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120 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
28169167 137 Design and synthesis of a novel series of 4-heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes asa7 nicotinic receptor agonists 2. Development of 4-heteroaryl SAR.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
27639361 88 Synthesis and biological evaluation of novel hybrids of highly potent and selectivea42-Nicotinic acetylcholine receptor (nAChR) partial agonists.EBI University of Illinois at Chicago
26706350 48 Modification of the anabaseine pyridine nucleus allows achieving binding and functional selectivity for thea34 nicotinic acetylcholine receptor subtype.EBI Universit£ degli Studi di Milano
26383127 13 Design of novel 3,6-diazabicyclo[3.1.1]heptane derivatives with potent and selective affinities fora42 neuronal nicotinic acetylcholine receptors.EBI University of Sassari
26301559 10 Exploration of the molecular architecture of the orthosteric binding site in thea42 nicotinic acetylcholine receptor with analogs of 3-(dimethylamino)butyl dimethylcarbamate (DMABC) and 1-(pyridin-3-yl)-1,4-diazepane.EBI University of Copenhagen
26164842 30 Bifunctional compounds targeting both D2 and non-a7 nACh receptors: design, synthesis and pharmacological characterization.EBI Universit£ degli Studi di Milano
26225816 25 Chemistry and Pharmacology of a Series of Unichiral Analogues of 2-(2-Pyrrolidinyl)-1,4-benzodioxane, Prolinol Phenyl Ether, and Prolinol 3-Pyridyl Ether Designed asa42-Nicotinic Acetylcholine Receptor Agonists.EBI Universit£ degli Studi di Milano
26142318 36 The twin drug approach for novel nicotinic acetylcholine receptor ligands.EBI University of Hawai'i at Hilo
24967667 45 Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonists.EBI AstraZeneca
24814197 63 Discovery of novel 2-((pyridin-3-yloxy)methyl)piperazines asa7 nicotinic acetylcholine receptor modulators for the treatment of inflammatory disorders.EBI Critical Therapeutics, Inc.
24187998 96 Design, synthesis, and biological evaluation of Erythrina alkaloid analogues as neuronal nicotinic acetylcholine receptor antagonists.EBI University of Copenhagen
24050653 59 Derivatives of dibenzothiophene for positron emission tomography imaging ofa7-nicotinic acetylcholine receptors.EBI The Johns Hopkins University School of Medicine
24365158 9 Synthesis and activity of substituted heteroaromatics as positive allosteric modulators fora42a5 nicotinic acetylcholine receptors.EBI The Scripps Research Institute
24200193 32 Characterization of a novela-conotoxin TxID from Conus textile that potently blocks rata34 nicotinic acetylcholine receptors.EBI Hainan University
24156938 12 The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor (nAChR) ligands. Part 1: the influence of different hydrogen bond acceptor systems on alkyl and (hetero)aryl substituents.EBI University of Bonn
24047231 52 Design, synthesis and discovery of picomolar selective α4β2 nicotinic acetylcholine receptor ligands.EBI Georgetown University
24128660 6 Design, synthesis and binding affinity of acetylcholine carbamoyl analogues.EBI Universit£ di Milano
24035337 10 2-Amino-6-chloro-3,4-dihydroquinazoline: A novel 5-HT3 receptor antagonist with antidepressant character.EBI Virginia Commonwealth University
23886687 9 QM-polarized ligand docking accurately predicts the trend in binding affinity of a series of arylmethylene quinuclidine-like derivatives at thea42 anda34 nicotinic acetylcholine receptors (nAChRs).EBI Targacept, Inc
23757208 29 Discovery of benzamide analogs as negative allosteric modulators of human neuronal nicotinic receptors: pharmacophore modeling and structure-activity relationship studies.EBI The Ohio State University
23734673 10 Chemistry, pharmacology, and behavioral studies identify chiral cyclopropanes as selectivea42-nicotinic acetylcholine receptor partial agonists exhibiting an antidepressant profile. Part II.EBI University of Illinois at Chicago
23692872 98 Novel nicotinic acetylcholine receptor agonists containing carbonyl moiety as a hydrogen bond acceptor.EBI Targacept, Inc.
