antimetastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts.EBI University of Manchester
22901388 76 Inhibition ofa-class cytosolic human carbonic anhydrases I, II, IX and XII, andß-class fungal enzymes by carboxylic acids and their derivatives: new isoform-I selective nanomolar inhibitors.EBI Universit£ di Sassari
22721713 200 Ureido-substituted sulfamates show potent carbonic anhydrase IX inhibitory and antiproliferative activities against breast cancer cell lines.EBI Ecole Nationale Sup£rieure de Chimie de Montpellier
22443141 115 Synthesis, structure-activity relationship studies, and X-ray crystallographic analysis of arylsulfonamides as potent carbonic anhydrase inhibitors.EBI Universit£ di Messina
22424239 42 Molecular cloning, characterization, and inhibition studies of aß-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.EBI Union Life Sciences Ltd.
22687439 51 Synthesis and carbonic anhydrase inhibitory properties of novel bromophenols and their derivatives including natural products: vidalol B.EBI Atat£rk University
22276570 112 Dithiocarbamates strongly inhibit carbonic anhydrases and show antiglaucoma action in vivo.EBI Universit£ degli Studi di Firenze
22487176 109 Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins.EBI Universit£ degli Studi di Cagliari
22440859 176 Design of [(2-pyrimidinylthio)acetyl]benzenesulfonamides as inhibitors of human carbonic anhydrases.EBI Vilnius University
21211980 47 Characterization and anions inhibition studies of ana-carbonic anhydrase from the teleost fish Dicentrarchus labrax.EBI Ondokuz Mayis University
20580561 33 Pteridine-sulfonamide conjugates as dual inhibitors of carbonic anhydrases and dihydrofolate reductase with potential antitumor activity.EBI Instituto Superior T£cnico
20674354 79 Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV.EBI Universit£ degli Studi di Firenze
20605094 91 Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors.EBI University of Florida
20598552 24 Coumarinyl-substituted sulfonamides strongly inhibit several human carbonic anhydrase isoforms: solution and crystallographic investigations.EBI University of Florida
20478708 28 New hydroxypyrimidinone-containing sulfonamides as carbonic anhydrase inhibitors also acting as MMP inhibitors.EBI LNEG
20472429 80 Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.EBI Istituto di Biostrutture e Bioimmagini-CNR
20363633 67 Thioether benzenesulfonamide inhibitors of carbonic anhydrases II and IV: structure-based drug design, synthesis, and biological evaluation.EBI Pfizer Global Research and Development
20201556 174 Sulfonamide linked neoglycoconjugates--a new class of inhibitors for cancer-associated carbonic anhydrases.EBI Griffith University
19388676 21 Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies.EBI Johnson& Johnson Pharmaceutical Research& Development
20006931 18 Synthesis, characterization and antiglaucoma activity of a novel proton transfer compound and a mixed-ligand Zn(II) complex.EBI Dumlupinar University
20185318 132 Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.EBI Universit£ degli Studi di Firenze
20148564 60 Highly potent first examples of dual aromatase-steroid sulfatase inhibitors based on a biphenyl template.EBI University of Bath
19911821 273 Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.EBI Universita degli Studi di Firenze
19854054 18 Nitric oxide-donating carbonic anhydrase inhibitors for the treatment of open-angle glaucoma.EBI NicOx Research Institute
19651511 62 Carbonic anhydrase inhibitors. Inhibition of the Rv1284 and Rv3273 beta-carbonic anhydrases from Mycobacterium tuberculosis with diazenylbenzenesulfonamides.EBI Universit£ degli Studi di Firenze
20028100 78 The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors.EBI Universit£ degli Studi di Firenze
19846301 75 Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c.EBI Universit£ degli Studi di Firenze
19827837 52 S-glycosyl primary sulfonamides--a new structural class for selective inhibition of cancer-associated carbonic anhydrases.EBI Griffith University
19520577 111 Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides.EBI MC-98000 Princ
19398204 44 Synthesis and evaluation of pharmacological profile of 1-aryl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamides.EBI Universit£ di Messina
19286378 75 Inhibition of carbonic anhydrase isozymes with benzene sulfonamides incorporating thio, sulfinyl and sulfonyl glycoside moieties.EBI Griffith University
