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127 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
28319392 216 Scaffold Repurposing of Nucleosides (Adenosine Receptor Agonists): Enhanced Activity at the Human Dopamine and Norepinephrine Sodium Symporters.EBI National Institute of Diabetes and Digestive and Kidney Diseases
2153204 6 Assessment of the in vivo and in vitro opioid activity of bridged hexahydroaporphine and isoquinoline molecules.EBI Creighton University
2709383 39 Synthesis and pharmacological evaluation of 4,4-disubstituted piperidines.EBI Anaquest Pharmaceuticals
2536439 10 Synthesis and biological evaluation of 14-alkoxymorphinans. 2. (-)-N-(cyclopropylmethyl)-4,14-dimethoxymorphinan-6-one, a selective mu opioid receptor antagonist.EBI University of Innsbruck
3039139 3 X-ray crystal structure of the opioid ligand naltrexonazine.EBI TBA
3012085 3 Probes for narcotic receptor mediated phenomena. 12. cis-(+)-3-Methylfentanyl isothiocyanate, a potent site-directed acylating agent for delta opioid receptors. Synthesis, absolute configuration, and receptor enantioselectivity.EBI TBA
3009813 3 Probes for narcotic receptor mediated phenomena. 9. Synthesis of (+/-)-(3 alpha,6a alpha,11a beta)-1,3,4,5,6,11a-hexahydro-2-methyl-2H-3,6a- methanobenzofuro[2,3-c]azocin-10-ol, an oxide-bridged 5-(m-hydroxyphenyl)morphan.EBI TBA
3023609 14 Probes for narcotic receptor mediated phenomena. 13. Potential irreversible narcotic antagonist-based ligands derived from 6,14-endo-ethenotetrahydronororipavine with 7-(methoxyfumaroyl)amino, (bromoacetyl)amino, or isothiocyanate electrophiles: chemistry, biochemistry, and pharmacology.EBI TBA
2876106 6 3,7-Diazabicyclane: a new narcotic analgesic.EBI TBA
3020246 11 Irreversible blockage of opioid receptor types by ester homologues of beta-funaltrexamine.EBI TBA
2863378 7 Acylmorphinans. A novel class of potent analgesic agents.EBI TBA
2409280 35 Opioid agonists and antagonists. 6-Desoxy-6-substituted lactone, epoxide, and glycidate ester derivatives of naltrexone and oxymorphone.EBI TBA
2999399 4 Novel nonnarcotic analgesics with an improved therapeutic ratio. Structure-activity relationships of 8-(methylthio)- and 8-(acylthio)-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines.EBI TBA
6088771 5 Potential synthetic codeine substitutes: (-)-3-O-aryl-N-methylmorphinans.EBI TBA
6094809 32 Synthesis and biological evaluation of 14-alkoxymorphinans. 1. Highly potent opioid agonists in the series of (-)-14-methoxy-N-methylmorphinan-6-ones.EBI TBA
6315939 2 14 beta-(2-bromoacetamido)morphine and 14 beta-(2-bromoacetamido)morphinone.EBI TBA
6600791 32 Synthesis and pharmacological studies of 4,4-disubstituted piperidines: a new class of compounds with potent analgesic properties.EBI TBA
6288945 28 Potential affinity labels for the opiate receptor based on fentanyl and related compounds.EBI TBA
6276546 12 Common anionic receptor site hypothesis: its relevance to the antagonist action of naloxone.EBI TBA
6268789 22 Synthesis of analogues of acetylmethadol and methadol as potential narcotic antagonists.EBI TBA
6268786 27 Opiate receptor interaction of compounds derived from or structurally related to fentanyl.EBI TBA
6273560 16 Preparation and analgesic properties of amino acid derivatives of (-)-5,9 alpha-diethyl-2'-hydroxybenzomorphan.EBI TBA
6249930 7 Synthesis and analgesic activity of some 5-(4-hydroxyphenyl)-2-azabicyclo[3.2.1]octanes.EBI TBA
6248644 4 Some spiro analogues of the potent analgesic ketobemidone.EBI TBA
6252322 19 Novel analogues of enkephalin: indentification of functional groups required for biological activity.EBI TBA