23602445 23 An analysis of the synthetic tryptamines AMT and 5-MeO-DALT: emerging 'Novel Psychoactive Drugs'.EBI UCL School of Pharmacy
23561269 53 Neonicotinic analogues: selective antagonists fora42 nicotinic acetylcholine receptors.EBI University of Chile
23507153 4 Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging ofa7 nicotinic acetylcholine receptors.EBI Helmholtz-Zentrum Dresden-Rossendorf
23414838 33 Discovery of a novel series of quinolonea7 nicotinic acetylcholine receptor agonists.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
23461628 9 (+)-Laburnamine, a natural selective ligand and partial agonist for the?4?2 nicotinic receptor subtype.EBI Universit£ degli Studi di Genova
23540678 26 Chemistry and pharmacological studies of 3-alkoxy-2,5-disubstituted-pyridinyl compounds as novel selectivea4ß2 nicotinic acetylcholine receptor ligands that reduce alcohol intake in rats.EBI Georgetown University Medical Center
23121096 86 Ion channels as therapeutic targets: a drug discovery perspective.EBI Pfizer Inc.
23256554 16 Synthesis, pharmacology, and biostructural characterization of novela4ß2 nicotinic acetylcholine receptor agonists.EBI University of Copenhagen
22285942 79 3D-QSAR and 3D-QSSR models of negative allosteric modulators facilitate the design of a novel selective antagonist of humana4ß2 neuronal nicotinic acetylcholine receptors.EBI The Ohio State University
22243960 88 Structure-based design, synthesis and structure-activity relationships of dibenzosuberyl- and benzoate-substituted tropines as ligands for acetylcholine-binding protein.EBI VU University Amsterdam
22177081 2 Discovery of novela7 nicotinic acetylcholine receptor ligands via pharmacophoric and docking studies of benzylidene anabaseine analogs.EBI Targacept Inc.
22060139 21 Structure-activity relationship studies of sulfonylpiperazine analogues as novel negative allosteric modulators of human neuronal nicotinic receptors.EBI The Ohio State University
21905680 26 Deconstruction of thea4ß2 nicotinic acetylcholine receptor positive allosteric modulator desformylflustrabromine.EBI Virginia Commonwealth University
20822184 27 Chemistry and pharmacological characterization of novel nitrogen analogues of AMOP-H-OH (Sazetidine-A, 6-[5-(azetidin-2-ylmethoxy)pyridin-3-yl]hex-5-yn-1-ol) asa4ß2-nicotinic acetylcholine receptor-selective partial agonists.EBI University of Illinois at Chicago
20591663 23 Identification of novel alpha7 nAChR positive allosteric modulators with the use of pharmacophore in silico screening methods.EBI GlaxoSmithKline
19301898 72 Complementary three-dimensional quantitative structure-activity relationship modeling of binding affinity and functional potency: a study on alpha4beta2 nicotinic ligands.EBI University of Turin
19026537 90 3D-QSAR and QSSR studies of 3,8-diazabicyclo[4.2.0]octane derivatives as neuronal nicotinic acetylcholine receptors by comparative molecular field analysis (CoMFA).EBI Burnham Institute for Medical Research
17889526 2 Unique spirocyclopiperazinium salt III: further investigation of monospirocyclopiperazinium (MSPZ) salts as potential analgesics.EBI Peking University
17994682 11 Synthesis and nicotinic acetylcholine receptor binding properties of bridged and fused ring analogues of epibatidine.EBI Research Triangle Institute
17929796 55 Synthesis and structure-activity relationship studies of 3,6-diazabicyclo[3.2.0]heptanes as novel alpha4beta2 nicotinic acetylcholine receptor selective agonists.EBI Neuroscience Research
17585748 31 Structure-activity studies and analgesic efficacy of N-(3-pyridinyl)-bridged bicyclic diamines, exceptionally potent agonists at nicotinic acetylcholine receptors.EBI Abbott Laboratories
17181167 50 Synthesis and structure-activity relationships of 3,8-diazabicyclo[4.2.0]octane ligands, potent nicotinic acetylcholine receptor agonists.EBI Abbott Laboratories
