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32 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
27591006 24 Discovery of N-(1-(3-(4-phenoxyphenyl)-1,2,4-oxadiazol-5-yl)ethyl)acetamides as novel acetyl-CoA carboxylase 2 (ACC2) inhibitors with peroxisome proliferator-activated receptora/d (PPARa/d) dual agonistic activity.EBI The University of Tokyo
26411795 40 Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase.EBI Pfizer
25333641 11 Recent advances in the development of acetyl-CoA carboxylase (ACC) inhibitors for the treatment of metabolic disease.EBI Amgen, Inc.
25423286 26 Decreasing the rate of metabolic ketone reduction in the discovery of a clinical acetyl-CoA carboxylase inhibitor for the treatment of diabetes.EBI Pfizer Inc.
24294923 65 Piperazine oxadiazole inhibitors of acetyl-CoA carboxylase.EBI Amgen Inc.
23981033 44 Spirolactam-based acetyl-CoA carboxylase inhibitors: toward improved metabolic stability of a chromanone lead structure.EBI Pfizer Inc.
21726077 51 The lipogenesis pathway as a cancer target.EBI Wayne State University
22677317 23 Symmetrical approach of spiro-pyrazolidinediones as acetyl-CoA carboxylase inhibitors.EBI Takeda Pharmaceutical Company, Ltd
22560583 48 Design, synthesis, and structure-activity relationships of novel spiro-piperidines as acetyl-CoA carboxylase inhibitors.EBI Takeda Pharmaceutical Company, Ltd
21324704 4 Discovery of novel (4-piperidinyl)-piperazines as potent and orally active acetyl-CoA carboxylase 1/2 non-selective inhibitors: F-Boc and triF-Boc groups are acid-stable bioisosteres for the Boc group.EBI Taisho Pharmaceutical Co., Ltd
16789734 42 Synthesis and structure-activity relationships of N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy derivatives as selective acetyl-CoA carboxylase 2 inhibitors.EBI Abbott Laboratories
22148323 53 Maximizing lipophilic efficiency: the use of Free-Wilson analysis in the design of inhibitors of acetyl-CoA carboxylase.EBI Pfizer Inc.
21944854 40 Design, synthesis, and structure-activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors.EBI Takeda Pharmaceutical Company, Ltd
21515056 61 Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats.EBI AstraZeneca Research and Development
21082864 87 Identification and synthesis of novel inhibitors of acetyl-CoA carboxylase with in vitro and in vivo efficacy on fat oxidation.EBI Sanofi-Aventis Deutschland GmbH
20219367 96 Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2.EBI Pfizer Global Research and Development
19853443 6 (4-Piperidinyl)-piperazine: a new platform for acetyl-CoA carboxylase inhibitors.EBI Taisho Pharmaceutical Co, Ltd
19740659 82 Potent biphenyl- and 3-phenyl pyridine-based inhibitors of acetyl-CoA carboxylase.EBI Bristol-Myers Squibb Research and Development
17383874 15 2-hydroxy-N-arylbenzenesulfonamides as ATP-citrate lyase inhibitors.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
17298049 28 N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1-methylprop-2-ynyl}carboxy derivatives as acetyl-coA carboxylase inhibitors--improvement of cardiovascular and neurological liabilities via structural modifications.EBI Abbott Laboratories
17267221 56 Phenoxy thiazole derivatives as potent and selective acetyl-CoA carboxylase 2 inhibitors: Modulation of isozyme selectivity by incorporation of phenyl ring substituents.EBI Abbott Laboratories
17234407 60 The synthesis and structure-activity relationship studies of selective acetyl-CoA carboxylase inhibitors containing 4-(thiazol-5-yl)but-3-yn-2-amino motif: polar region modifications.EBI Abbott Laboratories
16973360 82 Structure-activity relationships for a novel series of thiazolyl phenyl ether derivatives exhibiting potent and selective acetyl-CoA carboxylase 2 inhibitory activity.EBI Abbott Laboratories