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191 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
28613859 43 Donepezil-Based Central Acetylcholinesterase Inhibitors by Means of a"Bio-Oxidizable" Prodrug Strategy: Design, Synthesis, and in Vitro Biological Evaluation.EBI VFP Therapies
28279845 54 Design, synthesis and evaluation of novel ferulic acid-O-alkylamine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.EBI Nanyang Normal University
27744187 42 Design, synthesis and biological evaluation of bambuterol analogues as novel inhibitors of butyrylcholinesterase.EBI South China University of Technology
27936444 93 Amino derivatives of platanic acid act as selective and potent inhibitors of butyrylcholinesterase.EBI Martin-Luther-University Halle-Wittenberg
27918993 29 Tetrahydropyranodiquinolin-8-amines as new, non hepatotoxic, antioxidant, and acetylcholinesterase inhibitors for Alzheimer's disease therapy.EBI University of Sfax
28189420 28 3,4-Dihydroquinazoline derivatives inhibit the activities of cholinesterase enzymes.EBI Kyung Hee University
28126439 27 Design, synthesis and evaluation of some N-methylenebenzenamine derivatives as selective acetylcholinesterase (AChE) inhibitor and antioxidant to enhance learning and memory.EBI Indian Institute of Technology (Banaras Hindu University)
28089589 78 Synthesis, anticholinesterase activity and molecular modeling study of novel carbamate-substituted thymol/carvacrol derivatives.EBI Bezmialem Vakif University
27721157 32 Design, synthesis, in-silico and biological evaluation of novel donepezil derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease.EBI University of Delhi
27721153 18 Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation.EBI Jagiellonian University Medical College
27688184 29 New azepino[4,3-b]indole derivatives as nanomolar selective inhibitors of human butyrylcholinesterase showing protective effectsáagainst NMDA-induced neurotoxicity.EBI University of Bari"A. Moro"
27689726 89 Repurposing N,N'-bis-(arylamidino)-1,4-piperazinedicarboxamidines: An unexpected class of potent inhibitors of cholinesterases.EBI Martin-Luther-University Halle-Wittenberg
27592396 40 New piperidine-hydrazone derivatives: Synthesis, biological evaluations and molecular docking studies as AChE and BChE inhibitors.EBI Gaziantep University
27560283 58 Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HTEBI Jagiellonian University Collegium Medicum
27484514 107 Rational modification of donepezil as multifunctional acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.EBI China Pharmaceutical University
27376495 16 Avarol derivatives as competitive AChE inhibitors, non hepatotoxic and neuroprotective agents for Alzheimer's disease.EBI Istituto di Chimica Biomolecolare (ICB)
27343850 26 Design, synthesis and evaluation of 4-dimethylamine flavonoid derivatives as potential multifunctional anti-Alzheimer agents.EBI Henan University
27769620 59 Synthesis and biological evaluation of ranitidine analogs as multiple-target-directed cognitive enhancers for the treatment of Alzheimer's disease.EBI University of South Carolina
27214510 33 Synthesis and anticholinesterase activity of coumarin-3-carboxamides bearing tryptamine moiety.EBI Islamic Azad University
27227482 30 Synthesis and screening of triazolopyrimidine scaffold as multi-functional agents for Alzheimer's disease therapies.EBI Jamia Millia Islamia (Central University)
27096334 14 Alkaloids from Hippeastrum argentinum and Their Cholinesterase-Inhibitory Activities: An in Vitro and in Silico Study.EBI Universidad Nacional de San Juan
27492195 14 Cholinesterase inhibitory activity of isoquinoline alkaloids from three Cryptocarya species (Lauraceae).EBI University of Malaya
27460699 76 Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer's disease based on the fusion of donepezil and melatonin.EBI China Pharmaceutical University
27353888 30 Design, synthesis and evaluation of novel indandione derivatives as multifunctional agents with cholinesterase inhibition, anti-▀-amyloid aggregation, antioxidant and neuroprotection properties against Alzheimer's disease.EBI University of Delhi