27614411 25 Synthesis and biological evaluation of new aryl-alkyl(alkenyl)-4-benzylpiperidines, novel Sigma Receptor (SR) modulators, as potential anticancer-agents.EBI University of Pavia
26071858 116 New systematically modified vesamicol analogs and their affinity and selectivity for the vesicular acetylcholine transporter - A critical examination of the lead structure.EBI Institute of Radiopharmaceutical Cancer Research
23734634 33 Thes2 receptor: a novel protein for the imaging and treatment of cancer.EBI Washington University
8201608 28 Molecular similarity, quantitative chirality, and QSAR for chiral drugs.EBI University of Oxford
23566245 15 Synthesis and evaluation of novel (18)F-labeled spirocyclic piperidine derivatives ass1 receptor ligands for positron emission tomography imaging.EBI Key Laboratory of Radiopharmaceuticals Beijing Normal University
23414839 27 3D-QSAR and docking studies of pentacycloundecylamines at the sigma-1 (s1) receptor.EBI Northeast Ohio Medical University
23199475 9 Synthesis and biological evaluation of¹8F labeled fluoro-oligo-ethoxylated 4-benzylpiperazine derivatives for sigma-1 receptor imaging.EBI Key Laboratory of Radiopharmaceuticals (Beijing Normal University)
2824774 3 Quantitative structure-activity relationships and eudismic analyses of the presynaptic dopaminergic activity and dopamine D2 and sigma receptor affinities of 3-(3-hydroxyphenyl)piperidines and octahydrobenzo[f]quinolines.EBI University of Lausanne
23084435 17 Synthesis of N-phenyl-N-(3-(piperidin-1-yl)propyl)benzofuran-2-carboxamides as new selective ligands for sigma receptors.EBI Savannah State University
22959245 175 As(1) receptor pharmacophore derived from a series of N-substituted 4-azahexacyclo[5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)]dodecan-3-ols (AHDs).EBI The University of Sydney
23641311 38 From a42 Nicotinic Ligands to the Discovery of s1 Receptor Ligands: Pharmacophore Analysis and Rational Design.EBI TBA
22853801 7 New positron emission tomography (PET) radioligand for imagings-1 receptors in living subjects.EBI Stanford University
22850210 20 Exploration of ring size in a series of cyclic vicinal diamines withs1 receptor affinity.EBI The University of Sydney
22831799 22 Syntheses and in vitro evaluation of decalinvesamicol analogues as potential imaging probes for vesicular acetylcholine transporter (VAChT).EBI Kanazawa University
22515405 39 Thiophene bioisosteres of spirocyclics receptor ligands: relationships between substitution pattern ands receptor affinity.EBI Institut f£r Pharmazeutische und Medizinische Chemie der Universit£t M£nster
22607684 50 7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (s2) receptor ligands.EBI The University of Sydney
24900272 14 Homology Model and Docking-Based Virtual Screening for Ligands of the s1 Receptor.EBI TBA
19842660 49 Exploring the importance of piperazine N-atoms for sigma(2) receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28).EBI Universita degli Studi di Bari
19673530 41 Synthesis, biological evaluation, and three-dimensional in silico pharmacophore model for sigma(1) receptor ligands based on a series of substituted benzo[d]oxazol-2(3H)-one derivatives.EBI University of Trieste
18278854 20 Conversion of a highly selective sigma-1 receptor-ligand to sigma-2 receptor preferring ligands with anticocaine activity.EBI The University of Mississippi
18178434 1 Tritium radiolabelling of PB28, a potent sigma-2 receptor ligand: pharmacokinetic and pharmacodynamic characterization.EBI Universit£ degli Studi di Bari
16366605 62 Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma(1) receptor.EBI Universit£ di Bari