19269822 75 Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I, II, III, VII and XIII with less investigated inorganic anions.EBI Universit£ degli Studi di Firenze
19186056 60 A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.EBI Universit£ degli Studi di Firenze
19124253 111 Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates.EBI Balikesir University
18990571 65 Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV.EBI Ecole Nationale Sup£rieure de Chimie de Montpellier
18644716 52 Inhibition of human mitochondrial carbonic anhydrases VA and VB with para-(4-phenyltriazole-1-yl)-benzenesulfonamide derivatives.EBI Griffith University
18513964 45 Carbonic anhydrase inhibitors: design of spin-labeled sulfonamides incorporating TEMPO moieties as probes for cytosolic or transmembrane isozymes.EBI Universit£ degli Studi di Firenze
18501600 33 Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols.EBI Universit£ degli Studi di Firenze
18363349 53 Carbonic anhydrase-II inhibition. what are the true enzyme-inhibitory properties of the sulfamide cognate of topiramate?EBI Johnson& Johnson Pharmaceutical Research& Development
18359629 84 Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.EBI Istituto di Biostrutture e Bioimmagini-CNR
18042384 60 Carbonic anhydrase inhibitors: copper(II) complexes of polyamino-polycarboxylamido aromatic/heterocyclic sulfonamides are very potent inhibitors of the tumor-associated isoforms IX and XII.EBI Ecole Nationale Sup£rieure de Chimie de Montpellier
18260615 8 Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents.EBI University of Bath
18307288 70 Inhibition of carbonic anhydrases with glycosyltriazole benzene sulfonamides.EBI Griffith University
17475500 130 Carbonic anhydrases as targets for medicinal chemistry.EBI Universit£ degli Studi di Firenze
17826101 41 Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides.EBI Kochi Medical School
17681760 21 Inhibition of carbonic anhydrase isozymes I, II and IX with benzenesulfonamides containing an organometallic moiety.EBI Griffith University
17420132 4 Molecular modeling study for the binding of zonisamide and topiramate to the human mitochondrial carbonic anhydrase isoform VA.EBI Istituto di Biostrutture e Bioimmagini-CNR
17376683 63 Carbonic anhydrase inhibitors. Inhibition of isoforms I, II, IV, VA, VII, IX, and XIV with sulfonamides incorporating fructopyranose-thioureido tails.EBI Ecole Nationale Sup£rieure de Chimie de Montpellier
17314045 11 Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I.EBI Universit£ degli Studi di Firenze
17276072 95 Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with sulfonylated hydroxamates.EBI Universit£ di Pisa
17228881 141 Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.EBI Kochi Medical School
16759092 25 Inhibition of carbonic anhydrase-II by sulfamate and sulfamide groups: an investigation involving direct thermodynamic binding measurements.EBI Johnson& Johnson Pharmaceutical Research& Development
16459077 105 Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori.EBI Kochi Medical School
16290146 30 Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II"selective" inhibitor celecoxib.EBI Istituto di Biostrutture e Bioimmagini-CNR
16203142 55 Carbonic anhydrase inhibitors: inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides.EBI Universit£ degli Studi di Firenze
16220969 219 Designed multiple ligands. An emerging drug discovery paradigm.EBI Organon Laboratories
15771438 19 Comparison of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-II by using topiramate as a structural platform.EBI Johnson& Johnson Pharmaceutical Research& Development
15456265 52 Carbonic anhydrase inhibitors: the first on-resin screening of a 4-sulfamoylphenylthiourea library.EBI University of Florence
15837324 30 Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxysulfamides--a new zinc-binding function in the design of inhibitors.EBI Universit£ degli Studi di Firenze
15837316 6 Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies.EBI University of Naples Federico II
15686895 112 Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.EBI Universit£ degli Studi di Firenze
15686894 101 Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?EBI Universit£ degli Studi di Firenze
15686931 84 Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.EBI Universit£ degli Studi di Firenze
15664816 65 Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates.EBI Universit£ degli Studi di Firenze