27236720 18 Natural cholinesterase inhibitors from Myristica cinnamomea King.EBI University of Malaya
27190595 70 Design, Synthesis, and Evaluation of Donepezil-Like Compounds as AChE and BACE-1 Inhibitors.EBI Universit£ degli Studi della Magna Gr£cia Viale Europa
27328658 36 2-Benzoyl-6-benzylidenecyclohexanone analogs as potent dual inhibitors of acetylcholinesterase and butyrylcholinesterase.EBI Universiti Putra Malaysia
27061983 48 Design, synthesis and evaluation of novel tacrine-multialkoxybenzene hybrids as multi-targeted compounds against Alzheimer's disease.EBI Guangzhou Medical University
27017111 33 Design, synthesis and bioactivity of novel phthalimide derivatives as acetylcholinesterase inhibitors.EBI Chinese Academy of Agricultural Sciences
26995529 14 2-Phenylbenzofuran derivatives as butyrylcholinesterase inhibitors: Synthesis, biological activity and molecular modeling.EBI University of Cagliari
27083471 46 Biological evaluation of synthetica,▀-unsaturated carbonyl based cyclohexanone derivatives as neuroprotective novel inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid-▀ aggregation.EBI Wuhan University of Technology
26886849 72 Discovery of Highly Selective and Nanomolar Carbamate-Based Butyrylcholinesterase Inhibitors by Rational Investigation into Their Inhibition Mode.EBI Universit£t W£rzburg
26383128 121 Converting maslinic acid into an effective inhibitor of acylcholinesterases.EBI Martin-Luther-Universit£t Halle-Wittenberg
26947959 35 Synthesis, structural characterization, docking, lipophilicity and cytotoxicity of 1-[(1R)-1-(6-fluoro-1,3-benzothiazol-2-yl)ethyl]-3-alkyl carbamates, novel acetylcholinesterase and butyrylcholinesterase pseudo-irreversible inhibitors.EBI University of Pardubice
26917219 63 Design, synthesis and biological evaluation of novel donepezil-coumarin hybrids as multi-target agents for the treatment of Alzheimer's disease.EBI China Pharmaceutical University
26752094 39 Design, synthesis and evaluation of novel 7-aminoalkyl-substituted flavonoid derivatives with improved cholinesterase inhibitory activities.EBI Henan University
26783181 24 Design and discovery of Novel Thiazole acetamide derivatives as anticholinesterase agent for possible role in the management of Alzheimer's.EBI Linyi People's Hospital
26735910 23 Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease.EBI University of Bras£lia
26514744 46 Synthesis of donepezil-based multifunctional agents for the treatment of Alzheimer's disease.EBI Ataturk University
26454504 28 Design, synthesis, biological evaluation and docking study of 4-isochromanone hybrids bearing N-benzyl pyridinium moiety as dual binding site acetylcholinesterase inhibitors.EBI China Pharmaceutical University
26244990 78 Potential of aryl-urea-benzofuranylthiazoles hybrids as multitasking agents in Alzheimer's disease.EBI Bezmialem Vakif University
26337018 44 Multifunctional novel Diallyl disulfide (DADS) derivatives with▀-amyloid-reducing, cholinergic, antioxidant and metal chelating properties for the treatment of Alzheimer's disease.EBI University of Delhi
26242241 29 Synthesis, biological evaluation and molecular modeling of new tetrahydroacridine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.EBI Jagiellonian University Medical College
26278660 90 Evaluation of Homobivalent Carbolines as Designed Multiple Ligands for the Treatment of Neurodegenerative Disorders.EBI University of Jena
26212777 22 Discovery of new acetylcholinesterase inhibitors with small core structures through shape-based virtual screening.EBI Nanjing University of Chinese Medicine
25282654 56 Design, synthesis and evaluation of novel tacrine-(▀-carboline) hybrids as multifunctional agents for the treatment of Alzheimer's disease.EBI China Pharmaceutical University
25980913 9 Allobetulin derived seco-oleananedicarboxylates act as inhibitors of acetylcholinesterase.EBI Martin-Luther-Universit£t Halle-Wittenberg