12801223 71 Dual probes for the dopamine transporter and sigma1 receptors: novel piperazinyl alkyl-bis(4'-fluorophenyl)amine analogues as potential cocaine-abuse therapeutic agents.EBI NIDA-IRP
12383018 46 Novel sigma receptor ligands. Part 2. SAR of spiro[[2]benzopyran-1,4'-piperidines] and spiro[[2]benzofuran-1,4'-piperidines] with carbon substituents in position 3.EBI Pharmazeutisches Institut der Universit£t Freiburg
10649973 30 3,4-dihydro-2(1H)-quinolinone as a novel antidepressant drug: synthesis and pharmacology of 1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-3,4- dihydro-5-methoxy-2(1H)-quinolinone and its derivatives.EBI Otsuka Pharmaceutical Co., Ltd
10090790 131 Design, synthesis, structure-activity relationships, and biological characterization of novel arylalkoxyphenylalkylamine sigma ligands as potential antipsychotic drugs.EBI Taisho Pharmaceutical Company Ltd
10602703 73 A series of 6- and 7-piperazinyl- and -piperidinylmethylbenzoxazinones with dopamine D4 antagonist activity: discovery of a potential atypical antipsychotic agent.EBI Warner-Lambert Company
10543888 60 Structure-activity relationships at the monoamine transporters and sigma receptors for a novel series of 9-[3-(cis-3, 5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole) analogues.EBI National Institute on Drug Abuse-Intramural Research Program
9484497 17 Rigid phencyclidine analogues. Binding to the phencyclidine and sigma 1 receptors.EBI University of Illinois at Chicago
9599242 23 (R)-(+)-2-[[[3-(Morpholinomethyl)-2H-chromen-8-yl]oxy]methyl] morpholine methanesulfonate: a new selective rat 5-hydroxytryptamine1B receptor antagonist.EBI Astra Arcus AB
9083484 84 New benzocycloalkylpiperazines, potent and selective 5-HT1A receptor ligands.EBI Cooperation Pharmaceutique Fran�aise
8568804 42 New sigma and 5-HT1A receptor ligands: omega-(tetralin-1-yl)-n-alkylamine derivatives.EBI Universit£ di Bari
7636860 48 Synthesis and sigma binding properties of 2'-substituted 5,9 alpha-dimethyl-6,7-benzomorphans.EBI Research Triangle Institute
7783132 82 Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 2. Spiro-joined benzofuran, isobenzofuran, and benzopyran piperidines.EBI H. Lundbeck A/S
7783131 78 Sigma ligands with subnanomolar affinity and preference for the sigma 2 binding site. 1. 3-(omega-aminoalkyl)-1H-indoles.EBI H. Lundbeck A/S
8057277 54 Novel 1-phenylcycloalkanecarboxylic acid derivatives are potent and selective sigma 1 ligands.EBI National Institute on Drug Abuse-Intramural Research Program
8027978 50 Novel (4-phenylpiperidinyl)- and (4-phenylpiperazinyl)alkyl-spaced esters of 1-phenylcyclopentanecarboxylic acids as potent sigma-selective compounds.EBI Albany Molecular Research, Inc.
1361578 99 Synthesis and biological characterization of alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol and analogues as potential atypical antipsychotic agents.EBI Bristol-Myers Squibb Co.
1648139 34 Binding of substituted and conformationally restricted derivatives of N-(3-phenyl-n-propyl)-1-phenyl-2-aminopropane at sigma-receptors.EBI Virginia Commonwealth University
1848295 33 Identification and exploitation of the sigma-opiate pharmacophore.EBI Virginia Commonwealth University
1672156 81 Synthesis and biological evaluation of a series of substituted N-alkoxyimides and -amides as potential atypical antipsychotic agents.EBI Hoechst-Roussel Pharmaceuticals Inc
2167979 43 Photoactivatable opiate derivatives as irreversible probes of the mu-opioid receptor.EBI Universit£ Louis Pasteur
2542555 74 Phencyclidine-like effects of tetrahydroisoquinolines and related compounds.EBI G. D. Searle & Co.