15664814 55 Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.EBI Universit£ degli Studi di Firenze
15603956 63 Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX.EBI Harran University
16039848 93 Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.EBI Kochi Medical School
16039853 89 Carbonic anhydrase inhibitors: design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma.EBI Universita degli Studi
15905091 134 Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX.EBI Universit£ degli Studi di Firenze
15546717 130 Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.EBI Pennsylvania State University
15501040 26 Carbonic anhydrase inhibitors. Design of anticonvulsant sulfonamides incorporating indane moieties.EBI Universit£ Joseph Fourier de Grenoble
15501039 51 Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides derived from 4-isothiocyanato-benzolamide.EBI Universit£ degli Studi di Firenze
15501038 68 Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.EBI Universit£ degli Studi di Firenze
15454240 57 Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.EBI Universit£ degli Studi di Firenze
15454239 74 Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties.EBI Universit£ degli Studi di Firenze
15357993 82 Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions.EBI Universit£ degli Studi di Firenze
15139757 105 Carbonic anhydrase inhibitors: synthesis and topical intraocular pressure lowering effects of fluorine-containing inhibitors devoid of enhanced reactivity.EBI Universit£ degli Studi di Firenze
12747791 91 Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, tumor-associated isozyme IX with sulfamates including EMATE also acting as steroid sulfatase inhibitors.EBI Universit£ Montpellier II
11906288 713 Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.EBI Universit£ degli Studi di Firenze
11784136 100 Carbonic anhydrase inhibitors: anticonvulsant sulfonamides incorporating valproyl and other lipophilic moieties.EBI University of Namur
12166931 13 Nonaromatic sulfonamide group as an ideal anchor for potent human carbonic anhydrase inhibitors: role of hydrogen-bonding networks in ligand binding and drug design.EBI Universit£ degli Studi di Firenze
11123998 141 Carbonic anhydrase inhibitors: water-soluble 4-sulfamoylphenylthioureas as topical intraocular pressure-lowering agents with long-lasting effects.EBI Universit£ degli Studi di Firenze
11087579 465 Carbonic anhydrase inhibitors: perfluoroalkyl/aryl-substituted derivatives of aromatic/heterocyclic sulfonamides as topical intraocular pressure-lowering agents with prolonged duration of action.EBI Universit£ degli Studi di Firenze
10479300 383 Carbonic anhydrase inhibitors: synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route.EBI Universit£ degli Studi
10411484 176 Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?EBI Universit£ degli Studi
7608893 7 Secondary interactions significantly removed from the sulfonamide binding pocket of carbonic anhydrase II influence inhibitor binding constants.EBI University of Pennsylvania
8164249 46 Application of the three-dimensional structures of protein target molecules in structure-based drug design.EBI Abbott Laboratories
8295211 35 3-substituted thieno[2,3-b][1,4]thiazine-6-sulfonamides. A novel class of topically active carbonic anhydrase inhibitors.EBI Merck Research Laboratories
1433194 12 4-substituted thiophene- and furan-2-sulfonamides as topical carbonic anhydrase inhibitors.EBI Merck Research Laboratories
2061922 30 New isomeric classes of topically active ocular hypotensive carbonic anhydrase inhibitors: 5-substituted thieno[2,3-b]thiophene-2-sulfonamides and 5-substituted thieno[3,2-b]thiophene-2-sulfonamides.EBI Merck Sharp and Dohme Research Laboratories
2585439 15 Thienothiopyran-2-sulfonamides: novel topically active carbonic anhydrase inhibitors for the treatment of glaucoma.EBI Merck Sharp and Dohme-Chibret
3560154 15 Thienothiopyran-2-sulfonamides: a novel class of water-soluble carbonic anhydrase inhibitors.EBI TBA
15012984 192 Carbonic anhydrase inhibitors: the first selective, membrane-impermeant inhibitors targeting the tumor-associated isozyme IX.EBI Slovak Academy of Sciences
15081039 68 Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with fluorine-containing sulfonamides. The first subnanomolar CA IX inhibitor discovered.EBI Universit£ degli Studi di Firenze
14698154 26 Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with the antipsychotic drug sulpiride.EBI Bruker-AXS s.r.l.