26107513 172 Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases.EBI Universit£ degli Studi di Bari"Aldo Moro"
25969170 38 Design, synthesis and anticholinesterase activity of novel benzylidenechroman-4-ones bearing cyclic amine side chain.EBI Tehran University of Medicinal Sciences
25812965 80 Multi-target tacrine-coumarin hybrids: cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease.EBI China Pharmaceutical University
25793650 47 Novel multitarget-directed ligands (MTDLs) with acetylcholinesterase (AChE) inhibitory and serotonergic subtype 4 receptor (5-HT4R) agonist activities as potential agents against Alzheimer's disease: the design of donecopride.EBI CERMN
25768702 86 Blood-brain barrier permeable anticholinesterase aurones: synthesis, structure-activity relationship, and drug-like properties.EBI Universiti Sains Malaysia
25621991 62 Development of multifunctional, heterodimeric isoindoline-1,3-dione derivatives as cholinesterase and▀-amyloid aggregation inhibitors with neuroprotective properties.EBI Jagiellonian University Medical College
25656088 32 Multifunctional tacrine-trolox hybrids for the treatment of Alzheimer's disease with cholinergic, antioxidant, neuroprotective and hepatoprotective properties.EBI China Pharmaceutical University
25636055 13 Potent acetylcholinesterase inhibitors: design, synthesis, biological evaluation, and docking study of acridone linked to 1,2,3-triazole derivatives.EBI Tehran University of Medical Sciences
25868744 51 Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with▀-amyloid anti-aggregation properties and beneficial effects on memory in vivo.EBI Jagiellonian University
25724825 27 Design, synthesis and evaluation of novel 5,6,7-trimethoxyflavone-6-chlorotacrine hybrids as potential multifunctional agents for the treatment of Alzheimer's disease.EBI Wenzhou Medical University
25707322 47 Isoindoline-1,3-dione derivatives targeting cholinesterases: design, synthesis and biological evaluation of potential anti-Alzheimer's agents.EBI Jagiellonian University Medical College
25624107 74 Synthesis, biological evaluation and molecular docking study of novel piperidine and piperazine derivatives as multi-targeted agents to treat Alzheimer's disease.EBI University of Delhi
25597007 14 Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of AD.EBI Universit£ di Pisa
25047936 183 Amine substitution of quinazolinones leads to selective nanomolar AChE inhibitors with 'inverted' binding mode.EBI Universit£t Regensburg
25036795 45 Indolinone-based acetylcholinesterase inhibitors: synthesis, biological activity and molecular modeling.EBI Yazd University
25017625 45 Synthesis and cholinesterase inhibition of cativic acid derivatives.EBI Universidad Nacional del Sur
25462245 27 New tetracyclic tacrine analogs containing pyrano[2,3-c]pyrazole: efficient synthesis, biological assessment and docking simulation study.EBI Tehran University of Medical Sciences
24941128 41 Synthesis and anti-cholinesterase activity of new 7-hydroxycoumarin derivatives.EBI Tehran University of Medical Sciences
24853320 62 Amino derivatives of glycyrrhetinic acid as potential inhibitors of cholinesterases.EBI Martin-Luther-Universit£t Halle-Wittenberg
24835788 28 Preparation, anticholinesterase activity and molecular docking of new lupane derivatives.EBI Universidad Nacional del Sur
24813882 41 Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease.EBI Okayama University
24794747 36 Novel aromatic-polyamine conjugates as cholinesterase inhibitors with notable selectivity toward butyrylcholinesterase.EBI Henan University
24858540 12 Dibenzo[1,4,5]thiadiazepine: a hardly-known heterocyclic system with neuroprotective properties of potential usefulness in the treatment of neurodegenerative diseases.EBI Instituto de Qu£mica M£dica
24836068 19 Structural modifications of 4-aryl-4-oxo-2-aminylbutanamides and their acetyl- and butyrylcholinesterase inhibitory activity. Investigation of AChE-ligand interactions by docking calculations and molecular dynamics simulations.EBI Ratka Resanovica1
