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107 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
28337332 41 BMS-933043, a Selectivea7 nAChR Partial Agonist for the Treatment of Cognitive Deficits Associated with Schizophrenia.EBI Bristol-Myers Squibb Co.
28105289 51 Development of 4-Heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes] asa7 Nicotinic Receptor Agonists.EBI Bristol-Myers Squibb Research and Development
27212066 5 Conformational analysis of 2-substituted piperazines.EBI Retrophin, Inc.
26994846 50 Synthesis and biological activities of indolizine derivatives as alpha-7 nAChR agonists.EBI Peking University
26840365 3 New quinoline derivatives as nicotinic receptor modulators.EBI University of Florence
26706350 48 Modification of the anabaseine pyridine nucleus allows achieving binding and functional selectivity for thea3▀4 nicotinic acetylcholine receptor subtype.EBI Universit£ degli Studi di Milano
24901260 12 Recent developments in novel antidepressants targetinga4▀2-nicotinic acetylcholine receptors.EBI University of Illinois at Chicago
25393758 2 Dicarba analogues ofa-conotoxin RgIA. Structure, stability, and activity at potential pain targets.EBI Monash University (Parkville Campus)
25232969 23 Chalcones as positive allosteric modulators ofa7 nicotinic acetylcholine receptors: a new target for a privileged structure.EBI Instituto de Qu£mica M£dica (IQM-CSIC)
25192059 36 Semisynthetic analogues of toxiferine I and their pharmacological properties ata7 nAChRs, muscle-type nAChRs, and the allosteric binding site of muscarinic M2 receptors.EBI The German University in Cairo
24814197 63 Discovery of novel 2-((pyridin-3-yloxy)methyl)piperazines asa7 nicotinic acetylcholine receptor modulators for the treatment of inflammatory disorders.EBI Critical Therapeutics, Inc.
24187998 96 Design, synthesis, and biological evaluation of Erythrina alkaloid analogues as neuronal nicotinic acetylcholine receptor antagonists.EBI University of Copenhagen
24050653 59 Derivatives of dibenzothiophene for positron emission tomography imaging ofa7-nicotinic acetylcholine receptors.EBI The Johns Hopkins University School of Medicine
24200193 32 Characterization of a novela-conotoxin TxID from Conus textile that potently blocks rata3▀4 nicotinic acetylcholine receptors.EBI Hainan University
24156938 12 The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor (nAChR) ligands. Part 1: the influence of different hydrogen bond acceptor systems on alkyl and (hetero)aryl substituents.EBI University of Bonn
24090443 1 Expeditious synthesis, enantiomeric resolution, and enantiomer functional characterization of (4-(4-bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide (4BP-TQS): an allosteric agonist-positive allosteric modulator of α7 nicotinic acetylcholine receptors.EBI Northeastern University
24128660 6 Design, synthesis and binding affinity of acetylcholine carbamoyl analogues.EBI Universit£ di Milano
24098954 14 Design, synthesis, and activity of a series of arylpyrid-3-ylmethanones as type I positive allosteric modulators of a7 nicotinic acetylcholine receptors.EBI University of California Irvine
23692872 98 Novel nicotinic acetylcholine receptor agonists containing carbonyl moiety as a hydrogen bond acceptor.EBI Targacept Inc
23746476 1 Synthesis and evaluation of a conditionally-silent agonist for thea7 nicotinic acetylcholine receptor.EBI University of Florida
23713606 116 8-Benzamidochromen-4-one-2-carboxylic acids: potent and selective agonists for the orphan G protein-coupled receptor GPR35.EBI University of Bonn
23561269 53 Neonicotinic analogues: selective antagonists fora4▀2 nicotinic acetylcholine receptors.EBI University of Chile
23507153 4 Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging ofa7 nicotinic acetylcholine receptors.EBI Helmholtz-Zentrum Dresden-Rossendorf
23461628 9 (+)-Laburnamine, a natural selective ligand and partial agonist for the?4?2 nicotinic receptor subtype.EBI Universit£ degli Studi di Genova
24900666 6 Positive allosteric modulators of nicotinic acetylcholine receptor.EBI Dart Neuroscience LLC