15203157 68 Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.EBI University of Tampere
14684333 9 Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with EMATE, a dual inhibitor of carbonic anhydrases and steroid sulfatase.EBI Universit£ degli Studi di Firenze
14684332 27 Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-alpha-D-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits.EBI Universit£ Montpellier II
14684331 24 Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX.EBI Universit£ degli Studi di Firenze
12643899 127 Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.EBI Universit£ degli Studi di Firenze
12617909 6 Docking studies of sulphamate inhibitors of estrone sulphatase in human carbonic anhydrase II.EBI University of Bath
12617904 46 Carbonic anhydrase inhibitors: SAR and X-ray crystallographic study for the interaction of sugar sulfamates/sulfamides with isozymes I, II and IV.EBI Universit£ degli Studi di Firenze
12617903 65 Carbonic anhydrase inhibitors: inhibition of cytosolic isozymes I and II with sulfamide derivatives.EBI Universit£ degli Studi di Firenze
14611846 101 Carbonic anhydrase inhibitors: topically acting antiglaucoma sulfonamides incorporating esters and amides of 3- and 4-carboxybenzolamide.EBI Universit£ degli Studi
12039560 377 Carbonic anhydrase inhibitors. Preparation of potent sulfonamides inhibitors incorporating bile acid tails.EBI Universit£ degli Studi di Firenze
11229775 204 Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating dtpa tails and of their zinc complexes with powerful topical antiglaucoma properties.EBI Universit£ degli Studi
11425561 197 Carbonic anhydrase inhibitors: 4-sulfamoyl-benzenecarboxamides and 4-chloro-3-sulfamoyl-benzenecarboxamides with strong topical antiglaucoma properties.EBI Universit£ degli Studi
10762051 66 Carbonic anhydrase inhibitors: topical sulfonamide antiglaucoma agents incorporating secondary amine moieties.EBI Universit£ degli Studi
10843231 129 Carbonic anhydrase inhibitors: synthesis of N-morpholylthiocarbonylsulfenylamino aromatic/heterocyclic sulfonamides and their interaction with isozymes I, II and IV.EBI Universit£ degli Studi
22386980 7 Mutation of active site residues Asn67 to Ile, Gln92 to Val and Leu204 to Ser in human carbonic anhydrase II: influences on the catalytic activity and affinity for inhibitors.EBI Balikesir University
22377674 80 Novel coumarins and 2-thioxo-coumarins as inhibitors of the tumor-associated carbonic anhydrases IX and XII.EBI Universit£ degli Studi di Firenze
22370338 183 Design and synthesis of thiourea compounds that inhibit transmembrane anchored carbonic anhydrases.EBI Griffith University
22365761 144 New chemotypes acting as isozyme-selective carbonic anhydrase inhibitors with low affinity for the offtarget cytosolic isoform II.EBI Universit£ degli Studi di Firenze
22227210 74 Anion inhibition studies of ana-carbonic anhydrase from the living fossil Astrosclera willeyana.EBI Slovak Academy of Sciences
22285172 124 Cloning, characterization and sulfonamide inhibition studies of ana-carbonic anhydrase from the living fossil sponge Astrosclera willeyana.EBI Slovak Academy of Sciences
22245047 135 Structure-activity relationships for the interaction of 5,10-dihydroindeno[1,2-b]indole derivatives with human and bovine carbonic anhydrase isoforms I, II, III, IV and VI.EBI Ondokuz Mayis University
22230050 82 Synthesis and carbonic anhydrase inhibitory properties of novel cyclohexanonyl bromophenol derivatives.EBI Artvin£oruh University
22077347 44 Glycosyl coumarin carbonic anhydrase IX and XII inhibitors strongly attenuate the growth of primary breast tumors.EBI Ecole Nationale Sup£rieure de Chimie de Montpellier
22137345 36 5- and 6-membered (thio)lactones are prodrug type carbonic anhydrase inhibitors.EBI Universit£ degli Studi di Firenze
22041171 44 Synthesis and biological profile of new 1,2,3,4-tetrahydroisoquinolines as selective carbonic anhydrase inhibitors.EBI Universit£ di Messina
21852133 68 Phenylethynylbenzenesulfonamide regioisomers strongly and selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic isoforms I and II.EBI University of Alberta
21851094 92 Targeting hypoxic tumor cell viability with carbohydrate-based carbonic anhydrase IX and XII inhibitors.EBI Griffith University
21821413 65 Synthesis of rhodamine B-benzenesulfonamide conjugates and their inhibitory activity against humana- and bacterial/fungalß-carbonic anhydrases.EBI Ecole Nationale Sup£rieure de Chimie de Montpellier
21820216 75 Carbonic anhydrase inhibitors. Synthesis, molecular structures, and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with novel 3-pyridinesulfonamide derivatives.EBI Medical University of Gdansk