24819955 36 Identification of a neuroprotective and selective butyrylcholinesterase inhibitor derived from the natural alkaloid evodiamine.EBI University of W£rzburg
24731278 22 Synthesis and in vitro evaluation of anti-inflammatory activity of ester and amine derivatives of indoline in RAW 264.7 and peritoneal macrophages.EBI Bar-Ilan University
24726809 72 Design, synthesis and biological evaluation of benzylisoquinoline derivatives as multifunctional agents against Alzheimer's disease.EBI China Pharmaceutical University
24594354 46 Synthesis and discovery of highly functionalized mono- and bis-spiro-pyrrolidines as potent cholinesterase enzyme inhibitors.EBI Universiti Sains Malaysia
24681070 15 Novel structural hybrids of pyrazolobenzothiazines with benzimidazoles as cholinesterase inhibitors.EBI Government College Women University
24657052 42 Quinolone-benzylpiperidine derivatives as novel acetylcholinesterase inhibitor and antioxidant hybrids for Alzheimer disease.EBI Universit£ de Franche Comt£
24594525 25 Design, synthesis and biological evaluation of D-ring opened galantamine analogs as multifunctional anti-Alzheimer agents.EBI Southeast University
24530494 42 Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease.EBI Laboratorio de Quimica Medica (IQOG, CSIC)
24461561 24 Ionic liquid mediated synthesis of mono- and bis-spirooxindole-hexahydropyrrolidines as cholinesterase inhibitors and their molecular docking studies.EBI Universiti Sains Malaysia
24461494 28 Synthesis and biological evaluation of a new series of ebselen derivatives as glutathione peroxidase (GPx) mimics and cholinesterase inhibitors against Alzheimer's disease.EBI Sun Yat-sen University
24378710 18 Cannabinoid agonists showing BuChE inhibition as potential therapeutic agents for Alzheimer's disease.EBI Instituto de Qu£mica M£dica (CSIC)
24369842 62 Cholinesterase inhibitory activity versus aromatic core multiplicity: a facile green synthesis and molecular docking study of novel piperidone embedded thiazolopyrimidines.EBI Universiti Sains Malaysia
24220172 25 Novel tacrine-ebselen hybrids with improved cholinesterase inhibitory, hydrogen peroxide and peroxynitrite scavenging activity.EBI Sun Yat-sen University
24148835 41 Design, synthesis and evaluation of novel 4-dimethylamine flavonoid derivatives as potential multi-functional anti-Alzheimer agents.EBI Henan University
24128814 38 Inhibition of cholinesterase and monoamine oxidase-B activity by Tacrine-Homoisoflavonoid hybrids.EBI Sun Yat-sen University
24211638 28 Novel coumarin-3-carboxamides bearing N-benzylpiperidine moiety as potent acetylcholinesterase inhibitors.EBI Kerman University of Medical Sciences
24160297 37 Synthesis and evaluation of multi-target-directed ligands against Alzheimer's disease based on the fusion of donepezil and ebselen.EBI Sun Yat-sen University
24148993 4 Acetylcholinesterase inhibitors as Alzheimer therapy: from nerve toxins to neuroprotection.EBI Punjabi University
24095756 48 Multifunctional tacrine-flavonoid hybrids with cholinergic,▀-amyloid-reducing, and metal chelating properties for the treatment of Alzheimer's disease.EBI China Pharmaceutical University
23988412 39 Design, synthesis, docking study and biological evaluation of some novel tetrahydrochromeno [3',4':5,6]pyrano[2,3-b]quinolin-6(7H)-one derivatives against acetyl- and butyrylcholinesterase.EBI Tehran University of Medical Sciences
23988409 32 Design, synthesis, biological evaluation and docking study of 5-oxo-4,5-dihydropyrano[3,2-c]chromene derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors.EBI Tehran University of Medical Sciences
23932451 34 Synthesis and biological evaluation of berberine-thiophenyl hybrids as multi-functional agents: Inhibition of acetylcholinesterase, butyrylcholinesterase, and A▀ aggregation and antioxidant activity.EBI Sun Yat-sen University
23871902 42 An expedient, ionic liquid mediated multi-component synthesis of novel piperidone grafted cholinesterase enzymes inhibitors and their molecular modeling study.EBI Universiti Sains Malaysia