22468936 49 Discovery of a novel alpha-7 nicotinic acetylcholine receptor agonist series and characterization of the potent, selective, and orally efficacious agonist 5-(4-acetyl[1,4]diazepan-1-yl)pentanoic acid [5-(4-methoxyphenyl)-1H-pyrazol-3-yl] amide (SEN15924, WAY-361789).EBI Siena Biotech SpA
22243960 88 Structure-based design, synthesis and structure-activity relationships of dibenzosuberyl- and benzoate-substituted tropines as ligands for acetylcholine-binding protein.EBI VU University Amsterdam
21905680 26 Deconstruction of thea4ß2 nicotinic acetylcholine receptor positive allosteric modulator desformylflustrabromine.EBI Virginia Commonwealth University
20828128 66 Surface plasmon resonance biosensor based fragment screening using acetylcholine binding protein identifies ligand efficiency hot spots (LE hot spots) by deconstruction of nicotinic acetylcholine receptora7 ligands.EBI VU University Amsterdam
20591663 23 Identification of novel alpha7 nAChR positive allosteric modulators with the use of pharmacophore in silico screening methods.EBI GlaxoSmithKline
23126648 213 Discovery of (2S,3R)-N-[2-(Pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]benzo[b]furan-2-carboxamide (TC-5619), a selectivea7 nicotinic acetylcholine receptor agonist, for the treatment of cognitive disorders.EBI Targacept Inc
23092294 75 Discovery of highly potent and selectivea4ß2-nicotinic acetylcholine receptor (nAChR) partial agonists containing an isoxazolylpyridine ether scaffold that demonstrate antidepressant-like activity. Part II.EBI University of Illinois at Chicago
23083093 25 N-[5-(5-fluoropyridin-3-yl)-1H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide (SEN78702, WYE-308775): a medicinal chemistry effort toward ana7 nicotinic acetylcholine receptor agonist preclinical candidate.EBI Siena Biotech SpA
23025891 169 Structure-activity studies of 7-heteroaryl-3-azabicyclo[3.3.1]non-6-enes: a novel class of highly potent nicotinic receptor ligands.EBI Targacept Inc
22793665 190 Discovery of 3-(5-chloro-2-furoyl)-3,7-diazabicyclo[3.3.0]octane (TC-6683, AZD1446), a novel highly selectivea4ß2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders.EBI Targacept Inc
21919481 114 Discovery and development ofa7 nicotinic acetylcholine receptor modulators.EBI Targacept Inc
22591063 12 Synthesis and nicotinic receptor activity of chemical space analogues of N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide (PNU-282,987) and 1,4-diazabicyclo[3.2.2]nonane-4-carboxylic acid 4-bromophenyl ester (SSR180711).EBI University of Berne
22749278 16 Diazaspirocyclic compounds as selective ligands for thea4ß2 nicotinic acetylcholine receptor.EBI Targacept Inc
22503453 59 The discovery of 2-fluoro-N-(3-fluoro-4-(5-((4-morpholinobutyl)amino)-1,3,4-oxadiazol-2-yl)phenyl)benzamide, a full agonist of the alpha-7 nicotinic acetylcholine receptor showing efficacy in the novel object recognition model of cognition enhancement.EBI GlaxoSmithKline
22503248 61 Identification of a series of 1,3,4-oxadiazol-2-amines as potent alpha-7 agonists with efficacy in the novel object recognition model of cognition.EBI GlaxoSmithKline
20663668 43 A novel series of [3.2.1] azabicyclic biaryl ethers as alpha3beta4 and alpha6/4beta4 nicotinic receptor agonists.EBI Pfizer Inc
19954975 27 Structure-activity relationships of N-substituted ligands for the alpha7 nicotinic acetylcholine receptor.EBI Abbott Laboratories
19552432 90 Octahydropyrrolo[3,4-c]pyrrole: a diamine scaffold for construction of either alpha4beta2 or alpha7-selective nicotinic acetylcholine receptor (nAChR) ligands. Substitutions that switch subtype selectivity.EBI Abbott Laboratories
18989912 95 Novel acetylcholine and carbamoylcholine analogues: development of a functionally selective alpha4beta2 nicotinic acetylcholine receptor agonist.EBI University of Copenhagen
18826295 7 Modeling binding modes of alpha7 nicotinic acetylcholine receptor with ligands: the roles of Gln117 and other residues of the receptor in agonist binding.EBI University of Kentucky
18490160 13 Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide as an agonist of the alpha7 nicotinic acetylcholine receptor: in vitro and in vivo activity.EBI Pfizer Inc
18198823 5 Allosteric modulators of the alpha7 nicotinic acetylcholine receptor.EBI Abbott Laboratories
17470817 12 Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators.EBI University of California