21757360 86 Inhibition studies of theß-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.EBI Kochi Medical School
21515057 153 Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies.EBI Universit£ degli Studi di Firenze
21723123 48 N-ß-glycosyl sulfamides are selective inhibitors of the cancer associated carbonic anhydrase isoforms IX and XII.EBI Universidad Nacional de La Plata
21669522 23 In vitro inhibition ofa-carbonic anhydrase isozymes by some phenolic compounds.EBI Gumushane University
21620713 25 Conformational variability of different sulfonamide inhibitors with thienyl-acetamido moieties attributes to differential binding in the active site of cytosolic human carbonic anhydrase isoforms.EBI University of Florida
21470859 52 Sulfonamides incorporating boroxazolidone moieties are potent inhibitors of the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII.EBI Ecole Nationale Sup£rieure de Chimie de Montpellier
19435663 63 Carbonic anhydrase inhibitors. Phenacetyl-, pyridylacetyl- and thienylacetyl-substituted aromatic sulfonamides act as potent and selective isoform VII inhibitors.EBI Istanbul University
21506569 96 Anticonvulsant 4-aminobenzenesulfonamide derivatives with branched-alkylamide moieties: X-ray crystallography and inhibition studies of human carbonic anhydrase isoforms I, II, VII, and XIV.EBI The Hebrew University of Jerusalem
21570835 78 Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium.EBI Universit£ degli Studi di Firenze
21549597 71 Synthesis and crystallographic analysis of new sulfonamides incorporating NO-donating moieties with potent antiglaucoma action.EBI U.O. Oculistica Az. USL 3
21420862 4 Virtual screening-driven identification of human carbonic anhydrase inhibitors incorporating an original, new pharmacophore.EBI Universit£ di Sassari
21402476 79 Carbonic anhydrase inhibitors. Inhibition of the β-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with branched aliphatic/aromatic carboxylates and their derivatives.EBI Universit£ degli Studi di Firenze
21377369 60 Purification and inhibition studies with anions and sulfonamides of ana-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii.EBI Universit£ degli Studi di Firenze
21361354 112 Ureido-substituted benzenesulfonamides potently inhibit carbonic anhydrase IX and show antimetastatic activity in a model of breast cancer metastasis.EBI Universita` degli Studi di Firenze
21332115 162 Natural product-based phenols as novel probes for mycobacterial and fungal carbonic anhydrases.EBI Griffith University
21314129 76 Design, synthesis, and biological evaluation of novel carbohydrate-based sulfamates as carbonic anhydrase inhibitors.EBI Griffith University
21300547 64 (R)-/(S)-10-camphorsulfonyl-substituted aromatic/heterocyclic sulfonamides selectively inhibit mitochondrial over cytosolic carbonic anhydrases.EBI Universit£ degli Studi di Firenze
21251841 90 A newß-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth.EBI Universit£ Montpellier II
21282059 48 Kinetic and docking studies of phenol-based inhibitors of carbonic anhydrase isoforms I, II, IX and XII evidence a new binding mode within the enzyme active site.EBI University of Calgary
21145236 87 Inhibition ofß-carbonic anhydrases with ureido-substituted benzenesulfonamides.EBI Universit£ degli Studi di Firenze
21208801 275 Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.EBI Centre Scientifique de Monaco
21163660 31 Inhibition of theß-carbonic anhydrase from Streptococcus pneumoniae by inorganic anions and small molecules: Toward innovative drug design of antiinfectives?EBI Radboud University Nijmegen Medical Centre
21067924 88 7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range.EBI Università degli Studi di Firenze
20724038 78 Synthesis, characterization and antiglaucoma activity of some novel pyrazole derivatives of 5-amino-1,3,4-thiadiazole-2-sulfonamide.EBI Dumlupinar University
20926301 77 Indapamide-like benzenesulfonamides as inhibitors of carbonic anhydrases I, II, VII, and XIII.EBI Institute of Biotechnology
20889345 94 4-[N-(substituted 4-pyrimidinyl)amino]benzenesulfonamides as inhibitors of carbonic anhydrase isozymes I, II, VII, and XIII.EBI Vilnius University
20880712 69 Design, solid-phase synthesis, and biological evaluation of novel 1,5-diarylpyrrole-3-carboxamides as carbonic anhydrase IX inhibitors.EBI Univ Lille Nord de France
20833546 6 Paraoxon, 4-nitrophenyl phosphate and acetate are substrates ofa- but not ofß-,¿- and¿-carbonic anhydrases.EBI Università degli Studi di Firenze
