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99 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
28089347 6 Virtual screening and experimental validation identify novel modulators of nuclear receptor RXRa from Drugbank database.EBI Xiamen University
27994765 95 Discovery of Highly Potent Liver X Receptor▀ Agonists.EBI Bristol-Myers Squibb Co.
27326332 66 Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARa Selective Agonist.EBI Bristol-Myers Squibb Co.
27450787 2 Binding characterization, synthesis and biological evaluation of RXRa antagonists targeting the coactivator binding site.EBI Xiamen University
27261179 11 Identification of potent and selective retinoic acid receptor gamma (RAR┐) antagonists for the treatment of osteoarthritis pain using structure based drug design.EBI Eli Lilly and Company
26990539 79 Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR)▀ Agonist.EBI Vitae Pharmaceuticals Inc
26820900 11 Chiral Dihydrobenzofuran Acids Show Potent Retinoid X Receptor-Nuclear Receptor Related 1 Protein Dimer Activation.EBI University of Gothenburg
26819660 82 SAR Exploration Guided by LE and Fsp(3): Discovery of a Selective and Orally Efficacious ROR┐ Inhibitor.EBI Central Pharmaceutical Research Institute
26331194 20 Conformationally Defined Rexinoids and Their Efficacy in the Prevention of Mammary Cancers.EBI University of Alabama at Birmingham
25815156 5 Positron emission tomography to elucidate pharmacokinetic differences of regioisomeric retinoid x receptor agonists.EBI Okayama University Graduate School of Medicine
24959987 2 Rexinoids isolated from Sophora tonkinensis with a gene expression profile distinct from the synthetic rexinoid bexarotene.EBI Aichi Gakuin University
24831826 59 Small molecule inhibitors targeting activator protein 1 (AP-1).EBI University of Texas Medical Branch
25305688 41 Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for ROR▀ and ROR┐t.EBI Phenex Pharmaceuticals AG
24801499 31 Methyl substitution of a rexinoid agonist improves potency and reveals site of lipid toxicity.EBI University of Alabama at Birmingham
23434637 10 Synthesis and SAR study of modulators inhibiting tRXRa-dependent AKT activation.EBI Xiamen University
23391145 7 Mechanism of retinoid X receptor partial agonistic action of 1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5-carboxylic acid and structural development to increase potency.EBI Okayama University Graduate School of Medicine
23472886 21 Design, synthesis, and biological evaluation of indenoisoquinoline rexinoids with chemopreventive potential.EBI Purdue University
22712432 5 Identification, synthesis, and biological evaluation of the metabolites of 3-amino-6-(3'-aminopropyl)-5H-indeno[1,2-c]isoquinoline-5,11-(6H)dione (AM6-36), a promising rexinoid lead compound for the development of cancer chemotherapeutic and chemopreventive agents.EBI The University of Illinois at Chicago
24900488 1 RXR Partial Agonist CBt-PMN Exerts Therapeutic Effects on Type 2 Diabetes without the Side Effects of RXR Full Agonists.EBI TBA
24900278 3 Discovery of a Potent Retinoid X Receptor Antagonist Structurally Closely Related to RXR Agonist NEt-3IB.EBI TBA
21218783 117 Identification of diaryl ether-based ligands for estrogen-related receptora as potential antidiabetic agents.EBI Johnson & Johnson Pharmaceutical Research and Development LLC
18690216 5 Cytosporone B is an agonist for nuclear orphan receptor Nur77.EBI Xiamen University
24900241 15 Modification at the Lipophilic Domain of RXR Agonists Differentially Influences Activation of RXR Heterodimers.EBI TBA
20667726 3 Fluorescent retinoid X receptor ligands for fluorescence polarization assay.EBI Okayama University
20656484 3 Modification at the acidic domain of RXR agonists has little effect on permissive RXR-heterodimer activation.EBI Okayama University
20695472 1 Identification of a naturally occurring rexinoid, honokiol, that activates the retinoid X receptor.EBI Aichi Gakuin University
20638278 145 Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists.EBI Phenex Pharmaceuticals AG
19791803 8 Modeling, synthesis and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene).EBI Arizona State University
 61 Synthesis and structure-activity relationships of potent conformationally restricted retinoid X receptor ligandsEBI TBA
 99 Synthesis and structure-activity relationships of potent retinoid X receptor ligandsEBI TBA
 83 Synthesis of highly potent RXR-specific retinoids: The use of a cyclopropyl group as a double bond isostereEBI TBA
 31 Synthesis and pharmacological activity of conformationally restricted, acetylenic retinoid analogsEBI TBA
 54 Differential RXR & RAR activity of stilbene retinoid analogs bearing thiazole and imidazole carboxylic acidsEBI TBA
