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84 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
28603989 53 a-Conotoxin [S9A]TxID Potently Discriminates betweena3▀4 anda6/a3▀4 Nicotinic Acetylcholine Receptors.EBI Hainan University
28337332 41 BMS-933043, a Selectivea7 nAChR Partial Agonist for the Treatment of Cognitive Deficits Associated with Schizophrenia.EBI Bristol-Myers Squibb Co.
27958732 93 Design and Synthesis of a New Series of 4-Heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes asa7 Nicotinic Receptor Agonists. 1. Development of Pharmacophore and Early Structure-Activity Relationship.EBI Bristol-Myers Squibb Co.
27639361 88 Synthesis and biological evaluation of novel hybrids of highly potent and selectivea4▀2-Nicotinic acetylcholine receptor (nAChR) partial agonists.EBI University of Illinois at Chicago
27818109 30 Novel 5-substituted 3-hydroxyphenyl and 3-nitrophenyl ethers of S-prolinol asa4▀2-nicotinic acetylcholine receptor ligands.EBI Universit£ degli Studi di Milano
26706350 48 Modification of the anabaseine pyridine nucleus allows achieving binding and functional selectivity for thea3▀4 nicotinic acetylcholine receptor subtype.EBI Universit£ degli Studi di Milano
24844195 21 Synthesis and pharmacological characterization of new neuronal nicotinic acetylcholine receptor ligands derived from Sazetidine-A.EBI Georgetown University Medical Center
24942641 7 Molecular basis of the selective binding of MDMA enantiomers to the alpha4beta2 nicotinic receptor subtype: synthesis, pharmacological evaluation and mechanistic studies.EBI University of Barcelona
24187998 96 Design, synthesis, and biological evaluation of Erythrina alkaloid analogues as neuronal nicotinic acetylcholine receptor antagonists.EBI University of Copenhagen
24649848 47 Discovery of a potent and selectivea3▀4 nicotinic acetylcholine receptor antagonist from ana-conotoxin synthetic combinatorial library.EBI Torrey Pines Institute for Molecular Studies
9513595 2 Mono- and disubstituted-3,8-diazabicyclo[3.2.1]octane derivatives as analgesics structurally related to epibatidine: synthesis, activity, and modeling.EBI Universit£ degli Studi di Milano
9733494 12 2-, 5-, and 6-Halo-3-(2(S)-azetidinylmethoxy)pyridines: synthesis, affinity for nicotinic acetylcholine receptors, and molecular modeling.EBI National Institute on Drug Abuse
15050617 5 Subtype-selective nicotinic receptor antagonists: potential as tobacco use cessation agents.EBI University of Kentucky
15050615 36 Synthesis and pharmacological characterization of bivalent ligands of epibatidine at neuronal nicotinic acetylcholine receptors.EBI University of Illinois at Chicago
12639569 23 Binding of nicotine and homoazanicotine analogues at neuronal nicotinic acetylcholinergic (nACh) receptors.EBI Virginia Commonwealth University
12729652 1 Unique spirocyclopiperazinium salt. Part 2: synthesis and structure-activity relationship of dispirocyclopiperazinium salts as analgesics.EBI Peking University
9873625 45 Structure-activity studies related to ABT-594, a potent nonopioid analgesic agent: effect of pyridine and azetidine ring substitutions on nicotinic acetylcholine receptor binding affinity and analgesic activity in mice.EBI Abbott Laboratories
23121096 86 Ion channels as therapeutic targets: a drug discovery perspective.EBI Pfizer Inc
11405659 22 Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2-exo-2-(2'-substituted 5'-pyridinyl)-7-azabicyclo[2.2.1]heptanes. Epibatidine analogues.EBI Research Triangle Institute
10841800 4 Novel potent ligands for the central nicotinic acetylcholine receptor: synthesis, receptor binding, and 3D-QSAR analysis.EBI NeuroSearch A/S
12643898 4 Syntheses and biological properties of cysteine-reactive epibatidine derivatives.EBI Universit£ Louis Pasteur Strasbourg BP 24
10843217 24 Synthesis and structure-activity relationship of novel pyridyl ethers for the nicotinic acetylcholine receptor.EBI R. W. Johnson Pharmaceutical Research Institute
23641311 38 From a4▀2 Nicotinic Ligands to the Discovery of s1 Receptor Ligands: Pharmacophore Analysis and Rational Design.EBI TBA
22410083 17 Consequences of linker length alteration of thea7 nicotinic acetylcholine receptor (nAChR) agonist, SEN12333.EBI The University of Sydney