20554082 76 Carbonic anhydrase inhibitors. Regioselective synthesis of novel 1-substituted 1,4-dihydro-4-oxo-3-pyridinesulfonamides and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer-associated isozymes IX and XII.EBI Medical University of Gdansk
20624682 24 Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors.EBI Balikesir University
20590092 273 Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.EBI Universita degli Studi di Firenze
20554206 10 A novel and one-pot synthesis of new 1-tosyl pyrrol-2-one derivatives and analysis of carbonic anhydrase inhibitory potencies.EBI Atat£rk University
20202722 138 Carbonic anhydrase inhibitors: synthesis and inhibition of the human cytosolic isozymes I and II and transmembrane isozymes IX, XII (cancer-associated) and XIV with 4-substituted 3-pyridinesulfonamides.EBI Medical University of Gdansk
20430631 24 NO-releasing esters show carbonic anhydrase inhibitory action against human isoforms I and II.EBI Atat£rk University
20211561 20 Inhibition studies of a beta-carbonic anhydrase from Brucella suis with a series of water soluble glycosyl sulfanilamides.EBI Universit£ degli Studi di Firenze
20036446 2 Synthesis and investigation of inhibition effect of fluorinated sulfonamide derivatives on carbonic anhydrase.EBI Institut des Biomol£cules Max Mousseron UMR CNRS 5247 Universit£ de Montpellier I et de Montpellier II
19751975 6 The proteoglycan region of the tumor-associated carbonic anhydrase isoform IX acts as anintrinsic buffer optimizing CO2 hydration at acidic pH values characteristic of solid tumors.EBI Universita degli Studi di Firenze
19796939 20 Carbonic anhydrase II-induced selection of inhibitors from a dynamic combinatorial library of Schiff's bases.EBI ENSCM-UMII-CNRS 5635
19527930 53 The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian alpha-carbonic anhydrase isoforms.EBI University of Tampere and Tampere University Hospital
19375309 51 Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids.EBI Universit£ degli Studi di Firenze
19580287 27 Carbonic anhydrase-encoded dynamic constitutional libraries: toward the discovery of isozyme-specific inhibitors.EBI ENSCM/UMII/UMR-CNRS 5635
 109 Benzenesulfonamide-peptide conjugates as probes for secondary binding sites near the active site of carbonic anhydraseEBI TBA
19438226 80 Discovery of low nanomolar and subnanomolar inhibitors of the mycobacterial beta-carbonic anhydrases Rv1284 and Rv3273.EBI Istanbul University
19385640 1 2009 Edward E Smissman Award. Pharmaceutical"gold" from neurostabilizing agents: topiramate and successor molecules.EBI Johnson & Johnson Pharmaceutical Research & Development
19362844 107 Effects of new 5-amino-1,3,4-thiadiazole-2-sulfonamide derivatives on human carbonic anhydrase isozymes.EBI Dumlupinar University
19297172 28 Carbonic anhydrase inhibitors. Inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with aliphatic and aromatic carboxylates.EBI Università degli Studi di Firenze
19231207 22 Carbonic anhydrase inhibitors. Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols.EBI Ataturk University
19121582 15 Carbonic anhydrase inhibitors: inhibition studies of a coral secretory isoform with inorganic anions.EBI MC-98000 Princ
19097911 41 Ligand-based and structure-based virtual screening to identify carbonic anhydrase IX inhibitors.EBI University of Namur
19053764 101 Dual inhibitors of matrix metalloproteinases and carbonic anhydrases: iminodiacetyl-based hydroxamate-benzenesulfonamide conjugates.EBI Instituto Superior Técnico
18993072 18 Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with anions.EBI Balikesir University
18819808 40 In vitro inhibition of salicylic acid derivatives on human cytosolic carbonic anhydrase isozymes I and II.EBI Ataturk University
18572406 1 Carbonic anhydrase inhibitors: thioxolone versus sulfonamides for obtaining isozyme-selective inhibitors?EBI Università degli Studi di Firenze
18348513 19 Recent developments of carbonic anhydrase inhibitors as potential anticancer drugs.EBI University of Namur
18353640 6 Investigations of the esterase, phosphatase, and sulfatase activities of the cytosolic mammalian carbonic anhydrase isoforms I, II, and XIII with 4-nitrophenyl esters as substrates.EBI Universita degli Studi di Firenze
18295485 75 Carbonic anhydrase inhibitors: the very weak inhibitors dithiothreitol, beta-mercaptoethanol, tris(carboxyethyl)phosphine and threitol interfere with the binding of sulfonamides to isozymes II and IX.EBI Universita degli Studi di Firenze
17822907 90 Design, synthesis, and docking studies of new 1,3,4-thiadiazole-2-thione derivatives with carbonic anhydrase inhibitory activity.EBI Assiut University
17257840 20 Carbonic anhydrase inhibitors. Inhibition of transmembrane isozymes XII (cancer-associated) and XIV with anions.EBI Università degli Studi di Firenze