2824773 92 N-substituted 1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolines and 3-phenylpiperidines: effects on central dopamine and sigma receptors.EBI University of G£teborg
2888899 34 Combined analgesic/neuroleptic activity in N-butyrophenone prodine-like compounds.EBI Istituto Superiore di Sanit£
3007760 93 N-substituent modulation of opiate agonist/antagonist activity in resolved 3-methyl-3-(m-hydroxyphenyl)piperidines.EBI TBA
10498200 40 Sodium channel activity and sigma binding of 2-aminopropanamide anticonvulsants.EBI Pharmacia & Upjohn
22075234 35 Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities ass¿? receptor ligands.EBI Universit£ degli Studi di Bari
22055714 9 Electron-donating para-methoxy converts a benzamide-isoquinoline derivative into a highly Sigma-2 receptor selective ligand.EBI University of Wisconsin School of Medicine and Public Health
21871797 33 Effects of linker elongation in a series of N-(2-benzofuranylmethyl)-N'-(methoxyphenylalkyl)piperazines¿? receptor ligands.EBI The University of Sydney
21899931 27 Synthesis and pharmacological evaluation of indole-based sigma receptor ligands.EBI The University of Mississippi
21555222 25 Molecular hybridization of 4-azahexacyclo[5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)]dodecane-3-ol with sigma (s) receptor ligands modulates off-target activity and subtype selectivity.EBI The University of Sydney
21481592 6 Synthesis and biological evaluation of novel 4-benzylpiperazine ligands for sigma-1 receptor imaging.EBI Key Laboratory of Radiopharmaceuticals (Beijing Normal University)
21146989 46 Trishomocubane as a scaffold for the development of selective dopamine transporter (DAT) ligands.EBI The University of Sydney
20889347 14 3D QSAR study, synthesis, and in vitro evaluation of (+)-5-FBVM as potential PET radioligand for the vesicular acetylcholine transporter (VAChT).EBI University of Tours
20812727 157 Synthesis, structure-affinity relationships, and radiolabeling of selective high-affinity 5-HT4 receptor ligands as prospective imaging probes for positron emission tomography.EBI National Institute of Mental Health
20662542 64 Design, synthesis, and structure-affinity relationships of regioisomeric N-benzyl alkyl ether piperazine derivatives as sigma-1 receptor ligands.EBI University of Sydney
20338757 6 The effect of the pyridyl nitrogen position in pyridylpiperazine sigma ligands.EBI University of Maryland
20045339 16 Design, synthesis and SAR analysis of novel selective sigma1 ligands (Part 2).EBI University of Pavia
20055417 62 Synthesis and opioid activity of enantiomeric N-substituted 2,3,4,4a,5,6,7,7a-octahydro-1H-benzofuro[3,2-e]isoquinolines.EBI National Taiwan University
 48 (E) and (Z)-3-Styrylpiperidines as sigma ligandsEBI TBA
18783208 11 Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function.EBI National Institute of Mental Health
18461921 65 Trifluoromethoxyl substituted phenylethylene diamines as high affinity sigma receptor ligands with potent anti-cocaine actions.EBI University of Maryland
18440098 15 Substituted benzo[d]oxazol-2(3H)-one derivatives with preference for the sigma1 binding site.EBI University of Trieste
18069094 7 Substituted benzylaminoalkylindoles with preference for the sigma2 binding site.EBI University of Trieste
17988766 26 Nitrile analogs of meperidine as high affinity and selective sigma-1 receptor ligands.EBI University of Maryland
16250661 13 11C-labeling of n-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]arylcarboxamide derivatives and evaluation as potential radioligands for PET imaging of dopamine D3 receptors.EBI University of Milano/Bicocca
12570387 60 Synthesis and structure-affinity relationships of 1-[omega-(4-aryl-1-piperazinyl)alkyl]-1-aryl ketones as 5-HT(7) receptor ligands.EBI Università degli Studi di Bari
