BindingDB logo
myBDB logout

389 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
28300398 154 Novel Bivalent Ligands Based on the Sumanirole Pharmacophore Reveal Dopamine DEBI National Institute on Drug Abuse-Intramural Research Program
28248104 385 Discovery of G Protein-Biased Dopaminergics with a Pyrazolo[1,5-a]pyridine Substructure.EBI Friedrich-Alexander University Erlangen-N£rnberg
28182408 126 Design, Synthesis, Structure-Activity Relationship Studies, and Three-Dimensional Quantitative Structure-Activity Relationship (3D-QSAR) Modeling of a Series of O-Biphenyl Carbamates as Dual Modulators of Dopamine D3 Receptor and Fatty Acid Amide Hydrolase.EBI Universit£ di Bologna
28214075 30 Asymmetric total synthesis of tetrahydroprotoberberine derivatives and evaluation of their binding affinities at dopamine receptors.EBI Harvard Medical School
4045928 5 4-[2-(Di-n-propylamino)ethyl]-2(3H)-indolone: a prejunctional dopamine receptor agonist.EBI TBA
6306238 4 4-(Aminoalkyl)-7-hydroxy-2(3H)-indolones, a novel class of potent presynaptic dopamine receptor agonists.EBI TBA
11992776 70 Bicyclic piperazinylbenzenesulphonamides are potent and selective 5-HT6 receptor antagonists.EBI GlaxoSmithKline
11266169 27 Design and synthesis of novel 2,3-dihydro-1H-isoindoles with high affinity and selectivity for the dopamine D3 receptor.EBI SmithKline Beecham Pharmaceuticals
11597412 116 Novel (4-piperazin-1-ylquinolin-6-yl) arylsulfonamides with high affinity and selectivity for the 5-HT(6) receptor.EBI GlaxoSmithKline
11086728 30 Novel 2,3,4,5-tetrahydro-1H-3-benzazepines with high affinity and selectivity for the dopamine D3 receptor.EBI SmithKline Beecham Pharmaceuticals
10021923 54 Novel 1,2,3,4-tetrahydroisoquinolines with high affinity and selectivity for the dopamine D3 receptor.EBI SmithKline Beecham Pharmaceuticals
10509922 27 Heterocyclic analogues of 2-aminotetralins with high affinity and selectivity for the dopamine D3 receptor.EBI SmithKline Beecham Pharmaceuticals
10450981 58 Novel benzopyrano[3,4-c]pyrrole derivatives as potent and selective dopamine D3 receptor antagonist.EBI Centre de Recherches de Croissy
9873637 38 Fused aminotetralins: novel antagonists with high selectivity for the dopamine D3 receptor.EBI SmithKline Beecham Pharmaceuticals
27688181 40 Synthesis and evaluation of C9 alkoxy analogues of (-)-stepholidine as dopamine receptor ligands.EBI City University of New York
27876250 60 Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CHEBI Jagiellonian University Medical College
27487565 169 Synthesis and pharmacological characterization of novel N-(trans-4-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)cyclohexyl)amides as potential multireceptor atypical antipsychotics.EBI Shanghai Jiao Tong University
28029458 50 Design and synthesis of novel N-sulfonyl-2-indoles that behave as 5-HTEBI Universit£ de Montr£al
27839919 192 Decahydrobenzoquinolin-5-one sigma receptor ligands: Divergent development of both sigma 1 and sigma 2 receptor selective examples.EBI University of Kansas
27933960 122 Novel and High Affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues as Atypical Dopamine Transporter Inhibitors.EBI National Institute on Drug Abuse
27717652 275 Synthesis and evaluation of the structural elements in alkylated tetrahydroisoquinolines for binding to CNS receptors.EBI Florida A&M University
27564135 499 1,2,4-Triazolyl 5-Azaspiro[2.4]heptanes: Lead Identification and Early Lead Optimization of a New Series of Potent and Selective Dopamine D3 Receptor Antagonists.EBI Aptuit s.r.l.
27364609 230 Development of CNS multi-receptor ligands: Modification of known D2 pharmacophores.EBI Florida A&M University
27312422 219 Design and synthesis of dual 5-HT1A and 5-HT7 receptor ligands.EBI Florida A&M University
27132867 154 Structure-guided development of dual▀2 adrenergic/dopamine D2 receptor agonists.EBI Friedrich-Alexander University
27035329 113 Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity.EBI Columbia University College of Physicians and Surgeons
26876931 36 Optimization of N'-(arylsulfonyl)pyrazoline-1-carboxamidines by exploiting a novel interaction site in the 5-HT6 antagonistic binding pocket.EBI Abbott Healthcare Products B.V.
27080176 117 Synthesis and characterization of a series of chiral alkoxymethyl morpholine analogs as dopamine receptor 4 (D4R) antagonists.EBI Vanderbilt University
26988801 55 Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.EBI Jagiellonian University Medical College
26951894 376 1,2,4-Triazolyl octahydropyrrolo[2,3-b]pyrroles: A new series of potent and selective dopamine D3 receptor antagonists.EBI Aptuit s.r.l
27032890 52 Tetrahydroprotoberberine alkaloids with dopamine ands receptor affinity.EBI City University of New York
26704965 229 Further Advances in Optimizing (2-Phenylcyclopropyl)methylamines as Novel Serotonin 2C Agonists: Effects on Hyperlocomotion, Prepulse Inhibition, and Cognition Models.EBI University of Illinois at Chicago
26723530 68 Improving selectivity of dopamine D3 receptor ligands.EBI Bioprojet-Biotech
26739781 237 Receptor binding profiles and quantitative structure-affinity relationships of some 5-substituted-N,N-diallyltryptamines.EBI The Alexander Shulgin Research Institute
26786693 153 Novel morpholine scaffolds as selective dopamine (DA) D3 receptor antagonists.EBI Aptuit s.r.l
26483200 100 Synthesis and pharmacological evaluation of piperidine (piperazine)-substituted benzoxazole derivatives as multi-target antipsychotics.EBI Huazhong University of Science and Technology
26475518 19 Synthesis and evaluation of aporphine analogs containing C1 allyl isosteres at the h5-HT(2A) receptor.EBI City University of New York
26421921 43 Design, Synthesis, and Pharmacological Evaluation of 5,6-Disubstituted Pyridin-2(1H)-one Derivatives as Phosphodiesterase 10A (PDE10A) Antagonists.EBI Glenmark Research Centre
26288260 34 Multicomponent Synthesis and Biological Evaluation of a Piperazine-Based Dopamine Receptor Ligand Library.EBI Universit degli Studi di Milano
26299826 112 1,4-Disubstituted aromatic piperazines with high 5-HT2A/D2 selectivity: Quantitative structure-selectivity investigations, docking, synthesis and biological evaluation.EBI Friedrich-Alexander University
26164842 30 Bifunctional compounds targeting both D2 and non-a7 nACh receptors: design, synthesis and pharmacological characterization.EBI Universit£ degli Studi di Milano
26227779 37 Discovery of novel potent and selective ligands for 5-HT2A receptor with quinazoline scaffold.EBI Fudan University
26278029 6 Synthesis and evaluation of arylpiperazine-reverse amides as biased dopamine D3 receptor ligands.EBI Chonnam National University
26203768 104 High Affinity Dopamine D3 Receptor (D3R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D3R Knockout Mice.EBI National Institute on Drug Abuse- Intramural Research Program
25076379 87 Structural manipulation on the catecholic fragment of dopamine D(1) receptor agonist 1-phenyl-N-methyl-benzazepines.EBI Shanghai Institute of Materia Medica (SIMM)
25826710 21 Identifying Medication Targets for Psychostimulant Addiction: Unraveling the Dopamine D3 Receptor Hypothesis.EBI National Institute on Drug Abuse-Intramural Research Program
25650314 95 Using click chemistry toward novel 1,2,3-triazole-linked dopamine D3 receptor ligands.EBI National Institute on Drug Abuse-Intramural Research Program
25564378 56 Fluoro-substituted phenylazocarboxamides: Dopaminergic behavior and N-arylating properties for irreversible binding.EBI Friedrich-Alexander-Universit£t Erlangen-N£rnberg