 35 Structural basis for the differential RXR & RAR activity of stilbene retinoid analogsEBI TBA
19095448 24 Replacing alkyl sulfonamide with aromatic sulfonamide in sulfonamide-type RXR agonists favors switch towards antagonist activity.EBI Okayama University Graduate School of Medicine
17651969 96 Synthesis and structure-activity relationship of RXR antagonists based on the diazepinylbenzoic acid structure.EBI Tsukuba Research Institute
17651968 60 Synthesis and structure-activity relationship of novel RXR antagonists: orally active anti-diabetic and anti-obesity agents.EBI Tsukuba Research Institute
17490875 24 Dihydro-[1H]-quinolin-2-ones as retinoid X receptor (RXR) agonists for potential treatment of dyslipidemia.EBI Johnson and Johnson Pharmaceutical Research and Development
17485209 14 RXR-LXR heterodimer modulators for the potential treatment of dyslipidemia.EBI Johnson and Johnson Pharmaceutical Research and Development
16364638 99 Aza-retinoids as novel retinoid X receptor-specific agonists.EBI Ligand Pharmaceuticals Inc
16190748 10 Ligand recognition by RAR and RXR receptors: binding and selectivity.EBI Universidad de Santiago de Compostela
15317450 7 Determinants of retinoid X receptor transcriptional antagonism.EBI Institute
15125928 44 Design and synthesis of benzofused heterocyclic RXR modulators.EBI Eli Lilly and Company
15056000 82 Structure-based design of potent retinoid X receptor alpha agonists.EBI GlaxoSmithKline
15006411 126 Design, synthesis and structure-activity relationship of novel RXR-selective modulators.EBI Ligand Pharmaceuticals Inc
14592510 150 Design and synthesis of novel RXR-selective modulators with improved pharmacological profile.EBI Ligand Pharmaceuticals Inc
12951091 36 Design and synthesis of fluorinated RXR modulators.EBI Eli Lilly and Company
12801232 71 Novel (2E,4E,6Z)-7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic acid retinoid X receptor modulators are active in models of type 2 diabetes.EBI Ligand Pharmaceuticals Inc
12482435 75 Retinoic acid receptor ligands based on the 6-cyclopropyl-2,4-hexadienoic acid.EBI Ligand Pharmaceuticals Inc
12182871 3 Synthesis and characterization of a new RXR agonist based on the 6-tert-butyl-1,1-dimethylindanyl structure.EBI Universidade de Vigo
12161154 11 An improved synthesis of the C-linked glucuronide of N-(4-hydroxyphenyl)retinamide.EBI The Ohio State University
11906293 7 Novel 5-substituted 2,4-thiazolidinedione and 2,4-oxazolidinedione derivatives as insulin sensitizers with antidiabetic activities.EBI Takeda Chemical Industries, Ltd
32356658 32 l-Thyroxin and the Nonclassical Thyroid Hormone TETRAC Are Potent Activators of PPAR?.EBI Goethe-University Frankfurt
11428923 39 Enantioselective syntheses of potent retinoid X receptor ligands: differential biological activities of individual antipodes.EBI Allergan Inc
32391701 2 Structure-Activity Relationship Study Enables the Discovery of a Novel EBI Xiamen University
30776227 38 Discovery of Second Generation ROR? Inhibitors Composed of an Azole Scaffold.EBI Kyoto Prefectural University of Medicine
27503683 12 Non-canonical modulators of nuclear receptors.EBI Vitae Pharmaceuticals, Inc.
31160175 5 3H-Imidazo[4,5-b]pyridine-6-carboxylic acid derivatives as rexinoids with reduced teratogenicity.EBI Okayama University Graduate School of Medicine
27592633 13 Modeling, Synthesis, and Biological Evaluation of Potential Retinoid X Receptor (RXR)-Selective Agonists: Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and 6-(Ethyl(5,5,8,8-tetrahydronaphthalen-2-yl)amino)nicotinic Acid (NEt-TMN).EBI Arizona State University
30634084 4 Design, synthesis and biological evaluation of tetrazole-containing RXR? ligands as anticancer agents.EBI Xiamen University
31483660 20 Competitive Binding Assay with an Umbelliferone-Based Fluorescent Rexinoid for Retinoid X Receptor Ligand Screening.EBI Okayama University Graduate School of Medicine
30702885 256 Tuning Nuclear Receptor Selectivity of Wy14,643 towards Selective Retinoid X Receptor Modulation.EBI Goethe University Frankfurt
10585206 45 Structure-activity relationship studies of novel heteroretinoids: induction of apoptosis in the HL-60 cell line by a novel isoxazole-containing heteroretinoid.EBI Università di Ferrara
31940200 62 Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis.EBI Genomics Institute of the Novartis Research Foundation (GNF)
10098670 24 Stereoselective synthesis and receptor activity of conformationally defined retinoid X receptor selective ligands.EBI Allergan Inc
10052980 138 Synthesis of retinoid X receptor-specific ligands that are potent inducers of adipogenesis in 3T3-L1 cells.EBI Ligand Pharmaceuticals Inc
9733501 33 Synthesis and characterization of heteroarotinoids demonstrate structure specificity relationships.EBI University of Oklahoma Health Sciences Center
