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34 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
27855359 15 Discovery of benzimidazole derivatives as modulators of mitochondrial function: A potential treatment for Alzheimer's disease.EBI Korea Institute of Science and Technology
27933810 166 Structure-Based Scaffold Repurposing for G Protein-Coupled Receptors: Transformation of Adenosine Derivatives into 5HTEBI National Institute of Diabetes and Digestive and Kidney Diseases
26475518 19 Synthesis and evaluation of aporphine analogs containing C1 allyl isosteres at the h5-HT(2A) receptor.EBI City University of New York
26461041 10 First Demonstration of Positive Allosteric-like Modulation at the Human Wild Type Translocator Protein (TSPO).EBI University of New South Wales
26227772 22 C4 phenyl aporphines with selective h5-HT(2B) receptor affinity.EBI City University of New York
25725375 22 Ether analogues of DPA-714 with subnanomolar affinity for the translocator protein (TSPO).EBI Stanford University School of Medicine
24697290 6 Discovery of a neuroprotective chemical, (S)-N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-6-methoxypyridin-2-amine [(-)-P7C3-S243], with improved druglike properties.EBI University of Texas Southwestern Medical Center
24147864 6 Synthesis and evaluation in monkey of [(18)F]4-fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4-yl)thiazol-2-yl)benzamide ([(18)F]FIMX): a promising radioligand for PET imaging of brain metabotropic glutamate receptor 1 (mGluR1).EBI National Institute of Mental Health
24050790 1 Identification of a novel benzoxazolone derivative as a selective, orally active 18 kDa translocator protein (TSPO) ligand.EBI Dainippon Sumitomo Pharma Co., Ltd
24611085 101 Discovery of ML314, a Brain Penetrant Non-Peptidic?-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor.EBI Sanford-Burnham Medical Research Institute
8978853 57 Genetic neural networks for quantitative structure-activity relationships: improvements and application of benzodiazepine affinity for benzodiazepine/GABAA receptors.EBI Harvard University
21741237 6 Synthesis of 6-[¹8F]fluoro-PBR28, a novel radiotracer for imaging the TSPO 18 kDa with PET.EBI CEA
24900292 9 TSPO 18 kDa (PBR) Targeted Photosensitizers for Cancer Imaging (PET) and PDT.EBI TBA
21133364 26 Evaluation of novel N1-methyl-2-phenylindol-3-ylglyoxylamides as a new chemotype of 18 kDa translocator protein-selective ligand suitable for the development of positron emission tomography radioligands.EBI National Institute of Mental Health
18472268 15 Synthesis, fluorine-18 radiolabeling, and in vitro characterization of 1-iodophenyl-N-methyl-N-fluoroalkyl-3-isoquinoline carboxamide derivatives as potential PET radioligands for imaging peripheral benzodiazepine receptor.EBI Emory University
18176998 45 Discovery and biological evaluation of 5-aryl-2-furfuramides, potent and selective blockers of the Nav1.8 sodium channel with efficacy in models of neuropathic and inflammatory pain.EBI Abbott Laboratories
11585444 295 From hit to lead. Analyzing structure-profile relationships.EBI Universities of Lille
15203136 39 (+/-)8-Amino-5,6,7,8-tetrahydroisoquinolines as novel antinociceptive agents.EBI Virginia Commonwealth University
18852280 8 1,5-benzodiazepines, a novel class of hepatitis C virus polymerase nonnucleoside inhibitors.EBI Tibotec BVBA
19767206 9 Synthesis and in vitro autoradiographic evaluation of a novel high-affinity radioiodinated ligand for imaging brain cannabinoid subtype-1 receptors.EBI National Institute of Mental Health
19119848 4 Single-step high-yield radiosynthesis and evaluation of a sensitive 18F-labeled ligand for imaging brain peripheral benzodiazepine receptors with PET.EBI National Institute of Mental Health
18067245 11 Synthesis and evaluation in monkey of two sensitive 11C-labeled aryloxyanilide ligands for imaging brain peripheral benzodiazepine receptors in vivo.EBI National Institute of Mental Health
16722631 87 An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.EBI Predix Pharmaceuticals Ltd.
16458504 37 Synthesis, in vitro and in vivo evaluation of [O-methyl-11C] 2-{4-[4-(3-methoxyphenyl)piperazin-1-yl]-butyl}-4-methyl-2H-[1,2,4]-triazine-3,5-dione: a novel agonist 5-HT1A receptor PET ligand.EBI Columbia University College of Physicians and Surgeons
12482423 6 [18F]FMDAA1106 and [18F]FEDAA1106: two positron-emitter labeled ligands for peripheral benzodiazepine receptor (PBR).EBI National Institute of Radiological Sciences
32787142 88 Exploration of Alternative Scaffolds for P2YEBI National Institute of Diabetes and Digestive and Kidney Diseases
31404862 138 Imidazopyridine-based selective and multifunctional ligands of biological targets associated with psychiatric and neurodegenerative diseases.EBI Palack£ University
32271569 76 Truncated (N)-Methanocarba Nucleosides as Partial Agonists at Mouse and Human AEBI Medical College of Wisconsin
30605331 236 Design and in Vivo Characterization of AEBI Medical College of Wisconsin
31419132 66 First Nondiscriminating Translocator Protein Ligands Produced from a Carbazole Scaffold.EBI Macquarie University
29031071 12 Discovery of thienopyrrolotriazine derivatives to protect mitochondrial function against A?-induced neurotoxicity.EBI Korea Institute of Science and Technology (KIST)
28949521 88 Discovery of N-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor.EBI AbbVie Inc
15837308 19 Oximinoarylsulfonamides as potent HIV protease inhibitors.BDB Abbott Laboratories