25695425 62 Semisynthetic Studies on and Biological Evaluation of N-Methyllaurotetanine Analogues as Ligands for 5-HT Receptors.EBI City University of New York
25734236 83 Molecular determinants of biased agonism at the dopamine D2 receptor.EBI Friedrich Alexander University
25633969 96 Optimization of 2-phenylcyclopropylmethylamines as selective serotonin 2C receptor agonists and their evaluation as potential antipsychotic agents.EBI University of Illinois at Chicago
25557493 109 Novel 5-HT6 receptor antagonists/D2 receptor partial agonists targeting behavioral and psychological symptoms of dementia.EBI Jagiellonian University Collegium Medicum
25489882 63 Novel 2,4-disubstituted pyrimidines as potent, selective, and cell-permeable inhibitors of neuronal nitric oxide synthase.EBI Northwestern University
25126833 144 Design, synthesis, and structure-activity relationship studies of a series of [4-(4-carboxamidobutyl)]-1-arylpiperazines: insights into structural features contributing to dopamine D3 versus D2 receptor subtype selectivity.EBI Southern Research Institute
25070422 126 Further evaluation of the tropane analogs of haloperidol.EBI Florida A&M University
25065493 92 The identification of 7-[(R)-2-((1S,2S)-2-benzyloxycyclopentylamino)-1-hydroxyethyl]-4-hydroxybenzothiazolone as an inhaled long-acting▀2-adrenoceptor agonist.EBI Novartis Institutes for BioMedical Research
25047579 130 Synthesis and binding profile of haloperidol-based bivalent ligands targeting dopamine D(2)-like receptors.EBI Friedrich-Alexander University
25556097 70 Synthesis, pharmacological evaluation and molecular modeling studies of triazole containing dopamine D3 receptor ligands.EBI Washington University School of Medicine
25343529 221 Targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors for developing effective antipsychotics: synthesis, biological characterization, and behavioral studies.EBI Universit£ degli Studi di Siena
25308766 56 Design, synthesis and evaluation of benzo[a]thieno[3,2-g]quinolizines as novel l-SPD derivatives possessing dopamine D1, D2 and serotonin 5-HT1A multiple action profiles.EBI Chinese Academy of Sciences
25221667 66 Discovery and Characterization of ML398, a Potent and Selective Antagonist of the D4 Receptor with in Vivo Activity.EBI Vanderbilt University
25221658 6 Multiple fragment docking and linking in primary and secondary pockets of dopamine receptors.EBI Gedeon Richter Plc
24944737 20 Chiral Resolution and Serendipitous Fluorination Reaction for the Selective Dopamine D3 Receptor Antagonist BAK2-66.EBI National Institute on Drug Abuse-Intramural Research Program
24831693 116 Functionally selective dopamine D2, D3 receptor partial agonists.EBI Friedrich Alexander University
24805037 380 Novel arylsulfonamide derivatives with 5-HT6/5-HT7 receptor antagonism targeting behavioral and psychological symptoms of dementia.EBI Adamed Ltd.
24800940 146 Identification of a new selective dopamine D4 receptor ligand.EBI Florida A&M University
24848155 35 Tranylcypromine substituted cis-hydroxycyclobutylnaphthamides as potent and selective dopamine D3 receptor antagonists.EBI University of Michigan
24690494 92 Antagonists of the kappa opioid receptor.EBI The Scripps Research Institute
23734634 33 Thes2 receptor: a novel protein for the imaging and treatment of cancer.EBI Washington University School of Medicine
24666157 30 Discovery, optimization, and characterization of novel D2 dopamine receptor selective antagonists.EBI National Center for Advancing Translational Sciences
16730983 165 Diaryl substituted pyrrolidinones and pyrrolones as 5-HT2C inhibitors: synthesis and biological evaluation.EBI GlaxoSmithKline Psychiatry Centre of Excellence for Drug Discovery
24100078 59 Click chemistry based synthesis of dopamine D4 selective receptor ligands for the selection of potential PET tracers.EBI Friedrich-Alexander University
23730937 55 Functionally selective dopamine D2/D3 receptor agonists comprising an enyne moiety.EBI Friedrich Alexander University
23428965 20 Discovery of dopamine D4 receptor antagonists with planar chirality.EBI Friedrich Alexander University
24900647 8 Bodilisant-a novel fluorescent, highly affine histamine h3 receptor ligand.EBI Goethe University
23279866 69 Antidepressant and antipsychotic activity of new quinoline- and isoquinoline-sulfonamide analogs of aripiprazole targeting serotonin 5-HT1A/5-HT2A/5-HT7 and dopamine D2/D3 receptors.EBI Jagiellonian University Medical College
12443779 44 2-(Dimethylaminomethyl)-tetrahydroisoxazolopyridobenzazepine derivatives. Synthesis of a new 5-HT(2C) antagonist with potential anxiolytic properties.EBI Johnson& Johnson Pharmaceutical Research& Development
20692836 45 [3-azabicyclo[3.1.0]hex-1-yl]phenyl-benzenesulfonamides as selective dopamine D3 antagonists.EBI GlaxoSmithKline Medicines Research Centre
20005096 112 The identification of structurally novel, selective, orally bioavailable positive modulators of mGluR2.EBI GlaxoSmithKline
19635669 106 Dopamine D3 receptor antagonists: the quest for a potentially selective PET ligand. Part 3: Radiosynthesis and in vivo studies.EBI Imperial College London
19796944 38 Synthesis and binding affinity of potential atypical antipsychotics with the tetrahydroquinazolinone motif.EBI Universidad de Santiago de Compostela
19560918 101 Dopamine D3 receptor antagonists: the quest for a potentially selective PET ligand. Part one: lead identification.EBI Cancer Therapeutics
19553113 143 Dopamine D(3) receptor antagonists: The quest for a potentially selective PET ligand. Part two: Lead optimization.EBI GlaxoSmithKline
19324548 48 Modulations of the amide function of the preferential dopamine D3 agonist (R,R)-S32504: improvements of affinity and selectivity for D3 versus D2 receptors.EBI Institut de Recherches Servier
19146417 70 The discovery of a selective, small molecule agonist for the MAS-related gene X1 receptor.EBI GlaxoSmithKline Pharmaceuticals
18248991 323 New fused benzazepine as selective D3 receptor antagonists. Synthesis and biological evaluation. Part one: [h]-fused tricyclic systems.EBI GlaxoSmithKline
15808487 137 The role of QSAR in dopamine interactions.EBI Pomona College
9548813 53 The selective 5-HT1B receptor inverse agonist 1'-methyl-5-[[2'-methyl-4'-(5-methyl-1,2, 4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydro- spiro[furo[2,3-f]indole-3,4'-piperidine] (SB-224289) potently blocks terminal 5-HT autoreceptor function both in vitro and in vivo.EBI SmithKline Beecham Pharmaceuticals
9083471 30 GRID/GOLPE 3D quantitative structure-activity relationship study on a set of benzamides and naphthamides, with affinity for the dopamine D3 receptor subtype.EBI University Centre for Pharmacy
6737423 6 Aporphines. 58. N-(2-chloroethyl) [8,9-2H]norapomorphine, an irreversible ligand for dopamine receptors: synthesis and application.EBI TBA
11755365 113 Synthesis and structure-activity relationship of 2-(aminoalkyl)-2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a]azepine derivatives: a novel series of 5-HT(2A/2C) receptor antagonists. Part 2.EBI Janssen-Cilag
11755364 104 Synthesis and structure-activity relationship of 2-(aminoalkyl)-2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a]azepine derivatives: a novel series of 5-HT(2A/2C) receptor antagonists. Part 1.EBI Janssen-Cilag
11140733 92 Phenyl benzenesulfonamides are novel and selective 5-HT6 antagonists: identification of N-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide (SB-357134).EBI SmithKline Beecham Pharmaceuticals
