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38 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
25752984 32 Design and synthesis of a novel series of [1-(4-hydroxy-benzyl)-1H-indol-5-yloxy]-acetic acid compounds as potent, selective, thyroid hormone receptor▀ agonists.EBI Lilly Research Laboratories
25305688 41 Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for ROR▀ and ROR┐t.EBI Phenex Pharmaceuticals AG
24712661 47 Discovery of 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor▀ agonist in clinical trials for the treatment of dyslipidemia.EBI Madrigal Pharmaceuticals, Inc.
24290064 44 Synthesis and pharmacological characterization of 1-benzyl-4-aminoindole-based thyroid hormone receptor▀ agonists.EBI Sanwa Kagaku Kenkyusho Co., Ltd
23414840 285 Synthesis and evaluation of methylsulfonylnitrobenzamides (MSNBAs) as inhibitors of the thyroid hormone receptor-coactivator interaction.EBI St. Jude Children's Research Hospital
23276448 46 Design, synthesis, and structure-activity relationship (SAR) of N-[7-(4-hydroxyphenoxy)-6-methylindan-4-yl]malonamic acids as thyroid hormone receptorß (TRß) selective agonists.EBI Kissei Pharmaceutical Co., Ltd
17467994 136 2D QSAR studies on thyroid hormone receptor ligands.EBI Universidade de S£o Paulo
22512468 13 Selective thyromimetics using receptor and tissue selectivity approaches: prospects for dyslipidemia.EBI Zydus Research Centre
22324546 55 Synthesis and evaluation of sulfonylnitrophenylthiazoles (SNPTs) as thyroid hormone receptor-coactivator interaction inhibitors.EBI Institut Pasteur Korea
22542282 25 Discovery of novel indane derivatives as liver-selective thyroid hormone receptorß (TRß) agonists for the treatment of dyslipidemia.EBI Kissei Pharmaceutical Co., Ltd
17988877 60 Characterization of thyroid hormone receptor alpha (TRalpha)-specific analogs with varying inner- and outer-ring substituents.EBI University of California-San Francisco
15293993 172 Liver-selective glucocorticoid antagonists: a novel treatment for type 2 diabetes.EBI Abbott Laboratories
20638278 145 Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists.EBI Phenex Pharmaceuticals AG
19900809 12 Thyroid receptor agonists for the treatment of androgenetic alopecia.EBI Pfizer Global Research& Development
19469546 208 Improvement of pharmacological properties of irreversible thyroid receptor coactivator binding inhibitors.EBI St. Jude Children's Hospital
18975928 54 Synthesis and biological evaluation of a series of liver-selective phosphonic acid thyroid hormone receptor agonists and their prodrugs.EBI Metabasis Therapeutics, Inc.
18585912 6 Design and synthesis of novel 3-hydroxy-cyclobut-3-ene-1,2-dione derivatives as thyroid hormone receptor beta (TR-beta) selective ligands.EBI Zydus Research Centre
17878314 8 Targeting thyroid hormone receptor-beta agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index.EBI Metabasis Therapeutics, Inc.
16338239 26 Thyroid receptor ligands. Part 5: novel bicyclic agonist ligands selective for the thyroid hormone receptor beta.EBI Karo Bio AB
16099653 28 A new class of high affinity thyromimetics containing a phenyl-naphthylene core.EBI Pharmaceutical Research Institute
15780617 20 Novel heterocyclic thyromimetics.EBI BAYER HealthCare AG
12825953 12 Structural determinants of selective thyromimetics.EBI University of California
12565933 30 Discovery of a novel series of 6-azauracil-based thyroid hormone receptor ligands: potent, TR beta subtype-selective thyromimetics.EBI Pfizer Global Research and Development
12109914 24 Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment.EBI University of California
11806713 8 Synthesis and preliminary characterization of a novel antiarrhythmic compound (KB130015) with an improved toxicity profile compared with amiodarone.EBI Karo Bio AB
11597408 12 A designed antagonist of the thyroid hormone receptor.EBI University of California
15054115 11 DiPOA ([8-(3,3-diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic acid), a novel, systemically available, and peripherally restricted mu opioid agonist with antihyperalgesic activity: I. In vitro pharmacological characterization and pharmacokinetic properties.BDB Purdue Pharma Discovery Research
14517179 5 WAY-855 (3-amino-tricyclo[]heptane-1,3-dicarboxylic acid): a novel, EAAT2-preferring, nonsubstrate inhibitor of high-affinity glutamate uptake.BDB Wyeth Research
14522054 98 Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line.BDB Brigham and Women's Hospital