17181151 10 2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity.EBI University of Bath
16809036 100 Carbonic anhydrase inhibitors. Inhibition of the cytosolic human isozymes I and II, and the transmembrane, tumor-associated isozymes IX and XII with substituted aromatic sulfonamides activatable in hypoxic tumors.EBI Medical University of Gdansk
16759856 9 N-hydroxyurea--a versatile zinc binding function in the design of metalloenzyme inhibitors.EBI Università degli Studi di Firenze
16168653 100 Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides.EBI Università degli Studi di Firenze
16165351 45 Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with benzo[b]thiophene 1,1-dioxide sulfonamides.EBI Università degli Studi di Firenze
16033263 51 Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors.EBI Università degli Studi di Firenze
15908204 116 Carbonic anhydrase inhibitors. Inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with Schiff's bases incorporating chromone and aromatic sulfonamide moieties, and their zinc complexes.EBI Ospedale San Lazzaro
15908201 51 Carbonic anhydrase inhibitors. Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with boron-containing sulfonamides, sulfamides, and sulfamates: toward agents for boron neutron capture therapy of hypoxic tumors.EBI Università degli Studi di Firenze
15837325 69 Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds.EBI Ospedale San Lazzaro
15837323 66 Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II, and IX with a series of 1,3,4-thiadiazole- and 1,2,4-triazole-thiols.EBI University of Bucharest
15780637 3 Carbonic anhydrase inhibitors: X-ray crystal structure of a benzenesulfonamide strong CA II and CA IX inhibitor bearing a pentafluorophenylaminothioureido tail in complex with isozyme II.EBI University of Naples 'Federico II'
15780631 55 Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V and IX with complex fluorides, chlorides and cyanides.EBI Università degli Studi di Firenze
15745821 21 Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with organic phosphates and phosphonates.EBI Université Montpellier II
15664815 45 Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates.EBI Università degli Studi di Firenze
15501037 27 Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamoyl phosphate, and the phosphonate antiviral drug foscarnet.EBI Università degli Studi di Milano
15482952 48 Carbonic anhydrase inhibitors: inhibition of human cytosolic isozyme II and mitochondrial isozyme V with a series of benzene sulfonamide derivatives.EBI Università degli Studi di Firenze
15081040 4 Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with a topically acting antiglaucoma sulfonamide.EBI Bruker-AXS s.r.l.
14640555 96 Carbonic anhydrase inhibitors: inhibition of transmembrane, tumor-associated isozyme IX, and cytosolic isozymes I and II with aliphatic sulfamates.EBI Université Montpellier II
12873509 4 Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with a bis-sulfonamide-two heads are better than one?EBI Università degli Studi di Firenze
10969992 3 Arylsulfonyl-N,N-diethyl-dithiocarbamates: a novel class of antitumor agents.EBI Università degli Studi
10649985 390 Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes.EBI Università degli Studi
8340917 19 Sulfonylmethanesulfonamide inhibitors of carbonic anhydrase.EBI Merck Research Laboratories
8201598 15 Synthesis and carbonic anhydrase inhibitory activity of 4-substituted 2-thiophenesulfonamides.EBI Allergan Inc.
8027991 26 Identification of two hydrophobic patches in the active-site cavity of human carbonic anhydrase II by solution-phase and solid-state studies and their use in the development of tight-binding inhibitors.EBI Harvard University
1501230 8 Thieno[2,3-b]furan-2-sulfonamides as topical carbonic anhydrase inhibitors.EBI Merck Research Laboratories
28259376 11 Green synthesis, inhibition studies of yeast a-glucosidase and molecular docking of pyrazolylpyridazine amines.BDB University of the Punjab
27723749 4 SF2312 is a natural phosphonate inhibitor of enolase.BDB University of Texas MD Anderson Cancer Center
27570878 7 A Rapid and Efficient Assay for the Characterization of Substrates and Inhibitors of Nicotinamide N-Methyltransferase.BDB Utrecht University
26773755 20 Synthesis and tyrosinase inhibition activity of trans-stilbene derivatives.BDB Indian Institute of Integrative Medicine
24959717 30 Discovery of inter-domain stabilizers-a novel assay system for allosteric akt inhibitors.BDB Technische Universität Dortmund
12065583 3 Identification of a novel human eicosanoid receptor coupled to G(i/o).BDB Tanabe Seiyaku Co. Ltd.