23099096 88 Novel azulene derivatives for the treatment of erectile dysfunction.EBI Friedrich Alexander University
23084435 17 Synthesis of N-phenyl-N-(3-(piperidin-1-yl)propyl)benzofuran-2-carboxamides as new selective ligands for sigma receptors.EBI Savannah State University
23043306 69 Systematic in vivo screening of a series of 1-propyl-4-arylpiperidines against dopaminergic and serotonergic properties in rat brain: a scaffold-jumping approach.EBI NeuroSearch Sweden AB
22959245 175 As(1) receptor pharmacophore derived from a series of N-substituted 4-azahexacyclo[5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)]dodecan-3-ols (AHDs).EBI The University of Sydney
21413808 170 Synopsis of some recent tactical application of bioisosteres in drug design.EBI Bristol-Myers Squibb Pharmaceutical Research and Development
23275802 32 Novel bivalent ligands for D2/D3 dopamine receptors: Significant co-operative gain in D2 affinity and potency.EBI TBA
22125662 11 CJ-1639: A Potent and Highly Selective Dopamine D3 Receptor Full Agonist.EBI TBA
23134120 72 Discovery and pharmacological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective¿ opioid receptor agonist.EBI University of Innsbruck
22809299 4 A straightforward approach for engineering efficacy and selectivity at GPCRs.EBI Universit£ degli Studi di Siena
22632094 26 Molecular determinants of selectivity and efficacy at the dopamine D3 receptor.EBI National Institute on Drug Abuse-Intramural Research Program
23018094 16 Identification of a 2-phenyl-substituted octahydrobenzo[f]quinoline as a dopamine D3 receptor-selective full agonist ligand.EBI Purdue University
22642365 62 Structure-activity relationship study of N6-(2-(4-(1H-Indol-5-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine analogues: development of highly selective D3 dopamine receptor agonists along with a highly potent D2/D3 agonist and their pharmacological characterizatioEBI Wayne State University
24900202 38 Novel N-Substituted Benzimidazolones as Potent, Selective, CNS-Penetrant, and Orally Active M1 mAChR Agonists.EBI TBA
22871578 44 High-affinity and selective dopamine D3 receptor full agonists.EBI University of Michigan
22846798 48 Chemoenzymatic synthesis and evaluation of 3-azabicyclo[3.2.0]heptane derivatives as dopaminergic ligands.EBI University of Tartu
22607684 50 7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (s2) receptor ligands.EBI The University of Sydney
22313227 78 Radiosynthesis and evaluation of an (18)F-labeled positron emission tomography (PET) radioligand for brain histamine subtype-3 receptors based on a nonimidazole 2-aminoethylbenzofuran chemotype.EBI National Institute of Mental Health
22537450 54 Discovery of cariprazine (RGH-188): a novel antipsychotic acting on dopamine D3/D2 receptors.EBI Gedeon Richter Plc
21666830 82 Synthesis and Biological Evaluation of N-Fluoroalkyl and 2-Fluoroalkoxy Substituted Aporphines: Potential PET Ligands for Dopamine D(2) Receptors.EBI Harvard Medical School
21207959 69 Syntheses of 2-amino and 2-halothiazole derivatives as high-affinity metabotropic glutamate receptor subtype 5 ligands and potential radioligands for in vivo imaging.EBI National Institute of Mental Health
20875743 90 Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity relaEBI Pfizer Inc.
20684563 176 Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential.EBI H. Lundbeck A/S
20542439 115 Synthesis and characterization of selective dopamine D2 receptor antagonists. 2. Azaindole, benzofuran, and benzothiophene analogs of L-741,626.EBI Washington University School of Medicine
20408551 13 Lessons learned from herbal medicinal products: the example of St. John's Wort (perpendicular).EBI Westfalische Wilhelms-Universitat
19963380 38 Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine.EBI Hunter College and the Graduate Center of the City University of New York
19744859 90 Dibenzazecine scaffold rebuilding--is the flexibility always essential for high dopamine receptor affinities?EBI Friedrich-Schiller-Universit£t Jena
19091563 79 Potential utility of histamine H3 receptor antagonist pharmacophore in antipsychotics.EBI Johann Wolfgang Goethe Universit£t
19331412 122 N-(4-(4-(2,3-dichloro- or 2-methoxyphenyl)piperazin-1-yl)butyl)heterobiarylcarboxamides with functionalized linking chains as high affinity and enantioselective D3 receptor antagonists.EBI National Institute on Drug AbuseIntramural Research Program
18468904 48 High specific activity tritium-labeled N-(2-methoxybenzyl)-2,5-dimethoxy-4-iodophenethylamine (INBMeO): a high-affinity 5-HT2A receptor-selective agonist radioligand.EBI Purdue University
18164618 36 Discovery of a dopamine D4 selective PET ligand candidate taking advantage of a click chemistry based REM linker.EBI Clinic of Nuclear Medicine
18307287 60 Synthesis, radiofluorination, and in vitro evaluation of pyrazolo[1,5-a]pyridine-based dopamine D4 receptor ligands: discovery of an inverse agonist radioligand for PET.EBI Friedrich-Alexander University
17483457 58 A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.EBI Abbott Laboratories
18181565 71 Multi-target-directed ligands to combat neurodegenerative diseases.EBI University of Bologna
17407815 27 Tricyclic isoxazolines: identification of R226161 as a potential new antidepressant that combines potent serotonin reuptake inhibition and alpha2-adrenoceptor antagonism.EBI Johnson& Johnson Pharmaceutical Research& Development
17154515 40 trans-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline: synthesis, resolution, and preliminary pharmacological characterization of a new dopamine D1 receptor full agonist.EBI Purdue University
16789750 155 2-[(4-phenylpiperazin-1-yl)methyl]imidazo(di)azines as selective D4-ligands. Induction of penile erection by 2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo[1,2-a]pyridine (PIP3EA), a potent and selective D4 partial agonist.EBI Laboratoire de Chimie Th�rapeutique
16480278 279 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors.EBI Organix Inc.
16420061 161 Dopamine/serotonin receptor ligands. 10: SAR Studies on azecine-type dopamine receptor ligands by functional screening at human cloned D1, D2L, and D5 receptors with a microplate reader based calcium assay lead to a novel potent D1/D5 selective antagonist.EBI University of Bonn
16198561 99 Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis.EBI Novartis Institutes for BioMedical Research
16134944 85 Pharmacophore-guided drug discovery investigations leading to bioactive 5-aminotetrahydropyrazolopyridines. Implications for the binding mode of heterocyclic dopamine D3 receptor agonists.EBI Friedrich Alexander University
15658848 103 Discovery of 5-arylsulfonamido-3-(pyrrolidin-2-ylmethyl)-1H-indole derivatives as potent, selective 5-HT6 receptor agonists and antagonists.EBI Wyeth Research
15916420 68 Fancy bioisosteres: metallocene-derived G-protein-coupled receptor ligands with subnanomolar binding affinity and novel selectivity profiles.EBI Friedrich Alexander University
15916415 150 Dopamine D3 receptor partial agonists and antagonists as potential drug abuse therapeutic agents.EBI National Institute on Drug Abuse-Intramural Research Program
15357957 29 Synthesis, receptor binding and functional studies of mesoridazine stereoisomers.EBI Brigham& Women's Hospital
14998318 112 Selective optimization of side activities: another way for drug discovery.EBI Prestwick Chemical Inc.