23891231 42 Synthesis, biological activity and molecular modeling studies on 1H-benzimidazole derivatives as acetylcholinesterase inhibitors.EBI Ege University
23799643 5 Design, synthesis, and evaluation of multitarget-directed resveratrol derivatives for the treatment of Alzheimer's disease.EBI Sun Yat-sen University
23685572 55 Design, synthesis and evaluation of novel tacrine-coumarin hybrids as multifunctional cholinesterase inhibitors against Alzheimer's disease.EBI China Pharmaceutical University
23644208 40 Synthesis and evaluation of 4-substituted coumarins as novel acetylcholinesterase inhibitors.EBI University of Zanjan
23511019 60 Design, synthesis and evaluation of flavonoid derivatives as potential multifunctional acetylcholinesterase inhibitors against Alzheimer's disease.EBI China Pharmaceutical University
23602518 50 Microwave assisted synthesis, cholinesterase enzymes inhibitory activities and molecular docking studies of new pyridopyrimidine derivatives.EBI Universiti Sains Malaysia
23639542 32 NO-donating tacrine derivatives as potential butyrylcholinesterase inhibitors with vasorelaxation activity.EBI China Pharmaceutical University
23570788 23 A facile chemo-, regio- and stereoselective synthesis and cholinesterase inhibitory activity of spirooxindole-pyrrolizine-piperidine hybrids.EBI Universiti Sains Malaysia
23541836 24 Design, synthesis and evaluation of tacrine-flurbiprofen-nitrate trihybrids as novel anti-Alzheimer's disease agents.EBI China Pharmaceutical University
23501115 62 Synthesis and evaluation of 7,8-dehydrorutaecarpine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.EBI Sun Yat-sen University
23462716 49 Synthesis and in vitro evaluation of new derivatives of 2-substituted-6-fluorobenzo[d]thiazoles as cholinesterase inhibitors.EBI University of Pardubice
23454517 56 A novel series of tacrine-selegiline hybrids with cholinesterase and monoamine oxidase inhibition activities for the treatment of Alzheimer's disease.EBI Sun Yat-sen University
23454132 68 Synthesis and discovery of novel piperidone-grafted mono- and bis-spirooxindole-hexahydropyrrolizines as potent cholinesterase inhibitors.EBI Universiti Sains Malaysia
23376249 46 Synthesis and biological evaluation of 1,3,4-thiadiazole analogues as novel AChE and BuChE inhibitors.EBI University of Life Sciences
23273219 17 Synthesis, molecular modeling and evaluation of novel N'-2-(4-benzylpiperidin-/piperazin-1-yl)acylhydrazone derivatives as dual inhibitors for cholinesterases and Aß aggregation.EBI Baskent University
23199476 36 Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase.EBI Universit£ degli Studi di Bari Aldo Moro
20926161 21 Novel alkyl- and arylcarbamate derivatives with N-benzylpiperidine and N-benzylpiperazine moieties as cholinesterases inhibitors.EBI Jagiellonian University Medical College
20158205 34 Hybrid molecules from xanomeline and tacrine: enhanced tacrine actions on cholinesterases and muscarinic M1 receptors.EBI China Pharmaceutical University
23140986 38 Novel coumarin derivatives bearing N-benzyl pyridinium moiety: potent and dual binding site acetylcholinesterase inhibitors.EBI University College of Science
22624880 16 Tacrine-silibinin codrug shows neuro- and hepatoprotective effects in vitro and pro-cognitive and hepatoprotective effects in vivo.EBI Universit£t Regensburg
22512543 72 Tacrine-ferulic acid-nitric oxide (NO) donor trihybrids as potent, multifunctional acetyl- and butyrylcholinesterase inhibitors.EBI China Pharmaceutical University
23062825 37 Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.EBI Abo Akademi University
23000296 40 Novel multipotent phenylthiazole-tacrine hybrids for the inhibition of cholinesterase activity,ß-amyloid aggregation and Ca²¿ overload.EBI Huazhong University of Science and Technology
24900407 63 Neuroprotective Tri- and Tetracyclic BChE Inhibitors Releasing Reversible Inhibitors upon Carbamate Transfer.EBI TBA