19954975 27 Structure-activity relationships of N-substituted ligands for the alpha7 nicotinic acetylcholine receptor.EBI Abbott Laboratories
19576766 86 Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates--subtype selective, high affinity alpha7 nicotinic acetylcholine receptor agonists.EBI Pfizer Inc
19552432 90 Octahydropyrrolo[3,4-c]pyrrole: a diamine scaffold for construction of either alpha4beta2 or alpha7-selective nicotinic acetylcholine receptor (nAChR) ligands. Substitutions that switch subtype selectivity.EBI Abbott Laboratories
18989912 95 Novel acetylcholine and carbamoylcholine analogues: development of a functionally selective alpha4beta2 nicotinic acetylcholine receptor agonist.EBI University of Copenhagen
18605717 41 Discovery of (-)-7-methyl-2-exo-[3'-(6-[18F]fluoropyridin-2-yl)-5'-pyridinyl]-7-azabicyclo[2.2.1]heptane, a radiolabeled antagonist for cerebral nicotinic acetylcholine receptor (alpha4beta2-nAChR) with optimal positron emission tomography imaging properties.EBI The Johns Hopkins University School of Medicine
8759171 4 Lycaconitine revisited: partial synthesis and neuronal nicotinic acetylcholine receptor affinities.EBI Ohio Northern University
15715488 21 Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 3'-substituted deschloroepibatidine analogues. Novel nicotinic antagonists.EBI Research Triangle Institute
11855986 24 Synthesis and nicotinic binding studies on enantiopure diazine analogues of the novel (2-chloro-5-pyridyl)-9-azabicyclo[4.2.1]non-2-ene UB-165.EBI Institut f£r Pharmazeutische Chemie der Philipps-Universit£t Marburg
9622546 109 6beta-Acetoxynortropane: a potent muscarinic agonist with apparent selectivity toward M2-receptors.EBI National Institute of Diabetes and Digestive and Kidney Diseases
9435889 70 Neuronal nicotinic acetylcholine receptors as targets for drug discovery.EBI Abbott Laboratories
15050613 50 Pharmacology of the agonist binding sites of rat neuronal nicotinic receptor subtypes expressed in HEK 293 cells.EBI Georgetown University School of Medicine
12467625 32 N,N-disubstituted piperazines: synthesis and affinities at alpha4beta2(*) and alpha7(*) neuronal nicotinic acetylcholine receptors.EBI Chinese Academy of Sciences
12372503 76 bis-Azaaromatic quaternary ammonium analogues: ligands for alpha4beta2* and alpha7* subtypes of neuronal nicotinic receptors.EBI University of Kentucky
20932609 26 Synthesis of novel chiral¿2-isoxazoline derivatives related to ABT-418 and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes.EBI Universit£ degli Studi di Milano
20979364 40 Novela3ß4 nicotinic acetylcholine receptor-selective ligands. Discovery, structure-activity studies, and pharmacological evaluation.EBI SRI International
20880707 13 Identification of 9-fluoro substituted (-)-cytisine derivatives as ligands with high affinity for nicotinic receptors.EBI ENSICAEN-Université de Caen Basse-Normandie
20236734 186 A computational study of the binding of 3-(arylidene) anabaseines to two major brain nicotinic acetylcholine receptors and to the acetylcholine binding protein.EBI University of Florida
20472430 114 Syntheses and structure-activity relationship (SAR) studies of 2,5-diazabicyclo[2.2.1]heptanes as novel alpha7 neuronal nicotinic receptor (NNR) ligands.EBI Abbott Laboratories
20038125 28 Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 3'-(substituted phenyl)epibatidine analogues. Nicotinic partial agonists.EBI Research Triangle Institute
19481945 55 Synthesis and biological evaluation of novel carbon-11 labeled pyridyl ethers: candidate ligands for in vivo imaging of alpha4beta2 nicotinic acetylcholine receptors (alpha4beta2-nAChRs) in the brain with positron emission tomography.EBI The Johns Hopkins University School of Medicine
18851914 2 Tetrakis-azaaromatic quaternary ammonium salts: novel subtype-selective antagonists at neuronal nicotinic receptors that mediate nicotine-evoked dopamine release.EBI University of Kentucky
 18 Corrigendum to Epibatidine structureactivity relationshipsEBI TBA
19548687 67 Synthesis, binding, and modeling studies of new cytisine derivatives, as ligands for neuronal nicotinic acetylcholine receptor subtypes.EBI Università degli Studi di Genova
19232492 32 Preparation and characterization of N-(3-pyridinyl) spirocyclic diamines as ligands for nicotinic acetylcholine receptors.EBI Abbott Laboratories