11814827 10 N-arylalkylpiperidines as high-affinity sigma-1 and sigma-2 receptor ligands: phenylpropylamines as potential leads for selective sigma-2 agents.EBI University of Maryland
11784148 81 Novel spiropiperidines as highly potent and subtype selective sigma-receptor ligands. Part 1.EBI Pharmazeutisches Institut der Universität Freiburg
11150174 84 Synthesis and in vitro and in vivo activity of (-)-(1R,5R,9R)- and (+)-(1S,5S,9S)-N-alkenyl-, -N-alkynyl-, and -N-cyanoalkyl-5, 9-dimethyl-2'-hydroxy-6,7-benzomorphan homologues.EBI Virginia Commonwealth University
11052796 16 Radioiodinated N-(2-diethylaminoethyl)benzamide derivatives with high melanoma uptake: structure-affinity relationships, metabolic fate, and intracellular localization.EBI University of Heidelberg
10425095 26 Hydroxylated decahydroquinolines as ligands for the vesicular acetylcholine transporter: synthesis and biological evaluation.EBI University of Minnesota
9767631 19 N-[omega-(Tetralin-1-yl)alkyl] derivatives of 3,3-dimethylpiperidine are highly potent and selective sigma1 or sigma2 ligands.EBI Università di Bari
9171875 32 Halogenated 4-(phenoxymethyl)piperidines as potential radiolabeled probes for sigma-1 receptors: in vivo evaluation of [123I]-1-(iodopropen-2-yl)-4-[(4-cyanophenoxy)methyl]pip eri dine.EBI ANSTO
8411007 392 Chemistry, binding affinities, and behavioral properties of a new class of"antineophobic" mitochondrial DBI receptor complex (mDRC) ligands.EBI Mayo Foundation
8355251 8 Synthesis and binding properties of MK-801 isothiocyanates; (+)-3-isothiocyanato-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten- 5,10-imine hydrochloride: a new, potent and selective electrophilic affinity ligand for the NMDA receptor-coupled phencyclidine binding site.EBI National Institute of Diabetes and Digestive and Kidney Diseases
8246239 84 Development of high-affinity 5-HT3 receptor antagonists. Structure-affinity relationships of novel 1,7-annelated indole derivatives.EBI Solvay Duphar B.V.
8230107 61 Substituted 3-phenylpiperidines: new centrally acting dopamine autoreceptor antagonists.EBI University of Göteborg
7990123 30 Iodinated 2-aminotetralins and 3-amino-1-benzopyrans: ligands for dopamine D2 and D3 receptors.EBI University of Pennsylvania
7909336 27 A new arylpiperazine antipsychotic with high D2/D3/5-HT1A/alpha 1A-adrenergic affinity and a low potential for extrapyramidal effects.EBI R. W. Johnson Pharmaceutical Research Institute
7837240 19 Preparation of 18F-labeled muscarinic agonist with M2 selectivity.EBI National Institutes of Health
7636861 32 Synthesis and sigma binding properties of 1'- and 3'-halo- and 1',3'-dihalo-N-normetazocine analogues.EBI Research Triangle Institute
6313921 10 Synthesis and pharmacological characterization of (+/-)-5,9 alpha-dimethyl-2-[2-(4-fluorophenyl)ethyl]-2'-hydroxy-6,7-benzomorphan (fluorophen), a ligand suitable for visualization of opiate receptors in vivo.EBI TBA
3746815 15 In vitro labeling of serotonin-S2 receptors: synthesis and binding characteristics of [3H]-7-aminoketanserin.EBI TBA
2153212 87 Cholecystokinin-A receptor ligands based on the kappa-opioid agonist tifluadom.EBI Merck Sharp & Dohme Research Laboratories
28347632 18 Do spiroindolines have the potential to replace vesamicol as lead compound for the development of radioligands targeting the vesicular acetylcholine transporter?EBI Helmholtz-Zentrum Dresden-Rossendorf
1323682 61 Novel indolodioxanes with antihypertensive effects: potent ligands for the 5-HT1A receptor.EBI Upjohn Company
16242653 33 A proteome-wide CDK/CRK-specific kinase inhibitor promotes tumor cell death in the absence of cell cycle progression.BDB GPC Biotech, Inc.
16807364 18 Inhibition of the enzymatic activity of heme oxygenases by azole-based antifungal drugs.BDB Queen's University