23108363 6 Design, synthesis and biological evaluation of benzo[e][1,2,4]triazin-7(1H)-one and [1,2,4]-triazino[5,6,1-jk]carbazol-6-one derivatives as dual inhibitors of beta-amyloid aggregation and acetyl/butyryl cholinesterase.EBI Universit£ degli Studi di Bari Aldo Moro
22981331 14 Design, synthesis and pharmacological evaluation of novel tacrine-caffeic acid hybrids as multi-targeted compounds against Alzheimer's disease.EBI Sun Yat-sen University
22944335 43 O-Hydroxyl- or o-amino benzylamine-tacrine hybrids: multifunctional biometals chelators, antioxidants, and inhibitors of cholinesterase activity and amyloid-ß aggregation.EBI Sun Yat-sen University
23078965 19 Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: synthesis, biological assessment, and molecular modeling.EBI Instituto de Qu£mica Org£nica General (CSIC)
22704921 34 Development and evaluation of multifunctional agents for potential treatment of Alzheimer's disease: application to a pyrimidine-2,4-diamine template.EBI University of Waterloo
22633691 42 Design, synthesis, and evaluation of indanone derivatives as acetylcholinesterase inhibitors and metal-chelating agents.EBI Sun Yat-sen University
22420827 14 Multifunctional mercapto-tacrine derivatives for treatment of age-related neurodegenerative diseases.EBI Huazhong University of Science and Technology
21715067 15 Synthesis and pharmacological assessment of diversely substituted pyrazolo[3,4-b]quinoline, and benzo[b]pyrazolo[4,3-g][1,8]naphthyridine derivatives.EBI University of Lisbon
22472046 40 Inhibition of cholinesterase activity and amyloid aggregation by berberine-phenyl-benzoheterocyclic and tacrine-phenyl-benzoheterocyclic hybrids.EBI Sun Yat-sen University
22243648 112 New tacrine-4-oxo-4H-chromene hybrids as multifunctional agents for the treatment of Alzheimer's disease, with cholinergic, antioxidant, andß-amyloid-reducing properties.EBI Instituto de Qu£mica M£dica
22444876 34 Design, synthesis and evaluation of isaindigotone derivatives as dual inhibitors for acetylcholinesterase and amyloid beta aggregation.EBI Sun Yat-sen University
20575555 45 Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives.EBI Universidad Autonoma de Madrid
20350808 36 Bivalent 5,8,9,13b-tetrahydro-6H-isoquino[1,2-a]isoquinolines and -isoquinolinium salts: novel heterocyclic templates for butyrylcholinesterase inhibitors.EBI Friedrich-Schiller-Universit£t Jena
20176490 8 Acetylcholinesterase inhibitors from the toadstool Cortinarius infractus.EBI Institute of Plant Biochemistry
16989531 10 Taspine: bioactivity-guided isolation and molecular ligand-target insight of a potent acetylcholinesterase inhibitor from Magnolia x soulangiana.EBI Leopold-Franzens-Universit£t
18479118 114 Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.EBI Universit£ di Siena
17574306 29 Synthesis and biological evaluation of helicid analogues as novel acetylcholinesterase inhibitors.EBI Sun Yat-sen University
22341944 29 Novel oxoisoaporphine-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.EBI School of Chemistry & Chemical Engineering of Guangxi Normal University
21420206 38 N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease.EBI Instituto de Qu£mica M£dica
22023459 42 Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.EBI Universitat Aut£noma de Barcelona
22001085 22 Synthesis and testing of trifluoromethyl-containing phosphonate-peptide conjugates as inhibitors of serine hydrolases.EBI Moscow State University
22019228 52 Synthesis, biological evaluation of 9-N-substituted berberine derivatives as multi-functional agents of antioxidant, inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid-ß aggregation.EBI Sun Yat-sen University
22000936 33 Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues.EBI University of Lisbon
21873056 50 Development of 2-substituted-N-(naphth-1-ylmethyl) and N-benzhydrylpyrimidin-4-amines as dual cholinesterase and Aß-aggregation inhibitors: Synthesis and biological evaluation.EBI University of Waterloo
21871694 28 Hybrids of oxoisoaporphine-tacrine congeners: novel acetylcholinesterase and acetylcholinesterase-inducedß-amyloid aggregation inhibitors.EBI Guangxi Normal University