16722642 1 Synthesis and pharmacological characterization of nicotinic acetylcholine receptor properties of (+)- and (-)-pyrido-[3,4-b]homotropanes.EBI Research Triangle Institute
16412637 8 Synthesis and analgesic activity of secondary amine analogues of pyridylmethylamine and positional isomeric analogues of ABT-594.EBI Peking University
16289815 1 A novel nicotinic acetylcholine receptor antagonist radioligand for PET studies.EBI Brookhaven National Laboratory
15686946 36 Halogenated and isosteric cytisine derivatives with increased affinity and functional activity at nicotinic acetylcholine receptors.EBI National Institute of Diabetes and Digestive and Kidney Diseases
15050612 8 alpha4beta2 nACh receptor pharmacophore models.EBI Virginia Commonwealth University
14698195 20 3-(4-Aminobutyn-1-yl)pyridines: binding at alpha 4 beta 2 nicotinic cholinergic receptors.EBI Virginia Commonwealth University
23641311 38 From a42 Nicotinic Ligands to the Discovery of s1 Receptor Ligands: Pharmacophore Analysis and Rational Design.EBI TBA
23126648 213 Discovery of (2S,3R)-N-[2-(Pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]benzo[b]furan-2-carboxamide (TC-5619), a selectivea7 nicotinic acetylcholine receptor agonist, for the treatment of cognitive disorders.EBI Targacept, Inc.
23092294 75 Discovery of highly potent and selectivea4ß2-nicotinic acetylcholine receptor (nAChR) partial agonists containing an isoxazolylpyridine ether scaffold that demonstrate antidepressant-like activity. Part II.EBI University of Illinois at Chicago
23025891 169 Structure-activity studies of 7-heteroaryl-3-azabicyclo[3.3.1]non-6-enes: a novel class of highly potent nicotinic receptor ligands.EBI Targacept, Inc.
22928944 12 Insights into the structural determinants required for high-affinity binding of chiral cyclopropane-containing ligands toa4ß2-nicotinic acetylcholine receptors: an integrated approach to behaviorally active nicotinic ligands.EBI University of Illinois at Chicago
22793665 190 Discovery of 3-(5-chloro-2-furoyl)-3,7-diazabicyclo[3.3.0]octane (TC-6683, AZD1446), a novel highly selectivea4ß2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders.EBI Targacept, Inc.
21919481 114 Discovery and development ofa7 nicotinic acetylcholine receptor modulators.EBI Targacept, Inc
22591063 12 Synthesis and nicotinic receptor activity of chemical space analogues of N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide (PNU-282,987) and 1,4-diazabicyclo[3.2.2]nonane-4-carboxylic acid 4-bromophenyl ester (SSR180711).EBI University of Berne
22749278 16 Diazaspirocyclic compounds as selective ligands for thea4ß2 nicotinic acetylcholine receptor.EBI Targacept, Inc.
22171543 22 Chemistry and behavioral studies identify chiral cyclopropanes as selectivea4ß2-nicotinic acetylcholine receptor partial agonists exhibiting an antidepressant profile.EBI University of Illinois at Chicago
24936233 8 Discovery of Novel a42 Neuronal Nicotinic Receptor Modulators through Structure-Based Virtual Screening.EBI TBA
22503453 59 The discovery of 2-fluoro-N-(3-fluoro-4-(5-((4-morpholinobutyl)amino)-1,3,4-oxadiazol-2-yl)phenyl)benzamide, a full agonist of the alpha-7 nicotinic acetylcholine receptor showing efficacy in the novel object recognition model of cognition enhancement.EBI GlaxoSmithKline
22503248 61 Identification of a series of 1,3,4-oxadiazol-2-amines as potent alpha-7 agonists with efficacy in the novel object recognition model of cognition.EBI GlaxoSmithKline
21058665 52 Nicotinic Acetylcholine Receptor Efficacy and Pharmacological Properties of 3-(Substituted phenyl)-2ß-substituted Tropanes.EBI Research Triangle Institute
20684563 176 Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential.EBI H. Lundbeck A/S
20663668 43 A novel series of [3.2.1] azabicyclic biaryl ethers as alpha3beta4 and alpha6/4beta4 nicotinic receptor agonists.EBI Pfizer Inc.