17722904 146 Pharmacological characteristics and binding modes of caracurine V analogues and related compounds at the neuronal alpha7 nicotinic acetylcholine receptor.EBI University of Copenhagen
17276680 3 Quinuclidines as selective agonists for alpha-7 nicotinic acetylcholine receptors.EBI University of Florida
16279810 5 Synthesis and pharmacological characterization of exo-2-(2'-chloro-5-pyridinyl)-7-(endo and exo)-aminobicyclo[2.2.1]heptanes as novel epibatidine analogues.EBI Research Triangle Institute
16220969 219 Designed multiple ligands. An emerging drug discovery paradigm.EBI Organon Laboratories
16171993 45 3,5-Bicyclic aryl piperidines: a novel class of alpha4beta2 neuronal nicotinic receptor partial agonists for smoking cessation.EBI Pfizer Inc
16165358 26 High affinity ligands for the alpha7 nicotinic receptor that show no cross-reactivity with the 5-HT3 receptor.EBI Eli Lilly and Company
16033252 84 Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations.EBI The Danish University of Pharmaceutical Sciences
15908213 35 In pursuit of alpha4beta2 nicotinic receptor partial agonists for smoking cessation: carbon analogs of (-)-cytisine.EBI Pfizer Inc
11741488 19 2-(2-Piperidyl)- and 2-(2-pyrrolidyl)chromans as nicotine agonists: synthesis and preliminary pharmacological characterization.EBI University of Minnesota
9484491 23 Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors.EBI Abbott Laboratories
9435889 70 Neuronal nicotinic acetylcholine receptors as targets for drug discovery.EBI Abbott Laboratories
15203153 23 Structure activity studies of ring E analogues of methyllycaconitine. Part 2: Synthesis of antagonists to the alpha3beta4* nicotinic acetylcholine receptors through modifications to the ester.EBI Ohio University
11212100 27 The 5-HT3 antagonist tropisetron (ICS 205-930) is a potent and selective alpha7 nicotinic receptor partial agonist.EBI AstraZeneca
22281189 63 SAR ofa7 nicotinic receptor agonists derived from tilorone: exploration of a novel nicotinic pharmacophore.EBI Abbott Laboratories
22222032 3 Synthesis and binding affinity ata4ß2 anda7 nicotinic acetylcholine receptors of new analogs of epibatidine and epiboxidine containing the 7-azabicyclo[2.2.1]hept-2-ene ring system.EBI Universit£ degli Studi di Milano
22014558 21 New spirocyclic¿²-isoxazoline derivatives related to selective agonists ofa7 neuronal nicotinic acetylcholine receptors.EBI Universit£ degli Studi di Milano
21920761 52 Acetylcholine binding protein (AChBP) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors.EBI VU University Amsterdam
21824774 17 Synthesis and biological activity of a novel class nicotinic acetylcholine receptors (nAChRs) ligands structurally related to anatoxin-a.EBI University of Ferrara
21397497 18 Discovery of non-peptide, small molecule antagonists ofa9a10 nicotinic acetylcholine receptors as novel analgesics for the treatment of neuropathic and tonic inflammatory pain.EBI University of Kentucky
24900227 8 Exploring a7-Nicotinic Receptor Ligand Diversity by Scaffold Enumeration from the Chemical Universe Database GDB.EBI TBA
21216141 2 Synthesis and structure-analgesic activity relationships of a novel series of monospirocyclopiperazinium salts (MSPZ).EBI Peking University
20472430 114 Syntheses and structure-activity relationship (SAR) studies of 2,5-diazabicyclo[2.2.1]heptanes as novel alpha7 neuronal nicotinic receptor (NNR) ligands.EBI Abbott Laboratories
20043678 92 Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders in schizophrenia: synthesis, SAR development, and in vivo efficacy in cognition models.EBI Pfizer Inc
19419141 23 Discovery of 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a novel positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor.EBI Abbott Laboratories
19331415 23 Use of acetylcholine binding protein in the search for novel alpha7 nicotinic receptor ligands. In silico docking, pharmacological screening, and X-ray analysis.EBI Institute
19208472 52 Gamma-lactams--a novel scaffold for highly potent and selective alpha 7 nicotinic acetylcholine receptor agonists.EBI Novartis Institutes for BioMedical Research
19027295 108 Carbamoylcholine analogs as nicotinic acetylcholine receptor agonists--structural modifications of 3-(dimethylamino)butyl dimethylcarbamate (DMABC).EBI Copenhagen University