15239663 60 Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction.EBI Abbott Laboratories
14521403 49 Molecular modeling of the three-dimensional structure of dopamine 3 (D3) subtype receptor: discovery of novel and potent D3 ligands through a hybrid pharmacophore- and structure-based database searching approach.EBI University of Michigan
12519065 243 Synthesis and structure-affinity relationship investigations of 5-heteroaryl-substituted analogues of the antipsychotic sertindole. A new class of highly selective alpha(1) adrenoceptor antagonists.EBI H. Lundbeck A/S
12930145 77 Synthesis and pharmacological evaluation of potent and highly selective D3 receptor ligands: inhibition of cocaine-seeking behavior and the role of dopamine D3/D2 receptors.EBI Universit£ di Siena
12361386 113 Interactive SAR studies: rational discovery of super-potent and highly selective dopamine D3 receptor antagonists and partial agonists.EBI Friedrich-Alexander University
12213075 70 Lysergamides of isomeric 2,4-dimethylazetidines map the binding orientation of the diethylamide moiety in the potent hallucinogenic agent N,N-diethyllysergamide (LSD).EBI Purdue University
12086487 28 Further characterization of structural requirements for ligands at the dopamine D(2) and D(3) receptor: exploring the thiophene moiety.EBI University of Groningen
11170639 73 Current and novel approaches to the drug treatment of schizophrenia.EBI Merck Sharp and Dohme
11585444 295 From hit to lead. Analyzing structure-profile relationships.EBI F-59000 Lille
11543687 92 Design and synthesis of [(2,3-dichlorophenyl)piperazin-1-yl]alkylfluorenylcarboxamides as novel ligands selective for the dopamine D3 receptor subtype.EBI National Institute on Drug Abuse-Intramural Research Program
10691700 112 Conjugated enynes as nonaromatic catechol bioisosteres: synthesis, binding experiments, and computational studies of novel dopamine receptor agonists recognizing preferentially the D(3) subtype.EBI Friedrich-Alexander University
11087581 72 Cyanoindole derivatives as highly selective dopamine D(4) receptor partial agonists: solid-phase synthesis, binding assays, and functional experiments.EBI Friedrich-Alexander University
11000009 23 Thiazoloindans and thiazolobenzopyrans: a novel class of orally active central dopamine (partial) agonists.EBI University of Maastricht
10956195 38 Synthesis and pharmacological evaluation of thiopyran analogues of the dopamine D3 receptor-selective agonist (4aR,10bR)-(+)-trans-3,4,4a,10b-tetrahydro-4-n-propyl-2H,5H [1]b enzopyrano[4,3-b]-1,4-oxazin-9-ol (PD 128907).EBI University Centre for Pharmacy
10602703 73 A series of 6- and 7-piperazinyl- and -piperidinylmethylbenzoxazinones with dopamine D4 antagonist activity: discovery of a potential atypical antipsychotic agent.EBI Warner-Lambert Company
9703460 52 Studies on quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides. 8.1, 2 synthesis and pharmacological evaluation of tricyclic fused quinazolines and 1,2,4-benzothiadiazine 1,1-dioxides as potential alpha1-adrenoceptor antagonists.EBI National Taiwan University
9083484 84 New benzocycloalkylpiperazines, potent and selective 5-HT1A receptor ligands.EBI Cooperation Pharmaceutique Fran�aise
9435894 206 New generation dopaminergic agents. 1. Discovery of a novel scaffold which embraces the D2 agonist pharmacophore. Structure-activity relationships of a series of 2-(aminomethyl)chromans.EBI Wyeth-Ayerst Research Laboratories
8863800 115 Affinity for dopamine D2, D3, and D4 receptors of 2-aminotetralins. Relevance of D2 agonist binding for determination of receptor subtype selectivity.EBI University of Groningen
7731017 46 Synthesis and evaluation of pharmacological and pharmacokinetic properties of monopropyl analogs of 5-, 7-, and 8-[[(trifluoromethyl)sulfonyl]oxy]-2-aminotetralins: central dopamine and serotonin receptor activity.EBI University of G£teborg
8064801 232 Substituted (S)-phenylpiperidines and rigid congeners as preferential dopamine autoreceptor antagonists: synthesis and structure-activity relationships.EBI University of G£teborg
8246241 34 18F-labeled benzamides for studying the dopamine D2 receptor with positron emission tomography.EBI University of Pennsylvania
2903247 9 Synthesis and pharmacology of trans-4-n-propyl-3,4,4a,10b-tetrahydro-2H,5H-1-benzopyrano[4,3-b ]-1,4-oxazin-7- and -9-ols: the significance of nitrogen pKa values for central dopamine receptor activation.EBI State University of Groningen
15203136 39 (+/-)8-Amino-5,6,7,8-tetrahydroisoquinolines as novel antinociceptive agents.EBI Virginia Commonwealth University
12617906 46 Cyclic amidines as benzamide bioisosteres: EPC synthesis and SAR studies leading to the selective dopamine D4 receptor agonist FAUC 312.EBI Friedrich-Alexander University
11844688 102 Di- and trisubstituted pyrazolo[1,5-a]pyridine derivatives: synthesis, dopamine receptor binding and ligand efficacy.EBI Friedrich-Alexander University
11814775 35 New generation dopaminergic agents. Part 8: heterocyclic bioisosteres that exploit the 7-OH-2-(aminomethyl)chroman D(2) template.EBI Wyeth-Ayerst Research Laboratories
12113813 53 2,4-Disubstituted pyrroles: synthesis, traceless linking and pharmacological investigations leading to the dopamine D4 receptor partial agonist FAUC 356.EBI Friedrich-Alexander University
11992769 93 Design and synthesis of a piperazinylalkylisoxazole library for subtype selective dopamine receptor ligands.EBI Institute of Science and Technology
11549463 72 Benzamide bioisosteres incorporating dihydroheteroazole substructures: EPC synthesis and SAR leading to a selective dopamine D4 receptor partial agonist (FAUC 179).EBI Friedrich-Alexander University
10987445 140 Phenyloxazoles and phenylthiazoles as benzamide bioisosteres: synthesis and dopamine receptor binding profiles.EBI Friedrich-Alexander University
10206547 95 Enantio- and diastereocontrolled dopamine D1, D2, D3 and D4 receptor binding of N-(3-pyrrolidinylmethyl)benzamides synthesized from aspartic acid.EBI Universit£t Erlangen-N£rnberg
9990464 64 Azaindole derivatives with high affinity for the dopamine D4 receptor: synthesis, ligand binding studies and comparison of molecular electrostatic potential maps.EBI Universit£t Erlangen-N£rnberg
9873481 80 SAR of novel biarylmethylamine dopamine D4 receptor ligands.EBI Darmstadt
 70 Novel cyclohexyl amides as potent and selective D3 dopamine receptor ligandsEBI TBA
21888437 20 Chiral indolo[3,2-f][3]benzazecine-type dopamine receptor antagonists: synthesis and activity of racemic and enantiopure derivatives.EBI Martin Luther Universit£t Halle-Wittenberg
22336245 72 Structure-activity relationship studies of SYA 013, a homopiperazine analog of haloperidol.EBI Florida A&M University
22245230 128 Multi-receptor drug design: Haloperidol as a scaffold for the design and synthesis of atypical antipsychotic agents.EBI Florida A&M University