19954975 27 Structure-activity relationships of N-substituted ligands for the alpha7 nicotinic acetylcholine receptor.EBI Abbott Laboratories
19552432 90 Octahydropyrrolo[3,4-c]pyrrole: a diamine scaffold for construction of either alpha4beta2 or alpha7-selective nicotinic acetylcholine receptor (nAChR) ligands. Substitutions that switch subtype selectivity.EBI Abbott Laboratories
18989912 95 Novel acetylcholine and carbamoylcholine analogues: development of a functionally selective alpha4beta2 nicotinic acetylcholine receptor agonist.EBI University of Copenhagen
18605717 41 Discovery of (-)-7-methyl-2-exo-[3'-(6-[18F]fluoropyridin-2-yl)-5'-pyridinyl]-7-azabicyclo[2.2.1]heptane, a radiolabeled antagonist for cerebral nicotinic acetylcholine receptor (alpha4beta2-nAChR) with optimal positron emission tomography imaging properties.EBI The Johns Hopkins UniVersity School of Medicine
16934977 16 Epibatidine isomers and analogues: structure-activity relationships.EBI University of Leicester
16765047 23 Aryloxyethylamines: binding at alpha7 nicotinic acetylcholine receptors.EBI Virginia Commonwealth University
16171993 45 3,5-Bicyclic aryl piperidines: a novel class of alpha4beta2 neuronal nicotinic receptor partial agonists for smoking cessation.EBI Pfizer Global Research and Development
16033252 84 Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations.EBI The Danish University of Pharmaceutical Sciences
15808471 144 2-(Arylmethyl)-3-substituted quinuclidines as selective alpha 7 nicotinic receptor ligands.EBI Targacept, Inc.
15908213 35 In pursuit of alpha4beta2 nicotinic receptor partial agonists for smoking cessation: carbon analogs of (-)-cytisine.EBI Pfizer Global Research and Development
9484491 23 Identification and initial structure-activity relationships of (R)-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT-594), a potent, orally active, non-opiate analgesic agent acting via neuronal nicotinic acetylcholine receptors.EBI Abbott Laboratory
9435889 70 Neuronal nicotinic acetylcholine receptors as targets for drug discovery.EBI Abbott Laboratories
8765504 34 (S)-(-)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine maleate (SIB-1508Y): a novel anti-parkinsonian agent with selectivity for neuronal nicotinic acetylcholine receptors.EBI SIBIA Neurosciences Inc.
15050614 10 Activity of alpha7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes.EBI University of Florida
15203136 39 (+/-)8-Amino-5,6,7,8-tetrahydroisoquinolines as novel antinociceptive agents.EBI Virginia Commonwealth University
11212100 27 The 5-HT3 antagonist tropisetron (ICS 205-930) is a potent and selective alpha7 nicotinic receptor partial agonist.EBI AstraZeneca
22281189 63 SAR ofa7 nicotinic receptor agonists derived from tilorone: exploration of a novel nicotinic pharmacophore.EBI Abbott Laboratories
22222032 3 Synthesis and binding affinity ata4ß2 anda7 nicotinic acetylcholine receptors of new analogs of epibatidine and epiboxidine containing the 7-azabicyclo[2.2.1]hept-2-ene ring system.EBI Universit£ degli Studi di Milano
21905669 9 Discovery of isoxazole analogues of sazetidine-A as selectivea4ß2-nicotinic acetylcholine receptor partial agonists for the treatment of depression.EBI University of Illinois at Chicago
21920761 52 Acetylcholine binding protein (AChBP) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors.EBI VU University Amsterdam
21319801 54 Synthesis of 2-(substituted phenyl)-3,5,5-trimethylmorpholine analogues and their effects on monoamine uptake, nicotinic acetylcholine receptor function, and behavioral effects of nicotine.EBI Research Triangle Institute
21397497 18 Discovery of non-peptide, small molecule antagonists ofa9a10 nicotinic acetylcholine receptors as novel analgesics for the treatment of neuropathic and tonic inflammatory pain.EBI University of Kentucky