21546135 10 Mycobacterium tuberculosis and cholinesterase inhibitors from Voacanga globosa.EBI University of Santo Tomas
21459491 96 Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease.EBI Universit£ degli Studi di Genova
21497959 28 Synthesis and evaluation of heterobivalent tacrine derivatives as potential multi-functional anti-Alzheimer agents.EBI Sun Yat-sen University
21367493 32 Syntheses and characterization of novel oxoisoaporphine derivatives as dual inhibitors for cholinesterases and amyloid beta aggregation.EBI Sun Yat-sen University
21411323 24 Synthesis, biological assessment and molecular modeling of 14-aryl-10,11,12,14-tetrahydro-9H-benzo[5,6]chromeno[2,3-b]quinolin-13-amines.EBI Universit£ de Sfax
21232964 50 Probing the mid-gorge of cholinesterases with spacer-modified bivalent quinazolinimines leads to highly potent and selective butyrylcholinesterase inhibitors.EBI Queen's University Belfast
21111515 12 Synthesis, biological assessment and molecular modeling of new dihydroquinoline-3-carboxamides and dihydroquinoline-3-carbohydrazide derivatives as cholinesterase inhibitors, and Ca channel antagonists.EBI Université de Franche-Comté
20964319 7 Citrusosides A-D and furanocoumarins with cholinesterase inhibitory activity from the fruit peels of Citrus hystrix.EBI Ramkhamhaeng University
21163662 39 Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3-carbonitriles.EBI Laboratorio de Radicales Libres y Qu�mica Computacional (IQOG, CSIC)
20926162 14 Old phenothiazine and dibenzothiadiazepine derivatives for tomorrow's neuroprotective therapies against neurodegenerative diseases.EBI Instituto de Qu£mica M£dica
20545360 38 Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties.EBI Instituto de Quimica Medica
20471843 60 Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase.EBI Sun Yat-sen University
20472431 32 Design, synthesis and evaluation of 2,4-disubstituted pyrimidines as cholinesterase inhibitors.EBI University of Waterloo
20452769 74 Synthesis of 4-[(diethylamino)methyl]-phenol derivatives as novel cholinesterase inhibitors with selectivity towards butyrylcholinesterase.EBI Sun Yat-sen University
20361801 100 Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents.EBI Friedrich-Schiller-Universitat Jena
20350807 7 Molecular modelling, synthesis and acetylcholinesterase inhibition of ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate.EBI Laboratorio de Radicales Libres y Química Computacional (IQOG, CSIC)
20079560 28 Synthesis and evaluation of novel rutaecarpine derivatives and related alkaloids derivatives as selective acetylcholinesterase inhibitors.EBI Sun Yat-sen University
19856923 40 Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease.EBI Instituto de Quimica Medica (CSIC)
20056426 38 Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors.EBI Sun Yat-sen University
20149667 17 Interaction of (benzylidene-hydrazono)-1,4-dihydropyridines with beta-amyloid, acetylcholine, and butyrylcholine esterases.EBI Ege University
20061157 45 4-Aryl-4-oxo-N-phenyl-2-aminylbutyramides as acetyl- and butyrylcholinesterase inhibitors. Preparation, anticholinesterase activity, docking study, and 3D structure-activity relationship based on molecular interaction fields.EBI Institute
19243862 36 Synthesis, biological evaluation and molecular modeling of oxoisoaporphine and oxoaporphine derivatives as new dual inhibitors of acetylcholinesterase/butyrylcholinesterase.EBI Sun Yat-sen University
18585045 22 Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors.EBI Università di Bari
18524585 20 Design, synthesis and evaluation of isaindigotone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors.EBI Sun Yat-sen University
17624631 9 Chemiluminescent high-throughput microassay applied to imidazo[2,1-b]thiazole derivatives as potential acetylcholinesterase and butyrylcholinesterase inhibitors.EBI Università di Bologna
17067156 11 Microbial transformation and butyrylcholinesterase inhibitory activity of (-)-caryophyllene oxide and its derivatives.EBI University of Karachi