22100258 124 Bivalent molecular probes for dopamine D2-like receptors.EBI Friedrich Alexander University
22039961 21 Evaluation of 18F-labeled benzodioxine piperazine-based dopamine D4 receptor ligands: lipophilicity as a determinate of nonspecific binding.EBI Forschungszentrum J£lich GmbH
21999579 40 Development of a bivalent dopamine D2 receptor agonist.EBI Friedrich Alexander University
21899931 27 Synthesis and pharmacological evaluation of indole-based sigma receptor ligands.EBI The University of Mississippi
21823597 373 Design and synthesis of novel arylpiperazine derivatives containing the imidazole core targeting 5-HT(2A) receptor and 5-HT transporter.EBI Green Cross Corporation
21732626 60 Synthesis and in vitro biological evaluation of carbonyl group-containing analogues fors1 receptors.EBI Washington University
21536445 63 Synthesis and characterization of selective dopamine D2 receptor ligands using aripiprazole as the lead compound.EBI Washington University School of Medicine
21599022 66 Bivalent dopamine D2 receptor ligands: synthesis and binding properties.EBI Friedrich-Alexander University
21555222 25 Molecular hybridization of 4-azahexacyclo[5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)]dodecane-3-ol with sigma (s) receptor ligands modulates off-target activity and subtype selectivity.EBI The University of Sydney
21495689 134 N-(3-fluoro-4-(4-(2-methoxy or 2,3-dichlorophenyl)piperazine-1-yl)butyl)arylcarboxamides as selective dopamine D3 receptor ligands: critical role of the carboxamide linker for D3 receptor selectivity.EBI National Institute on Drug Abuse-Intramural Research Program
21273071 73 Aromatic ring functionalization of benzolactam derivatives: new potent dopamine D3 receptor ligands.EBI University of Santiago de Compostela
21388142 57 Highly potent 5-aminotetrahydropyrazolopyridines: enantioselective dopamine D3 receptor binding, functional selectivity, and analysis of receptor-ligand interactions.EBI Friedrich Alexander University
21348515 75 Synthesis and pharmacological evaluation of fluorine-containing D3 dopamine receptor ligands.EBI Washington University School of Medicine
21334902 46 Further SAR study on 11-O-substituted aporphine analogues: identification of highly potent dopamine D3 receptor ligands.EBI Chinese Academy of Sciences
21280602 2 Biotin ergopeptide probes for dopamine receptors.EBI University of Barcelona
21146989 46 Trishomocubane as a scaffold for the development of selective dopamine transporter (DAT) ligands.EBI The University of Sydney
21190848 61 1-(Arylsulfonyl)-2,3-dihydro-1H-quinolin-4-one derivatives as 5-HT(6) serotonin receptor ligands.EBI Korea Research Institute of Chemical Technology
21030255 18 Synthesis, biological evaluation and radiolabelling by 18F-fluoroarylation of a dopamine D3-selective ligand as prospective imaging probe for PET.EBI Friedrich-Alexander-Universität Erlangen-Nürnberg
20860381 61 Novel pyridylmethylamines as highly selective 5-HT(1A) superagonists.EBI Friedrich Alexander University
20839776 105 Bioisosteric replacement leading to biologically active [2.2]paracyclophanes with altered binding profiles for aminergic G-protein-coupled receptors.EBI Friedrich Alexander University
20605099 42 Further delineation of hydrophobic binding sites in dopamine D(2)/D(3) receptors for N-4 substituents on the piperazine ring of the hybrid template 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol.EBI Wayne State University
20813948 63 Spiroindolones, a potent compound class for the treatment of malaria.EBI Swiss Tropical and Public Health Institute
20709559 16 Facile synthesis of octahydrobenzo[h]isoquinolines: novel and highly potent D1 dopamine agonists.EBI Purdue University
20708933 60 Synthesis and evaluation of amides surrogates of dopamine D3 receptor ligands.EBI Université de Rennes I
20655748 92 Synthesis and SAR of (piperazin-1-yl-phenyl)-arylsulfonamides: a novel series of atypical antipsychotic agents.EBI Korea Research Institute of Chemical Technology
20384344 42 Role of hydrophobic substituents on the terminal nitrogen of histamine in receptor binding and agonist activity: development of an orally active histamine type 3 receptor agonist and evaluation of its antistress activity in mice.EBI Meiji Seika Kaisha, Ltd.
20223662 174 Synthesis and biological evaluation of 3-aminopyrrolidine derivatives as CC chemokine receptor 2 antagonists.EBI Yangji Chemicals
20180564 24 Dopamine receptor ligands. Part 18: (1) modification of the structural skeleton of indolobenzazecine-type dopamine receptor antagonists.EBI Friedrich-Schiller-Universit£t Jena
20149649 133 Arylpiperazine-containing pyrrole 3-carboxamide derivatives targeting serotonin 5-HT(2A), 5-HT(2C), and the serotonin transporter as a potential antidepressant.EBI Green Cross Corporation
20137933 218 Identification of piperazine-bisamide GHSR antagonists for the treatment of obesity.EBI Amgen Inc.
20146482 19 Discovery of 4-(4-(2-((5-Hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)(propyl)amino)ethyl)piperazin-1-yl)quinolin-8-ol and its analogues as highly potent dopamine D2/D3 agonists and as iron chelator: in vivo activity indicates potential application in symptomatic and neuroprotective therapy for ParkinEBI Wayne State University
20038106 48 Development of (S)-N6-(2-(4-(isoquinolin-1-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]-thiazole-2,6-diamine and its analogue as a D3 receptor preferring agonist: potent in vivo activity in Parkinson's disease animal models.EBI Wayne State University
19523834 79 Novel 1-aminoethyl-3-arylsulfonyl-1H-pyrrolo[2,3-b]pyridines are potent 5-HT(6) agonists.EBI Wyeth Research
19807103 14 1,1'-Disubstituted ferrocenes as molecular hinges in mono- and bivalent dopamine receptor ligands.EBI Friedrich Alexander University
19783143 65 Special ergolines are highly selective, potent antagonists of the chemokine receptor CXCR3: discovery, characterization and preliminary SAR of a promising lead.EBI Novartis Institutes for BioMedical Research
19592258 20 Parallel synthesis of potent dopaminergic N-phenyltriazole carboxamides applying a novel click chemistry based phenol linker.EBI Friedrich Alexander University
19481941 80 Design, synthesis and dopamine D4 receptor binding activities of new N-heteroaromatic 5/6-ring Mannich bases.EBI Friedrich-Alexander-Universit£t
19719241 55 Synthesis, potency, and in vivo evaluation of 2-piperazin-1-ylquinoline analogues as dual serotonin reuptake inhibitors and serotonin 5-HT1A receptor antagonists.EBI Wyeth Research
19427222 44 Investigation of various N-heterocyclic substituted piperazine versions of 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol: effect on affinity and selectivity for dopamine D3 receptor.EBI Wayne State University