10945872 14 Pharmacological actions of a novel, high-affinity, and selective human dopamine D(3) receptor antagonist, SB-277011-A.BDB SmithKline Beecham Pharmaceuticals
10900230 11 Agonist-directed trafficking of porcine alpha(2A)-adrenergic receptor signaling in Chinese hamster ovary cells: l-isoproterenol selectively activates G(s).BDB University of Michigan
7830490 21 SR 142801, the first potent non-peptide antagonist of the tachykinin NK3 receptor.BDB Sanofi Recherche
7815325 65 Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues.BDB Duke University
7796807 51 The 5-HT4 receptor: molecular cloning and pharmacological characterization of two splice variants.BDB Synaptic Pharmaceutical Corporation
3130534 3 7-[3-(4-[2,3-Dimethylphenyl]piperazinyl)propoxy]-2(1H)-quinolinone (OPC-4392), a presynaptic dopamine autoreceptor agonist and postsynaptic D2 receptor antagonist.BDB Tokushima Research Institute
2664084 17 Detection of a novel serotonin receptor subtype (5-HT1E) in human brain: interaction with a GTP-binding protein.BDB Albany Medical College
2547939 11 Characterization of the striatal M2 muscarinic receptor mediating inhibition of cyclic AMP using selective antagonists: a comparison with the brainstem M2 receptor.BDB Abbott Laboratories
2537406 2 Pharmacological characterization of the M1 muscarinic receptors expressed in murine fibroblast B82 cells.BDB University of Arizona
14703393 52 Thermodynamics of the molecular and chiral recognition of cycloalkanols and camphor by modified beta-cyclodextrins possessing simple aromatic tethers.BDB Nankai University
19900814 15 Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part II: exploration of 6-6 fused rings as alternative S1 moieties.BDB Daiichi Sankyo Co, Ltd
19884015 17 Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part I: exploration of 5-6 fused rings as alternative S1 moieties.BDB Daiichi Sankyo Co, Ltd
19201197 17 Carbonic anhydrase inhibitors. The nematode alpha-carbonic anhydrase of Caenorhabditis elegans CAH-4b is highly inhibited by 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides.BDB Istanbul University
19900813 12 Optimization of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine-5-ylidene)acetamide derivatives as arginine vasopressin V2 receptor agonists and discussion of their binding modes.BDB Astellas Pharma Inc.
19764794 60 Selective inhibitors of the mutant B-Raf pathway: discovery of a potent and orally bioavailable aminoisoquinoline.BDB Amgen
19682971 48 A fluorescence quenching assay to discriminate between specific and nonspecific inhibitors of dengue virus protease.BDB Novartis Institute for Tropical Diseases
19603809 59 Identification of N,1,4,4-Tetramethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide (PHA-848125), a Potent, Orally Available Cyclin Dependent Kinase Inhibitor.BDB Nerviano Medical Sciences Srl
18621523 10 Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064.BDB GSK
19394217 14 2-Cyclohexylcarbonylbenzimidazoles as potent, orally available and brain-penetrable opioid receptor-like 1 (ORL1) antagonists.BDB Banyu Pharmaceutical Co.
18799592 17 Novel peroxisome proliferator-activated receptor alpha agonists lower low-density lipoprotein and triglycerides, raise high-density lipoprotein, and synergistically increase cholesterol excretion with a liver X receptor agonist.BDB Bristol-Myers Squibb Company
19345582 30 1-Sulfonylindazoles as potent and selective 5-HT6 ligands.BDB Wyeth Research
19267461 53 Novel tricyclic inhibitors of IkappaB kinase.BDB Bristol-Myers Squibb Company
19007201 20 Design of annulated pyrazoles as inhibitors of HIV-1 reverse transcriptase.BDB Roche Palo Alto LLC
19175319 19 Novel Indazole Non-Nucleoside Reverse Transcriptase Inhibitors Using Molecular Hybridization Based on Crystallographic Overlays (dagger).BDB Pfizer
19102698 16 Discovery of 1-[9-(4-chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxylic acid amide hydrochloride (CP-945,598), a novel, potent, and selective cannabinoid type 1 receptor antagonist.BDB Pfizer
17459705 26 Novel inhibitors of fatty acid amide hydrolase.BDB Bristol-Myers Squibb Company