16378379 3 Nostocarboline: isolation and synthesis of a new cholinesterase inhibitor from Nostoc 78-12A.EBI University of Zürich
11421762 6 Steroidal alkaloids from the leaves of Sarcococca coriacea of Nepalese origin.EBI Tribhuvan University
28605675 26 Isosteroidal alkaloids as potent dual-binding site inhibitors of both acetylcholinesterase and butyrylcholinesterase from the bulbs of Fritillaria walujewii.EBI Tianjin University of Technology
28587871 34 Synthesis, docking study and neuroprotective effects of some novel pyrano[3,2-c]chromene derivatives bearing morpholine/phenylpiperazine moiety.EBI Tehran University of Medical Sciences
28578994 28 Synthesis, molecular docking, and biological activity of polyfluoroalkyl dihydroazolo[5,1-c][1,2,4]triazines as selective carboxylesterase inhibitors.EBI Urals Branch of Russian Academy of Sciences
28576634 17 BACE1 inhibitory activity and molecular docking analysis of meroterpenoids from Sargassum serratifolium.EBI Pukyong National University
29033233 56 Design, synthesis and biological evaluation of 2-acetyl-5-O-(amino-alkyl)phenol derivatives as multifunctional agents for the treatment of Alzheimer's disease.EBI Nanyang Normal University
29033232 164 Design, synthesis and biological evaluation of phthalimide-alkylamine derivatives as balanced multifunctional cholinesterase and monoamine oxidase-B inhibitors for the treatment of Alzheimer's disease.EBI Nanyang Normal University
28986116 87 9-Substituted acridine derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors possessing antioxidant activity for Alzheimer's disease treatment.EBI Institute of Physiologically Active Compounds Russian Academy of Sciences
27863370 36 Novel tacrine-1,2,3-triazole hybrids: Inávitro, inávivo biological evaluation and docking study of cholinesterase inhibitors.EBI Tehran University of Medical Sciences
27744252 102 Synthesis and evaluation of 7-substituted coumarin derivatives as multimodal monoamine oxidase-B and cholinesterase inhibitors for the treatment of Alzheimer's disease.EBI University of the Western Cape
28302511 34 Design, synthesis and biological evaluation of multifunctional tacrine-curcumin hybrids as new cholinesterase inhibitors with metal ions-chelating and neuroprotective property.EBI China Pharmaceutical University
28282613 21 Design, synthesis and evaluation of novel feruloyl-donepezil hybrids as potential multitarget drugs for the treatment of Alzheimer's disease.EBI Federal University of Alfenas
28487125 174 Design, synthesis and biological evaluation of 3,4-dihydro-2(1H)-quinoline-O-alkylamine derivatives as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.EBI Nanyang Normal University
28416102 19 Synthesis, biochemical evaluation, and molecular modeling studies of aryl and arylalkyl di-n-butyl phosphates, effective butyrylcholinesterase inhibitors.EBI California State University
28388521 28 Design, synthesis and biological activity of novel donepezil derivatives bearing N-benzyl pyridinium moiety as potent and dual binding site acetylcholinesterase inhibitors.EBI Shanghai University of Traditional Chinese Medicine
28371641 32 Recent progress in the identification of selective butyrylcholinesterase inhibitors for Alzheimer's disease.EBI China Pharmaceutical University
29400965 83 Structure-Activity Relationships and Computational Investigations into the Development of Potent and Balanced Dual-Acting Butyrylcholinesterase Inhibitors and Human Cannabinoid Receptor 2 Ligands with Pro-Cognitive in Vivo Profiles.EBI Julius Maximilian University of W£rzburg
28457693 18 Antioxidant and anticholinesterase potential of diterpenoid alkaloids from Aconitum heterophyllum.EBI University of Malakand
28454848 32 Design, synthesis, and evaluation of multitarget-directed ligands against Alzheimer's disease based on the fusion of donepezil and curcumin.EBI Sun Yat-sen University
28404526 23 Stereospecific cholinesterase inhibition by O,S-diethylphenylphosphonothioate.EBI University of Missouri St. Louis