19606869 41 Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding.EBI Friedrich Alexander University
 26 Hindered rotation congeners of mazapertine: High affinity ligands for the 5-HT1A receptorEBI TBA
 40 (Dipropylamino)-tetrahydronaphthofurans: centrally acting serotonin agonists and dopamine agonists-antagonistsEBI TBA
 32 A new series of selective dopamine D4 ligands: 3-([4-arylpiperazin-1-yl]alkylamino)-2H-1,4-benzoxazinesEBI TBA
 39 4-Heterocyclyl tetrahydropyridines as selective ligands for the human dopamine D4 receptorEBI TBA
 25 Discovery of selective dopamine D4 receptor antagonists: 1-Aryloxy-3-(4-aryloxypiperidinyl)-2-propanolsEBI TBA
 46 4-bromo-1-methoxy-N-[2-(4-aryl-1-piperazinyl)ethyl]-2-naphthalenecarboxamides: Selective dopamine D3 receptor partial agonistsEBI TBA
 20 Discovery of selective dopamine D3 ligands: II. 2-[4-[3-(4-aryl-1-piperazinyl)propoxy]phenyl]benzimidazole partial agonistsEBI TBA
 34 Discovery of selective dopamine D3 ligands: I. Dimeric 2-[4-(3-aminopropoxy)phenyl]benzimidazole antagonistsEBI TBA
 25 Synthesis and biological activity of C-5 modified derivatives of (+)-AJ76 and (+)-UH232: Increased dopamine D3 receptor preference and improved pharmacokinetic propertiesEBI TBA
19217777 2 Synthesis, binding affinity and SAR of new benzolactam derivatives as dopamine D3 receptor ligands.EBI Universidad de Santiago de Compostela
19155177 52 Synthesis and evaluation of ligands for D2-like receptors: the role of common pharmacophoric groups.EBI Florida A&M University
19081257 37 Design, synthesis, and binding affinities of potential positron emission tomography (PET) ligands with optimal lipophilicity for brain imaging of the dopamine D3 receptor. Part II.EBI Università degli Studi di Bari
19072656 110 Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior.EBI University of Siena
18834111 68 Novel D3 selective dopaminergics incorporating enyne units as nonaromatic catechol bioisosteres: synthesis, bioactivity, and mutagenesis studies.EBI Friedrich Alexander University
18774793 85 Structure-activity relationships for a novel series of dopamine D2-like receptor ligands based on N-substituted 3-aryl-8-azabicyclo[3.2.1]octan-3-ol.EBI National Institute on Drug Abuses
18701276 97 Highly functionalized 7-azaindoles as selective PPAR gamma modulators.EBI Merck Research Laboratories
18602261 65 Synthesis and structure-activity relationship of 1H-indole-3-carboxylic acid pyridine-3-ylamides: a novel series of 5-HT2C receptor antagonists.EBI Korea Research Institute of Chemical Technology
18595716 142 Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-chlorophenyl)-1,4-diazepan-1-yl]-1-(4-fluorophenyl)butan-1-one.EBI Florida A&M University
18534857 2 [11C]cyclopropyl-FLB 457: a PET radioligand for low densities of dopamine D2 receptors.EBI Institutet
18410082 50 Bioisosteric heterocyclic versions of 7-{[2-(4-phenyl-piperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol: identification of highly potent and selective agonists for dopamine D3 receptor with potent in vivo activity.EBI Wayne State University
18072730 48 Further structure-activity relationships study of hybrid 7-{[2-(4-phenylpiperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol analogues: identification of a high-affinity D3-preferring agonist with potent in vivo activity with long duration of action.EBI Wayne State University
18053713 78 Discovery of 3-aryl-3-methyl-1H-quinoline-2,4-diones as a new class of selective 5-HT6 receptor antagonists.EBI Korea Research Institute of Chemical Technology
17976986 80 Design and synthesis of a functionally selective D3 agonist and its in vivo delivery via the intranasal route.EBI Pfizer Global Research & Development
17850060 33 4-[omega-[4-arylpiperazin-1-yl]alkoxy]phenyl)imidazo[1,2-a]pyridine derivatives: fluorescent high-affinity dopamine D3 receptor ligands as potential probes for receptor visualization.EBI Università degli Studi di Bari
17827018 64 Click chemistry based solid phase supported synthesis of dopaminergic phenylacetylenes.EBI Friedrich Alexander University
17826096 86 Hybrid approach for the design of highly affine and selective dopamine D(3) receptor ligands using privileged scaffolds of biogenic amine GPCR ligands.EBI Johann Wolfgang Goethe-University
17765546 36 In vitro affinities of various halogenated benzamide derivatives as potential radioligands for non-invasive quantification of D(2)-like dopamine receptors.EBI Johannes Gutenberg-University
17676831 67 Dopamine/serotonin receptor ligands. 16.(1) Expanding dibenz[d,g]azecines to 11- and 12-membered homologues. Interaction with dopamine D(1)-D(5) receptors.EBI Friedrich-Schiller-Universität Jena
17672446 149 Heterocyclic analogues of N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)arylcarboxamides with functionalized linking chains as novel dopamine D3 receptor ligands: potential substance abuse therapeutic agents.EBI National Institute on Drug Abuse-Intramural Research Program
17576067 68 Synthesis of novel lactam derivatives and their evaluation as ligands for the dopamine receptors, leading to a D(4)-selective ligand.EBI Cairo University
17571866 49 Synthesis and simple 18F-labeling of 3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethynyl)benzonitrile as a high affinity radioligand for imaging monkey brain metabotropic glutamate subtype-5 receptors with positron emission tomography.EBI National Institute of Mental Health
17524641 69 3-Arylamino-2H-1,2,4-benzothiadiazin-5-ol 1,1-dioxides as novel and selective CXCR2 antagonists.EBI GlaxoSmithKline
17316913 15 Asymmetric synthesis of chiral piperazinylpropylisoxazoline ligands for dopamine receptors.EBI Sungshin Women's University
17266201 13 Structure-selectivity investigations of D2-like receptor ligands by CoMFA and CoMSIA guiding the discovery of D3 selective PET radioligands.EBI Friedrich Alexander University
17188870 36 Dopamine/serotonin receptor ligands. Part 15: Oxygenation of the benz-indolo-azecine LE 300 leads to novel subnanomolar dopamine D1/D5 antagonists.EBI Friedrich-Schiller-Universität Jena
17095222 134 Analogues of the dopamine D2 receptor antagonist L741,626: Binding, function, and SAR.EBI National Institute on Drug Abuse-Intramural Research Program
17034146 24 Dopamine/serotonin receptor ligands. 13: Homologization of a benzindoloazecine-type dopamine receptor antagonist modulates the affinities for dopamine D(1)-D(5) receptors.EBI Friedrich-Schiller-Universität Jena
16759104 46 Fancy bioisosteres: novel paracyclophane derivatives as super-affinity dopamine D3 receptor antagonists.EBI Friedrich Alexander University
16722655 28 Discovery of a novel, orally active, small molecule gonadotropin-releasing hormone (GnRH) receptor antagonist.EBI Pfizer Global Research & Development
16722631 87 An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.EBI Predix Pharmaceuticals Ltd.