18789861 26 Discovery and optimization of substituted piperidines as potent, selective, CNS-penetrant alpha4beta2 nicotinic acetylcholine receptor potentiators.EBI Amgen Inc
17827002 6 Synthesis of poison-frog alkaloids 233A, 235U, and 251AA and their inhibitory effects on neuronal nicotinic acetylcholine receptors.EBI University of Toyama
17604168 3 Synthesis of desformylflustrabromine and its evaluation as an alpha4beta2 and alpha7 nACh receptor modulator.EBI Virginia Commonwealth University
17391965 28 Aporphine metho salts as neuronal nicotinic acetylcholine receptor blockers.EBI University of Chile
15686879 9 6'-Methylpyrido[3,4-b]norhomotropane: synthesis and outstanding potency in relation to the alpha4beta2 nicotinic receptor pharmacophore model.EBI University of California
15050620 6 Sensitivity of neuronal nicotinic acetylcholine receptors to the opiate antagonists naltrexone and naloxone: receptor blockade and up-regulation.EBI University of Maryland
12565964 4 5-Azidoepibatidine: an exceptionally potent photoaffinity ligand for neuronal alpha 4 beta 2 and alpha 7 nicotinic acetylcholine receptors.EBI University of California
10447950 15 Molecular recognition in nicotinic acetylcholine receptors: the importance of pi-cation interactions.EBI Targacept Inc
10377231 2 Synthesis and nicotinic acetylcholine receptor in vivo binding properties of 2-fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine: a new positron emission tomography ligand for nicotinic receptors.EBI CEA
9022806 7 Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties.EBI Abbott Laboratories
11312774 36 Neonicotinoid insecticides: molecular features conferring selectivity for insect versus mammalian nicotinic receptors.EBI University of California
22959526 14 Identification of novel ?7 nicotinic receptor ligands by in silico screening against the crystal structure of a chimeric ?7 receptor ligand binding domain.EBI Bezmialem Vakif University
30403486 35 Potent Antiglioblastoma Agents by Hybridizing the Onium-Alkyloxy-Stilbene Based Structures of an ?7-nAChR, ?9-nAChR Antagonist and of a Pro-Oxidant Mitocan.EBI Universit£ degli Studi di Milano
29671588 35 Absolute Configuration and Pharmacology of the Poison Frog Alkaloid Phantasmidine.EBI Indiana State University
29634269 11 Drimane Sesquiterpenoids Noncompetitively Inhibit Human ?4?2 Nicotinic Acetylcholine Receptors with Higher Potency Compared to Human ?3?4 and ?7 Subtypes.EBI California Northstate University College of Medicine
29541351 10 Allosteric Modulators of Nicotinic Acetylcholine Receptors Useful for the Treatment of Cognitive Impairment.EBI Temple University School of Pharmacy
28606760 57 Progress in the discovery of small molecule modulators of the Cys-loop superfamily receptors.EBI Amgen Inc.
29050783 40 Design and synthesis of a novel series of (1'S,2R,4'S)-3H-4'-azaspiro[benzo[4,5]imidazo[2,1-b]oxazole-2,2'-bicyclo[2.2.2]octanes] with high affinity for the ?7 neuronal nicotinic receptor.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
29384668 249 Dual Nicotinic Acetylcholine Receptor ?4?2 Antagonists/?7 Agonists: Synthesis, Docking Studies, and Pharmacological Evaluation of Tetrahydroisoquinolines and Tetrahydroisoquinolinium Salts.EBI University of Copenhagen
27993517 43 Development of spiroguanidine-derived?7 neuronal nicotinic receptor partial agonists.EBI Bristol-Myers Squibb Research and Development
28404523 2 Structure, synthesis and biological properties of the pentacyclic guanidinium alkaloids.EBI NC State University
28885019 6 Sulfonium as a Surrogate for Ammonium: A New?7 Nicotinic Acetylcholine Receptor Partial Agonist with Desensitizing Activity.EBI University of Florida
23406473 4 New chemotypes as Trypanosoma cruzi triosephosphate isomerase inhibitors: a deeper insight into the mechanism of inhibition.BDB Universidad de la Rep˙blica
27552286 22 FABP1: A Novel Hepatic Endocannabinoid and Cannabinoid Binding Protein.BDB Avanti Polar Lipids
9802390 14 Cloning and functional expression of the guinea pig neuropeptide Y Y2 receptor.BDB Uppsala University
19351152 34 Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases.BDB University of Leeds