19097783 26 5-(2-Pyrrolidinyl)oxazolidinones and 2-(2-pyrrolidinyl)benzodioxanes: synthesis of all the stereoisomers and alpha4beta2 nicotinic affinity.EBI Università di Milano Pietro Pratesi
18938077 13 Synthesis of 3,6-diazabicyclo[3.1.1]heptanes as novel ligands for neuronal nicotinic acetylcholine receptors.EBI Università di Sassari
18789861 26 Discovery and optimization of substituted piperidines as potent, selective, CNS-penetrant alpha4beta2 nicotinic acetylcholine receptor potentiators.EBI Amgen Inc
18644719 18 Epiboxidine and novel-related analogues: a convenient synthetic approach and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes.EBI Università degli Studi di Milano
17850058 19 Design, synthesis, and preliminary pharmacological evaluation of new quinoline derivatives as nicotinic ligands.EBI University of Florence
16905316 42 Des-keto lobeline analogs with increased potency and selectivity at dopamine and serotonin transporters.EBI University of Kentucky
16005216 20 The characterization of a novel rigid nicotine analog with alpha7-selective nAChR agonist activity and modulation of agonist properties by boron inclusion.EBI University of Florida
15771418 38 Novel pyridyl ring C5 substituted analogues of epibatidine and 3-(1-methyl-2(S)-pyrrolidinylmethoxy)pyridine (A-84543) as highly selective agents for neuronal nicotinic acetylcholine receptors containing beta2 subunits.EBI University of Illinois at Chicago
15501049 18 Synthesis and alpha4beta2 nicotinic affinity of 2-pyrrolidinylmethoxyimines and prolinal oxime ethers.EBI Università di Milano
15050621 100 Epibatidine structure-activity relationships.EBI Research Triangle Institute
15050620 6 Sensitivity of neuronal nicotinic acetylcholine receptors to the opiate antagonists naltrexone and naloxone: receptor blockade and up-regulation.EBI University of Maryland
15050618 32 Development of subtype-selective ligands as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release.EBI University of Kentucky
14611837 18 Synthesis and nicotinic binding of novel phenyl derivatives of UB-165. Identifying factors associated with alpha7 selectivity.EBI University of Bristol
12061886 11 Synthesis and evaluation of a novel series of 2-chloro-5-((1-methyl-2-(S)-pyrrolidinyl)methoxy)-3-(2-(4-pyridinyl)vinyl)pyridine analogues as potential positron emission tomography imaging agents for nicotinic acetylcholine receptors.EBI National Institute on Drug Abuse
11266158 29 Synthesis and structure-activity relationships of 5-substituted pyridine analogues of 3.EBI Abbott Laboratories
11150171 2 5-Azidoimidacloprid and an acyclic analogue as candidate photoaffinity probes for mammalian and insect nicotinic acetylcholine receptors.EBI University of California
11063601 29 (-)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin-2'-one], a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the alpha 7 nicotinic acetylcholine receptor.EBI AstraZeneca R&D Boston
10509928 31 Structure-activity studies on a novel series of cholinergic channel activators based on a heteroaryl ether framework.EBI Abbott Laboratories
9871663 49 Synthesis and structure-activity relationships of pyridine-modified analogs of 3-[2-((S)-pyrrolidinyl)methoxy]pyridine, A-84543, a potent nicotinic acetylcholine receptor agonist.EBI Abbott Laboratories
27810599 14 From pyrrolidinyl-benzodioxane to pyrrolidinyl-pyridodioxanes, or from unselective antagonism to selective partial agonism at?4?2 nicotinic acetylcholine receptor.EBI Universit£ degli Studi di Milano
29178785 61 Highly Selective and Potent?4?2 nAChR Antagonist Inhibits Nicotine Self-Administration and Reinstatement in Rats.EBI Torrey Pines Institute for Molecular Studies
27282729 22 4-amino-6-alkyloxy-2-alkylthiopyrimidine derivatives as novel non-nucleoside agonists for the adenosine A1 receptor.BDB UniversitÓ di Napoli Federico II
27428767 6 Fluorescent Farnesyl Diphosphate Analogue: A Probe To Validate trans-Prenyltransferase Inhibitors.BDB Academia Sinica
27285276 66 2,5-Diaryloxadiazoles and their precursors as novel inhibitors of cathepsins B, H and L.BDB Kurukshetra University
26218717 25 Inhibitor Fingerprinting of Rhomboid Proteases by Activity-Based Protein Profiling Reveals Inhibitor Selectivity and Rhomboid Autoprocessing.BDB Technische Universitńt MŘnchen