16621538 35 Evaluation of the eutomer of 4-{3-(4-chlorophenyl)-3-hydroxypyrrolidin-1-yl}-1-(4-fluorophenyl)butan-1-one, {(+)-SYA 09}, a pyrrolidine analog of haloperidol.EBI Florida A& M University
16563764 100 Synthesis and biological investigations of dopaminergic partial agonists preferentially recognizing the D4 receptor subtype.EBI Friedrich-Alexander University
16539400 97 Dopamine/serotonin receptor ligands. 12(1): SAR studies on hexahydro-dibenz[d,g]azecines lead to 4-chloro-7-methyl-5,6,7,8,9,14-hexahydrodibenz[d,g]azecin-3-ol, the first picomolar D5-selective dopamine-receptor antagonist.EBI Friedrich-Schiller-Universität Jena
16458504 37 Synthesis, in vitro and in vivo evaluation of [O-methyl-11C] 2-{4-[4-(3-methoxyphenyl)piperazin-1-yl]-butyl}-4-methyl-2H-[1,2,4]-triazine-3,5-dione: a novel agonist 5-HT1A receptor PET ligand.EBI Columbia University College of Physicians and Surgeons
16439127 48 Synthesis and SAR of highly potent and selective dopamine D3-receptor antagonists: variations on the 1H-pyrimidin-2-one theme.EBI Abbott GmbH & Co. KG
16392820 52 Design, synthesis, and binding affinities of potential positron emission tomography (PET) ligands for visualization of brain dopamine D3 receptors.EBI Università degli Studi di Bari
16392798 46 Synthesis and in vivo validation of [O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)piperazin- 1-yl]butyl}-4-methyl-2H-[1,2,4]triazine-3,5-dione: a novel 5-HT1A receptor agonist positron emission tomography ligand.EBI Columbia University College of Physicians and Surgeons
16335915 16 First structure-activity relationship study on dopamine D3 receptor agents with N-[4-(4-arylpiperazin-1-yl)butyl]arylcarboxamide structure.EBI Università degli Studi di Bari
16290141 40 Synthesis and SAR of highly potent and selective dopamine D(3)-receptor antagonists: 1H-pyrimidin-2-one derivatives.EBI Abbott GmbH & Co. KG
16271293 35 Synthesis and SAR of highly potent and selective dopamine D(3)-receptor antagonists: Quinolin(di)one and benzazepin(di)one derivatives. herve.geneste@abbott.com.EBI Abbott GmbH & Co. KG
16219465 82 Synthesis and SAR of highly potent dual 5-HT1A and 5-HT1B antagonists as potential antidepressant drugs.EBI Abbott GmbH & Co. KG
16143528 213 Synthesis of potent and selective serotonin 5-HT1B receptor ligands.EBI Columbia University College of Physicians and Surgeons
16139501 54 Synthesis and evaluation of 18F-labeled dopamine D3 receptor ligands as potential PET imaging agents.EBI University of Erlangen-Nuremberg
16134937 154 6-Acylamino-2-aminoquinolines as potent melanin-concentrating hormone 1 receptor antagonists. Identification, structure-activity relationship, and investigation of binding mode.EBI 7TM Pharma A/S
15801839 51 CoMFA and CoMSIA investigations revealing novel insights into the binding modes of dopamine D3 receptor agonists.EBI Friedrich-Alexander University
15771448 187 Discovery of a new series of centrally active tricyclic isoxazoles combining serotonin (5-HT) reuptake inhibition with alpha2-adrenoceptor blocking activity.EBI Johnson & Johnson Pharmaceutical Research & Development
15771415 155 Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents.EBI Johnson & Johnson Pharmaceutical Research & Development
15771414 36 Novel atypical antipsychotic agents: rational design, an efficient palladium-catalyzed route, and pharmacological studies.EBI Università di Siena
15689168 89 Novel heterocyclic trans olefin analogues of N-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl}arylcarboxamides as selective probes with high affinity for the dopamine D3 receptor.EBI National Institute on Drug Abuse-Intramural Research Program
15689154 27 Modeling the similarity and divergence of dopamine D2-like receptors and identification of validated ligand-receptor complexes.EBI Friedrich-Alexander University
15603958 77 N1-arylsulfonyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives are potent and selective 5-HT6 receptor antagonists.EBI Wyeth Research
15341483 110 Indolebutylamines as selective 5-HT(1A) agonists.EBI Merck KGaA
15293986 65 Dopamine/serotonin receptor ligands. 9. Oxygen-containing midsized heterocyclic ring systems and nonrigidized analogues. A step toward dopamine D5 receptor selectivity.EBI Friedrich-Schiller-Universität Jena
15225707 42 Synthesis and radioiodination of selective ligands for the dopamine D3 receptor subtype.EBI University of Erlangen-Nuremberg
15012999 166 Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 3: SAR studies on the benzylpyrazole segment.EBI Merck Research Laboratories
14643338 124 Binding of beta-carbolines at 5-HT(2) serotonin receptors.EBI Virginia Commonwealth University
14611858 65 1H-Pyrazolo-[3,4-c]cyclophepta[1,2-c]thiophenes: a unique structural class of dopamine D4 selective ligands.EBI Neurogen Corporation
14552786 88 Structure-activity relationship of triaryl propionic acid analogues on the human EP3 prostanoid receptor.EBI Merck Frosst Centre for Therapeutic Research
14552778 18 The acute EPS of haloperidol may be unrelated to its metabolic transformation to BCPP+.EBI Florida A & M University
12951112 150 Stereocontrolled dopamine receptor binding and subtype selectivity of clebopride analogues synthesized from aspartic acid.EBI Friedrich Alexander University
12930150 155 N-(omega-(4-(2-methoxyphenyl)piperazin-1-yl)alkyl)carboxamides as dopamine D2 and D3 receptor ligands.EBI Johann Wolfgang Goethe-Universität
12824018 6 Semisynthetic preparation of amentoflavone: A negative modulator at GABA(A) receptors.EBI University of Sydney
12798330 63 N-(4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl, butenyl and butynyl)arylcarboxamides as novel dopamine D(3) receptor antagonists.EBI National Institute on Drug Abuse-Intramural Research Program
12643910 55 Identification of a novel series of selective 5-HT7 receptor antagonists.EBI GlaxoSmithKline
12161137 39 Fused azaindole derivatives: molecular design, synthesis and in vitro pharmacology leading to the preferential dopamine D3 receptor agonist FAUC 725.EBI Friedrich-Alexander University
12109911 47 Synthesis and pharmacological testing of 1,2,3,4,10,14b-hexahydro-6-methoxy-2-methyldibenzo[c,f]pyrazino[1,2-a]azepin and its enantiomers in comparison with the two antidepressants mianserin and mirtazapine.EBI University Center for Pharmacy
11844685 20 A novel series of hybrid compounds derived by combining 2-aminotetralin and piperazine fragments: binding activity at D2 and D3 receptors.EBI Wayne State University
11689074 112 N-Arylsulfonylindole derivatives as serotonin 5-HT(6) receptor ligands.EBI Merck Sharp & Dohme Research Laboratories
11597417 73 Dopaminergic 7-aminotetrahydroindolizines: ex-chiral pool synthesis and preferential D3 receptor binding.EBI Friedrich-Alexander University
11514164 36 Conformationally restricted indolopiperidine derivatives as potent CCR2B receptor antagonists.EBI GlaxoSmithKline Pharmaceuticals
11495580 35 Rationally based efficacy tuning of selective dopamine d4 receptor ligands leading to the complete antagonist 2-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 213).EBI Friedrich-Alexander University
11327592 9 1,2,5-Thiadiazole derivatives are potent and selective ligands at human 5-HT1A receptors.EBI Wyeth-Ayerst Research
10841797 110 Design, synthesis, and structure-activity relationships of phthalimide-phenylpiperazines: a novel series of potent and selective alpha(1)(a)-adrenergic receptor antagonists.EBI The R.W. Johnson Pharmaceutical Research Institute
10560741 60 Piperidinylpyrroles: design, synthesis and binding properties of novel and selective dopamine D4 receptor ligands.EBI Friedrich-Alexander University