30783504 87 Computer-Assisted Discovery and Structural Optimization of a Novel Retinoid X Receptor Agonist Chemotype.EBI Goethe-University Frankfurt
9435893 46 Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers.EBI University of Tokyo
30594433 90 Discovery of potent and selective PPAR?/? dual antagonists and initial biological studies.EBI Inception Sciences
31729873 43 Structure-Based and Property-Driven Optimization of EBI Global Discovery Chemistry
31038949 2 Cytotoxic Components from Hypericum elodeoides Targeting RXR? and Inducing HeLa Cell Apoptosis through Caspase-8 Activation and PARP Cleavage.EBI Xiamen University
8809153 60 Conformationally defined 6-s-trans-retinoic acid analogs. 3. Structure-activity relationships for nuclear receptor binding, transcriptional activity, and cancer chemopreventive activity.EBI University of Alabama at Birmingham
8784454 76 Synthesis and structure-activity relationships of retinoid X receptor selective diaryl sulfide analogs of retinoic acid.EBI Allergan Inc
31531208 46 A Novel Biphenyl-based Chemotype of Retinoid X Receptor Ligands Enables Subtype and Heterodimer Preferences.EBI Goethe-University Frankfurt
8765503 39 Identification of the first retinoid X, receptor homodimer antagonist.EBI Ligand Pharmaceuticals Inc
8709094 41 Discovery of novel retinoic acid receptor agonists having potent antiproliferative activity in cervical cancer cells.EBI Ligand Pharmaceuticals Inc
26355531 7 Structure-activity relationships for lipoprotein lipase agonists that lower plasma triglycerides in vivo.EBI Ume£ University
25057340 2 Identification of a New RXR? Antagonist Targeting the Coregulator-Binding Site.EBI Xiamen University
8410972 52 Conformational effects on retinoid receptor selectivity. 1. Effect of 9-double bond geometry on retinoid X receptor activity.EBI SRI International
8308867 72 Synthesis of high specific activity [3H]-9-cis-retinoic acid and its application for identifying retinoids with unusual binding properties.EBI Ligand Pharmaceuticals Inc
8071941 240 Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids.EBI Ligand Pharmaceuticals Inc
23707260 4 Discovery of a small molecular compound simultaneously targeting RXR and HADC: design, synthesis, molecular docking and bioassay.EBI Shenyang Pharmaceutical University
23217961 2 Structure-activity relationship study on benzoic acid part of diphenylamine-based retinoids.EBI Tohoku Pharmaceutical University
7650690 64 Conformational effects on retinoid receptor selectivity. 2. Effects of retinoid bridging group on retinoid X receptor activity and selectivity.EBI SRI International
7636877 96 Design and synthesis of potent retinoid X receptor selective ligands that induce apoptosis in leukemia cells.EBI Ligand Pharmaceuticals Inc
7636843 40 Synthesis and structure-activity relationships of stilbene retinoid analogs substituted with heteroaromatic carboxylic acids.EBI Allergan Inc
7608895 61 Conformationally defined 6-s-trans-retinoic acid analogs. 2. Selective agonists for nuclear receptor binding and transcriptional activity.EBI University of Alabama at Birmingham
7490725 9 Synthesis and characterization of a highly potent and effective antagonist of retinoic acid receptors.EBI Allergan Inc
30193216 12 Sulfonyl-containing phenyl-pyrrolyl pentane analogues: Novel non-secosteroidal vitamin D receptor modulators with favorable physicochemical properties, pharmacokinetic properties and anti-tumor activity.EBI China Pharmaceutical University
29288071 16 Design and synthesis of a potent, highly selective, orally bioavailable, retinoic acid receptor alpha agonist.EBI King's College
29901398 29 Computer-Assisted Discovery of Retinoid X Receptor Modulating Natural Products and Isofunctional Mimetics.EBI Swiss Federal Institute of Technology (ETH)
28735214 54 Indazole-based ligands for estrogen-related receptor ? as potential anti-diabetic agents.EBI Janssen Research and Development LLC
28850227 85 Natural-Products-Inspired Use of the gem-Dimethyl Group in Medicinal Chemistry.EBI St. John's University
15016836 90 The comparative pharmacology and up-regulation of rat neuronal nicotinic receptor subtype binding sites stably expressed in transfected mammalian cells.BDB Georgetown University
9479476 10 Engineering novel specificities for ligand-activated transcription in the nuclear hormone receptor RXR.BDB University of Texas Southwestern Medical Center
19361210 44 8-(4-Methoxyphenyl)pyrazolo[1,5-a]-1,3,5-triazines: selective and centrally active corticotropin-releasing factor receptor-1 (CRF1) antagonists.BDB Bristol-Myers Squibb Co.
11020282 512 Carbonic anhydrase and matrix metalloproteinase inhibitors: sulfonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of CA isozymes I, II, and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes.BDB Universita degli Studi