20509659 182 Synthesis and characterization of in vitro and in vivo profiles of hydroxybupropion analogues: aids to smoking cessation.EBI Barrow Neurological Institute
20465311 36 Novel alpha-7 nicotinic acetylcholine receptor agonists containing a urea moiety: identification and characterization of the potent, selective, and orally efficacious agonist 1-[6-(4-fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) urea (SEN34625/WYE-103914).EBI Siena Biotech SpA
20158204 136 Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation.EBI Research Triangle Institute
 11 Novel 2-(2′-furo[3,2-b]pyridinyl) pyrrolidines: potent neuronal nicotinic acetylcholine receptor ligandsEBI TBA
19331415 23 Use of acetylcholine binding protein in the search for novel alpha7 nicotinic receptor ligands. In silico docking, pharmacological screening, and X-ray analysis.EBI Institute
19232492 32 Preparation and characterization of N-(3-pyridinyl) spirocyclic diamines as ligands for nicotinic acetylcholine receptors.EBI Abbott Laboratories
19208472 52 Gamma-lactams--a novel scaffold for highly potent and selective alpha 7 nicotinic acetylcholine receptor agonists.EBI Novartis Institutes for Biomedical Research
19027295 108 Carbamoylcholine analogs as nicotinic acetylcholine receptor agonists--structural modifications of 3-(dimethylamino)butyl dimethylcarbamate (DMABC).EBI Copenhagen University
18789861 26 Discovery and optimization of substituted piperidines as potent, selective, CNS-penetrant alpha4beta2 nicotinic acetylcholine receptor potentiators.EBI Amgen Inc.
18644719 18 Epiboxidine and novel-related analogues: a convenient synthetic approach and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes.EBI Università degli Studi di Milano
17827002 6 Synthesis of poison-frog alkaloids 233A, 235U, and 251AA and their inhibitory effects on neuronal nicotinic acetylcholine receptors.EBI University of Toyama
17604168 3 Synthesis of desformylflustrabromine and its evaluation as an alpha4beta2 and alpha7 nACh receptor modulator.EBI Virginia Commonwealth University
17391965 28 Aporphine metho salts as neuronal nicotinic acetylcholine receptor blockers.EBI University of Chile
14684341 15 Synthesis and nicotinic receptor activity of a hydroxylated tropane.EBI University of Wollongong
12565964 4 5-Azidoepibatidine: an exceptionally potent photoaffinity ligand for neuronal alpha 4 beta 2 and alpha 7 nicotinic acetylcholine receptors.EBI University of California
12061885 22 Structural features of azidopyridinyl neonicotinoid probes conferring high affinity and selectivity for mammalian alpha4beta2 and Drosophila nicotinic receptors.EBI University of California
10447950 15 Molecular recognition in nicotinic acetylcholine receptors: the importance of pi-cation interactions.EBI Targacept Inc.
10377231 2 Synthesis and nicotinic acetylcholine receptor in vivo binding properties of 2-fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine: a new positron emission tomography ligand for nicotinic receptors.EBI CEA/DSV
9873508 3 Conformationally restricted analogues of nicotine and anabasine.EBI SIBIA Neurosciences Inc.
9871663 49 Synthesis and structure-activity relationships of pyridine-modified analogs of 3-[2-((S)-pyrrolidinyl)methoxy]pyridine, A-84543, a potent nicotinic acetylcholine receptor agonist.EBI Abbott Laboratories
27552286 22 FABP1: A Novel Hepatic Endocannabinoid and Cannabinoid Binding Protein.BDB Avanti Polar Lipids
23661699 15 Structural and biochemical characterization of compounds inhibiting Mycobacterium tuberculosis pantothenate kinase.BDB Uppsala University
25626527 6 Novel Diketopiperazine Dihydroorotate Dehydrogenase Inhibitors Purified from Traditional Tibetan Animal Medicine Osteon Myospalacem Baileyi.BDB Chinese Academy of Sciences