10498215 60 New generation dopaminergic agents. 7. Heterocyclic bioisosteres that exploit the 3-OH-phenoxyethylamine D2 template.EBI Wyeth-Ayerst Research Laboratories
10479303 36 Design, synthesis, and evaluation of chromen-2-ones as potent and selective human dopamine D4 antagonists.EBI Warner-Lambert Company
10464021 59 N-Substituted (2,3-dihydro-1,4-benzodioxin-2-yl)methylamine derivatives as D(2) antagonists/5-HT(1A) partial agonists with potential as atypical antipsychotic agents.EBI Knoll Pharmaceuticals
10450964 35 2,2-Dicyanovinyl as a nonaromatic aryl bioisostere: synthesis, binding experiments and SAR studies of highly selective dopamine D4 receptor ligands.EBI Universität Erlangen - Nürnberg
10411491 96 1-(3-Cyanobenzylpiperidin-4-yl)-5-methyl-4-phenyl-1, 3-dihydroimidazol-2-one: a selective high-affinity antagonist for the human dopamine D(4) receptor with excellent selectivity over ion channels.EBI Merck Sharp and Dohme Research Laboratories
10377229 107 New (sulfonyloxy)piperazinyldibenzazepines as potential atypical antipsychotics: chemistry and pharmacological evaluation.EBI University of Göteborg
10340615 51 4-N-linked-heterocyclic piperidine derivatives with high affinity and selectivity for human dopamine D4 receptors.EBI Merck Sharp and Dohme Research Laboratories
10098669 33 Synthesis and sar of 2- and 3-substituted 7-azaindoles as potential dopamine D4 ligands.EBI Merck Sharp & Dohme Research Laboratories
9934472 12 Phenylpiperazine derivatives with strong affinity for 5HT1A, D2A and D3 receptors.EBI University of Vigo
9876110 58 7-[3-(1-piperidinyl)propoxy]chromenones as potential atypical antipsychotics. 2. Pharmacological profile of 7-[3-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)-piperidin-1-yl]propoxy]-3-(hydroxymeth yl)chromen -4-one (abaperidone, FI-8602).EBI Centro de Investigación Grupo Ferrer
9873609 15 NGB 2904 and NGB 2849: two highly selective dopamine D3 receptor antagonists.EBI Neurogen Corporation
9873601 45 New generation dopaminergic agents. 5. Heterocyclic bioisosteres that exploit the 3-OH-N1-phenylpiperazine dopaminergic template.EBI Wyeth-Ayerst Research Laboratory
9873377 54 Isoindolinone enantiomers having affinity for the dopamine D4 receptor.EBI Parke-Davis Pharmaceutical Research
9871673 79 New generation dopaminergic agents. 2. Discovery of 3-OH-phenoxyethylamine and 3-OH-N1-phenylpiperazine dopaminergic templates.EBI Wyeth-Ayerst Research Laboratories
9871530 41 Synthesis, SAR and pharmacology of CP-293,019: a potent, selective dopamine D4 receptor antagonist.EBI Pfizer Central Research
9513604 76 Aminopyrimidines with high affinity for both serotonin and dopamine receptors.EBI Warner-Lambert Company
9406594 82 (Aryloxy)alkylamines as selective human dopamine D4 receptor antagonists: potential antipsychotic agents.EBI Warner-Lambert Company
9276014 62 Chromeno[3,4-c]pyridin-5-ones: selective human dopamine D4 receptor antagonists as potential antipsychotic agents.EBI Warner-Lambert Company
9240352 111 4-Heterocyclylpiperidines as selective high-affinity ligands at the human dopamine D4 receptor.EBI Merck Sharp and Dohme
9191952 63 Substituted [(4-phenylpiperazinyl)-methyl]benzamides: selective dopamine D4 agonists.EBI Warner-Lambert Company
9057850 27 Synthesis and biological activities of (R)-5,6-dihydro-N,N-dimethyl-4H-imidazo[4,5,1-ij]quinolin-5-amine and its metabolites.EBI Pharmacia & Upjohn
9016321 30 2-Phenyl-4(5)-[[4-(pyrimidin-2-yl)piperazin-1-yl]methyl]imidazole. A highly selective antagonist at cloned human D4 receptors.EBI Neurogen Corporation
9003524 23 3-[[(4-Aryl-1-piperazinyl)alkyl]cyclohexyl]-1H-indoles as dopamine D2 partial agonists and autoreceptor agonists.EBI Division of Warner Lambert Company
8893836 50 Novel (R)-2-amino-5-fluorotetralins: dopaminergic antagonists and inverse agonists.EBI Uppsala University
8759640 61 Aryl 1-but-3-ynyl-4-phenyl-1,2,3,6-tetrahydropyridines as potential antipsychotic agents: synthesis and structure-activity relationships.EBI Warner-Lambert Company
8642551 27 5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole: a potent, selective antagonist at human cloned dopamine D4 receptors.EBI Merck Sharp and Dohme
8642550 30 3-((4-(4-Chlorophenyl)piperazin-1-yl)-methyl)-1H-pyrrolo-2,3-b-pyridine: an antagonist with high affinity and selectivity for the human dopamine D4 receptor.EBI Merck Sharp and Dohme Research Laboratories
8544176 16 Identification, characterization and pharmacological profile of three metabolites of (R)-(+)-1,2,3,6-tetrahydro-4-phenyl-1-[(3-phenylcyclohexen-1- yl)methyl]pyridine (CI-1007), a dopamine autoreceptor agonist and potential antipsychotic agent.EBI Warner-Lambert Company
8230107 61 Substituted 3-phenylpiperidines: new centrally acting dopamine autoreceptor antagonists.EBI University of Göteborg
7990123 30 Iodinated 2-aminotetralins and 3-amino-1-benzopyrans: ligands for dopamine D2 and D3 receptors.EBI University of Pennsylvania
7932581 32 The discovery and structure-activity relationships of 1,2,3,6-tetrahydro-4-phenyl-1-[(arylcyclohexenyl)alkyl]pyridines. Dopamine autoreceptor agonists and potential antipsychotic agents.EBI Parke-Davis Pharmaceutical Research
7902870 24 Evaluation of the effects of the enantiomers of reduced haloperidol, azaperol, and related 4-amino-1-arylbutanols on dopamine and sigma receptors.EBI Warner-Lambert Company
7636875 21 Synthesis and dopaminergic activity of pyridine analogs of 5-hydroxy-2-(di-n-propylamino)tetralin.EBI Warner-Lambert Company
2391685 10 N-fluoroalkylated and N-alkylated analogues of the dopaminergic D-2 receptor antagonist raclopride.EBI Washington University School of Medicine
23356363 215 Benzenesulfonamides with benzimidazole moieties as inhibitors of carbonic anhydrases I, II, VII, XII and XIII.BDB Vilnius University
22809106 4 Synthesis, inhibitory activity and molecular docking studies of two Cu(II) complexes against Helicobacter pylori urease.BDB Wuhan Textile University
21299452 7 Steroidal 5a-reductase inhibitors using 4-androstenedione as substrate.BDB Metropolitan University-Xochimilco
28111099 4 Talaromyces marneffei Mp1p Is a Virulence Factor that Binds and Sequesters a Key Proinflammatory Lipid to Dampen Host Innate Immune Response.BDB The University of Hong Kong
26833890 18 Synthesis, Biological Evaluation, and Molecular Docking of 8-imino-2-oxo-2H,8H-pyrano[2,3-f]chromene Analogs: New Dual AChE Inhibitors as Potential Drugs for the Treatment of Alzheimer's Disease.BDB Yogi Vemana University
26943478 16 Synthesis and anti-acetylcholinesterase activity of scopoletin derivatives.BDB Chulabhorn Research Institute
26851737 36 One-pot synthesis of tetrazole-1,2,5,6-tetrahydronicotinonitriles and cholinesterase inhibition: Probing the plausible reaction mechanism via computational studies.BDB University of Karachi
26717022 13 Design, synthesis and in-vitro evaluation of novel tetrahydroquinoline carbamates as HIV-1 RT inhibitor and their antifungal activity.BDB Birla Institute of Technology & Science
26077890 33 Design, Synthesis, Biological Evaluation, and Docking Study of Acetylcholinesterase Inhibitors: New Acridone-1,2,4-oxadiazole-1,2,3-triazole Hybrids.BDB Tehran University of Medical Sciences
26469307 7 Phosphorylation of Capsaicinoid Derivatives Provides Highly Potent and Selective Inhibitors of the Transcription Factor STAT5b.BDB University of Leipzig
26218629 26 Small Molecule Inhibitors of 8-Oxoguanine DNA Glycosylase-1 (OGG1).BDB Oregon Health & Science University
26123174 9 Discovery of novel purine-based heterocyclic P2X7 receptor antagonists.BDB Gwangju Institute of Science and Technology
17391964 54 Further modification on phenyl acetic acid based quinolines as liver X receptor modulators.BDB Wyeth Research